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Science 13 January 1995: Vol. 267. no. 5195, pp. 246 - 249 DOI: 10.1126/science.7809630
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Articles
Science, Vol 267, Issue 5195, 246-249
Copyright © 1995 by American Association for the Advancement of Science
Requirement of FGF-4 for postimplantation mouse development
B Feldman,
W Poueymirou,
VE Papaioannou,
TM DeChiara,
and
M Goldfarb
Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Fibroblast growth factors (FGFs) are thought to influence many processes in vertebrate development because of their diverse sites of expression and wide range of biological activities in in vitro culture systems. As a means of elucidating embryonic functions of FGF-4, gene targeting was used to generate mice harboring a disrupted Fgf4 gene. Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter. As was consistent with their behavior in vivo, Fgf4 null embryos cultured in vitro displayed severely impaired proliferation of the inner cell mass, whereas growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein.
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Genes & Dev.
9, 2105-2116
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- Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality..
- L E Stephens, A E Sutherland, I V Klimanskaya, A Andrieux, J Meneses, R A Pedersen, and C H Damsky (1995)
Genes & Dev.
9, 1883-1895
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- Expression of a truncated FGF receptor results in defective lens development in transgenic mice.
- M. Robinson, L. MacMillan-Crow, J. Thompson, and P. Overbeek (1995)
Development
121, 3959-3967
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- FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens.
- R. Chow, G. Roux, M Roghani, M. Palmer, D. Rifkin, D. Moscatelli, and R. Lang (1995)
Development
121, 4383-4393
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- Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern.
- T. Lamb and R. Harland (1995)
Development
121, 3627-3636
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- Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud.
- D. Chan, A Wynshaw-Boris, and P Leder (1995)
Development
121, 3151-3162
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- Modulation of the Activity of Multiple Transcriptional Activation Domains by the DNA Binding Domains Mediates the Synergistic Action of Sox2 and Oct-3 on the Fibroblast Growth Factor-4 Enhancer.
- D.-C. Ambrosetti, H. R. Scholer, L. Dailey, and C. Basilico (2000)
J. Biol. Chem.
275, 23387-23397
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- Maintenance of Vascular Integrity in the Embryo Requires Signaling through the Fibroblast Growth Factor Receptor.
- S. H. Lee, D. J. Schloss, and J. L. Swain (2000)
J. Biol. Chem.
275, 33679-33687
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