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Science 17 February 1995:
Vol. 267. no. 5200, pp. 1024 - 1027
DOI: 10.1126/science.7863329

Articles

Science, Vol 267, Issue 5200, 1024-1027
Copyright © 1995 by American Association for the Advancement of Science


articles

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

SB Parker, G Eichele, P Zhang, A Rawls, AT Sands, A Bradley, EN Olson, JW Harper, and SJ Elledge

Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.

Terminal differentiation is coupled to withdrawal from the cell cycle. The cyclin-dependent kinase inhibitor (CKI) p21Cip1 is transcriptionally regulated by p53 and can induce growth arrest. CKIs are therefore potential mediators of developmental control of cell proliferation. The expression pattern of mouse p21 correlated with terminal differentiation of multiple cell lineages including skeletal muscle, cartilage, skin, and nasal epithelium in a p53-independent manner. Although the muscle-specific transcription factor MyoD is sufficient to activate p21 expression in 10T1/2 cells, p21 was expressed in myogenic cells of mice lacking the genes encoding MyoD and myogenin, demonstrating that p21 expression does not require these transcription factors. The p21 protein may function during development as an inducible growth inhibitor that contributes to cell cycle exit and differentiation.


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Role of the Increase in p21 in Cisplatin-Induced Acute Renal Failure in Rats.
T. MIYAJI, A. KATO, H. YASUDA, Y. FUJIGAKI, and A. HISHIDA (2001)
J. Am. Soc. Nephrol. 12, 900-908
   Abstract »    Full Text »
'Mitotic drive' of expanded CTG repeats in myotonic dystrophy type 1 (DM1).
M. Khajavi, A. M. Tari, N. B. Patel, K. Tsuji, D. R. Siwak, M. L. Meistrich, N. H. A. Terry, and T. Ashizawa (2001)
Hum. Mol. Genet. 10, 855-863
   Abstract »    Full Text »    PDF »
Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.
P. Gunning, V Ferguson, K. Brennan, and E. Hardeman (2001)
J. Cell Sci. 114, 513-524
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Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells.
O. Bang, E. Park, S. Yang, S. Lee, T. Franke, and S. Kang (2001)
J. Cell Sci. 114, 81-88
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Targeted Inactivation of the p21WAF1/cip1 Gene Enhances Apc-initiated Tumor Formation and the Tumor-promoting Activity of a Western-Style High-Risk Diet by Altering Cell Maturation in the Intestinal Mucosa.
W. C. Yang, J. Mathew, A. Velcich, W. Edelmann, R. Kucherlapati, M. Lipkin, K. Yang, and L. H. Augenlicht (2001)
Cancer Res. 61, 565-569
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Rat Protein Tyrosine Phosphatase eta Suppresses the Neoplastic Phenotype of Retrovirally Transformed Thyroid Cells through the Stabilization of p27Kip1.
F. Trapasso, R. Iuliano, A. Boccia, A. Stella, R. Visconti, P. Bruni, G. Baldassarre, M. Santoro, G. Viglietto, and A. Fusco (2000)
Mol. Cell. Biol. 20, 9236-9246
   Abstract »    Full Text »
P53 Regulates Myogenesis by Triggering the Differentiation Activity of Prb.
A. Porrello, M. A. Cerone, S. Coen, A. Gurtner, G. Fontemaggi, L. Cimino, G. Piaggio, A. Sacchi, and S. Soddu (2000)
J. Cell Biol. 151, 1295-1304
   Abstract »    Full Text »    PDF »
Coordinate Control of Muscle Cell Survival by Distinct Insulin-like Growth Factor Activated Signaling Pathways.
M. A. Lawlor and P. Rotwein (2000)
J. Cell Biol. 151, 1131-1140
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Expression of Cyclin-Dependent Kinase Inhibitors in Epiphyseal Chondrocytes Induced to Terminally Differentiate with Thyroid Hormone.
R. T. Ballock, X. Zhou, L. M. Mink, D. H. C. Chen, B. C. Mita, and M. C. Stewart (2000)
Endocrinology 141, 4552-4557
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Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1.
S. Zhang, V. A. Lawless, and M. H. Kaplan (2000)
J. Immunol. 165, 6270-6277
   Abstract »    Full Text »    PDF »
Retinoic Acid Induces Neuronal Differentiation of Embryonal Carcinoma Cells by Reducing Proteasome-dependent Proteolysis of the Cyclin-dependent Inhibitor p27.
G. Baldassarre, A. Boccia, P. Bruni, C. Sandomenico, M. V. Barone, S. Pepe, T. Angrisano, B. Belletti, M. L. Motti, A. Fusco, et al. (2000)
Cell Growth Differ. 11, 517-526
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p27Kip1 is an inducer of intestinal epithelial cell differentiation.
A. Quaroni, J. Q. Tian, P. Seth, and C. Ap Rhys (2000)
Am J Physiol Cell Physiol 279, C1045-C1057
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A Repertoire of Cell Cycle Regulators Whose Expression Is Coordinated with Human Cytotrophoblast Differentiation.
O. Genbacev, M. T. McMaster, and S. J. Fisher (2000)
Am. J. Pathol. 157, 1337-1351
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Cyclin-Dependent Kinase Inhibitory Protein Expression in Human Choroidal Melanoma Tumors.
F. Mouriaux, C.-A. Maurage, P. Labalette, B. Sablonnière, F. Malecaze, and J.-M. Darbon (2000)
Invest. Ophthalmol. Vis. Sci. 41, 2837-2843
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HES-1 Repression of Differentiation and Proliferation in PC12 Cells: Role for the Helix 3-Helix 4 Domain in Transcription Repression.
P. Castella, S. Sawai, K. Nakao, J. A. Wagner, and M. Caudy (2000)
Mol. Cell. Biol. 20, 6170-6183
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Establishment of Irreversible Growth Arrest in Myogenic Differentiation Requires the RB LXCXE-Binding Function.
T.-T. Chen and J. Y. J. Wang (2000)
Mol. Cell. Biol. 20, 5571-5580
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Nuclear Factor {{kappa}}B Subunits Induce Epithelial Cell Growth Arrest.
C. S. Seitz, H. Deng, K. Hinata, Q. Lin, and P. A. Khavari (2000)
Cancer Res. 60, 4085-4092
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A Role for p27/Kip1 in the Control of Cerebellar Granule Cell Precursor Proliferation.
K. Miyazawa, T. Himi, V. Garcia, H. Yamagishi, S. Sato, and Y. Ishizaki (2000)
J. Neurosci. 20, 5756-5763
   Abstract »    Full Text »    PDF »



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