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Science 3 February 1995: Vol. 267. no. 5198, pp. 688 - 693 DOI: 10.1126/science.7839146
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Articles
Science, Vol 267, Issue 5198, 688-693
Copyright © 1995 by American Association for the Advancement of Science
Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
B Lilly,
B Zhao,
G Ranganayakulu,
BM Paterson,
RA Schulz,
and
EN Olson
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and Drosophila embryos. These factors bind an adenine-thymidine-rich DNA sequence associated with muscle-specific genes. The function of MEF2 was determined by generating a loss-of-function of the single mef2 gene in Drosophila (D-mef2). In loss-of-function embryos, somatic, cardiac, and visceral muscle cells did not differentiate, but myoblasts were normally specified and positioned. These results demonstrate that different muscle cell types share a common myogenic differentiation program controlled by MEF2.
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- A Dominant-Negative Form of Transcription Factor MEF2 Inhibits Myogenesis.
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- The Mesodermal Expression of rolling stone (rost) Is Essential for Myoblast Fusion in Drosophila and Encodes a Potential Transmembrane Protein.
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- Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory Elements.
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- Identification of a Novel Marker for Primordial Smooth Muscle and Its Differential Expression Pattern in Contractile vs Noncontractile Cells.
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Development
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- The single MyoD family gene of Ciona intestinalis encodes two differentially expressed proteins: implications for the evolution of chordate muscle gene regulation.
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Development
124, 1711-1721
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- CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
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Development
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- The Specification of Muscle in Drosophila.
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Cold Spring Harb Symp Quant Biol
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Cold Spring Harb Symp Quant Biol
62, 405-411
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