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Science 10 February 1995:
Vol. 267. no. 5199, pp. 891 - 893
DOI: 10.1126/science.7531366

Articles

Science, Vol 267, Issue 5199, 891-893
Copyright © 1995 by American Association for the Advancement of Science


articles

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix

N Boudreau, CJ Sympson, Z Werb, and MJ Bissell

Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720.

Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.


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Calreticulin Couples Calcium Release and Calcium Influx in Integrin-mediated Calcium Signaling.
M. S. Kwon, C. S. Park, K.-r. Choi, C.-S. Park, J. Ahnn, J. I. Kim, S. H. Eom, S. J. Kaufman, and W. K. Song (2000)
Mol. Biol. Cell 11, 1433-1443
   Abstract »    Full Text »
Two Independent Signaling Pathways Mediate the Antiapoptotic Action of Macrophage-Stimulating Protein on Epithelial Cells.
A. Danilkovitch, S. Donley, A. Skeel, and E. J. Leonard (2000)
Mol. Cell. Biol. 20, 2218-2227
   Abstract »    Full Text »
Polyamine depletion delays apoptosis of rat intestinal epithelial cells.
R. M. Ray, M. J. Viar, Q. Yuan, and L. R. Johnson (2000)
Am J Physiol Cell Physiol 278, C480-C489
   Abstract »    Full Text »    PDF »
Caspase-mediated Cleavage of p130cas in Etoposide-induced Apoptotic Rat-1 Cells.
S. Kook, S. R. Shim, S. J. Choi, J. Ahnn, J. I. Kim, S. H. Eom, Y. K. Jung, S. G. Paik, and W. K. Song (2000)
Mol. Biol. Cell 11, 929-939
   Abstract »    Full Text »
Upstream Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Element-1, a Novel and Essential Regulatory DNA Motif in the Human TIMP-1 Gene Promoter, Directly Interacts with a 30-kDa Nuclear Protein.
J. E. Trim, S. K. Samra, M. J. P. Arthur, M. C. Wright, M. McAulay, R. Beri, and D. A. Mann (2000)
J. Biol. Chem. 275, 6657-6663
   Abstract »    Full Text »    PDF »
Interferon-{gamma} Induces Interleukin-1 Converting Enzyme Expression in Pancreatic Islets by an Interferon Regulatory Factor-1-Dependent Mechanism.
A. E. Karlsen, D. Pavlovic, K. Nielsen, J. Jensen, H. U. Andersen, F. Pociot, T. Mandrup-Poulsen, D. L. Eizirik, and J. Nerup (2000)
J. Clin. Endocrinol. Metab. 85, 830-836
   Abstract »    Full Text »
Cooperative Effect of Hepatocyte Growth Factor and Fibronectin in Anchorage-independent Survival of Mammary Carcinoma Cells: Requirement for Phosphatidylinositol 3-Kinase Activity.
H. Qiao, R. Saulnier, A. Patryzkat, N. Rahimi, L. Raptis, J. Rossiter, E. Tremblay, and B. Elliott (2000)
Cell Growth Differ. 11, 123-133
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Lactational competence and involution of the mouse mammary gland require plasminogen.
L. Lund, S. Bjorn, M. Sternlicht, B. Nielsen, H Solberg, P. Usher, R Osterby, I. Christensen, R. Stephens, T. Bugge, et al. (2000)
Development 127, 4481-4492
   Abstract »    PDF »
alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.
C. DiPersio, R van der Neut, E Georges-Labouesse, J. Kreidberg, A Sonnenberg, and R. Hynes (2000)
J. Cell Sci. 113, 3051-3062
   Abstract »    PDF »
Molecular mechanisms of hormone-mediated Mullerian duct regression: involvement of beta-catenin.
S Allard, P Adin, L Gouedard, N di Clemente, N Josso, M. Orgebin-Crist, J. Picard, and F Xavier (2000)
Development 127, 3349-3360
   Abstract »    PDF »
Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.
A. Nguyen and J. Pollard (2000)
Development 127, 3107-3118
   Abstract »    PDF »
Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling.
P Schedin, R Strange, T Mitrenga, P Wolfe, and M Kaeck (2000)
J. Cell Sci. 113, 795-806
   Abstract »    PDF »
Nidogen-1 regulates laminin-1-dependent mammary-specific gene expression.
P Pujuguet, M Simian, J Liaw, R Timpl, Z Werb, and M. Bissell (2000)
J. Cell Sci. 113, 849-858
   Abstract »    PDF »
Interaction with Endothelial Cells Is a Prerequisite for Branching Ductal-Alveolar Morphogenesis and Hyperplasia of Preneoplastic Human Breast Epithelial Cells: Regulation by Estrogen.
M. P. V. Shekhar, J. Werdell, and L. Tait (2000)
Cancer Res. 60, 439-449
   Abstract »    Full Text »
Lymphoid adhesion promotes human thymic epithelial cell survival via NF-(kappa)B activation.
M. Scupoli, E Fiorini, P. Marchisio, O Poffe, E Tagliabue, M Brentegani, G Tridente, and D Ramarli (2000)
J. Cell Sci. 113, 169-177
   Abstract »    PDF »
ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization.
R. E. Laliberte, J. Eggler, and C. A. Gabel (1999)
J. Biol. Chem. 274, 36944-36951
   Abstract »    Full Text »    PDF »



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