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Science 20 January 1995:
Vol. 267. no. 5196, pp. 389 - 393
DOI: 10.1126/science.7824938
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Articles

Science, Vol 267, Issue 5196, 389-393
Copyright © 1995 by American Association for the Advancement of Science

articles

Transcription factor ATF2 regulation by the JNK signal transduction pathway

S Gupta, D Campbell, B Derijard, and RJ Davis

Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605.

Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. These mutations also inhibited ATF2-stimulated gene expression mediated by the retinoblastoma (Rb) tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein. Furthermore, expression of dominant-negative JNK inhibited ATF2 transcriptional activity. Together, these data demonstrate a role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2.


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Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity.
A. Bhoumik, N. Jones, and Z. Ronai (2004)
PNAS 101, 4222-4227
   Abstract »    Full Text »    PDF »
Induction of CHOP Expression by Amino Acid Limitation Requires Both ATF4 Expression and ATF2 Phosphorylation.
J. Averous, A. Bruhat, C. Jousse, V. Carraro, G. Thiel, and P. Fafournoux (2004)
J. Biol. Chem. 279, 5288-5297
   Abstract »    Full Text »    PDF »
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
M. Short, R. A. Nemenoff, W. M. Zawada, K. R. Stenmark, and M. Das (2004)
Am J Physiol Cell Physiol 286, C416-C425
   Abstract »    Full Text »
Global Gene Expression Responses of Fission Yeast to Ionizing Radiation.
A. Watson, J. Mata, J. Bahler, A. Carr, and T. Humphrey (2004)
Mol. Biol. Cell 15, 851-860
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Suppression by p38 MAP Kinase Inhibitors (Pyridinyl Imidazole Compounds) of Ah Receptor Target Gene Activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Possible Mechanism.
M. Shibazaki, T. Takeuchi, S. Ahmed, and H. Kikuchi (2004)
J. Biol. Chem. 279, 3869-3876
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Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1.
N. Allaman-Pillet, J. Storling, A. Oberson, R. Roduit, S. Negri, C. Sauser, P. Nicod, J. S. Beckmann, D. F. Schorderet, T. Mandrup-Poulsen, et al. (2003)
J. Biol. Chem. 278, 48720-48726
   Abstract »    Full Text »    PDF »
p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase.
T.-S. Chang, M. J. Kim, K. Ryoo, J. Park, S.-J. Eom, J. Shim, K. I. Nakayama, K. Nakayama, M. Tomita, K. Takahashi, et al. (2003)
J. Biol. Chem. 278, 48092-48098
   Abstract »    Full Text »    PDF »
Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization.
J. J. Song and Y. J. Lee (2003)
J. Biol. Chem. 278, 47245-47252
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Disruption of the c-JUN-JNK Complex by a Cell-permeable Peptide Containing the c-JUN {delta} Domain Induces Apoptosis and Affects a Distinct Set of Interleukin-1-induced Inflammatory Genes.
D. Holzberg, C. G. Knight, O. Dittrich-Breiholz, H. Schneider, A. Dorrie, E. Hoffmann, K. Resch, and M. Kracht (2003)
J. Biol. Chem. 278, 40213-40223
   Abstract »    Full Text »    PDF »
A Peptide Inhibitor of c-Jun N-Terminal Kinase Protects against Both Aminoglycoside and Acoustic Trauma-Induced Auditory Hair Cell Death and Hearing Loss.
J. Wang, T. R. Van De Water, C. Bonny, F. de Ribaupierre, J. L. Puel, and A. Zine (2003)
J. Neurosci. 23, 8596-8607
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p38 Kinase Is a Key Signaling Molecule for H-Ras-induced Cell Motility and Invasive Phenotype in Human Breast Epithelial Cells.
M.-S. Kim, E.-J. Lee, H.-R. C. Kim, and A. Moon (2003)
Cancer Res. 63, 5454-5461
   Abstract »    Full Text »    PDF »
Identification of Cdc37 as a Novel Regulator of the Stress-Responsive Mitogen-Activated Protein Kinase.
H. Tatebe and K. Shiozaki (2003)
Mol. Cell. Biol. 23, 5132-5142
   Abstract »    Full Text »    PDF »
The effect of RU486 on the gene expression profile in an endometrial explant model.
R.D. Catalano, A. Yanaihara, A.L. Evans, D. Rocha, A. Prentice, S. Saidi, C.G. Print, D.S. Charnock-Jones, A.M. Sharkey, and S.K. Smith (2003)
Mol. Hum. Reprod. 9, 465-473
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c-Jun N-terminal Kinase Contributes to Apoptotic Synergy Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand plus DNA Damage in Chemoresistant, p53 Inactive Mesothelioma Cells.
C. Vivo, W. Liu, and V. C. Broaddus (2003)
J. Biol. Chem. 278, 25461-25467
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Photodynamic Therapy Mediates Immediate Loss of Cellular Responsiveness to Cytokines and Growth Factors.
T.-W. Wong, E. Tracy, A. R Oseroff, and H. Baumann (2003)
Cancer Res. 63, 3812-3818
   Abstract »    Full Text »    PDF »
A High-throughput Quantitative Multiplex Kinase Assay for Monitoring Information Flow in Signaling Networks: Application to Sepsis-Apoptosis.
K. A. Janes, J. G. Albeck, L. X. Peng, P. K. Sorger, D. A. Lauffenburger, and M. B. Yaffe (2003)
Mol. Cell. Proteomics 2, 463-473
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Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi.
R. Elsby, N. R. Kitteringham, C. E. Goldring, C. A. Lovatt, M. Chamberlain, C. J. Henderson, C. R. Wolf, and B. K. Park (2003)
J. Biol. Chem. 278, 22243-22249
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Apoptosis-Signal Regulating Kinase-1 Is Involved in the Low Potassium-Induced Activation of p38 Mitogen-Activated Protein Kinase and c-Jun in Cultured Cerebellar Granule Neurons.
S. Yamagishi, M. Yamada, H. Koshimizu, S. Takai, H. Hatanaka, K. Takeda, H. Ichijo, K. Shimoke, and T. Ikeuchi (2003)
J. Biochem. 133, 719-724
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TNF-induced death of adult human oligodendrocytes is mediated by c-jun NH2-terminal kinase-3.
A. Jurewicz, M. Matysiak, K. Tybor, and K. Selmaj (2003)
Brain 126, 1358-1370
   Abstract »    Full Text »    PDF »
Recent Advances in the Understanding of Amino Acid Regulation of Gene Expression.
J. Averous, A. Bruhat, S. Mordier, and P. Fafournoux (2003)
J. Nutr. 133, 2040S-2045
   Abstract »    Full Text »    PDF »


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