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Science 23 December 1994:
Vol. 266. no. 5193, pp. 2002 - 2006
DOI: 10.1126/science.7801128
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Articles

Science, Vol 266, Issue 5193, 2002-2006
Copyright © 1994 by American Association for the Advancement of Science

articles

Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

GV Kalpana, S Marmon, W Wang, GR Crabtree, and SP Goff

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032.

Upon entry into a host cell, retroviruses direct the reverse transcription of the viral RNA genome and the establishment of an integrated proviral DNA. The retroviral integrase protein (IN) is responsible for the insertion of the viral DNA into host chromosomal targets. The two-hybrid system was used to identify a human gene product that binds tightly to the human immunodeficiency virus-type 1 (HIV-1) integrase in vitro and stimulates its DNA-joining activity. The sequence of the gene suggests that the protein is a human homolog of yeast SNF5, a transcriptional activator required for high-level expression of many genes. The gene, termed INI1 (for integrase interactor 1), may encode a nuclear factor that promotes integration and targets incoming viral DNA to active genes.


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J. Virol. 80, 11498-11509
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C. J. Guidi, R. Mudhasani, K. Hoover, A. Koff, I. Leav, A. N. Imbalzano, and S. N. Jones (2006)
Cancer Res. 66, 8076-8082
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Inhibition of Early Steps of HIV-1 Replication by SNF5/Ini1.
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J. Virol. 80, 7275-7280
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J. Virol. 80, 5670-5677
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Promoter methylation of helicase-like transcription factor is associated with the early stages of gastric cancer with family history.
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Ann. Onc. 17, 657-662
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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.
F. Turlure, G. Maertens, S. Rahman, P. Cherepanov, and A. Engelman (2006)
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Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus.
L. Vandekerckhove, F. Christ, B. Van Maele, J. De Rijck, R. Gijsbers, C. Van den Haute, M. Witvrouw, and Z. Debyser (2006)
J. Virol. 80, 1886-1896
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The p270 (ARID1A/SMARCF1) Subunit of Mammalian SWI/SNF-Related Complexes Is Essential for Normal Cell Cycle Arrest.
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Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication.
S. Emiliani, A. Mousnier, K. Busschots, M. Maroun, B. Van Maele, D. Tempe, L. Vandekerckhove, F. Moisant, L. Ben-Slama, M. Witvrouw, et al. (2005)
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Cancer Res. 65, 4012-4019
   Abstract »    Full Text »    PDF »
The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding.
K. Busschots, J. Vercammen, S. Emiliani, R. Benarous, Y. Engelborghs, F. Christ, and Z. Debyser (2005)
J. Biol. Chem. 280, 17841-17847
   Abstract »    Full Text »    PDF »
The Cellular Protein Daxx Interacts with Avian Sarcoma Virus Integrase and Viral DNA To Repress Viral Transcription.
J. G. Greger, R. A. Katz, A. M. Ishov, G. G. Maul, and A. M. Skalka (2005)
J. Virol. 79, 4610-4618
   Abstract »    Full Text »    PDF »
Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant.
M. E. Gelbart, N. Bachman, J. Delrow, J. D. Boeke, and T. Tsukiyama (2005)
Genes & Dev. 19, 942-954
   Abstract »    Full Text »    PDF »
The ups and downs of gene expression and retroviral DNA integration.
A. Engelman (2005)
PNAS 102, 1275-1276
   Full Text »    PDF »
Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase.
P. Cherepanov, E. Devroe, P. A. Silver, and A. Engelman (2004)
J. Biol. Chem. 279, 48883-48892
   Abstract »    Full Text »    PDF »
Host Factors That Affect Ty3 Retrotransposition in Saccharomyces cerevisiae.
M. Aye, B. Irwin, N. Beliakova-Bethell, E. Chen, J. Garrus, and S. Sandmeyer (2004)
Genetics 168, 1159-1176
   Abstract »    Full Text »    PDF »
LEDGF/p75 Determines Cellular Trafficking of Diverse Lentiviral but Not Murine Oncoretroviral Integrase Proteins and Is a Component of Functional Lentiviral Preintegration Complexes.
M. Llano, M. Vanegas, O. Fregoso, D. Saenz, S. Chung, M. Peretz, and E. M. Poeschla (2004)
J. Virol. 78, 9524-9537
   Abstract »    Full Text »    PDF »
SNR1 (INI1/SNF5) Mediates Important Cell Growth Functions of the Drosophila Brahma (SWI/SNF) Chromatin Remodeling Complex.
C. B. Zraly, D. R. Marenda, and A. K. Dingwall (2004)
Genetics 168, 199-214
   Abstract »    Full Text »    PDF »
Interaction between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase Proteins.
E. A. Hehl, P. Joshi, G. V. Kalpana, and V. R. Prasad (2004)
J. Virol. 78, 5056-5067
   Abstract »    Full Text »    PDF »
The Chromatin-Remodeling BAF Complex Mediates Cellular Antiviral Activities by Promoter Priming.
K. Cui, P. Tailor, H. Liu, X. Chen, K. Ozato, and K. Zhao (2004)
Mol. Cell. Biol. 24, 4476-4486
   Abstract »    Full Text »    PDF »
Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.
N. Shkriabai, S. S. Patil, S. Hess, S. R. Budihas, R. Craigie, T. R. Burke Jr., S. F. J. Le Grice, and M. Kvaratskhelia (2004)
PNAS 101, 6894-6899
   Abstract »    Full Text »    PDF »
Specificity of Interaction of INI1/hSNF5 with Retroviral Integrases and Its Functional Significance.
E. Yung, M. Sorin, E.-J. Wang, S. Perumal, D. Ott, and G. V. Kalpana (2004)
J. Virol. 78, 2222-2231
   Abstract »    Full Text »    PDF »
Transcriptional Compensation for Loss of an Allele of the Ini1 Tumor Suppressor.
C. J. Guidi, T. M. Veal, S. N. Jones, and A. N. Imbalzano (2004)
J. Biol. Chem. 279, 4180-4185
   Abstract »    Full Text »    PDF »
p16INK4a Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells.
I. Oruetxebarria, F. Venturini, T. Kekarainen, A. Houweling, L. M. P. Zuijderduijn, A. Mohd-Sarip, R. G. J. Vries, R. C. Hoeben, and C. P. Verrijzer (2004)
J. Biol. Chem. 279, 3807-3816
   Abstract »    Full Text »    PDF »
The Human Polycomb Group EED Protein Interacts with the Integrase of Human Immunodeficiency Virus Type 1.
S. Violot, S. S. Hong, D. Rakotobe, C. Petit, B. Gay, K. Moreau, G. Billaud, S. Priet, J. Sire, O. Schwartz, et al. (2003)
J. Virol. 77, 12507-12522
   Abstract »    Full Text »    PDF »
Heterologous Human Immunodeficiency Virus Type 1 Lentiviral Vectors Packaging a Simian Immunodeficiency Virus-Derived Genome Display a Specific Postentry Transduction Defect in Dendritic Cells.
C. Goujon, L. Jarrosson-Wuilleme, J. Bernaud, D. Rigal, J.-L. Darlix, and A. Cimarelli (2003)
J. Virol. 77, 9295-9304
   Abstract »    Full Text »    PDF »
Integration by design.
S. Sandmeyer (2003)
PNAS 100, 5586-5588
   Full Text »    PDF »
From the Cover: Controlling integration specificity of a yeast retrotransposon.
Y. Zhu, J. Dai, P. G. Fuerst, and D. F. Voytas (2003)
PNAS 100, 5891-5895
   Abstract »    Full Text »    PDF »
Advances in the Diagnosis, Molecular Genetics, and Treatment of Pediatric Embryonal CNS Tumors.
T. J. MacDonald, B. R. Rood, M. R. Santi, G. Vezina, K. Bingaman, P. H. Cogen, and R. J. Packer (2003)
Oncologist 8, 174-186
   Abstract »    Full Text »    PDF »
Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.
S. Hwang, D. Lee, Y. Gwack, H. Min, and J. Choe (2003)
J. Gen. Virol. 84, 665-676
   Abstract »    Full Text »    PDF »
HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells.
P. Cherepanov, G. Maertens, P. Proost, B. Devreese, J. Van Beeumen, Y. Engelborghs, E. De Clercq, and Z. Debyser (2003)
J. Biol. Chem. 278, 372-381
   Abstract »    Full Text »    PDF »
Cellular Gene Expression upon Human Immunodeficiency Virus Type 1 Infection of CD4+-T-Cell Lines.
A. B. van 't Wout, G. K. Lehrman, S. A. Mikheeva, G. C. O'Keeffe, M. G. Katze, R. E. Bumgarner, G. K. Geiss, and J. I. Mullins (2002)
J. Virol. 77, 1392-1402
   Abstract »    Full Text »    PDF »
Cofactors for Human Immunodeficiency Virus Type 1 cDNA Integration In Vitro.
K. Gao, R. J. Gorelick, D. G. Johnson, and F. Bushman (2002)
J. Virol. 77, 1598-1603
   Abstract »    Full Text »    PDF »
Alterations of the hSNF5/INI1 Gene in Central Nervous System Atypical Teratoid/Rhabdoid Tumors and Renal and Extrarenal Rhabdoid Tumors.
J. A. Biegel, L. Tan, F. Zhang, L. Wainwright, P. Russo, and L. B. Rorke (2002)
Clin. Cancer Res. 8, 3461-3467
   Abstract »    Full Text »    PDF »
Characterization of Moloney Murine Leukemia Virus p12 Mutants Blocked during Early Events of Infection.
B. Yuan, A. Fassati, A. Yueh, and S. P. Goff (2002)
J. Virol. 76, 10801-10810
   Abstract »    Full Text »    PDF »
Cell Cycle Arrest and Repression of Cyclin D1 Transcription by INI1/hSNF5.
Z.-K. Zhang, K. P. Davies, J. Allen, L. Zhu, R. G. Pestell, D. Zagzag, and G. V. Kalpana (2002)
Mol. Cell. Biol. 22, 5975-5988
   Abstract »    Full Text »    PDF »
AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time.
T. J. Sarnowski, S. Swiezewski, K. Pawlikowska, S. Kaczanowski, and A. Jerzmanowski (2002)
Nucleic Acids Res. 30, 3412-3421
   Abstract »    Full Text »    PDF »
Design of a nonviral vector for site-selective, efficient integration into the human genome.
J. M. KAMINSKI, M. R. HUBER, J. B. SUMMERS, and M. B. WARD (2002)
FASEB J 16, 1242-1247
   Abstract »    Full Text »    PDF »
The Human SNF5/INI1 Protein Facilitates the Function of the Growth Arrest and DNA Damage-inducible Protein (GADD34) and Modulates GADD34-bound Protein Phosphatase-1 Activity.
D. Y. Wu, D. C. Tkachuck, R. S. Roberson, and W. H. Schubach (2002)
J. Biol. Chem. 277, 27706-27715
   Abstract »    Full Text »    PDF »
SWI/SNF Complex Interacts with Tumor Suppressor p53 and Is Necessary for the Activation of p53-mediated Transcription.
D. Lee, J. W. Kim, T. Seo, S. G. Hwang, E.-J. Choi, and J. Choe (2002)
J. Biol. Chem. 277, 22330-22337
   Abstract »    Full Text »    PDF »
Rhesus Macaque Resistance to Mucosal Simian Immunodeficiency Virus Infection Is Associated with a Postentry Block in Viral Replication.
B. Peng, R. Voltan, L. Lim, Y. Edghill-Smith, S. Phogat, D. S. Dimitrov, K. Arora, M. Leno, S. Than, R. Woodward, et al. (2002)
J. Virol. 76, 6016-6026
   Abstract »    Full Text »    PDF »
Transcription Activator Interactions with Multiple SWI/SNF Subunits.
K. E. Neely, A. H. Hassan, C. E. Brown, L. Howe, and J. L. Workman (2002)
Mol. Cell. Biol. 22, 1615-1625
   Abstract »    Full Text »    PDF »
SYT Associates with Human SNF/SWI Complexes and the C-terminal Region of Its Fusion Partner SSX1 Targets Histones.
H. Kato, A. Tjernberg, W. Zhang, A. N. Krutchinsky, W. An, T. Takeuchi, Y. Ohtsuki, S. Sugano, D. R. de Bruijn, B. T. Chait, et al. (2002)
J. Biol. Chem. 277, 5498-5505
   Abstract »    Full Text »    PDF »
HIV-1 Preintegration Complexes Preferentially Integrate into Longer Target DNA Molecules in Solution as Detected by a Sensitive, Polymerase Chain Reaction-based Integration Assay.
A. Brooun, D. D. Richman, and R. S. Kornbluth (2001)
J. Biol. Chem. 276, 46946-46952
   Abstract »    Full Text »    PDF »
Functional Interactions of Human Immunodeficiency Virus Type 1 Integrase with Human and Yeast HSP60.
V. Parissi, C. Calmels, V. R. De Soultrait, A. Caumont, M. Fournier, S. Chaignepain, and S. Litvak (2001)
J. Virol. 75, 11344-11353
   Abstract »    Full Text »
A Truncation Mutant of the 95-Kilodalton Subunit of Transcription Factor IIIC Reveals Asymmetry in Ty3 Integration.
M. Aye, S. L. Dildine, J. A. Claypool, S. Jourdain, and S. B. Sandmeyer (2001)
Mol. Cell. Biol. 21, 7839-7851
   Abstract »    Full Text »    PDF »
Assembly and Catalysis of Concerted Two-End Integration Events by Moloney Murine Leukemia Virus Integrase.
F. Yang and M. J. Roth (2001)
J. Virol. 75, 9561-9570
   Abstract »    Full Text »    PDF »
Targeting of the Yeast Ty5 Retrotransposon to Silent Chromatin Is Mediated by Interactions between Integrase and Sir4p.
W. Xie, X. Gai, Y. Zhu, D. C. Zappulla, R. Sternglanz, and D. F. Voytas (2001)
Mol. Cell. Biol. 21, 6606-6614
   Abstract »    Full Text »    PDF »
Essential Roles of Snf5p in Snf-Swi Chromatin Remodeling In Vivo.
F. Geng, Y. Cao, and B. C. Laurent (2001)
Mol. Cell. Biol. 21, 4311-4320
   Abstract »    Full Text »    PDF »
Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice.
C. J. Guidi, A. T. Sands, B. P. Zambrowicz, T. K. Turner, D. A. Demers, W. Webster, T. W. Smith, A. N. Imbalzano, and S. N. Jones (2001)
Mol. Cell. Biol. 21, 3598-3603
   Abstract »    Full Text »
Retroviral cDNA Integration: Stimulation by HMG I Family Proteins.
L. Li, K. Yoder, M. S. T. Hansen, J. Olvera, M. D. Miller, and F. D. Bushman (2000)
J. Virol. 74, 10965-10974
   Abstract »    Full Text »
BRG1, a Component of the SWI-SNF Complex, Is Mutated in Multiple Human Tumor Cell Lines.
A. K. C. Wong, F. Shanahan, Y. Chen, L. Lian, P. Ha, K. Hendricks, S. Ghaffari, D. Iliev, B. Penn, A.-M. Woodland, et al. (2000)
Cancer Res. 60, 6171-6177
   Abstract »    Full Text »
Relationship between Retroviral DNA Integration and Gene Expression.
J. B. Weidhaas, E. L. Angelichio, S. Fenner, and J. M. Coffin (2000)
J. Virol. 74, 8382-8389
   Abstract »    Full Text »
The Karyophilic Properties of Human Immunodeficiency Virus Type 1 Integrase Are Not Required for Nuclear Import of Proviral DNA.
C. Petit, O. Schwartz, and F. Mammano (2000)
J. Virol. 74, 7119-7126
   Abstract »    Full Text »
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
P. CHEREPANOV, W. PLUYMERS, A. CLAEYS, P. PROOST, E. DE CLERCQ, and Z. DEBYSER (2000)
FASEB J 14, 1389-1399
   Abstract »    Full Text »
Mutations of the INI1 Rhabdoid Tumor Suppressor Gene in Medulloblastomas and Primitive Neuroectodermal Tumors of the Central Nervous System.
J. A. Biegel, B. Fogelgren, J.-Y. Zhou, C. D. James, A. J. Janss, J. C. Allen, D. Zagzag, C. Raffel, and L. B. Rorke (2000)
Clin. Cancer Res. 6, 2759-2763
   Abstract »    Full Text »
Identification of Critical Amino Acid Residues in Human Immunodeficiency Virus Type 1 IN Required for Efficient Proviral DNA Formation at Steps prior to Integration in Dividing and Nondividing Cells.
N. Tsurutani, M. Kubo, Y. Maeda, T. Ohashi, N. Yamamoto, M. Kannagi, and T. Masuda (2000)
J. Virol. 74, 4795-4806
   Abstract »    Full Text »
Mammalian SWI-SNF Complexes Contribute to Activation of the hsp70 Gene.
I. L. de la Serna, K. A. Carlson, D. A. Hill, C. J. Guidi, R. O. Stephenson, S. Sif, R. E. Kingston, and A. N. Imbalzano (2000)
Mol. Cell. Biol. 20, 2839-2851
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Nuclear Import of Moloney Murine Leukemia Virus DNA Mediated by Adenovirus Preterminal Protein Is Not Sufficient for Efficient Retroviral Transduction in Nondividing Cells.
A. Lieber, M. A. Kay, and Z.-Y. Li (2000)
J. Virol. 74, 721-734
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Targeting Human Immunodeficiency Virus (HIV) Type 2 Integrase Protein into HIV Type 1.
H. Liu, X. Wu, H. Xiao, and J. C. Kappes (1999)
J. Virol. 73, 8831-8836
   Abstract »    Full Text »    PDF »
Coupled Integration of Human Immunodeficiency Virus Type 1 cDNA Ends by Purified Integrase In Vitro: Stimulation by the Viral Nucleocapsid Protein.
S. Carteau, R. J. Gorelick, and F. D. Bushman (1999)
J. Virol. 73, 6670-6679
   Abstract »    Full Text »
The Integration Machinery of ZAM, a Retroelement from Drosophila melanogaster, Acts as a Sequence-Specific Endonuclease.
P. Leblanc, B. Dastugue, and C. Vaury (1999)
J. Virol. 73, 7061-7064
   Abstract »    Full Text »
Frequent Deletion of hSNF5/INI1, a Component of the SWI/SNF Complex, in Chronic Myeloid Leukemia.
F. Grand, S. Kulkarni, A. Chase, J. M. Goldman, M. Gordon, and N. C. P. Cross (1999)
Cancer Res. 59, 3870-3874
   Abstract »    Full Text »    PDF »
Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase.
C. Petit, O. Schwartz, and F. Mammano (1999)
J. Virol. 73, 5079-5088
   Abstract »    Full Text »
Cytogenetics and molecular genetics of childhood brain tumors.
J. A. Biegel (1999)
Neuro-oncol 1, 139-151
   Abstract »    PDF »
Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex.
X. Wu, H. Liu, H. Xiao, J. A. Conway, E. Hehl, G. V. Kalpana, V. Prasad, and J. C. Kappes (1999)
J. Virol. 73, 2126-2135
   Abstract »    Full Text »
Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest.
F. Shanahan, W. Seghezzi, D. Parry, D. Mahony, and E. Lees (1999)
Mol. Cell. Biol. 19, 1460-1469
   Abstract »    Full Text »    PDF »
Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching.
D. O'Neill, J. Yang, H. Erdjument-Bromage, K. Bornschlegel, P. Tempst, and A. Bank (1999)
PNAS 96, 349-354
   Abstract »    Full Text »    PDF »
HEED, the Product of the Human Homolog of the Murine eed Gene, Binds to the Matrix Protein of HIV-1.
R. Peytavi, S. S. Hong, B. Gay, A. D. d'Angeac, L. Selig, S. Benichou, R. Benarous, and P. Boulanger (1999)
J. Biol. Chem. 274, 1635-1645
   Abstract »    Full Text »    PDF »
Germ-Line and Acquired Mutations of INI1 in Atypical Teratoid and Rhabdoid Tumors.
J. A. Biegel, J.-Y. Zhou, L. B. Rorke, C. Stenstrom, L. M. Wainwright, and B. Fogelgren (1999)
Cancer Res. 59, 74-79
   Abstract »    Full Text »    PDF »
Processing of an HIV Replication Intermediate by the Human DNA Replication Enzyme FEN1.
J. A. Rumbaugh, G. M. Fuentes, and R. A. Bambara (1998)
J. Biol. Chem. 273, 28740-28745
   Abstract »    Full Text »    PDF »
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.
S. Sif, P. T. Stukenberg, M. W. Kirschner, and R. E. Kingston (1998)
Genes & Dev. 12, 2842-2851
   Abstract »    Full Text »
A Preferred Target DNA Structure for Retroviral Integrase in Vitro.
R. A. Katz, K. Gravuer, and A. M. Skalka (1998)
J. Biol. Chem. 273, 24190-24195
   Abstract »    Full Text »    PDF »
Structure-Based Mutational Analysis of the C-Terminal DNA-Binding Domain of Human Immunodeficiency Virus Type 1 Integrase: Critical Residues for Protein Oligomerization and DNA Binding.
R. A. P. Lutzke and R. H. A. Plasterk (1998)
J. Virol. 72, 4841-4848
   Abstract »    Full Text »    PDF »
Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery.
M. Hampsey (1998)
Microbiol. Mol. Biol. Rev. 62, 465-503
   Abstract »    Full Text »    PDF »
A Chimeric Ty3/Moloney Murine Leukemia Virus Integrase Protein Is Active In Vivo.
S. L. Dildine, J. Respess, D. Jolly, and S. B. Sandmeyer (1998)
J. Virol. 72, 4297-4307
   Abstract »    Full Text »    PDF »
Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding.
J. Cote, C. L. Peterson, and J. L. Workman (1998)
PNAS 95, 4947-4952
   Abstract »    Full Text »    PDF »
The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex.
O. Rozenblatt-Rosen, T. Rozovskaia, D. Burakov, Y. Sedkov, S. Tillib, J. Blechman, T. Nakamura, C. M. Croce, A. Mazo, and E. Canaani (1998)
PNAS 95, 4152-4157
   Abstract »    Full Text »    PDF »
Posttranslational Inhibition of Ty1 Retrotransposition by Nucleotide Excision Repair/Transcription Factor TFIIH Subunits Ssl2p and Rad3p.
B.-S. Lee, C. P. Lichtenstein, B. Faiola, L. A. Rinckel, W. Wysock, M. J. Curcio, and D. J. Garfinkel (1998)
Genetics 148, 1743-1761
   Abstract »    Full Text »    PDF »


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