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Science 27 January 1995:
Vol. 267. no. 5197, pp. 528 - 531
DOI: 10.1126/science.7824953
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Articles

Science, Vol 267, Issue 5197, 528-531
Copyright © 1995 by American Association for the Advancement of Science

articles

Sex differences in regional cerebral glucose metabolism during a resting state

RC Gur, LH Mozley, PD Mozley, SM Resnick, JS Karp, A Alavi, SE Arnold, and RE Gur

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104.

Positron emission tomography was used to evaluate the regional distribution of cerebral glucose metabolism in 61 healthy adults at rest. Although the profile of metabolic activity was similar for men and women, some sex differences and hemispheric asymmetries were detectable. Men had relatively higher metabolism than women in temporal-limbic regions and cerebellum and relatively lower metabolism in cingulate regions. In both sexes, metabolism was relatively higher in left association cortices and the cingulate region and in right ventro-temporal limbic regions and their projections. These results are consistent with the hypothesis that differences in cognitive and emotional processing have biological substrates.


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