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Science 10 February 1995: Vol. 267. no. 5199, pp. 891 - 893 DOI: 10.1126/science.7531366
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Articles
Science, Vol 267, Issue 5199, 891-893
Copyright © 1995 by American Association for the Advancement of Science
Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
N Boudreau,
CJ Sympson,
Z Werb,
and
MJ Bissell
Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720.
Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.
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Mol. Cell. Biol.
20, 5184-5195
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- Glucocorticoids Maintain the Extracellular Matrix of Differentiated Mammary Tissue During Explant and Whole Organ Culture.
- T. M. Casey, A. Boecker, J.-F. Chiu, and K. Plaut (2000)
Experimental Biology and Medicine
224, 76-86
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- The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells.
- G. Tezel and M. B. Wax (2000)
J. Neurosci.
20, 3552-3562
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- The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1{beta}-Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells.
- J. L. Young, G. K. Sukhova, D. Foster, W. Kisiel, P. Libby, and U. Schonbeck (2000)
J. Exp. Med.
191, 1535-1544
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- Mouse proximal tubular cell-cell adhesion inhibits apoptosis by a cadherin-dependent mechanism.
- E. Bergin, J. S. Levine, J. S. Koh, and W. Lieberthal (2000)
Am J Physiol Renal Physiol
278, F758-F768
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- Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization.
- A. P. Gilmore, A. D. Metcalfe, L. H. Romer, and C. H. Streuli (2000)
J. Cell Biol.
149, 431-446
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- Calreticulin Couples Calcium Release and Calcium Influx in Integrin-mediated Calcium Signaling.
- M. S. Kwon, C. S. Park, K.-r. Choi, C.-S. Park, J. Ahnn, J. I. Kim, S. H. Eom, S. J. Kaufman, and W. K. Song (2000)
Mol. Biol. Cell
11, 1433-1443
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- Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells.
- A. Danilkovitch, S. Donley, A. Skeel, and E. J. Leonard (2000)
Mol. Cell. Biol.
20, 2218-2227
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- Polyamine depletion delays apoptosis of rat intestinal epithelial cells.
- R. M. Ray, M. J. Viar, Q. Yuan, and L. R. Johnson (2000)
Am J Physiol Cell Physiol
278, C480-C489
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- Caspase-mediated Cleavage of p130cas in Etoposide-induced Apoptotic Rat-1 Cells.
- S. Kook, S. R. Shim, S. J. Choi, J. Ahnn, J. I. Kim, S. H. Eom, Y. K. Jung, S. G. Paik, and W. K. Song (2000)
Mol. Biol. Cell
11, 929-939
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- Upstream Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Element-1, a Novel and Essential Regulatory DNA Motif in the Human TIMP-1 Gene Promoter, Directly Interacts with a 30-kDa Nuclear Protein.
- J. E. Trim, S. K. Samra, M. J. P. Arthur, M. C. Wright, M. McAulay, R. Beri, and D. A. Mann (2000)
J. Biol. Chem.
275, 6657-6663
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- Interferon-{gamma} Induces Interleukin-1 Converting Enzyme Expression in Pancreatic Islets by an Interferon Regulatory Factor-1-Dependent Mechanism.
- A. E. Karlsen, D. Pavlovic, K. Nielsen, J. Jensen, H. U. Andersen, F. Pociot, T. Mandrup-Poulsen, D. L. Eizirik, and J. Nerup (2000)
J. Clin. Endocrinol. Metab.
85, 830-836
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- Cooperative Effect of Hepatocyte Growth Factor and Fibronectin in Anchorage-independent Survival of Mammary Carcinoma Cells: Requirement for Phosphatidylinositol 3-Kinase Activity.
- H. Qiao, R. Saulnier, A. Patryzkat, N. Rahimi, L. Raptis, J. Rossiter, E. Tremblay, and B. Elliott (2000)
Cell Growth Differ.
11, 123-133
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- Lactational competence and involution of the mouse mammary gland require plasminogen.
- L. Lund, S. Bjorn, M. Sternlicht, B. Nielsen, H Solberg, P. Usher, R Osterby, I. Christensen, R. Stephens, T. Bugge, et al. (2000)
Development
127, 4481-4492
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- alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.
- C. DiPersio, R van der Neut, E Georges-Labouesse, J. Kreidberg, A Sonnenberg, and R. Hynes (2000)
J. Cell Sci.
113, 3051-3062
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- Molecular mechanisms of hormone-mediated Mullerian duct regression: involvement of beta-catenin.
- S Allard, P Adin, L Gouedard, N di Clemente, N Josso, M. Orgebin-Crist, J. Picard, and F Xavier (2000)
Development
127, 3349-3360
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- Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.
- A. Nguyen and J. Pollard (2000)
Development
127, 3107-3118
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- Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling.
- P Schedin, R Strange, T Mitrenga, P Wolfe, and M Kaeck (2000)
J. Cell Sci.
113, 795-806
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- Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression.
- P Pujuguet, M Simian, J Liaw, R Timpl, Z Werb, and M. Bissell (2000)
J. Cell Sci.
113, 849-858
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- Interaction with Endothelial Cells Is a Prerequisite for Branching Ductal-Alveolar Morphogenesis and Hyperplasia of Preneoplastic Human Breast Epithelial Cells: Regulation by Estrogen.
- M. P. V. Shekhar, J. Werdell, and L. Tait (2000)
Cancer Res.
60, 439-449
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- Lymphoid adhesion promotes human thymic epithelial cell survival via NF-(kappa)B activation.
- M. Scupoli, E Fiorini, P. Marchisio, O Poffe, E Tagliabue, M Brentegani, G Tridente, and D Ramarli (2000)
J. Cell Sci.
113, 169-177
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- ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization.
- R. E. Laliberte, J. Eggler, and C. A. Gabel (1999)
J. Biol. Chem.
274, 36944-36951
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