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Science 3 February 1995:
Vol. 267. no. 5198, pp. 679 - 681
DOI: 10.1126/science.7839143
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Articles

Science, Vol 267, Issue 5198, 679-681
Copyright © 1995 by American Association for the Advancement of Science

articles

Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension

SW John, JH Krege, PM Oliver, Hagaman JR, JB Hodgin, SC Pang, TG Flynn, and O Smithies

Department of Pathology, University of North Carolina, Chapel Hill 27599.

To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene. Homozygous mutants had no circulating or atrial ANP, and their blood pressures were elevated by 8 to 23 millimeters of mercury when they were fed standard (0.5 percent sodium chloride) and intermediate (2 percent sodium chloride) salt diets. On standard salt diets, heterozygotes had normal amounts of circulating ANP and normal blood pressures. However, on high (8 percent sodium chloride) salt diets they were hypertensive, with blood pressures elevated by 27 millimeters of mercury. These results demonstrate that genetically reduced production of ANP can lead to salt-sensitive hypertension.


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