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Science 17 February 1995:
Vol. 267. no. 5200, pp. 1016 - 1018
DOI: 10.1126/science.7863326
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Articles

Science, Vol 267, Issue 5200, 1016-1018
Copyright © 1995 by American Association for the Advancement of Science

articles

Peptide specificity in the recognition of MHC class I by natural killer cell clones

MS Malnati, M Peruzzi, KC Parker, WE Biddison, E Ciccone, A Moretta, and EO Long

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, MD 20852.

Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.


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