Related Content
Search Google Scholar for:
|
|
Science 3 February 1995:
Vol. 267. no. 5198, pp. 643 - 647
DOI: 10.1126/science.7530860
|
|
Articles
Science, Vol 267, Issue 5198, 643-647
Copyright © 1995 by American Association for the Advancement of Science
Aminoacyl-RNA synthesis catalyzed by an RNA
M Illangasekare,
G Sanchez,
T Nickles,
and
M Yarus
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347.
An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (> or = 10(5) times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Efficiency of a self-aminoacylating ribozyme: Effect of the length and base-composition of its 3' extension.
- J. Lehmann, A. Reichel, A. Buguin, and A. Libchaber (2007)
RNA
13, 1191-1197
| Abstract »
| Full Text »
| PDF »
- Emergence of the universal genetic code imprinted in an RNA record.
- M. J. Hohn, H.-S. Park, P. O'Donoghue, M. Schnitzbauer, and D. Soll (2006)
PNAS
103, 18095-18100
| Abstract »
| Full Text »
| PDF »
- Pre-transfer Editing by Class II Prolyl-tRNA Synthetase: ROLE OF AMINOACYLATION ACTIVE SITE IN "SELECTIVE RELEASE" OF NONCOGNATE AMINO ACIDS.
- S. Hati, B. Ziervogel, J. SternJohn, F.-C. Wong, M. C. Nagan, A. E. Rosen, P. G. Siliciano, J. W. Chihade, and K. Musier-Forsyth (2006)
J. Biol. Chem.
281, 27862-27872
| Abstract »
| Full Text »
| PDF »
- Chiral-selective aminoacylation of an RNA minihelix: Mechanistic features and chiral suppression.
- K. Tamura and P. R. Schimmel (2006)
PNAS
103, 13750-13752
| Abstract »
| Full Text »
| PDF »
- Selection and evolution of NTP-specific aptamers.
- L. Weill, D. Louis, and B. Sargueil (2004)
Nucleic Acids Res.
32, 5045-5058
| Abstract »
| Full Text »
| PDF »
- RNA-Mediated Metal-Metal Bond Formation in the Synthesis of Hexagonal Palladium Nanoparticles.
- L. A. Gugliotti, D. L. Feldheim, and B. E. Eaton (2004)
Science
304, 850-852
| Abstract »
| Full Text »
| PDF »
- tRNA synthetase paralogs: Evolutionary links in the transition from tRNA-dependent amino acid biosynthesis to de novo biosynthesis.
- C. Francklyn (2003)
PNAS
100, 9650-9652
| Full Text »
| PDF »
- Peptide synthesis with a template-like RNA guide and aminoacyl phosphate adaptors.
- K. Tamura and P. Schimmel (2003)
PNAS
100, 8666-8669
| Abstract »
| Full Text »
| PDF »
- Finding specific RNA motifs: Function in a zeptomole world?.
- R. KNIGHT and M. YARUS (2003)
RNA
9, 218-230
| Abstract »
| Full Text »
| PDF »
- Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups.
- S. I. Chamberlin, E. J. Merino, and K. M. Weeks (2002)
PNAS
99, 14688-14693
| Abstract »
| Full Text »
| PDF »
- Construction of block-shuffled libraries of DNA for evolutionary protein engineering: Y-ligation-based block shuffling.
- K. Kitamura, Y. Kinoshita, S. Narasaki, N. Nemoto, Y. Husimi, and K. Nishigaki (2002)
Protein Eng. Des. Sel.
15, 843-853
| Abstract »
| Full Text »
| PDF »
- Minihelix-loop RNAs: minimal structures for aminoacylation catalysts.
- K. Ramaswamy, K. Wei, and H. Suga (2002)
Nucleic Acids Res.
30, 2162-2171
| Abstract »
| Full Text »
| PDF »
- In Vitro Selection of Ligase Ribozymes Containing 2'-Amino Groups.
- N. Teramoto, Y. Imanishi, and Y. Ito (2000)
Journal of Bioactive and Compatible Polymers
15, 297-308
| Abstract »
| PDF »
- DzyNA-PCR: Use of DNAzymes to Detect and Quantify Nucleic Acid Sequences in a Real-Time Fluorescent Format.
- A. V. Todd, C. J. Fuery, H. L. Impey, T. L. Applegate, and M. A. Haughton (2000)
Clin. Chem.
46, 625-630
| Abstract »
| Full Text »
| PDF »
- Specific, rapid synthesis of Phe-RNA by RNA.
- M. Illangasekare and M. Yarus (1999)
PNAS
96, 5470-5475
| Abstract »
| Full Text »
| PDF »
- Genetic code origins: Experiments confirm phylogenetic predictions and may explain a puzzle.
- P. Schimmel and L. Ribas de Pouplana (1999)
PNAS
96, 327-328
| Full Text »
| PDF »
- Genetic code origins: tRNAs older than their synthetases?.
- L. R. de Pouplana, R. J. Turner, B. A. Steer, and P. Schimmel (1998)
PNAS
95, 11295-11300
| Abstract »
| Full Text »
| PDF »
- Diverse RNA substrates for aminoacylation: Clues to origins?.
- P. Schimmel and R. Alexander (1998)
PNAS
95, 10351-10353
| Full Text »
| PDF »
- RNA-directed amino acid homochirality.
- J. M. Bailey (1998)
FASEB J
12, 503-507
| Abstract »
| Full Text »
- In vitro selection of self-cleaving RNAs with a low pH optimum.
- V. K. Jayasena and L. Gold (1997)
PNAS
94, 10612-10617
| Abstract »
| Full Text »
| PDF »
- Versatile 5' phosphoryl coupling of small and large molecules to an RNA.
- F. Huang and M. Yarus (1997)
PNAS
94, 8965-8969
| Abstract »
| Full Text »
| PDF »
- The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
- J. G. Arnez, J. G. Augustine, D. Moras, and C. S. Francklyn (1997)
PNAS
94, 7144-7149
| Abstract »
| Full Text »
| PDF »
- Structurally complex and highly active RNA ligases derived from random RNA sequences.
- E. Ekland, J. Szostak, and D. Bartel (1995)
Science
269, 364-370
| Abstract »
| PDF »
- Adenine-Aptamer Complexes. A BIPARTITE RNA SITE THAT BINDS THE ADENINE NUCLEIC BASE.
- M. Meli, J. Vergne, J.-L. Decout, and M.-C. Maurel (2002)
J. Biol. Chem.
277, 2104-2111
| Abstract »
| Full Text »
| PDF »
|
|
