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Science 16 December 1994: Vol. 266. no. 5192, pp. 1865 - 1869 DOI: 10.1126/science.7997879
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Articles
Science, Vol 266, Issue 5192, 1865-1869
Copyright © 1994 by American Association for the Advancement of Science
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Y Chang,
E Cesarman,
MS Pessin,
F Lee,
J Culpepper,
DM Knowles,
and
PS Moore
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
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- J. Liu, H. J. Martin, G. Liao, and S. D. Hayward (2007)
J. Virol.
81, 10451-10459
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- Imaging Features of Pulmonary Kaposi Sarcoma Associated Immune Reconstitution Syndrome.
- M. C. B. Godoy, H. Rouse, J. A. Brown, P. Phillips, D. M. Forrest, and N. L. Muller (2007)
Am. J. Roentgenol.
189, 956-965
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- Direct Interactions of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Protein with the Cellular Protein Octamer-1 and DNA Are Critical for Specifying Transactivation of a Delayed-Early Promoter and Stimulating Viral Reactivation.
- K. D. Carroll, F. Khadim, S. Spadavecchia, D. Palmeri, and D. M. Lukac (2007)
J. Virol.
81, 8451-8467
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- Cannabinoid Modulation of Kaposi's Sarcoma Associated Herpesvirus Infection and Transformation.
- X. Zhang, J. F. Wang, G. Kunos, and J. E. Groopman (2007)
Cancer Res.
67, 7230-7237
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- Evidence for a Multiclonal Origin of Multicentric Advanced Lesions of Kaposi Sarcoma.
- R. Duprez, V. Lacoste, J. Briere, P. Couppie, C. Frances, D. Sainte-Marie, E. Kassa-Kelembho, M.-J. Lando, J.-L. Essame Oyono, B. Nkegoum, et al. (2007)
J Natl Cancer Inst
99, 1086-1094
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- Hypoxia Enhances the Phosphorylation and Cytotoxicity of Ganciclovir and Zidovudine in Kaposi's Sarcoma-Associated Herpesvirus Infected Cells.
- D. A. Davis, K. E. Singer, I. P. Reynolds, M. Haque, and R. Yarchoan (2007)
Cancer Res.
67, 7003-7010
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- Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Invasion of Primary Human Umbilical Vein Endothelial Cells by Inducing Matrix Metalloproteinases.
- L.-W. Qian, J. Xie, F. Ye, and S.-J. Gao (2007)
J. Virol.
81, 7001-7010
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- Familial blood vessel tumors and subsequent cancers.
- J Ji and K Hemminki (2007)
Ann. Onc.
18, 1260-1267
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- AIDS-Related Cancer and Severity of Immunosuppression in Persons With AIDS.
- R. J. Biggar, A. K. Chaturvedi, J. J. Goedert, and E. A. Engels (2007)
J Natl Cancer Inst
99, 962-972
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- The Transcriptional Repressor K-RBP Modulates RTA-Mediated Transactivation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus.
- Z. Yang and C. Wood (2007)
J. Virol.
81, 6294-6306
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- Kaposi Sarcoma-associated Herpes Virus Targets the Lymphotactin Receptor with Both a Broad Spectrum Antagonist vCCL2 and a Highly Selective and Potent Agonist vCCL3.
- H. R. Luttichau, A. H. Johnsen, J. Jurlander, M. M. Rosenkilde, and T. W. Schwartz (2007)
J. Biol. Chem.
282, 17794-17805
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- Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.
- L. Wang, M. M. Brinkmann, M. Pietrek, M. Ottinger, O. Dittrich-Breiholz, M. Kracht, and T. F. Schulz (2007)
J. Gen. Virol.
88, 1698-1707
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- Human herpes virus 8 infection in kidney transplant patients from an area of northwestern Italy (Piemonte region).
- M. Bergallo, C. Costa, S. Margio, F. Sidoti, D. Re, G. P. Segoloni, and R. Cavallo (2007)
Nephrol. Dial. Transplant.
22, 1757-1761
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- Signaling Cascades Triggered by Bacterial Metabolic End Products during Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
- T. L. Morris, R. R. Arnold, and J. Webster-Cyriaque (2007)
J. Virol.
81, 6032-6042
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- Epstein-Barr Virus Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication in Primary Effusion Lymphomas.
- D. Xu, T. Coleman, J. Zhang, A. Fagot, C. Kotalik, L. Zhao, P. Trivedi, C. Jones, and L. Zhang (2007)
J. Virol.
81, 6068-6078
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- Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Lytic Switch Protein Functions as a Tetramer.
- W. Bu, K. D. Carroll, D. Palmeri, and D. M. Lukac (2007)
J. Virol.
81, 5788-5806
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