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Science 17 February 1995: Vol. 267. no. 5200, pp. 1022 - 1024 DOI: 10.1126/science.7863328
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Articles
Science, Vol 267, Issue 5200, 1022-1024
Copyright © 1995 by American Association for the Advancement of Science
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
SX Skapek,
J Rhee,
DB Spicer,
and
AB Lassar
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Although the myogenic regulator MyoD is expressed in proliferating myoblasts, differentiation of these cells is limited to the G0 phase of the cell cycle. Forced expression of cyclin D1, but not cyclins A, B, or E, inhibited the ability of MyoD to transactivate muscle-specific genes and correlated with phosphorylation of MyoD. Transfection of myoblasts with cyclin-dependent kinase (Cdk) inhibitors p21 and p16 augmented muscle-specific gene expression in cells maintained in high concentrations of serum, suggesting that an active cyclin-Cdk complex suppresses MyoD function in proliferating cells.
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| Abstract »
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12, 900-908
| Abstract »
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| Abstract »
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| PDF »
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- P Goichberg, M Shtutman, A Ben-Ze'ev, and B Geiger (2001)
J. Cell Sci.
114, 1309-1319
| Abstract »
| PDF »
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- E Lamar, C Kintner, and M Goulding (2001)
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| Abstract »
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58, 837-844
| Abstract »
| Full Text »
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- U. Delling, J. Tureckova, H. W. Lim, L. J. De Windt, P. Rotwein, and J. D. Molkentin (2000)
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20, 6600-6611
| Abstract »
| Full Text »
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- Z. Wu, P. J. Woodring, K. S. Bhakta, K. Tamura, F. Wen, J. R. Feramisco, M. Karin, J. Y. J. Wang, and P. L. Puri (2000)
Mol. Cell. Biol.
20, 3951-3964
| Abstract »
| Full Text »
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- S. L. Chen, D. H. Dowhan, B. M. Hosking, and G. E.O. Muscat (2000)
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14, 1209-1228
| Abstract »
| Full Text »
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- D. G. Farwell, K. A. Shera, J. I. Koop, G. A. Bonnet, C. P. Matthews, G. W. Reuther, M. D. Coltrera, J. K. McDougall, and A. J. Klingelhutz (2000)
Am. J. Pathol.
156, 1537-1547
| Abstract »
| Full Text »
| PDF »
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- A. Mal, D. Chattopadhyay, M. K. Ghosh, R. Y.C. Poon, T. Hunter, and M. L. Harter (2000)
J. Cell Biol.
149, 281-292
| Abstract »
| Full Text »
| PDF »
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- S. X. Skapek, D. Jansen, T.-F. Wei, T. McDermott, W. Huang, E. N. Olson, and E. Y.-H. P. Lee (2000)
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275, 7212-7223
| Abstract »
| Full Text »
| PDF »
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- T. Adell, A. Gómez-Cuadrado, A. Skoudy, O. S. Pettengill, D. S. Longnecker, and F. X. Real (2000)
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11, 137-147
| Abstract »
| Full Text »
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- Y. Miwa, T. Sasaguri, C. Kosaka, Y. Taba, A. Ishida, T. Abumiya, and Y. Kubohara (2000)
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86, 68-75
| Abstract »
| Full Text »
| PDF »
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- E. G. Reynaud, K. Pelpel, M. Guillier, M. P. Leibovitch, and S. A. Leibovitch (1999)
Mol. Cell. Biol.
19, 7621-7629
| Abstract »
| Full Text »
| PDF »
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- R. J. Bova, D. I. Quinn, J. S. Nankervis, I. E. Cole, B. F. Sheridan, M. J. Jensen, G. J. Morgan, C. J. Hughes, and R. L. Sutherland (1999)
Clin. Cancer Res.
5, 2810-2819
| Abstract »
| Full Text »
| PDF »
- Elevated Cyclin E Levels, Inactive Retinoblastoma Protein, and Suppression of the p27KIP1 Inhibitor Characterize Early Development of Promyeloid Cells into Macrophages.
- Q. Liu, R. W. VanHoy, J. H. Zhou, R. Dantzer, G. G. Freund, and K. W. Kelley (1999)
Mol. Cell. Biol.
19, 6229-6239
| Abstract »
| Full Text »
| PDF »
- The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation.
- R. G. Pestell, C. Albanese, A. T. Reutens, J. E. Segall, R. J. Lee, and A. Arnold (1999)
Endocr. Rev.
20, 501-534
| Abstract »
| Full Text »
| PDF »
- NF-kappa B Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1.
- D. C. Guttridge, C. Albanese, J. Y. Reuther, R. G. Pestell, and A. S. Baldwin Jr. (1999)
Mol. Cell. Biol.
19, 5785-5799
| Abstract »
| Full Text »
| PDF »
- Critical Role Played by Cyclin D3 in the MyoD-Mediated Arrest of Cell Cycle during Myoblast Differentiation.
- C. Cenciarelli, F. De Santa, P. L. Puri, E. Mattei, L. Ricci, F. Bucci, A. Felsani, and M. Caruso (1999)
Mol. Cell. Biol.
19, 5203-5217
| Abstract »
| Full Text »
| PDF »
- The Nuclear Receptor Corepressor N-CoR Regulates Differentiation: N-CoR Directly Interacts with MyoD.
- P. Bailey, M. Downes, P. Lau, J. Harris, S. L. Chen, Y. Hamamori, V. Sartorelli, and G. E. O. Muscat (1999)
Mol. Endocrinol.
13, 1155-1168
| Abstract »
| Full Text »
- Voltage-Activated K+ Channels and Membrane Depolarization Regulate Accumulation of the Cyclin-Dependent Kinase Inhibitors p27Kip1 and p21CIP1 in Glial Progenitor Cells.
- C. A. Ghiani, X. Yuan, A. M. Eisen, P. L. Knutson, R. A. DePinho, C. J. McBain, and V. Gallo (1999)
J. Neurosci.
19, 5380-5392
| Abstract »
| Full Text »
| PDF »
- cdk1- and cdk2-Mediated Phosphorylation of MyoD Ser200 in Growing C2 Myoblasts: Role in Modulating MyoD Half-Life and Myogenic Activity.
- M. Kitzmann, M. Vandromme, V. Schaeffer, G. Carnac, J.-C. Labbe, N. Lamb, and A. Fernandez (1999)
Mol. Cell. Biol.
19, 3167-3176
| Abstract »
| Full Text »
| PDF »
- Reduced Differentiation Potential of Primary MyoD-/- Myogenic Cells Derived from Adult Skeletal Muscle.
- L. A. Sabourin, A. Girgis-Gabardo, P. Seale, A. Asakura, and M. A. Rudnicki (1999)
J. Cell Biol.
144, 631-643
| Abstract »
| Full Text »
| PDF »
- p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step.
- P. Zhang, C. Wong, D. Liu, M. Finegold, J. W. Harper, and S. J. Elledge (1999)
Genes & Dev.
13, 213-224
| Abstract »
| Full Text »
- Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors.
- C. Ghiani, A. Eisen, X Yuan, R. DePinho, C. McBain, and V Gallo (1999)
Development
126, 1077-1090
| Abstract »
| PDF »
- Direct Involvement of N-Cadherin-mediated Signaling in Muscle Differentiation.
- P. Goichberg and B. Geiger (1998)
Mol. Biol. Cell
9, 3119-3131
| Abstract »
| Full Text »
- Cooperation between the Cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development.
- P. Zhang, C. Wong, R. A. DePinho, J. W. Harper, and S. J. Elledge (1998)
Genes & Dev.
12, 3162-3167
| Abstract »
| Full Text »
- Purification, Characterization, and Kinetic Mechanism of Cyclin D1·CDK4, a Major Target for Cell Cycle Regulation.
- A. K. Konstantinidis, R. Radhakrishnan, F. Gu, R. N. Rao, and W.-K. Yeh (1998)
J. Biol. Chem.
273, 26506-26515
| Abstract »
| Full Text »
| PDF »
- The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle-specific Expression in Muscle Cells.
- M. Kitzmann, G. Carnac, M. Vandromme, M. Primig, N. J.C. Lamb, and A. Fernandez (1998)
J. Cell Biol.
142, 1447-1459
| Abstract »
| Full Text »
| PDF »
- Proliferation-independent Induction of Macrophage Cyclin D2, and Repression of Cyclin D1, by Lipopolysaccharide.
- P. K. Vadiveloo, G. Vairo, A. K. Royston, U. Novak, and J. A. Hamilton (1998)
J. Biol. Chem.
273, 23104-23109
| Abstract »
| Full Text »
| PDF »
- Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation.
- A. Song, Q. Wang, M. G. Goebl, and M. A. Harrington (1998)
Mol. Cell. Biol.
18, 4994-4999
| Abstract »
| Full Text »
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- T. Bellido, C. A. O'Brien, P. K. Roberson, and S. C. Manolagas (1998)
J. Biol. Chem.
273, 21137-21144
| Abstract »
| Full Text »
| PDF »
- Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein.
- H. H. Shih, S. G. Tevosian, and A. S. Yee (1998)
Mol. Cell. Biol.
18, 4732-4743
| Abstract »
| Full Text »
- Arresting developments in the cardiac myocyte cell cycle: Role of cyclin-dependent kinase inhibitors.
- G. Brooks, R. A Poolman, and J.-M. Li (1998)
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39, 301-311
| Abstract »
| Full Text »
| PDF »
- Bcl-2 Expression Identifies an Early Stage of Myogenesis and Promotes Clonal Expansion of Muscle Cells.
- J. A. Dominov, J. J. Dunn, and J. B. Miller (1998)
J. Cell Biol.
142, 537-544
| Abstract »
| Full Text »
| PDF »
- Up-Regulation of p21WAF1 by Phorbol Ester and Calcium in Human Keratinocytes through a Protein Kinase C-Dependent Pathway.
- C. Todd and N. J. Reynolds (1998)
Am. J. Pathol.
153, 39-45
| Abstract »
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- C. Neuveut, K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and K.-T. Jeang (1998)
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18, 3620-3632
| Abstract »
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- B. Tong, H. L. Grimes, T.-Y. Yang, S. E. Bear, Z. Qin, K. Du, W. S. El-Deiry, and P. N. Tsichlis (1998)
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18, 2462-2473
| Abstract »
| Full Text »
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- K. Inoue and C. J. Sherr (1998)
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18, 1590-1600
| Abstract »
| Full Text »
- Increase in p202 Expression during Skeletal Muscle Differentiation: Inhibition of MyoD Protein Expression and Activity by p202.
- B. Datta, W. Min, S. Burma, and P. Lengyel (1998)
Mol. Cell. Biol.
18, 1074-1083
| Abstract »
| Full Text »
- Cell Cycle-regulated Expression of the Muscle Determination Factor Myf5 in Proliferating Myoblasts.
- C. Lindon, D. Montarras, and C. Pinset (1998)
J. Cell Biol.
140, 111-118
| Abstract »
| Full Text »
| PDF »
- Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation.
- B. Harvat, A Wang, P Seth, and A. Jetten (1998)
J. Cell Sci.
111, 1185-1196
| Abstract »
| PDF »
- A Role for the Putative Tumor Suppressor Bin1 in Muscle Cell Differentiation.
- R. J. Wechsler-Reya, K. J. Elliott, and G. C. Prendergast (1998)
Mol. Cell. Biol.
18, 566-575
| Abstract »
| Full Text »
- Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.
- W. R. Sellers, B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar, and W. G. Kaelin Jr. (1998)
Genes & Dev.
12, 95-106
| Abstract »
| Full Text »
- Differential Phosphorylation of T-47D Human Breast Cancer Cell Substrates by D1-, D3-, E-, and A-type Cyclin-CDK Complexes.
- B. Sarcevic, R. Lilischkis, and R. L. Sutherland (1997)
J. Biol. Chem.
272, 33327-33337
| Abstract »
| Full Text »
| PDF »
- Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases.
- A. M. Bennett and N. K. Tonks (1997)
Science
278, 1288-1291
| Abstract »
| Full Text »
- Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1.
- S. D. Groshong, G. I. Owen, B. Grimison, I. E. Schauer, M. C. Todd, T. A. Langan, R. A. Sclafani, C. A. Lange, and K. B. Horwitz (1997)
Mol. Endocrinol.
11, 1593-1607
| Abstract »
| Full Text »
- A Novel, Nerve Growth Factor-activated Pathway Involving Nitric Oxide, p53, and p21WAF1 Regulates Neuronal Differentiation of PC12 Cells.
- W. Poluha, C. M. Schonhoff, K. S. Harrington, M. B. Lachyankar, N. E. Crosbie, D. A. Bulseco, and A. H. Ross (1997)
J. Biol. Chem.
272, 24002-24007
| Abstract »
| Full Text »
| PDF »
- Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.
- P. Casaccia-Bonnefil, R. Tikoo, H. Kiyokawa, V. Friedrich Jr., M. V. Chao, and A. Koff (1997)
Genes & Dev.
11, 2335-2346
| Abstract »
| Full Text »
| PDF »
- PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.
- S. Altiok, M. Xu, and B. M. Spiegelman (1997)
Genes & Dev.
11, 1987-1998
| Abstract »
| Full Text »
| PDF »
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