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Science 23 December 1994:
Vol. 266. no. 5193, pp. 2011 - 2015
DOI: 10.1126/science.7605428
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Articles

Science, Vol 266, Issue 5193, 2011-2015
Copyright © 1994 by American Association for the Advancement of Science

articles

Specific association of human telomerase activity with immortal cells and cancer

NW Kim, MA Piatyszek, KR Prowse, CB Harley, MD West, PL Ho, GM Coviello, WE Wright, SL Weinrich, and JW Shay

Geron Corporation, Menlo Park, CA 94025.

Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.


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Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita.
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