Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 2 December 1994:
Vol. 266. no. 5190, pp. 1566 - 1569
DOI: 10.1126/science.7985027
Prev | Table of Contents | Next

Articles

Science, Vol 266, Issue 5190, 1566-1569
Copyright © 1994 by American Association for the Advancement of Science

articles

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

F Sanderson, MJ Kleijmeer, A Kelly, D Verwoerd, A Tulp, JJ Neefjes, HJ Geuze, and J Trowsdale

Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Holborn, London, UK.

The HLA-DM genes encode an unconventional HLA (human leukocyte antigen) class II molecule that is required for appropriate binding of peptide to classical HLA class II products. In the absence of DM, other class II molecules are unstable upon electrophoresis in sodium dodecyl sulfate and are largely associated with a nested set of peptides derived from the invariant chain called CLIP, for class II-associated invariant chain peptides. DMA and DMB associated and accumulated in multilaminar, intracellular compartments with classical class II molecules, but were found infrequently, if at all, at the cell surface. Thus, DM may facilitate peptide binding to class II molecules within these intracellular compartments.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential signal transduction, membrane trafficking, and immune effector functions mediated by Fc{gamma}RI versus Fc{gamma}RIIa.
X. Dai, M. Jayapal, H. K. Tay, R. Reghunathan, G. Lin, C. T. Too, Y. T. Lim, S. H. Chan, D. M. Kemeny, R. A. Floto, et al. (2009)
Blood 114, 318-327
   Abstract »    Full Text »    PDF »
In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange.
M. J. Call, X. Xing, G. D. Cuny, N. P. Seth, D. M. Altmann, L. Fugger, M. Krogsgaard, R. L. Stein, and K. W. Wucherpfennig (2009)
J. Immunol. 182, 6342-6352
   Abstract »    Full Text »    PDF »
Requirement for Phosphoinositide 3-Kinase p110{delta} Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation.
M. M. Al-Alwan, K. Okkenhaug, B. Vanhaesebroeck, J. S. Hayflick, and A. J. Marshall (2007)
J. Immunol. 178, 2328-2335
   Abstract »    Full Text »    PDF »
Major Histocompatibility Complex Class II Molecules Promote Human Immunodeficiency Virus Type 1 Assembly and Budding to Late Endosomal/Multivesicular Body Compartments.
A. Finzi, A. Brunet, Y. Xiao, J. Thibodeau, and E. A. Cohen (2006)
J. Virol. 80, 9789-9797
   Abstract »    Full Text »    PDF »
An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs.
Y. Xing, T. Yu, Y. N. Wu, M. Roy, J. Kim, and C. Lee (2006)
Nucleic Acids Res. 34, 3150-3160
   Abstract »    Full Text »    PDF »
Polarized Expression of CD74 by Gastric Epithelial Cells.
C. A. Barrera, E. J. Beswick, J. C. Sierra, D. Bland, R. Espejo, R. Mifflin, P. Adegboyega, S. E. Crowe, P. B. Ernst, and V. E. Reyes (2005)
J. Histochem. Cytochem. 53, 1481-1489
   Abstract »    Full Text »    PDF »
HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing.
A. Bellemare-Pelletier, J. Tremblay, S. Beaulieu, M.-R. Boulassel, J.-P. Routy, B. Massie, R. Lapointe, and J. Thibodeau (2005)
J. Leukoc. Biol. 78, 95-105
   Abstract »    Full Text »    PDF »
A Defective Viral Superantigen-Presenting Phenotype in HLA-DR Transfectants Is Corrected by CIITA.
G. A. Azar, R.-P. Sekaly, and J. Thibodeau (2005)
J. Immunol. 174, 7548-7557
   Abstract »    Full Text »    PDF »
The pathway for MHCII-mediated presentation of endogenous proteins involves peptide transport to the endo-lysosomal compartment.
A. Dani, A. Chaudhry, P. Mukherjee, D. Rajagopal, S. Bhatia, A. George, V. Bal, S. Rath, and S. Mayor (2004)
J. Cell Sci. 117, 4219-4230
   Abstract »    Full Text »    PDF »
Herpes Simplex Virus Type 1 Targets the MHC Class II Processing Pathway for Immune Evasion.
J. Neumann, A. M. Eis-Hubinger, and N. Koch (2003)
J. Immunol. 171, 3075-3083
   Abstract »    Full Text »    PDF »
Analysis of H2-O Influence on Antigen Presentation by B Cells.
C. Alfonso, G. S. Williams, J.-O. Han, J. A. Westberg, O. Winqvist, and L. Karlsson (2003)
J. Immunol. 171, 2331-2337
   Abstract »    Full Text »    PDF »
Localization of the Epstein-Barr virus protein LMP 1 to exosomes.
J. Flanagan, J. Middeldorp, and T. Sculley (2003)
J. Gen. Virol. 84, 1871-1879
   Abstract »    Full Text »    PDF »
Point Mutations in or Near the Antigen-Binding Groove of HLA-DR3 Implicate Class II-Associated Invariant Chain Peptide Affinity as a Constraint on MHC Class II Polymorphism.
R. C. Doebele, A. Pashine, W. Liu, D. M. Zaller, M. Belmares, R. Busch, and E. D. Mellins (2003)
J. Immunol. 170, 4683-4692
   Abstract »    Full Text »    PDF »
Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO.
C. Chalouni, J. Banchereau, A. B. Vogt, V. Pascual, and J. Davoust (2003)
Int. Immunol. 15, 457-466
   Abstract »    Full Text »    PDF »
HLA-DR4 Molecules in Neuroendocrine Epithelial Cells Associate to a Heterogeneous Repertoire of Cytoplasmic and Surface Self Peptides.
A. Muntasell, M. Carrascal, L. Serradell, P. v. Veelen, F. Verreck, F. Koning, G. Raposo, J. Abian, and D. Jaraquemada (2002)
J. Immunol. 169, 5052-5060
   Abstract »    Full Text »    PDF »
Differentiation of Immunostimulatory Stem-Cell- and Monocyte-Derived Dendritic Cells Involves Maturation of Intracellular Compartments Responsible for Antigen Presentation and Secretion.
S. N. Bykovskaia, G. V. Shurin, S. Graner, M. L. Bunker, W. Olson, R. Thomas, M. R. Shurin, S. Marks, W. J. Storkus, and J. Shogan (2002)
Stem Cells 20, 380-393
   Abstract »    Full Text »    PDF »
In Vivo and In Vitro Modulation of HLA-DM and HLA-DO Is Induced by B Lymphocyte Activation.
C. Roucard, C. Thomas, M.-A. Pasquier, J. Trowsdale, J.-J. Sotto, J. Neefjes, and M. van Ham (2001)
J. Immunol. 167, 6849-6858
   Abstract »    Full Text »    PDF »
The Impact of H2-DM on Humoral Immune Responses.
C. Alfonso, J.-O. Han, G. S. Williams, and L. Karlsson (2001)
J. Immunol. 167, 6348-6355
   Abstract »    Full Text »    PDF »
Regulation of MHC Class II Antigen Presentation by Sorting of Recycling HLA-DM/DO and Class II within the Multivesicular Body.
M. van Lith, M. van Ham, A. Griekspoor, E. Tjin, D. Verwoerd, J. Calafat, H. Janssen, E. Reits, L. Pastoors, and J. Neefjes (2001)
J. Immunol. 167, 884-892
   Abstract »    Full Text »    PDF »
Genome-wide detection of alternative splicing in expressed sequences of human genes.
B. Modrek, A. Resch, C. Grasso, and C. Lee (2001)
Nucleic Acids Res. 29, 2850-2859
   Abstract »    Full Text »    PDF »
Interaction of Mycobacterium avium-Containing Phagosomes with the Antigen Presentation Pathway.
H.-J. Ullrich, W. L. Beatty, and D. G. Russell (2000)
J. Immunol. 165, 6073-6080
   Abstract »    Full Text »    PDF »
Identification of Class II Transcriptional Activator-Induced Genes by Representational Difference Analysis: Discoordinate Regulation of the DN{alpha}/DO{beta} Heterodimer.
D. J. Taxman, D. E. Cressman, and J. P.-Y. Ting (2000)
J. Immunol. 165, 1410-1416
   Abstract »    Full Text »    PDF »
Lysosome-related organelles.
E. C. DELL’ANGELICA, C. MULLINS, S. CAPLAN, and J. S. BONIFACINO (2000)
FASEB J 14, 1265-1278
   Abstract »    Full Text »
Phagosomes Acquire Nascent and Recycling Class II MHC Molecules but Primarily Use Nascent Molecules in Phagocytic Antigen Processing.
L. Ramachandra and C. V. Harding (2000)
J. Immunol. 164, 5103-5112
   Abstract »    Full Text »    PDF »
Modulation of the Major Histocompatibility Complex Class II-associated Peptide Repertoire by Human Histocompatibility Leukocyte Antigen (HLA)-DO.
M. van Ham, M. van Lith, B. Lillemeier, E. Tjin, U. Gruneberg, D. Rahman, L. Pastoors, K. van Meijgaarden, C. Roucard, J. Trowsdale, et al. (2000)
J. Exp. Med. 191, 1127-1136
   Abstract »    Full Text »    PDF »
The Formation of Immunogenic Major Histocompatibility Complex Class II-Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli.
K. Inaba, S. Turley, T. Iyoda, F. Yamaide, S. Shimoyama, C. R. e Sousa, R. N. Germain, I. Mellman, and R. M. Steinman (2000)
J. Exp. Med. 191, 927-936
   Abstract »    Full Text »    PDF »
Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT).
B. Arunachalam, U. T. Phan, H. J. Geuze, and P. Cresswell (2000)
PNAS 97, 745-750
   Abstract »    Full Text »    PDF »
Polarized Transport of MHC Class II Molecules in Madin-Darby Canine Kidney Cells Is Directed by a Leucine-Based Signal in the Cytoplasmic Tail of the {beta}-Chain.
A. Simonsen, K. W. Pedersen, T. W. Nordeng, A. von der Lippe, E. Stang, E. O. Long, and O. Bakke (1999)
J. Immunol. 163, 2540-2548
   Abstract »    Full Text »    PDF »
Phagosomes Are Fully Competent Antigen-Processing Organelles That Mediate the Formation of Peptide:Class II MHC Complexes.
L. Ramachandra, R. Song, and C. V. Harding (1999)
J. Immunol. 162, 3263-3272
   Abstract »    Full Text »    PDF »
Involvement of MIIC-Like Late Endosomes in B Cell Receptor-Mediated Antigen Processing in Murine B Cells.
J. R. Drake, T. A. Lewis, K. B. Condon, R. N. Mitchell, and P. Webster (1999)
J. Immunol. 162, 1150-1155
   Abstract »    Full Text »    PDF »
Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments.
R Wubbolts, M Fernandez-Borja, I Jordens, E Reits, S Dusseljee, C Echeverri, R. Vallee, and J Neefjes (1999)
J. Cell Sci. 112, 785-795
   Abstract »    PDF »
Cellular distribution of a mixed MHC class II heterodimer between DR{alpha} and a chimeric DOß chain.
A. Samaan, J. Thibodeau, W. Mahana, F. Castellino, P. A. Cazenave, and T. J. Kindt (1999)
Int. Immunol. 11, 99-111
   Abstract »    Full Text »    PDF »
Enhanced Interaction of HLA-DM with HLA-DR in Enlarged Vacuoles of Hereditary and Infectious Lysosomal Diseases.
L. Lem, D. A. Riethof, M. Scidmore-Carlson, G. M. Griffiths, T. Hackstadt, and F. M. Brodsky (1999)
J. Immunol. 162, 523-532
   Abstract »    Full Text »    PDF »
The Tetraspan Protein CD82 Is a Resident of MHC Class II Compartments Where It Associates with HLA-DR, -DM, and -DO Molecules.
C. Hammond, L. K. Denzin, M. Pan, J. M. Griffith, H. J. Geuze, and P. Cresswell (1998)
J. Immunol. 161, 3282-3291
   Abstract »    Full Text »    PDF »
Deficient Major Histocompatibility Complex Class II Antigen Presentation in a Subset of Hodgkin's Disease Tumor Cells.
H. Bosshart and R. F. Jarrett (1998)
Blood 92, 2252-2259
   Abstract »    Full Text »    PDF »
Antigen Processing of Two H2-IEd-Restricted Epitopes Is Differentially Influenced by the Structural Changes in a Viral Glycoprotein.
K. A. Chianese-Bullock, H. I. Russell, C. Moller, W. Gerhard, J. J. Monaco, and L. C. Eisenlohr (1998)
J. Immunol. 161, 1599-1607
   Abstract »    Full Text »    PDF »
DR/CLIP (Class II-Associated Invariant Chain Peptides) and DR/Peptide Complexes Colocalize in Prelysosomes in Human B Lymphoblastoid Cells.
E. Stang, C. B. Guerra, M. Amaya, Y. Paterson, O. Bakke, and E. D. Mellins (1998)
J. Immunol. 160, 4696-4707
   Abstract »    Full Text »    PDF »
Mtv-1 Superantigen Trafficks Independently of Major Histocompatibility Complex Class II Directly to the B-Cell Surface by the Exocytic Pathway.
M. E. Grigg, C. W. McMahon, S. Morkowski, A. Y. Rudensky, and A. M. Pullen (1998)
J. Virol. 72, 2577-2588
   Abstract »    Full Text »    PDF »
A Dominant-negative Clathrin Mutant Differentially Affects Trafficking of Molecules with Distinct Sorting Motifs in the Class II Major Histocompatibility Complex (MHC) Pathway.
S.-H. Liu, M. S. Marks, and F. M. Brodsky (1998)
J. Cell Biol. 140, 1023-1037
   Abstract »    Full Text »    PDF »
Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo.
D. J. Lee, A. Abeyratne, D. A. Carson, and M. Corr (1998)
J. Exp. Med. 187, 433-438
   Abstract »    Full Text »    PDF »
Invariant Chain-independent Function of H-2M in the Formation of Endogenous Peptide-Major Histocompatibility Complex Class II Complexes In Vivo.
S. Kovats, C. E. Grubin, S. Eastman, P. deRoos, A. Dongre, L. V. Kaer, and A. Y. Rudensky (1998)
J. Exp. Med. 187, 245-251
   Abstract »    Full Text »    PDF »
Aberrant Intermolecular Disulfide Bonding in a Mutant HLA-DM Molecule: Implications for Assembly, Maturation, and Function.
R. Busch, R. C. Doebele, E. von Scheven, J. Fahrni, and E. D. Mellins (1998)
J. Immunol. 160, 734-743
   Abstract »    Full Text »    PDF »
Actin microfilaments control the MHC class II antigen presentation pathway in B cells.
N Barois, F Forquet, and J Davoust (1998)
J. Cell Sci. 111, 1791-1800
   Abstract »    PDF »
Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules.
G. Ferrari, A. M. Knight, C. Watts, and J. Pieters (1997)
J. Cell Biol. 139, 1433-1446
   Abstract »    Full Text »    PDF »
Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.
H. J. Ullrich, K. Doring, U. Gruneberg, F. Jahnig, J. Trowsdale, and S. M. van Ham (1997)
PNAS 94, 13163-13168
   Abstract »    Full Text »    PDF »
Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments.
M. J. Kleijmeer, S. Morkowski, J. M. Griffith, A. Y. Rudensky, and H. J. Geuze (1997)
J. Cell Biol. 139, 639-649
   Abstract »    Full Text »    PDF »
Novel Mutants Define Genes Required for the Expression of Human Histocompatibility Leukocyte Antigen DM: Evidence for Loci on Human Chromosome 6p.
S. P. Fling, J. Rak, K. A. Muczynski, B. Arp, and D. Pious (1997)
J. Exp. Med. 186, 1469-1480
   Abstract »    Full Text »    PDF »
Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae.
I. H. Hung, M. Suzuki, Y. Yamaguchi, D. S. Yuan, R. D. Klausner, and J. D. Gitlin (1997)
J. Biol. Chem. 272, 21461-21466
   Abstract »    Full Text »    PDF »
Decreased Endosomal Delivery of Major Histocompatibility Complex Class II-invariant Chain Complexes in Dynamin-deficient Cells.
K. Wang, P. A. Peterson, and L. Karlsson (1997)
J. Biol. Chem. 272, 17055-17060
   Abstract »    Full Text »    PDF »
Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes.
V. Brachet, G. Raposo, S. Amigorena, and I. Mellman (1997)
J. Cell Biol. 137, 51-65
   Abstract »    Full Text »    PDF »
HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules.
L. K. Denzin, C. Hammond, and P. Cresswell (1996)
J. Exp. Med. 184, 2153-2166
   Abstract »    Full Text »    PDF »
Conformation of Human Leukocyte Antigen Class II Molecules. EVIDENCE FOR SUPERDIMERS AND EMPTY MOLECULES ON HUMAN ANTIGEN PRESENTING CELLS.
C. Roucard, F. Garban, N. A. Mooney, D. J. Charron, and M. L. Ericson (1996)
J. Biol. Chem. 271, 13993-14000
   Abstract »    Full Text »    PDF »
Self-Release of CLIP in Peptide Loading of HLA-DR Molecules.
H. Kropshofer, A. B. Vogt, L. J. Stern, and Gün. J. Hämmerling (1995)
Science 270, 1357-1359
   Abstract »    PDF »
Assembly and Intracellular Transport of MHC Class I and Class II Molecules.
M.R. Jackson, K. Fruh, L. Karlsson, L. Teyton, Y. Yang, and P.A. Peterson (1995)
Cold Spring Harb Symp Quant Biol 60, 249-261
   Abstract »    PDF »
H2-Mbeta 1 and H2-Mbeta 2 Heterodimers Equally Promote CLIP Removal in I-Aq Molecules from Autoimmune-prone DBA/1 Mice.
W. Walter, C. Scheuer, M. Loos, T. E. Reichert, and M. J. Maeurer (2001)
J. Biol. Chem. 276, 11086-11091
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)