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Science 2 December 1994:
Vol. 266. no. 5190, pp. 1566 - 1569
DOI: 10.1126/science.7985027
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Articles

Science, Vol 266, Issue 5190, 1566-1569
Copyright © 1994 by American Association for the Advancement of Science

articles

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

F Sanderson, MJ Kleijmeer, A Kelly, D Verwoerd, A Tulp, JJ Neefjes, HJ Geuze, and J Trowsdale

Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Holborn, London, UK.

The HLA-DM genes encode an unconventional HLA (human leukocyte antigen) class II molecule that is required for appropriate binding of peptide to classical HLA class II products. In the absence of DM, other class II molecules are unstable upon electrophoresis in sodium dodecyl sulfate and are largely associated with a nested set of peptides derived from the invariant chain called CLIP, for class II-associated invariant chain peptides. DMA and DMB associated and accumulated in multilaminar, intracellular compartments with classical class II molecules, but were found infrequently, if at all, at the cell surface. Thus, DM may facilitate peptide binding to class II molecules within these intracellular compartments.


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