Science 13 January 1995: Vol. 267. no. 5195, pp. 249 - 252 DOI: 10.1126/science.7809631

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Articles

Influences of TP53 expression on cellular radiation response and its relevance to diagnostic biodosimetry for mission environmental monitoring.

J. Lu-Hesselmann, D. van Beuningen, V. Meineke, and E. Franke (2006)
Radiat Prot Dosimetry 122, 237-243
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Dysregulated Expression of Stem Cell Factor Bmi1 in Precancerous Lesions of the Gastrointestinal Tract.

K. Tateishi, M. Ohta, F. Kanai, B. Guleng, Y. Tanaka, Y. Asaoka, M. Tada, M. Seto, A. Jazag, L. Lianjie, et al. (2006)
Clin. Cancer Res. 12, 6960-6966
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High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL..

A. M. Goldstein, M. Chan, M. Harland, E. M. Gillanders, N. K. Hayward, M.-F. Avril, E. Azizi, G. Bianchi-Scarra, D. T. Bishop, B. Bressac-de Paillerets, et al. (2006)
Cancer Res. 66, 9818-9828
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Surprising Dependency for Retinoblastoma Protein in Ras-Mediated Tumorigenesis.

J. DeGregori (2006)
Mol. Cell. Biol. 26, 1165-1169
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Melanocortin-1 Receptor (MC1R) Gene Variants and Dysplastic Nevi Modify Penetrance of CDKN2A Mutations in French Melanoma-Prone Pedigrees.

V. Chaudru, K. Laud, M.-F. Avril, A. Miniere, A. Chompret, B. Bressac-de Paillerets, F. Demenais, and The French Familial Melanoma Study Group (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 2384-2390
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Long-term Exposure to Nicotine, via Ras Pathway, Induces Cyclin D1 to Stimulate G1 Cell Cycle Transition.

M. Chu, J. Guo, and C.-Y. Chen (2005)
J. Biol. Chem. 280, 6369-6379
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Human Papillomavirus Type 16 E6 Promotes Retinoblastoma Protein Phosphorylation and Cell Cycle Progression.

I. Malanchi, R. Accardi, F. Diehl, A. Smet, E. Androphy, J. Hoheisel, and M. Tommasino (2004)
J. Virol. 78, 13769-13778
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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

D. W. Fry, P. J. Harvey, P. R. Keller, W. L. Elliott, M. Meade, E. Trachet, M. Albassam, X. Zheng, W. R. Leopold, N. K. Pryer, et al. (2004)
Mol. Cancer Ther. 3, 1427-1438
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Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation.

M. N. Garnovskaya, Y. V. Mukhin, T. M. Vlasova, J. S. Grewal, M. E. Ullian, B. G. Tholanikunnel, and J. R. Raymond (2004)
J. Biol. Chem. 279, 24899-24905
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Influence of Genes, Nevi, and Sun Sensitivity on Melanoma Risk in a Family Sample Unselected by Family History and in Melanoma-Prone Families.

V. Chaudru, A. Chompret, B. Bressac-de Paillerets, A. Spatz, M.-F. Avril, and F. Demenais (2004)
J Natl Cancer Inst 96, 785-795
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The Role of Ink4a/Arf in ErbB2 Mammary Gland Tumorigenesis.

M. D'Amico, K. Wu, D. Di Vizio, A. T. Reutens, M. Stahl, M. Fu, C. Albanese, R. G. Russell, W. J. Muller, M. White, et al. (2003)
Cancer Res. 63, 3395-3402
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Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors.

A. S. Tam, T. R. Devereux, A. C. Patel, J. F. Foley, R. R. Maronpot, and T. E. Massey (2003)
Carcinogenesis 24, 121-132
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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.

X. Zou, D. Ray, A. Aziyu, K. Christov, A. D. Boiko, A. V. Gudkov, and H. Kiyokawa (2002)
Genes & Dev. 16, 2923-2934
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Role of CXCL1 in tumorigenesis of melanoma.

P. Dhawan and A. Richmond (2002)
J. Leukoc. Biol. 72, 9-18
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Geographical Variation in the Penetrance of CDKN2A Mutations for Melanoma.

D. T. Bishop, F. Demenais, A. M. Goldstein, W. Bergman, J. N. Bishop, B. B.-d. Paillerets, A. Chompret, P. Ghiorzo, N. Gruis, J. Hansson, et al. (2002)
J Natl Cancer Inst 94, 894-903
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Methylthioadenosine Phosphorylase Gene Deletions Are Common in Osteosarcoma.

J. M. Garcia-Castellano, A. Villanueva, J. H. Healey, R. Sowers, C. Cordon-Cardo, A. Huvos, J. R. Bertino, P. Meyers, and R. Gorlick (2002)
Clin. Cancer Res. 8, 782-787
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Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame.

J. Yang, J. Luan, Y. Yu, C. Li, R. A. DePinho, L. Chin, and A. Richmond (2001)
Cancer Res. 61, 8150-8157
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The influence of INK4 proteins on growth and self-renewal kinetics of hematopoietic progenitor cells.

J. L. Lewis, W. Chinswangwatanakul, B. Zheng, S. B. Marley, D. X. Nguyen, N. C. P. Cross, L. Banerji, J. Glassford, N. S. B. Thomas, J. M. Goldman, et al. (2001)
Blood 97, 2604-2610
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Comparative Genome-Scale Analysis of Gene Expression Profiles in T Cell Lymphoma Cells during Malignant Progression Using a Complementary DNA Microarray.

S. Li, D. T. Ross, M. E. Kadin, P. O. Brown, and M. A. Wasik (2001)
Am. J. Pathol. 158, 1231-1237
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Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver.

A Tannapfel, M Benicke, A Katalinic, D Uhlmann, F Kockerling, J Hauss, and C Wittekind (2000)
Gut 47, 721-727
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Control of the eukaryotic cell cycle by MAP kinase signaling pathways.

M. G. WILKINSON and J. B. A. MILLAR (2000)
FASEB J 14, 2147-2157
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Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines.

T. Jonuleit, H. van der Kuip, C. Miething, H. Michels, M. Hallek, J. Duyster, and W. E. Aulitzky (2000)
Blood 96, 1933-1939
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Early Deregulation of the p16ink4a-Cyclin D1/Cyclin-dependent Kinase 4-Retinoblastoma Pathway in Cell Proliferation-driven Esophageal Tumorigenesis in Zinc-deficient Rats.

L. Y. Y. Fong, V. T. Nguyen, J. L. Farber, K. Huebner, and P. N. Magee (2000)
Cancer Res. 60, 4589-4595
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Adenovirus-mediated Overexpression of p15INK4B Inhibits Human Glioma Cell Growth, Induces Replicative Senescence, and Inhibits Telomerase Activity Similarly to p16INK4A.

J. Fuxe, G. Akusjärvi, H. M. Goike, G. Roos, V. P. Collins, and R. F. Pettersson (2000)
Cell Growth Differ. 11, 373-384
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The Oncoprotein Kinase Chaperone CDC37 Functions as an Oncogene in Mice and Collaborates with Both c-myc and Cyclin D1 in Transformation of Multiple Tissues.

L. Stepanova, M. Finegold, F. DeMayo, E. V. Schmidt, and J. W. Harper (2000)
Mol. Cell. Biol. 20, 4462-4473
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The INK4a/ARF locus in murine tumorigenesis.

M. Serrano (2000)
Carcinogenesis 21, 865-869
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Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by Telomerase.

D. G. Farwell, K. A. Shera, J. I. Koop, G. A. Bonnet, C. P. Matthews, G. W. Reuther, M. D. Coltrera, J. K. McDougall, and A. J. Klingelhutz (2000)
Am. J. Pathol. 156, 1537-1547
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Cellular Response to Oncogenic Ras Involves Induction of the Cdk4 and Cdk6 Inhibitor p15INK4b.

M. Malumbres, I. Pérez De Castro, M. I. Hernández, M. Jiménez, T. Corral, and A. Pellicer (2000)
Mol. Cell. Biol. 20, 2915-2925
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Molecular and Genetic Aspects of Lung Cancer.

W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG (2000)
Am. J. Respir. Crit. Care Med. 161, 1355-1367
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A Cyclin D-Cdk4 Activity Required for G2 Phase Cell Cycle Progression Is Inhibited in Ultraviolet Radiation-induced G2 Phase Delay.

B. G. Gabrielli, B. Sarcevic, J. Sinnamon, G. Walker, M. Castellano, X.-Q. Wang, and K. A. O. Ellem (1999)
J. Biol. Chem. 274, 13961-13969
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Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a.

J. Mitra, C. Y. Dai, K. Somasundaram, W. S. El-Deiry, K. Satyamoorthy, M. Herlyn, and G. H. Enders (1999)
Mol. Cell. Biol. 19, 3916-3928
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Loss of the ARF Tumor Suppressor Reverses Premature Replicative Arrest but not Radiation Hypersensitivity Arising from Disabled Atm Function.

T. Kamijo, E. van de Kamp, M. J. Chong, F. Zindy, J. A. Diehl, C. J. Sherr, and P. J. McKinnon (1999)
Cancer Res. 59, 2464-2469
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Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes.

B. B. McConnell, F. J. Gregory, F. J. Stott, E. Hara, and G. Peters (1999)
Mol. Cell. Biol. 19, 1981-1989
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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma -irradiation.

J. Brugarolas, K. Moberg, S. D. Boyd, Y. Taya, T. Jacks, and J. A. Lees (1999)
PNAS 96, 1002-1007
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Regulation of Exit from Quiescence by p27 and Cyclin D1-CDK4.

M. H. Ladha, K. Y. Lee, T. M. Upton, M. F. Reed, and M. E. Ewen (1998)
Mol. Cell. Biol. 18, 6605-6615
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Specific K-ras2 Mutations in Human Sporadic Colorectal Adenomas Are Associated with DNA Near-Diploid Aneuploidy and Inhibition of Proliferation.

W. Giaretti, A. Rapallo, E. Geido, A. Sciutto, F. Merlo, M. Risio, and F. P. Rossini (1998)
Am. J. Pathol. 153, 1201-1209
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Loss of p16/INK4A Protein Expression in Non-Hodgkin's Lymphomas Is a Frequent Finding Associated with Tumor Progression.

R. Villuendas, M. Sanchez-Beato, J. C. Martinez, A. I. Saez, B. Martinez-Delgado, J. F. Garcia, M. S. Mateo, L. Sanchez-Verde, J. Benitez, P. Martinez, et al. (1998)
Am. J. Pathol. 153, 887-897
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Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.

A. I. Robles, M. L. Rodriguez-Puebla, A. B. Glick, C. Trempus, L. Hansen, P. Sicinski, R. W. Tennant, R. A. Weinberg, S. H. Yuspa, and C. J. Conti (1998)
Genes & Dev. 12, 2469-2474
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Rac and Cdc42 Are Potent Stimulators of E2F-dependent Transcription Capable of Promoting Retinoblastoma Susceptibility Gene Product Hyperphosphorylation.

O. Gjoerup, J. Lukas, J. Bartek, and B. M. Willumsen (1998)
J. Biol. Chem. 273, 18812-18818
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Differential Regulation of Discrete Apoptotic Pathways by Ras.

C.-Y. Chen, J. Liou, L. W. Forman, and D. V. Faller (1998)
J. Biol. Chem. 273, 16700-16709
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p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin's Lymphomas.

M. Pinyol, F. Cobo, S. Bea, P. Jares, I. Nayach, P. L. Fernandez, E. Montserrat, A. Cardesa, and E. Campo (1998)
Blood 91, 2977-2984
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Expression of the pRb-Binding Regions of E1A Enables Efficient Transformation of Primary Epithelial Cells by v-src.

R. S. Fischer and M. P. Quinlan (1998)
J. Virol. 72, 2815-2824
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Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism.

K. Inoue and C. J. Sherr (1998)
Mol. Cell. Biol. 18, 1590-1600
 |  Abstract »  |  Full Text »

p16/INK4a and p15/INK4b Gene Methylation and Absence of p16/INK4a mRNA and Protein Expression in Burkitt's Lymphoma.

U. Klangby, I. Okan, K. P. Magnusson, M. Wendland, P. Lind, and K. G. Wiman (1998)
Blood 91, 1680-1687
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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).

M. Cheng, V. Sexl, C. J. Sherr, and M. F. Roussel (1998)
PNAS 95, 1091-1096
 |  Abstract »  |  Full Text »  |  PDF »

p16INK4A Participates in a G1 Arrest Checkpoint in Response to DNA Damage.

G. I. Shapiro, C. D. Edwards, M. E. Ewen, and B. J. Rollins (1998)
Mol. Cell. Biol. 18, 378-387
 |  Abstract »  |  Full Text »

p16INK4A Promotes Differentiation and Inhibits Apoptosis of JKB Acute Lymphoblastic Leukemia Cells.

M. Urashima, J. A. DeCaprio, D. Chauhan, G. Teoh, A. Ogata, S. P. Treon, Y. Hoshi, and K. C. Anderson (1997)
Blood 90, 4106-4115
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-activating Factor (PAF) Induces Growth Stimulation, Inhibition, and Suppression of Oncogenic Transformation in NRK Cells Overexpressing the PAF Receptor.

K. Kume and T. Shimizu (1997)
J. Biol. Chem. 272, 22898-22904
 |  Abstract »  |  Full Text »  |  PDF »

Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D-Dependent Kinases.

M. Adachi, M. F. Roussel, K. Havenith, and C. J. Sherr (1997)
Blood 90, 126-137
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Cooperating oncogenes converge to regulate cyclin/cdk complexes..

A C Lloyd, F Obermuller, S Staddon, C F Barth, M McMahon, and H Land (1997)
Genes & Dev. 11, 663-677
 |  Abstract »  |  PDF »

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

D. E. Quelle, M. Cheng, R. A. Ashmun, and C. J. Sherr (1997)
PNAS 94, 669-673
 |  Abstract »  |  Full Text »  |  PDF »

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein..

N A Timchenko, M Wilde, M Nakanishi, J R Smith, and G J Darlington (1996)
Genes & Dev. 10, 804-815
 |  Abstract »  |  PDF »

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity..

J DeGregori, G Leone, K Ohtani, A Miron, and J R Nevins (1995)
Genes & Dev. 9, 2873-2887
 |  Abstract »  |  PDF »

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

T Wolfel, M Hauer, J Schneider, M Serrano, C Wolfel, E Klehmann-Hieb, E De Plaen, T Hankeln, K. Meyer zum Buschenfelde, and D Beach (1995)
Science 269, 1281-1284
 |  Abstract »  |  PDF »

Inhibitors of mammalian G1 cyclin-dependent kinases..

C J Sherr and J M Roberts (1995)
Genes & Dev. 9, 1149-1163
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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1.

M. Collado, R. H. Medema, I. Garcia-Cao, M. L. N. Dubuisson, M. Barradas, J. Glassford, C. Rivas, B. M. T. Burgering, M. Serrano, and E. W.-F. Lam (2000)
J. Biol. Chem. 275, 21960-21968
 |  Abstract »  |  Full Text »  |  PDF »

Cdk2-dependent Phosphorylation and Functional Inactivation of the pRB-related p130 Protein in pRB(-), p16INK4A(+) Tumor Cells.

L. Cheng, F. Rossi, W. Fang, T. Mori, and D. Cobrinik (2000)
J. Biol. Chem. 275, 30317-30325
 |  Abstract »  |  Full Text »  |  PDF »

Wnt1 and MEK1 Cooperate to Promote Cyclin D1 Accumulation and Cellular Transformation.

R. A. Rimerman, A. Gellert-Randleman, and J. A. Diehl (2000)
J. Biol. Chem. 275, 14736-14742
 |  Abstract »  |  Full Text »  |  PDF »

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