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Science 17 February 1995:
Vol. 267. no. 5200, pp. 1018 - 1021
DOI: 10.1126/science.7863327

Articles

Science, Vol 267, Issue 5200, 1018-1021
Copyright © 1995 by American Association for the Advancement of Science


articles

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

O Halevy, BG Novitch, DB Spicer, SX Skapek, J Rhee, GJ Hannon, D Beach, and AB Lassar

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Skeletal muscle differentiation entails the coordination of muscle-specific gene expression and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb). The function of Rb is negatively regulated by cyclin-dependent kinases (Cdks), which are controlled by Cdk inhibitors. Expression of MyoD, a skeletal muscle-specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells. MyoD-mediated induction of p21 did not require the tumor suppressor protein p53 and correlated with cell cycle withdrawal. Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.


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P. Riou, M. Vandromme, and L. Gazzolo (2001)
Cell Growth Differ. 12, 613-622
   Abstract »    Full Text »    PDF »
Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes.
V. Baccini, L. Roy, N. Vitrat, H. Chagraoui, S. Sabri, J.-P. L. Couedic, N. Debili, F. Wendling, and W. Vainchenker (2001)
Blood 98, 3274-3282
   Abstract »    Full Text »    PDF »
Common Regulation of Growth Arrest and Differentiation of Osteoblasts by Helix-Loop-Helix Factors.
N. Funato, K. Ohtani, K. Ohyama, T. Kuroda, and M. Nakamura (2001)
Mol. Cell. Biol. 21, 7416-7428
   Abstract »    Full Text »    PDF »
Up-Regulation of p27Kip1 by Progestins Is Involved in the Growth Suppression of the Normal and Malignant Human Endometrial Glandular Cells.
T. Shiozawa, A. Horiuchi, K. Kato, M. Obinata, I. Konishi, S. Fujii, and T. Nikaido (2001)
Endocrinology 142, 4182-4188
   Abstract »    Full Text »    PDF »
Tumor Susceptibility of p21Waf1/Cip1-deficient Mice.
J. Martin-Caballero, J. M. Flores, P. Garcia-Palencia, and M. Serrano (2001)
Cancer Res. 61, 6234-6238
   Abstract »    Full Text »    PDF »
p21cip1 Degradation in Differentiated Keratinocytes Is Abrogated by Costabilization with Cyclin E Induced by Human Papillomavirus E7.
F. Noya, W.-M. Chien, T. R. Broker, and L. T. Chow (2001)
J. Virol. 75, 6121-6134
   Abstract »    Full Text »    PDF »
The third wave of myotome colonization by mitotically competent progenitors: regulating the balance between differentiation and proliferation during muscle development.
N. Kahane, Y. Cinnamon, I. Bachelet, and C. Kalcheim (2001)
Development 128, 2187-2198
   Abstract »    Full Text »    PDF »
Role of the Increase in p21 in Cisplatin-Induced Acute Renal Failure in Rats.
T. MIYAJI, A. KATO, H. YASUDA, Y. FUJIGAKI, and A. HISHIDA (2001)
J. Am. Soc. Nephrol. 12, 900-908
   Abstract »    Full Text »
'Mitotic drive' of expanded CTG repeats in myotonic dystrophy type 1 (DM1).
M. Khajavi, A. M. Tari, N. B. Patel, K. Tsuji, D. R. Siwak, M. L. Meistrich, N. H. A. Terry, and T. Ashizawa (2001)
Hum. Mol. Genet. 10, 855-863
   Abstract »    Full Text »    PDF »
MyoD and Myogenin Expression Patterns in Cultures of Fetal and Adult Chicken Myoblasts.
Z. Yablonka–Reuveni and B. M. Paterson (2001)
J. Histochem. Cytochem. 49, 455-462
   Abstract »    Full Text »
Coordinated Regulation of Rap1 and Thyroid Differentiation by Cyclic AMP and Protein Kinase A.
O. M. Tsygankova, A. Saavedra, J. F. Rebhun, L. A. Quilliam, and J. L. Meinkoth (2001)
Mol. Cell. Biol. 21, 1921-1929
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Recruitment of (&bgr;)-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction.
P Goichberg, M Shtutman, A Ben-Ze'ev, and B Geiger (2001)
J. Cell Sci. 114, 1309-1319
   Abstract »    PDF »
Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle.
P. Gunning, V Ferguson, K. Brennan, and E. Hardeman (2001)
J. Cell Sci. 114, 513-524
   Abstract »    PDF »
p53 Regulates Myogenesis by Triggering the Differentiation Activity of pRb.
A. Porrello, M. A. Cerone, S. Coen, A. Gurtner, G. Fontemaggi, L. Cimino, G. Piaggio, A. Sacchi, and S. Soddu (2000)
J. Cell Biol. 151, 1295-1304
   Abstract »    Full Text »    PDF »
Coordinate Control of Muscle Cell Survival by Distinct Insulin-like Growth Factor Activated Signaling Pathways.
M. A. Lawlor and P. Rotwein (2000)
J. Cell Biol. 151, 1131-1140
   Abstract »    Full Text »    PDF »
Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21.
M. A. Lawlor and P. Rotwein (2000)
Mol. Cell. Biol. 20, 8983-8995
   Abstract »    Full Text »



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