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Science 9 December 1994:
Vol. 266. no. 5191, pp. 1723 - 1726
DOI: 10.1126/science.7992058
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Articles

Science, Vol 266, Issue 5191, 1723-1726
Copyright © 1994 by American Association for the Advancement of Science

articles

Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog

H Liu, J Kohler, and GR Fink

Whitehead Institute for Biomedical Research, Cambridge, MA 02142.

A Candida albicans gene (CPH1) was cloned that encodes a protein homologous to Saccharomyces cerevisiae Ste12p, a transcription factor that is the target of the pheromone response mitogen-activated protein kinase cascade. CPH1 complements both the mating defect of ste12 haploids and the filamentous growth defect of ste12/ste12 diploids. Candida albicans strains without a functional CPH1 gene (cph1/cph1) show suppressed hyphal formation on solid medium. However, cph1/cph1 strains can still form hyphae in liquid culture and in response to serum. Thus, filamentous growth may be activated in C. albicans by the same signaling kinase cascade that activates Ste12p in S. cerevisiae; however, alternative pathways may exist in C. albicans.


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S. Krishnamurthy, A. Plaine, J. Albert, T. Prasad, R. Prasad, and J. F. Ernst (2004)
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Eukaryot. Cell 3, 724-734
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P. Staib, A. Binder, M. Kretschmar, T. Nichterlein, K. Schroppel, and J. Morschhauser (2004)
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Mol. Cell. Biol. 22, 8669-8680
   Abstract »    Full Text »    PDF »
Gpa2, a G-Protein {alpha} Subunit Required for Hyphal Development in Candida albicans.
C. Sanchez-Martinez and J. Perez-Martin (2002)
Eukaryot. Cell 1, 865-874
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Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis.
D. A. Davis, V. M. Bruno, L. Loza, S. G. Filler, and A. P. Mitchell (2002)
Genetics 162, 1573-1581
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Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence.
C.-S. Hwang, G.-e. Rhie, J.-H. Oh, W.-K. Huh, H.-S. Yim, and S.-O. Kang (2002)
Microbiology 148, 3705-3713
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A Forkhead Transcription Factor Is Important for True Hyphal as well as Yeast Morphogenesis in Candida albicans.
E. S. Bensen, S. G. Filler, and J. Berman (2002)
Eukaryot. Cell 1, 787-798
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The Golgi GDPase of the Fungal Pathogen Candida albicans Affects Morphogenesis, Glycosylation, and Cell Wall Properties.
A. B. Herrero, D. Uccelletti, C. B. Hirschberg, A. Dominguez, and C. Abeijon (2002)
Eukaryot. Cell 1, 420-431
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Divergent Subunit Interactions among Fungal mRNA 5'-Capping Machineries.
T. Takagi, E.-J. Cho, R. T. K. Janoo, V. Polodny, Y. Takase, M.-C. Keogh, S.-A. Woo, L. D. Fresco-Cohen, C. S. Hoffman, and S. Buratowski (2002)
Eukaryot. Cell 1, 448-457
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Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.
O. Zaragoza, C. de Virgilio, J. Ponton, and C. Gancedo (2002)
Microbiology 148, 1281-1290
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Lack of Catheter Infection by the efg1/efg1cph1/cph1 Double-Null Mutant, a Candida albicans Strain That Is Defective in Filamentous Growth.
R. E. Lewis, H.-J. Lo, I. I. Raad, and D. P. Kontoyiannis (2002)
Antimicrob. Agents Chemother. 46, 1153-1155
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Conserved Serine/Threonine Kinase Encoded by CBK1 Regulates Expression of Several Hypha-Associated Transcripts and Genes Encoding Cell Wall Proteins in Candida albicans.
M. D. McNemar and W. A. Fonzi (2002)
J. Bacteriol. 184, 2058-2061
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Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans.
P. Wang, C. B. Nichols, K. B. Lengeler, M. E. Cardenas, G. M. Cox, J. R. Perfect, and J. Heitman (2002)
Eukaryot. Cell 1, 257-272
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Invasive Filamentous Growth of Candida albicans Is Promoted by Czf1p-Dependent Relief of Efg1p-Mediated Repression.
A. D. Giusani, M. Vinces, and C. A. Kumamoto (2002)
Genetics 160, 1749-1753
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Transcriptional Regulators Cph1p and Efg1p Mediate Activation of the Candida albicans Virulence Gene SAP5 during Infection.
P. Staib, M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhauser (2002)
Infect. Immun. 70, 921-927
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