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Science 6 January 1995:
Vol. 267. no. 5194, pp. 108 - 111
DOI: 10.1126/science.7528941
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Articles

Science, Vol 267, Issue 5194, 108-111
Copyright © 1995 by American Association for the Advancement of Science

articles

Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

VM Coghlan, BA Perrino, M Howard, LK Langeberg, JB Hicks, WM Gallatin, and JD Scott

Vollum Institute, Oregon Health Sciences University, Portland 97201.

Specificity of protein kinases and phosphatases may be achieved through compartmentalization with preferred substrates. In neurons, adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase (PKA) is localized at postsynaptic densities by association of its regulatory subunit with an A kinase anchor protein, AKAP79. Interaction cloning experiments demonstrated that AKAP79 also binds protein phosphatase 2B, or calcineurin (CaN). A ternary complex of PKA, AKAP, and CaN was isolated from bovine brain, and colocalization of the kinase and the phosphatase was established in neurites of cultured hippocampal neurons. The putative CaN-binding domain of AKAP79 is similar to that of the immunophilin FKBP-12, and AKAP79 inhibited CaN phosphatase activity. These results suggest that both PKA and CaN are targeted to subcellular sites by association with a common anchor protein and thereby regulate the phosphorylation state of key neuronal substrates.


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J. Biol. Chem. 273, 35048-35055
   Abstract »    Full Text »    PDF »
An X-linked Gene Encodes a Major Human Sperm Fibrous Sheath Protein, hAKAP82. GENOMIC ORGANIZATION, PROTEIN KINASE A-RII BINDING, AND DISTRIBUTION OF THE PRECURSOR IN THE SPERM TAIL.
R. M. O. Turner, L. R. Johnson, L. Haig-Ladewig, G. L. Gerton, and S. B. Moss (1998)
J. Biol. Chem. 273, 32135-32141
   Abstract »    Full Text »    PDF »
AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region.
A. Kashishian, M. Howard, C. Loh, W. M. Gallatin, M. F. Hoekstra, and Y. Lai (1998)
J. Biol. Chem. 273, 27412-27419
   Abstract »    Full Text »    PDF »
Expression of A Kinase Anchor Protein 121 Is Regulated by Hormones in Thyroid and Testicular Germ Cells.
A. Feliciello, C. S. Rubin, E. V. Avvedimento, and M. E. Gottesman (1998)
J. Biol. Chem. 273, 23361-23366
   Abstract »    Full Text »    PDF »
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
A. Takashima, M. Murayama, O. Murayama, T. Kohno, T. Honda, K. Yasutake, N. Nihonmatsu, M. Mercken, H. Yamaguchi, S. Sugihara, et al. (1998)
PNAS 95, 9637-9641
   Abstract »    Full Text »    PDF »
Cain, A Novel Physiologic Protein Inhibitor of Calcineurin.
M. M. Lai, P. E. Burnett, H. Wolosker, S. Blackshaw, and S. H. Snyder (1998)
J. Biol. Chem. 273, 18325-18331
   Abstract »    Full Text »    PDF »
RACK1, a Receptor for Activated C Kinase and a Homolog of the beta  Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells.
B. Y. Chang, K. B. Conroy, E. M. Machleder, and C. A. Cartwright (1998)
Mol. Cell. Biol. 18, 3245-3256
   Abstract »    Full Text »
Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin.
C. B. Klee, H. Ren, and X. Wang (1998)
J. Biol. Chem. 273, 13367-13370
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Molecular and Genetic Analysis of Two Closely Linked Genes That Encode, Respectively, a Protein Phosphatase 1/2A/2B Homolog and a Protein Kinase Homolog in the Cyanobacterium Anabaena sp. Strain PCC 7120.
C.-C. Zhang, A. Friry, and L. Peng (1998)
J. Bacteriol. 180, 2616-2622
   Abstract »    Full Text »
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus.
A. Sik, N. Hajos, A. Gulacsi, I. Mody, and T. F. Freund (1998)
PNAS 95, 3245-3250
   Abstract »    Full Text »    PDF »


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