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Science 2 December 1994:
Vol. 266. no. 5190, pp. 1573 - 1576
DOI: 10.1126/science.7985029
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Articles

Science, Vol 266, Issue 5190, 1573-1576
Copyright © 1994 by American Association for the Advancement of Science

articles

Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays

RH Schiestl, F Khogali, and N Carls

Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115.

Deletions and other genome rearrangements can be caused by radiation and are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p(un)) mutation in the mouse is caused by a gene duplication and reverts to wild type by deletion of one copy. Reversion events in the mouse embryo were detected as black spots on the fur of the animals or microscopically as partially black hair in a background of colorless hair. The frequency of partially black hair was increased by x-rays at very low doses. A linear dose-response relation was found between 1 and 100 centigray.


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Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice.
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Carcinogenesis 27, 240-244
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{zeta}-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation.
A. Leder, J. McMenamin, K. Fontaine, A. Bishop, and P. Leder (2005)
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Effect of N-Acetyl Cysteine on Oxidative DNA Damage and the Frequency of DNA Deletions in Atm-Deficient Mice.
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Cancer Res. 64, 5148-5153
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Susceptibility of proliferating cells to benzo[a]pyrene-induced homologous recombination in mice.
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Homologous recombination as a mechanism for genome rearrangements: environmental and genetic effects.
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Cancer Res. 60, 395-399
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Involvement of p53 in X-ray induced intrachromosomal recombination in mice.
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Carcinogenesis 20, 2229-2236
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Effect of ionizing radiation on transgenerational appearance of pun reversions in mice.
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Chimerism in humans after intragenic recombination at the haptoglobin locus during early embryogenesis.
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Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding.
Q. Zhan, I-T. Chen, M. J. Antinore, and A. J. Fornace Jr. (1998)
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Carcinogens induce reversion of the mouse pink-eyed unstable mutation.
R. H. Schiestl, J. Aubrecht, F. Khogali, and N. Carls (1997)
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