Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 January 1995:
Vol. 267. no. 5197, pp. 531 - 536
DOI: 10.1126/science.7824954
Prev | Table of Contents | Next

Articles

Science, Vol 267, Issue 5197, 531-536
Copyright © 1995 by American Association for the Advancement of Science

articles

Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators

CM Chiang and RG Roeder

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021.

TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). The TAFs in TFIID are essential for activator-dependent transcription. The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described. TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain. The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110. Thus, this human TFIID TAF may be a co-activator that mediates a response to multiple activators through a distinct mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Target Gene Specificity of USF-1 Is Directed via p38-mediated Phosphorylation-dependent Acetylation.
S. Corre, A. Primot, Y. Baron, J. Le Seyec, C. Goding, and M.-D. Galibert (2009)
J. Biol. Chem. 284, 18851-18862
   Abstract »    Full Text »    PDF »
Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP.
P. Pelka, J. N. G. Ablack, J. Torchia, A. S. Turnell, R. J. A. Grand, and J. S. Mymryk (2009)
Nucleic Acids Res. 37, 1095-1106
   Abstract »    Full Text »    PDF »
Nuclear Factor Y Is Required for Basal Activation and Chromatin Accessibility of Fibroblast Growth Factor Receptor 2 Promoter in Osteoblast-like Cells.
F. Sun, Q. Xie, J. Ma, S. Yang, Q. Chen, and A. Hong (2009)
J. Biol. Chem. 284, 3136-3147
   Abstract »    Full Text »    PDF »
Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.
K. J. Wright and R. Tjian (2009)
PNAS 106, 55-60
   Abstract »    Full Text »    PDF »
Identification of a Second CtBP Binding Site in Adenovirus Type 5 E1A Conserved Region 3.
R. K. Bruton, P. Pelka, K. L. Mapp, G. J. Fonseca, J. Torchia, A. S. Turnell, J. S. Mymryk, and R. J. A. Grand (2008)
J. Virol. 82, 8476-8486
   Abstract »    Full Text »    PDF »
A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene.
N. A. Ciccone, C. T. Lacza, M. Y. Hou, S. J. Gregory, K.-Y. Kam, S. Xu, and U. B. Kaiser (2008)
Mol. Endocrinol. 22, 1908-1923
   Abstract »    Full Text »    PDF »
Transcription Factors Sp1 and Sp3 Regulate Expression of Human Extracellular Superoxide Dismutase in Lung Fibroblasts.
I. N. Zelko, M. R. Mueller, and R. J. Folz (2008)
Am. J. Respir. Cell Mol. Biol. 39, 243-251
   Abstract »    Full Text »    PDF »
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
A. Gegonne, J. D. Weissman, H. Lu, M. Zhou, A. Dasgupta, R. Ribble, J. N. Brady, and D. S. Singer (2008)
PNAS 105, 5367-5372
   Abstract »    Full Text »    PDF »
Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders.
A. Rada-Iglesias, A. Ameur, P. Kapranov, S. Enroth, J. Komorowski, T. R. Gingeras, and C. Wadelius (2008)
Genome Res. 18, 380-392
   Abstract »    Full Text »    PDF »
Control of the Calcitonin Gene-related Peptide Enhancer by Upstream Stimulatory Factor in Trigeminal Ganglion Neurons.
K.-Y. Park and A. F. Russo (2008)
J. Biol. Chem. 283, 5441-5451
   Abstract »    Full Text »    PDF »
Cloning and Characterization of the Rat Lysyl Oxidase Gene Promoter: IDENTIFICATION OF CORE PROMOTER ELEMENTS AND FUNCTIONAL NUCLEAR FACTOR I-BINDING SITES.
S. Gao, Y. Zhao, L. Kong, P. Toselli, I.-N. Chou, P. Stone, and W. Li (2007)
J. Biol. Chem. 282, 25322-25337
   Abstract »    Full Text »    PDF »
Epigenetic regulation of human {alpha}1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.
G. A. Michelotti, D. M. Brinkley, D. P. Morris, M. P. Smith, R. J. Louie, and D. A. Schwinn (2007)
FASEB J 21, 1979-1993
   Abstract »    Full Text »    PDF »
Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome.
M. G. Pezzolesi, K. M. Zbuk, K. A. Waite, and C. Eng (2007)
Hum. Mol. Genet. 16, 1058-1071
   Abstract »    Full Text »    PDF »
Abnormal Sperm in Mice Lacking the Taf7l Gene.
Y. Cheng, M. G. Buffone, M. Kouadio, M. Goodheart, D. C. Page, G. L. Gerton, I. Davidson, and P. J. Wang (2007)
Mol. Cell. Biol. 27, 2582-2589
   Abstract »    Full Text »    PDF »
Identification of clustered YY1 binding sites in imprinting control regions.
J. Do Kim, A. K. Hinz, A. Bergmann, J. M. Huang, I. Ovcharenko, L. Stubbs, and J. Kim (2006)
Genome Res. 16, 901-911
   Abstract »    Full Text »    PDF »
TAF7: A possible transcription initiation check-point regulator.
A. Gegonne, J. D. Weissman, M. Zhou, J. N. Brady, and D. S. Singer (2006)
PNAS 103, 602-607
   Abstract »    Full Text »    PDF »
HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells.
R. L. Caldwell, R. Gadipatti, K. B. Lane, and V. L. Shepherd (2006)
J. Leukoc. Biol. 79, 192-201
   Abstract »    Full Text »    PDF »
Functional Characterization of Core Promoter Elements: the Downstream Core Element Is Recognized by TAF1.
D.-H. Lee, N. Gershenzon, M. Gupta, I. P. Ioshikhes, D. Reinberg, and B. A. Lewis (2005)
Mol. Cell. Biol. 25, 9674-9686
   Abstract »    Full Text »    PDF »
Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis.
A. Krippner-Heidenreich, G. Walsemann, M. J. Beyrouthy, S. Speckgens, R. Kraft, H. Thole, R. V. Talanian, M. M. Hurt, and B. Luscher (2005)
Mol. Cell. Biol. 25, 3704-3714
   Abstract »    Full Text »    PDF »
TATA-binding Protein-associated Factor 7 Regulates Polyamine Transport Activity and Polyamine Analog-induced Apoptosis.
J. Fukuchi, R. A. Hiipakka, J. M. Kokontis, K. Nishimura, K. Igarashi, and S. Liao (2004)
J. Biol. Chem. 279, 29921-29929
   Abstract »    Full Text »    PDF »
The Basic Leucine Zipper Domain of c-Jun Functions in Transcriptional Activation through Interaction with the N Terminus of Human TATA-binding Protein-associated Factor-1 (Human TAFII250).
T. N. Lively, T. N. Nguyen, S. K. Galasinski, and J. A. Goodrich (2004)
J. Biol. Chem. 279, 26257-26265
   Abstract »    Full Text »    PDF »
Molecular Cloning and Functional Characterization of the Transcription Factor YY2.
N. Nguyen, X. Zhang, N. Olashaw, and E. Seto (2004)
J. Biol. Chem. 279, 25927-25934
   Abstract »    Full Text »    PDF »
Physical and Functional Interactions between USF and Sp1 Proteins Regulate Human Deoxycytidine Kinase Promoter Activity.
Y. Ge, T. L. Jensen, L. H. Matherly, and J. W. Taub (2003)
J. Biol. Chem. 278, 49901-49910
   Abstract »    Full Text »    PDF »
Glom Is a Novel Mitochondrial DNA Packaging Protein in Physarum polycephalum and Causes Intense Chromatin Condensation without Suppressing DNA Functions.
N. Sasaki, H. Kuroiwa, C. Nishitani, H. Takano, T. Higashiyama, T. Kobayashi, Y. Shirai, A. Sakai, S. Kawano, K. Murakami-Murofushi, et al. (2003)
Mol. Biol. Cell 14, 4758-4769
   Abstract »    Full Text »    PDF »
Sex-Linked Mammalian Sperm Proteins Evolve Faster Than Autosomal Ones.
D. G. Torgerson and R. S. Singh (2003)
Mol. Biol. Evol. 20, 1705-1709
   Abstract »    Full Text »
Cloning and Characterization of the Human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 Gene Promoters: DIFFERENTIAL REGULATION THROUGH AN INITIATOR-LIKE REGION.
P. A. Gregory, D. A. Gardner-Stephen, R. H. Lewinsky, K. N. Duncliffe, and P. I. Mackenzie (2003)
J. Biol. Chem. 278, 36107-36114
   Abstract »    Full Text »    PDF »
In Vivo Functional Analysis of the Histone 3-like TAF9 and a TAF9-related Factor, TAF9L.
Z. Chen and J. L. Manley (2003)
J. Biol. Chem. 278, 35172-35183
   Abstract »    Full Text »    PDF »
Human Mediator Enhances Activator-Facilitated Recruitment of RNA Polymerase II and Promoter Recognition by TATA-Binding Protein (TBP) Independently of TBP-Associated Factors.
S.-Y. Wu, T. Zhou, and C.-M. Chiang (2003)
Mol. Cell. Biol. 23, 6229-6242
   Abstract »    Full Text »    PDF »
TAF7 (TAFII55) Plays a Role in the Transcription Activation by c-Jun.
C. Munz, E. Psichari, D. Mandilis, A.-C. Lavigne, M. Spiliotaki, T. Oehler, I. Davidson, L. Tora, P. Angel, and A. Pintzas (2003)
J. Biol. Chem. 278, 21510-21516
   Abstract »    Full Text »    PDF »
The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.
J.-C. Pointud, G. Mengus, S. Brancorsini, L. Monaco, M. Parvinen, P. Sassone-Corsi, and I. Davidson (2003)
J. Cell Sci. 116, 1847-1858
   Abstract »    Full Text »    PDF »
Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons.
W. G. Chen, A. E. West, X. Tao, G. Corfas, M. N. Szentirmay, M. Sawadogo, C. Vinson, and M. E. Greenberg (2003)
J. Neurosci. 23, 2572-2581
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Mouse delta -Opioid Receptor Gene. IKAROS-2 AND UPSTREAM STIMULATORY FACTOR SYNERGIZE IN TRANS-ACTIVATING MOUSE delta -OPIOID RECEPTOR GENE IN T CELLS.
P. Sun and H. H. Loh (2003)
J. Biol. Chem. 278, 2304-2308
   Abstract »    Full Text »    PDF »
ESE-1, an Enterocyte-specific Ets Transcription Factor, Regulates MIP-3alpha Gene Expression in Caco-2 Human Colonic Epithelial Cells.
J. H. Kwon, S. Keates, S. Simeonidis, F. Grall, T. A. Libermann, and A. C. Keates (2003)
J. Biol. Chem. 278, 875-884
   Abstract »    Full Text »    PDF »
Sp1 and AP2 regulate but do not constitute TATA-less human TAFII55 core promoter activity.
T. Zhou and C.-M. Chiang (2002)
Nucleic Acids Res. 30, 4145-4157
   Abstract »    Full Text »    PDF »
Functional interaction between TATA and upstream CACGTG elements regulates the temporally specific expression of Otx mRNAs during early embryogenesis of the sea urchin, Hemicentrotus pulcherrimus.
A. Kobayashi, K. Akasaka, M. Kawaichi, and T. Kokubo (2002)
Nucleic Acids Res. 30, 3034-3044
   Abstract »    Full Text »    PDF »
Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease.
A. W. Dunah, H. Jeong, A. Griffin, Y.-M. Kim, D. G. Standaert, S. M. Hersch, M. M. Mouradian, A. B. Young, N. Tanese, and D. Krainc (2002)
Science 296, 2238-2243
   Abstract »    Full Text »    PDF »
Phosphorylation of Transcription Factor Sp1 during Herpes Simplex Virus Type 1 Infection.
D.-B. Kim and N. A. DeLuca (2002)
J. Virol. 76, 6473-6479
   Abstract »    Full Text »    PDF »
The Viral Transactivator E1A Regulates the Mouse Mammary Tumor Virus Promoter in an Isoform- and Chromatin-specific Manner.
E. Soeth, D. B. Thurber, and C. L. Smith (2002)
J. Biol. Chem. 277, 19847-19854
   Abstract »    Full Text »    PDF »
Modulation of Human Immunodeficiency Virus 1 Replication by Interferon Regulatory Factors.
M. Sgarbanti, A. Borsetti, N. Moscufo, M. C. Bellocchi, B. Ridolfi, F. Nappi, G. Marsili, G. Marziali, E. M. Coccia, B. Ensoli, et al. (2002)
J. Exp. Med. 195, 1359-1370
   Abstract »    Full Text »    PDF »
Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors.
S. B. Kennett, K. S. Moorefield, and J. M. Horowitz (2002)
J. Biol. Chem. 277, 9780-9789
   Abstract »    Full Text »    PDF »
Upstream Stimulatory Factors Binding to an E Box Motif in the R Region of the Bovine Leukemia Virus Long Terminal Repeat Stimulates Viral Gene Expression.
C. Calomme, T. L.-A. Nguyen, Y. de Launoit, V. Kiermer, L. Droogmans, A. Burny, and C. Van Lint (2002)
J. Biol. Chem. 277, 8775-8789
   Abstract »    Full Text »    PDF »
ZBP-89, Sp1, and Nuclear Factor-kappa B Regulate Epithelial Neutrophil-activating Peptide-78 Gene Expression in Caco-2 Human Colonic Epithelial Cells.
A. C. Keates, S. Keates, J. H. Kwon, K. O. Arseneau, D. J. Law, L. Bai, J. L. Merchant, T. C. Wang, and C. P. Kelly (2001)
J. Biol. Chem. 276, 43713-43722
   Abstract »    Full Text »    PDF »
Positive and Negative TAFII Functions That Suggest a Dynamic TFIID Structure and Elicit Synergy with TRAPs in Activator-Induced Transcription.
M. Guermah, Y. Tao, and R. G. Roeder (2001)
Mol. Cell. Biol. 21, 6882-6894
   Abstract »    Full Text »    PDF »
YY1 Is a Positive Regulator of Transcription of the Col1a1 Gene.
F. B. Riquet, L. Tan, B. K. Choy, M. Osaki, G. Karsenty, T. F. Osborne, P. E. Auron, and M. B. Goldring (2001)
J. Biol. Chem. 276, 38665-38672
   Abstract »    Full Text »    PDF »
Molecular Genetic Dissection of TAF25, an Essential Yeast Gene Encoding a Subunit Shared by TFIID and SAGA Multiprotein Transcription Factors.
J. Kirchner, S. L. Sanders, E. Klebanow, and P. A. Weil (2001)
Mol. Cell. Biol. 21, 6668-6680
   Abstract »    Full Text »    PDF »
Regulation of Transcription Factor YY1 by Acetylation and Deacetylation.
Y.-L. Yao, W.-M. Yang, and E. Seto (2001)
Mol. Cell. Biol. 21, 5979-5991
   Abstract »    Full Text »    PDF »
Upstream stimulating factor affects human immunodeficiency virus type 1 (HIV-1) long terminal repeat-directed transcription in a cell-specific manner, independently of the HIV-1 subtype and the core-negative regulatory element.
M. H. Naghavi, M. C. Estable, S. Schwartz, R. G. Roeder, and A. Vahlne (2001)
J. Gen. Virol. 82, 547-559
   Abstract »    Full Text »
Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters.
Q. Wu, T. Zhang, J.-F. Cheng, Y. Kim, J. Grimwood, J. Schmutz, M. Dickson, J. P. Noonan, M. Q. Zhang, R. M. Myers, et al. (2001)
Genome Res. 11, 389-404
   Abstract »    Full Text »
The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1.
J. J. Coull, F. Romerio, J.-M. Sun, J. L. Volker, K. M. Galvin, J. R. Davie, Y. Shi, U. Hansen, and D. M. Margolis (2000)
J. Virol. 74, 6790-6799
   Abstract »    Full Text »
Sp1 Binding Sites and An Estrogen Response Element Half-Site Are Involved in Regulation of the Human Progesterone Receptor A Promoter.
L. N. Petz and A. M. Nardulli (2000)
Mol. Endocrinol. 14, 972-985
   Abstract »    Full Text »
The Zinc Finger Repressor, ZBP-89, Binds to the Silencer Element of the Human Vimentin Gene and Complexes with the Transcriptional Activator, Sp1.
E. Wieczorek, Z. Lin, E. B. Perkins, D. J. Law, J. L. Merchant, and Z. E. Zehner (2000)
J. Biol. Chem. 275, 12879-12888
   Abstract »    Full Text »    PDF »
Bromodomain factor 1 corresponds to a missing piece of yeast TFIID.
O. Matangkasombut, R. M. Buratowski, N. W. Swilling, and S. Buratowski (2000)
Genes & Dev. 14, 951-962
   Abstract »    Full Text »
Cell Cycle-Regulated Transcription by the Human Immunodeficiency Virus Type 1 Tat Transactivator.
F. Kashanchi, E. T. Agbottah, C. A. Pise-Masison, R. Mahieux, J. Duvall, A. Kumar, and J. N. Brady (2000)
J. Virol. 74, 652-660
   Abstract »    Full Text »
Alleviation of Human Papillomavirus E2-Mediated Transcriptional Repression via Formation of a TATA Binding Protein (or TFIID)-TFIIB-RNA Polymerase II-TFIIF Preinitiation Complex.
S. Y. Hou, S.-Y. Wu, T. Zhou, M. C. Thomas, and C.-M. Chiang (2000)
Mol. Cell. Biol. 20, 113-125
   Abstract »    Full Text »
Characterization of Activity and Expression of Isocitrate Lyase in Mycobacterium avium and Mycobacterium tuberculosis.
K. Höner Zu Bentrup, A. Miczak, D. L. Swenson, and D. G. Russell (1999)
J. Bacteriol. 181, 7161-7167
   Abstract »    Full Text »
Isolation of Mouse TFIID and Functional Characterization of TBP and TFIID in Mediating Estrogen Receptor and Chromatin Transcription.
S. Y. Wu, M. C. Thomas, S. Y. Hou, V. Likhite, and C. M. Chiang (1999)
J. Biol. Chem. 274, 23480-23490
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Mouse delta -Opioid Receptor Gene.
H.-C. Liu, J.-T. Shen, L. B. Augustin, J. L. Ko, and H. H. Loh (1999)
J. Biol. Chem. 274, 23617-23626
   Abstract »    Full Text »    PDF »
Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1.
A. Doetzlhofer, H. Rotheneder, G. Lagger, M. Koranda, V. Kurtev, G. Brosch, E. Wintersberger, and C. Seiser (1999)
Mol. Cell. Biol. 19, 5504-5511
   Abstract »    Full Text »    PDF »
Specific Interactions with TBP and TFIIB in Vitro Suggest That 14-3-3 Proteins May Participate in the Regulation of Transcription When Part of a DNA Binding Complex.
S. Pan, P. C. Sehnke, R. J. Ferl, and W. B. Gurley (1999)
PLANT CELL 11, 1591-1602
   Abstract »    Full Text »
The Cyclic AMP Response Element Modulator Family Regulates the Insulin Gene Transcription by Interacting with Transcription Factor IID.
A. Inada, Y. Someya, Y. Yamada, Y. Ihara, A. Kubota, N. Ban, R. Watanabe, K. Tsuda, and Y. Seino (1999)
J. Biol. Chem. 274, 21095-21103
   Abstract »    Full Text »    PDF »
Characterization of the ptr6+ Gene in Fission Yeast: A Possible Involvement of a Transcriptional Coactivator TAF in Nucleocytoplasmic Transport of mRNA.
T. Shibuya, S. Tsuneyoshi, A. K. Azad, S. Urushiyama, Y. Ohshima, and T. Tani (1999)
Genetics 152, 869-880
   Abstract »    Full Text »
DNA Bending and Wrapping around RNA Polymerase: a ""Revolutionary"" Model Describing Transcriptional Mechanisms.
B. Coulombe and Z. F. Burton (1999)
Microbiol. Mol. Biol. Rev. 63, 457-478
   Abstract »    Full Text »    PDF »
SREBP-1 Binds to Multiple Sites and Transactivates the Human ApoA-II Promoter In Vitro : SREBP-1 Mutants Defective in DNA Binding or Transcriptional Activation Repress ApoA-II Promoter Activity.
P. Pissios, H.-Y. Kan, S. Nagaoka, and V. I. Zannis (1999)
Arterioscler Thromb Vasc Biol 19, 1456-1469
   Abstract »    Full Text »    PDF »
B Cell-specific Activator Protein Prevents Two Activator Factors from Binding to the Immunoglobulin J Chain Promoter until the Antigen-driven Stages of B Cell Development.
J. J. Wallin, J. L. Rinkenberger, S. Rao, E. R. Gackstetter, M. E. Koshland, and P. Zwollo (1999)
J. Biol. Chem. 274, 15959-15965
   Abstract »    Full Text »    PDF »
Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1.
F. Macian and A. Rao (1999)
Mol. Cell. Biol. 19, 3645-3653
   Abstract »    Full Text »    PDF »
The CREB Constitutive Activation Domain Interacts with TATA-binding Protein-associated Factor 110 (TAF110) through Specific Hydrophobic Residues in One of the Three Subdomains Required for Both Activation and TAF110 Binding.
E. A. Felinski and P. G. Quinn (1999)
J. Biol. Chem. 274, 11672-11678
   Abstract »    Full Text »    PDF »
Synergism with Germ Line Transcription Factor Oct-4: Viral Oncoproteins Share the Ability To Mimic a Stem Cell-Specific Activity.
A. Brehm, K. Ohbo, W. Zwerschke, V. Botquin, P. Jansen-Durr, and H. R. Scholer (1999)
Mol. Cell. Biol. 19, 2635-2643
   Abstract »    Full Text »    PDF »
Transcriptional activation by artificial recruitment in mammalian cells.
J. Nevado, L. Gaudreau, M. Adam, and M. Ptashne (1999)
PNAS 96, 2674-2677
   Abstract »    Full Text »    PDF »
Tat-associated Kinase (P-TEFb): a Component of Transcription Preinitiation and Elongation Complexes.
Y.-H. Ping and T. M. Rana (1999)
J. Biol. Chem. 274, 7399-7404
   Abstract »    Full Text »    PDF »
Involvement of Polyomavirus Enhancer Activator 3 in the Regulation of Expression of Gamma-Glutamyl Transpeptidase Messenger Ribonucleic Acid-IV in the Rat Epididymis.
Z.-J. Lan, R. J. Lye, N. Holic, J. C. Labus, and B. T. Hinton (1999)
Biol Reprod 60, 664-673
   Abstract »    Full Text »
Growth/Cell Cycle Regulation of Sp1 Phosphorylation.
A. R. Black, D. Jensen, S.-Y. Lin, and J. C. Azizkhan (1999)
J. Biol. Chem. 274, 1207-1215
   Abstract »    Full Text »    PDF »
Characterization of tGLP-1, a Golgi and lysosome-associated, transmembrane glycoprotein of African trypanosomes.
A Lingnau, R Zufferey, M Lingnau, and D. Russell (1999)
J. Cell Sci. 112, 3061-3070
   Abstract »    PDF »
The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-gamma Promoter in T Cells.
M. T. Sweetser, T. Hoey, Y.-L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson (1998)
J. Biol. Chem. 273, 34775-34783
   Abstract »    Full Text »    PDF »
Immunoaffinity Purification and Functional Characterization of Human Transcription Factor IIH and RNA Polymerase II from Clonal Cell Lines That Conditionally Express Epitope-tagged Subunits of the Multiprotein Complexes.
E. Kershnar, S.-Y. Wu, and C. M. Chiang (1998)
J. Biol. Chem. 273, 34444-34453
   Abstract »    Full Text »    PDF »
The Dystrophin Promoter Is Negatively Regulated by YY1 in Undifferentiated Muscle Cells.
F. Galvagni, E. Cartocci, and S. Oliviero (1998)
J. Biol. Chem. 273, 33708-33713
   Abstract »    Full Text »    PDF »
A 69-Base Pair Fragment Derived from Human Transcobalamin II Promoter Is Sufficient for High Bidirectional Activity in the Absence of a TATA Box and an Initiator Element in Transfected Cells. ROLE OF AN E BOX IN TRANSCRIPTIONAL ACTIVITY.
N. Li and B. Seetharam (1998)
J. Biol. Chem. 273, 28170-28177
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of TIEG2 Reveals a New Subfamily of Transforming Growth Factor-beta -inducible Sp1-like Zinc Finger-encoding Genes Involved in the Regulation of Cell Growth.
T. Cook, B. Gebelein, K. Mesa, A. Mladek, and R. Urrutia (1998)
J. Biol. Chem. 273, 25929-25936
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Generic Promoter III of the Rat Prolactin Receptor Gene by C/EBPbeta and Sp1.
Z.-Z. Hu, L. Zhuang, J. Meng, and M. L. Dufau (1998)
J. Biol. Chem. 273, 26225-26235
   Abstract »    Full Text »    PDF »
Distinct Subdomains of Human TAFII130 Are Required for Interactions with Glutamine-Rich Transcriptional Activators.
D. Saluja, M. F. Vassallo, and N. Tanese (1998)
Mol. Cell. Biol. 18, 5734-5743
   Abstract »    Full Text »
HIV-1 Tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.
J. D. Weissman, J. A. Brown, T. K. Howcroft, J. Hwang, A. Chawla, P. A. Roche, L. Schiltz, Y. Nakatani, and D. S. Singer (1998)
PNAS 95, 11601-11606
   Abstract »    Full Text »    PDF »
Activation of Integrated Provirus Requires Histone Acetyltransferase. p300 AND P/CAF ARE COACTIVATORS FOR HIV-1 Tat.
M. Benkirane, R. F. Chun, H. Xiao, V. V. Ogryzko, B. H. Howard, Y. Nakatani, and K.-T. Jeang (1998)
J. Biol. Chem. 273, 24898-24905
   Abstract »    Full Text »    PDF »
Identification of a Novel RING Finger Protein as a Coregulator in Steroid Receptor-Mediated Gene Transcription.
A.-M. Moilanen, H. Poukka, U. Karvonen, M. Häkli, O. A. Jänne, and J. J. Palvimo (1998)
Mol. Cell. Biol. 18, 5128-5139
   Abstract »    Full Text »
GC- and E-box Motifs as Regulatory Elements in the Proximal Promoter Region of the Neuronal Nicotinic Receptor alpha 7 Subunit Gene.
C. Carrasco-Serrano, A. Campos-Caro, S. Viniegra, J. J. Ballesta, and M. Criado (1998)
J. Biol. Chem. 273, 20021-20028
   Abstract »    Full Text »    PDF »
Nuclear Factor I (NFI) Isoforms Differentially Activate Simple versus Complex NFI-responsive Promoters.
A. Z. Chaudhry, A. D. Vitullo, and R. M. Gronostajski (1998)
J. Biol. Chem. 273, 18538-18546
   Abstract »    Full Text »    PDF »
AR1 Is an Integral Part of the Adenovirus Type 2 E1A-CR3 Transactivation Domain.
A.-C. Strom, P. Ohlsson, and G. Akusjarvi (1998)
J. Virol. 72, 5978-5983
   Abstract »    Full Text »    PDF »
Recruitment of Human TBP Selectively Activates RNA Polymerase II TATA-dependent Promoters.
B. Majello, G. Napolitano, P. De Luca, and L. Lania (1998)
J. Biol. Chem. 273, 16509-16516
   Abstract »    Full Text »    PDF »
Involvement of TFIID and USA Components in Transcriptional Activation of the Human Immunodeficiency Virus Promoter by NF-kappa B and Sp1.
M. Guermah, S. Malik, and R. G. Roeder (1998)
Mol. Cell. Biol. 18, 3234-3244
   Abstract »    Full Text »
Properties of PC4 and an RNA Polymerase II Complex in Directing Activated and Basal Transcription in Vitro.
S. Y. Wu and C. M. Chiang (1998)
J. Biol. Chem. 273, 12492-12498
   Abstract »    Full Text »    PDF »
Regulation of gene expression by TBP-associated proteins.
T. I. Lee and R. A. Young (1998)
Genes & Dev. 12, 1398-1408
   Full Text »
Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat.
R. F. Chun, O. J. Semmes, C. Neuveut, and K.-T. Jeang (1998)
J. Virol. 72, 2615-2629
   Abstract »    Full Text »    PDF »
SP1/SP3-Binding Sites and Adjacent Elements Contribute to Basal and Cyclic Adenosine 3',5'-Monophosphate-Stimulated Transcriptional Activation of the Rhesus Growth Hormone-Variant Gene in Trophoblasts.
J. T. Schanke, M. Durning, K. J. Johnson, L. K. Bennett, and T. G. Golos (1998)
Mol. Endocrinol. 12, 405-417
   Abstract »    Full Text »
Studying the recruitment of Sp1 to the beta -globin promoter with an in vivo method: Protein position identification with nuclease tail (PIN*POINT).
J.-S. Lee, C.-H. Lee, and J. H. Chung (1998)
PNAS 95, 969-974
   Abstract »    Full Text »    PDF »
The Yeast TAF145 Inhibitory Domain and TFIIA Competitively Bind to TATA-Binding Protein.
T. Kokubo, M. J. Swanson, J.-i. Nishikawa, A. G. Hinnebusch, and Y. Nakatani (1998)
Mol. Cell. Biol. 18, 1003-1012
   Abstract »    Full Text »
Interaction of Elongation Factors TFIIS and Elongin A with a Human RNA Polymerase II Holoenzyme Capable of Promoter-specific Initiation and Responsive to Transcriptional Activators.
G. Pan, T. Aso, and J. Greenblatt (1997)
J. Biol. Chem. 272, 24563-24571
   Abstract »    Full Text »    PDF »
The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII130 and mediates long-range activation of the alpha - and beta -globin gene loci in an erythroid cell line.
P. J. Amrolia, L. Ramamurthy, D. Saluja, N. Tanese, S. M. Jane, and J. M. Cunningham (1997)
PNAS 94, 10051-10056
   Abstract »    Full Text »    PDF »
Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions?.
A. Hoffmann, T. Oelgeschlager, and R. G. Roeder (1997)
PNAS 94, 8928-8935
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor.
G.-Z. Yan and E. B. Ziff (1997)
J. Neurosci. 17, 6122-6132
   Abstract »    Full Text »    PDF »
HIV-1 Tat Induces the Expression of the Interleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting with CAAT Enhancer-binding Protein beta  (NF-IL6) Transcription Factors.
C. Ambrosino, M. R. Ruocco, X. Chen, M. Mallardo, F. Baudi, S. Trematerra, I. Quinto, S. Venuta, and G. Scala (1997)
J. Biol. Chem. 272, 14883-14892
   Abstract »    Full Text »    PDF »
Phylogenetic Footprinting of Hypersensitive Site 3 of the beta -Globin Locus Control Region.
D. A. Shelton, L. Stegman, R. Hardison, W. Miller, J. H. Bock, J. L. Slightom, M. Goodman, and D. L. Gumucio (1997)
Blood 89, 3457-3469
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)