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Science 16 December 1994:
Vol. 266. no. 5192, pp. 1862 - 1865
DOI: 10.1126/science.7527937
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Articles

Science, Vol 266, Issue 5192, 1862-1865
Copyright © 1994 by American Association for the Advancement of Science

articles

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

WM Kavanaugh and LT Williams

Department of Medicine, University of California, San Francisco 94143.

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that participate in signaling by growth factors and oncogenes. A protein domain was identified that bound specifically to the tyrosine-phosphorylated form of its target protein but differs from known SH2 sequences. Phosphotyrosine-binding (PTB) domains were found in two proteins: SHC, a protein implicated in signaling through Ras; and SCK, encoded by a previously uncharacterized gene. The PTB domain of SHC specifically bound to a tyrosine-phosphorylated 145-kilodalton protein. PTB domains are an alternative to SH2 domains for specifically recruiting tyrosine-phosphorylated proteins into signaling complexes and are likely to take part in signaling by many growth factors.


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Blood 89, 55-64
   Abstract »    Full Text »    PDF »
Interferon-beta Interrupts Interleukin-6-Dependent Signaling Events in Myeloma Cells.
L. C. Berger and R. G. Hawley (1997)
Blood 89, 261-271
   Abstract »    Full Text »    PDF »
Characterization of the Phosphotyrosine-binding Domain of the Drosophila Shc Protein.
S.-C. Li, K.-M. V. Lai, G. D. Gish, W. E. Parris, P. van der Geer, J. Forman-Kay, and T. Pawson (1996)
J. Biol. Chem. 271, 31855-31862
   Abstract »    Full Text »    PDF »
Grb7 is a Downstream Signaling Component of Platelet-derived Growth Factor alpha - and beta -Receptors.
K. Yokote, B. Margolis, C.-H. Heldin, and L. Claesson-Welsh (1996)
J. Biol. Chem. 271, 30942-30949
   Abstract »    Full Text »    PDF »
The Inositol 5'-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation.
M. A. Osborne, G. Zenner, M. Lubinus, X. Zhang, Z. Songyang, L. C. Cantley, P. Majerus, P. Burn, and J. P. Kochan (1996)
J. Biol. Chem. 271, 29271-29278
   Abstract »    Full Text »    PDF »
Controlling Epidermal Growth Factor (EGF)-stimulated Ras Activation in Intact Cells by a Cell-permeable Peptide Mimicking Phosphorylated EGF Receptor.
M. Rojas, S. Yao, and Y.-Z. Lin (1996)
J. Biol. Chem. 271, 27456-27461
   Abstract »    Full Text »    PDF »
Growth and Survival Signals transmitted via Two Distinct NPXY Motifs within Leukocyte Tyrosine Kinase, an Insulin Receptor-related Tyrosine Kinase.
H. Ueno, K. Sasaki, H. Kozutsumi, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1996)
J. Biol. Chem. 271, 27707-27714
   Abstract »    Full Text »    PDF »
Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells.
S. E. Nicholson, R. Starr, U. Novak, D. J. Hilton, and J. E. Layton (1996)
J. Biol. Chem. 271, 26947-26953
   Abstract »    Full Text »    PDF »
Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2Domains in Insulin and Epidermal Growth Factor Signaling.
W. A. Ricketts, D. W. Rose, S. Shoelson, and J. M. Olefsky (1996)
J. Biol. Chem. 271, 26165-26169
   Abstract »    Full Text »    PDF »
A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells.
M. L. Lupher Jr., K. A. Reedquist, S. Miyake, W. Y. Langdon, and H. Band (1996)
J. Biol. Chem. 271, 24063-24068
   Abstract »    Full Text »    PDF »
The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1.
L. Yenush, K. J. Makati, J. Smith-Hall, O. Ishibashi, M. G. Myers Jr., and M. F. White (1996)
J. Biol. Chem. 271, 24300-24306
   Abstract »    Full Text »    PDF »
Alteration of B-cell Antigen Receptor Signaling by CD19 Co-ligation. A STUDY WITH BISPECIFIC ANTIBODIES.
A. C. Lankester, P. M.L. Rood, G. M.W. van Schijndel, B. Hooibrink, A. J. Verhoeven, and R. A.W. van Lier (1996)
J. Biol. Chem. 271, 22326-22330
   Abstract »    Full Text »    PDF »
Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase.
T. M. Fournier, D. Kamikura, K. Teng, and M. Park (1996)
J. Biol. Chem. 271, 22211-22217
   Abstract »    Full Text »    PDF »
Phosphatidylinositol-3' Kinase Is Not Required for Mitogenesis or Internalization of the Flt3/Flk2 Receptor Tyrosine Kinase.
N. Beslu, J. LaRose, N. Casteran, D. Birnbaum, E. Lecocq, P. Dubreuil, and R. Rottapel (1996)
J. Biol. Chem. 271, 20075-20081
   Abstract »    Full Text »    PDF »
A Mutation at Tyrosine 1062in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins.
N. Asai, H. Murakami, T. Iwashita, and M. Takahashi (1996)
J. Biol. Chem. 271, 17644-17649
   Abstract »    Full Text »    PDF »
Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase.
E. Fournier, O. Rosnet, S. Marchetto, C. W. Turck, R. Rottapel, P. G. Pelicci, D. Birnbaum, and J.-P. Borg (1996)
J. Biol. Chem. 271, 12956-12963
   Abstract »    Full Text »    PDF »
Evidence for a Physical Association between the Shc-PTB Domain and the beta(c) Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor.
J. C. Pratt, M. Weiss, C. A. Sieff, S. E. Shoelson, S. J. Burakoff, and K. S. Ravichandran (1996)
J. Biol. Chem. 271, 12137-12140
   Abstract »    Full Text »    PDF »
Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors.
W. He, A. Craparo, Y. Zhu, T. J. O'Neill, L.-M. Wang, J. H. Pierce, and T. A. Gustafson (1996)
J. Biol. Chem. 271, 11641-11645
   Abstract »    Full Text »    PDF »
Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC.
J. P. O'Bryan, C. B. Martin, Z. Songyang, L. C. Cantley, and C. J. Der (1996)
J. Biol. Chem. 271, 11787-11791
   Abstract »    Full Text »    PDF »
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity..
M N Lioubin, P A Algate, S Tsai, K Carlberg, A Aebersold, and L R Rohrschneider (1996)
Genes & Dev. 10, 1084-1095
   Abstract »    PDF »
Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST.
A. Charest, J. Wagner, S. Jacob, C. J. McGlade, and M. L. Tremblay (1996)
J. Biol. Chem. 271, 8424-8429
   Abstract »    Full Text »    PDF »


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