Science 2 December 1994: Vol. 266. no. 5190, pp. 1528 - 1537 DOI: 10.1126/science.7985023

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Articles

Degenerate evolution of the hedgehog gene in a hemichordate lineage.

A. Sato, H. White-Cooper, K. Doggett, and P. W. H. Holland (2009)
PNAS 106, 7491-7494
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Hedgehog Signaling in Human Cancer: Basic Mechanisms and Clinical Implications.

J. Xie (2009)
Am. Assoc. Cancer Res. Educ. Book 2009, 25-41
 |  Full Text »  |  PDF »

The Hedgehog Signaling Pathway in Cancer.

F. J. de Sauvage, J. C. Marsters Jr., and J. A. Low (2009)
ASCO Educational Book 2009, 157-161
 |  Abstract »  |  Full Text »  |  PDF »

Hedgehog: functions and mechanisms.

M. Varjosalo and J. Taipale (2008)
Genes & Dev. 22, 2454-2472
 |  Abstract »  |  Full Text »  |  PDF »

Hedgehog signalling in endocrine development and disease.

P. J King, L. Guasti, and E. Laufer (2008)
J. Endocrinol. 198, 439-450
 |  Abstract »  |  Full Text »  |  PDF »

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network.

E. Dessaud, A. P. McMahon, and J. Briscoe (2008)
Development 135, 2489-2503
 |  Abstract »  |  Full Text »  |  PDF »

Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation.

Y. Zavros, M. A. Orr, C. Xiao, and D. H. Malinowska (2008)
Am J Physiol Gastrointest Liver Physiol 295, G99-G111
 |  Abstract »  |  Full Text »  |  PDF »

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity.

S. F. Farzan, S. Singh, N. S. Schilling, and D. J. Robbins (2008)
Am J Physiol Gastrointest Liver Physiol 294, G844-G849
 |  Abstract »  |  Full Text »  |  PDF »

The Hedgehog Signaling Pathway in Cancer.

F. J. de Sauvage and J. C. Marsters Jr. (2008)
ASCO Educational Book 2008, e1-e4
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation.

Y. Zavros, M. Waghray, A. Tessier, L. Bai, A. Todisco, D. L. Gumucio, L. C. Samuelson, A. Dlugosz, and J. L. Merchant (2007)
J. Biol. Chem. 282, 33265-33274
 |  Abstract »  |  Full Text »  |  PDF »

Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract.

G. R. van den Brink (2007)
Physiol Rev 87, 1343-1375
 |  Abstract »  |  Full Text »  |  PDF »

Wnt signaling interacts with Shh to regulate taste papilla development.

K. Iwatsuki, H.-X. Liu, A. Gronder, M. A. Singer, T. F. Lane, R. Grosschedl, C. M. Mistretta, and R. F. Margolskee (2007)
PNAS 104, 2253-2258
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor-{kappa}B Contributes to Hedgehog Signaling Pathway Activation through Sonic Hedgehog Induction in Pancreatic Cancer..

H. Nakashima, M. Nakamura, H. Yamaguchi, N. Yamanaka, T. Akiyoshi, K. Koga, K. Yamaguchi, M. Tsuneyoshi, M. Tanaka, and M. Katano (2006)
Cancer Res. 66, 7041-7049
 |  Abstract »  |  Full Text »  |  PDF »

Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"?.

V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara (2006)
Am. J. Respir. Cell Mol. Biol. 35, 3-9
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Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.

S. Dorus, J. R. Anderson, E. J. Vallender, S. L. Gilbert, L. Zhang, L. G. Chemnick, O. A. Ryder, W. Li, and B. T. Lahn (2006)
Hum. Mol. Genet. 15, 2031-2037
 |  Abstract »  |  Full Text »  |  PDF »

Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis.

J.-x. Zhou, L.-w. Jia, W.-m. Liu, C.-l. Miao, S. Liu, Y.-j. Cao, and E.-k. Duan (2006)
Hum. Reprod. 21, 1698-1704
 |  Abstract »  |  Full Text »  |  PDF »

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase.

T. Koide, T. Hayata, and K. W. Y. Cho (2006)
Development 133, 2395-2405
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Chemorepellent Slit2 Inhibits Vascular Smooth Muscle Cell Migration by Suppressing Small GTPase Rac1 Activation.

D. Liu, J. Hou, X. Hu, X. Wang, Y. Xiao, Y. Mou, and H. De Leon (2006)
Circ. Res. 98, 480-489
 |  Abstract »  |  Full Text »  |  PDF »

A Highly Conserved Amino-terminal Region of Sonic Hedgehog Is Required for the Formation of Its Freely Diffusible Multimeric Form.

J. A. Goetz, S. Singh, L. M. Suber, F. J. Kull, and D. J. Robbins (2006)
J. Biol. Chem. 281, 4087-4093
 |  Abstract »  |  Full Text »  |  PDF »

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix.

A. Callejo, C. Torroja, L. Quijada, and I. Guerrero (2006)
Development 133, 471-483
 |  Abstract »  |  Full Text »  |  PDF »

A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis.

P. Canto, F. Vilchis, D. Soderlund, E. Reyes, and J.P. Mendez (2005)
Mol. Hum. Reprod. 11, 833-836
 |  Abstract »  |  Full Text »  |  PDF »

Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow.

E. M. Rogers, C. A. Brennan, N. T. Mortimer, S. Cook, A. R. Morris, and K. Moses (2005)
Development 132, 4833-4843
 |  Abstract »  |  Full Text »  |  PDF »

Splitting the Hedgehog signal: sex and patterning in Drosophila.

J. I. Horabin (2005)
Development 132, 4801-4810
 |  Abstract »  |  Full Text »  |  PDF »

The MUC1 SEA Module Is a Self-cleaving Domain.

F. Levitin, O. Stern, M. Weiss, C. Gil-Henn, R. Ziv, Z. Prokocimer, N. I. Smorodinsky, D. B. Rubinstein, and D. H. Wreschner (2005)
J. Biol. Chem. 280, 33374-33386
 |  Abstract »  |  Full Text »  |  PDF »

A Genetic Screen in Drosophila for Identifying Novel Components of the Hedgehog Signaling Pathway.

R. T. Collins and S. M. Cohen (2005)
Genetics 170, 173-184
 |  Abstract »  |  Full Text »  |  PDF »

Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells.

V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco (2005)
J. Biol. Chem. 280, 15700-15708
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Is Produced by Follicular Dendritic Cells and Protects Germinal Center B Cells from Apoptosis.

R. Sacedon, B. Diez, V. Nunez, C. Hernandez-Lopez, C. Gutierrez-Frias, T. Cejalvo, S. V. Outram, T. Crompton, A. G. Zapata, A. Vicente, et al. (2005)
J. Immunol. 174, 1456-1461
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Biography of Philip A. Beachy.

M. Marino (2004)
PNAS 101, 17897-17899
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PHCCC, a Specific Enhancer of Type 4 Metabotropic Glutamate Receptors, Reduces Proliferation and Promotes Differentiation of Cerebellar Granule Cell Neuroprecursors.

A. M. Canudas, V. Di Giorgi-Gerevini, L. Iacovelli, G. Nano, M. D'Onofrio, A. Arcella, F. Giangaspero, C. Busceti, L. Ricci-Vitiani, G. Battaglia, et al. (2004)
J. Neurosci. 24, 10343-10352
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of Sonic Hedgehog Mutations Associated with Holoprosencephaly.

E. Traiffort, C. Dubourg, H. Faure, D. Rognan, S. Odent, M.-R. Durou, V. David, and M. Ruat (2004)
J. Biol. Chem. 279, 42889-42897
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Desert hedgehog (DHH) Gene in Patients with 46,XY Complete Pure Gonadal Dysgenesis.

P. Canto, D. Soderlund, E. Reyes, and J. P. Mendez (2004)
J. Clin. Endocrinol. Metab. 89, 4480-4483
 |  Abstract »  |  Full Text »  |  PDF »

Autocatalytic Cleavage of the EMR2 Receptor Occurs at a Conserved G Protein-coupled Receptor Proteolytic Site Motif.

H.-H. Lin, G.-W. Chang, J. Q. Davies, M. Stacey, J. Harris, and S. Gordon (2004)
J. Biol. Chem. 279, 31823-31832
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients.

S. Couve-Privat, M. Le Bret, E. Traiffort, S. Queille, J. Coulombe, B. Bouadjar, M. F. Avril, M. Ruat, A. Sarasin, and L. Daya-Grosjean (2004)
Cancer Res. 64, 3559-3565
 |  Abstract »  |  Full Text »  |  PDF »

Attenuation of Experimental Autoimmune Encephalomyelitis and Nonimmune Demyelination by IFN-{beta} plus Vitamin B12: Treatment to Modify Notch-1/Sonic Hedgehog Balance.

F. G. Mastronardi, W. Min, H. Wang, S. Winer, M. Dosch, J. M. Boggs, and M. A. Moscarello (2004)
J. Immunol. 172, 6418-6426
 |  Abstract »  |  Full Text »  |  PDF »

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction.

C. Torroja, N. Gorfinkiel, and I. Guerrero (2004)
Development 131, 2395-2408
 |  Abstract »  |  Full Text »  |  PDF »

Role of Cholesterol in the Regulation of Growth Plate Chondrogenesis and Longitudinal Bone Growth.

S. Wu and F. De Luca (2004)
J. Biol. Chem. 279, 4642-4647
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process.

C. Han, T. Y. Belenkaya, B. Wang, and X. Lin (2004)
Development 131, 601-611
 |  Abstract »  |  Full Text »  |  PDF »

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.

R. Nusse (2003)
Development 130, 5297-5305
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Hedgehog Proteins in the Human Thymus.

R. Sacedon, A. Varas, C. Hernandez-Lopez, C. Gutierrez-deFrias, T. Crompton, A. G. Zapata, and A. Vicente (2003)
J. Histochem. Cytochem. 51, 1557-1566
 |  Abstract »  |  Full Text »  |  PDF »

The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient.

F. G Mastronardi, L. A. daCruz, H. Wang, J. Boggs, and M. A Moscarello (2003)
Multiple Sclerosis 9, 362-371
 |  Abstract »  |  PDF »

Molecular mechanisms underlying limb anomalies associated with cholesterol deficiency during gestation: implications of Hedgehog signaling.

F. Gofflot, C. Hars, F. Illien, F. Chevy, C. Wolf, J. J. Picard, and C. Roux (2003)
Hum. Mol. Genet. 12, 1187-1198
 |  Abstract »  |  Full Text »  |  PDF »

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

A. J. Zhu, L. Zheng, K. Suyama, and M. P. Scott (2003)
Genes & Dev. 17, 1240-1252
 |  Abstract »  |  Full Text »  |  PDF »

A hedgehog homolog regulates gut formation in leech (Helobdella).

D. Kang, F. Huang, D. Li, M. Shankland, W. Gaffield, and D. A. Weisblat (2003)
Development 130, 1645-1657
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells.

L. Lum, S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, M. Nirenberg, and P. A. Beachy (2003)
Science 299, 2039-2045
 |  Abstract »  |  Full Text »  |  PDF »

Megalin and the neurodevelopmental biology of sonic hedgehog and retinol.

R. A. McCarthy and W. S. Argraves (2003)
J. Cell Sci. 116, 955-960
 |  Abstract »  |  Full Text »  |  PDF »

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.

T. Kawakami, T'N. Kawcak, Y.-J. Li, W. Zhang, Y. Hu, and P.-T. Chuang (2003)
Development 129, 5753-5765
 |  Abstract »  |  Full Text »  |  PDF »

rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.

C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon (2003)
Development 129, 843-851
 |  Abstract »  |  Full Text »  |  PDF »

A yeast-based growth assay for the analysis of site-specific proteases.

F. Kohler (2003)
Nucleic Acids Res. 31, e16
 |  Abstract »  |  Full Text »  |  PDF »

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.

M. Wijgerde, J. A. McMahon, M. Rule, and A. P. McMahon (2002)
Genes & Dev. 16, 2849-2864
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells.

G. A. Stewart, J. A. Lowrey, S. J. Wakelin, P. M. Fitch, S. Lindey, M. J. Dallman, J. R. Lamb, and S. E. M. Howie (2002)
J. Immunol. 169, 5451-5457
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Promotes Cell Cycle Progression in Activated Peripheral CD4+ T Lymphocytes.

J. A. Lowrey, G. A. Stewart, S. Lindey, G. F. Hoyne, M. J. Dallman, S. E. M. Howie, and J. R. Lamb (2002)
J. Immunol. 169, 1869-1875
 |  Abstract »  |  Full Text »  |  PDF »

Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA.

R. A. Deckelbaum, G. Chan, D. Miao, D. Goltzman, and A. C. Karaplis (2002)
J. Cell Sci. 115, 3015-3025
 |  Abstract »  |  Full Text »  |  PDF »

Cerebellar proteoglycans regulate sonic hedgehog responses during development.

J. B. Rubin, Y. Choi, and R. A. Segal (2002)
Development 129, 2223-2232
 |  Abstract »  |  Full Text »  |  PDF »

Diversity and Specificity of Actions of Slit2 Proteolytic Fragments in Axon Guidance.

K. T. N. Ba-Charvet, K. Brose, L. Ma, K. H. Wang, V. Marillat, C. Sotelo, M. Tessier-Lavigne, and A. Chedotal (2001)
J. Neurosci. 21, 4281-4289
 |  Abstract »  |  Full Text »  |  PDF »

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless.

G. Baeg, X Lin, N Khare, S Baumgartner, and N Perrimon (2001)
Development 128, 87-94
 |  Abstract »  |  PDF »

Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation.

R. K. Guy (2000)
PNAS 97, 7307-7312
 |  Abstract »  |  Full Text »  |  PDF »

Mapping Sonic Hedgehog-Receptor Interactions by Steric Interference.

R. B. Pepinsky, P. Rayhorn, E. S. Day, A. Dergay, K. P. Williams, A. Galdes, F. R. Taylor, P. A. Boriack-Sjodin, and E. A. Garber (2000)
J. Biol. Chem. 275, 10995-11001
 |  Abstract »  |  Full Text »  |  PDF »

The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors.

D Summerbell, P. Ashby, O Coutelle, D Cox, S Yee, and P. Rigby (2000)
Development 127, 3745-3757
 |  Abstract »  |  PDF »

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched.

N. Fuse, T. Maiti, B. Wang, J. A. Porter, T. M. T. Hall, D. J. Leahy, and P. A. Beachy (1999)
PNAS 96, 10992-10999
 |  Abstract »  |  Full Text »  |  PDF »

Autoproteolysis in nucleoporin biogenesis.

J. S. Rosenblum and G. Blobel (1999)
PNAS 96, 11370-11375
 |  Abstract »  |  Full Text »  |  PDF »

Actions of Hedgehog Proteins on Skeletal Cells.

M. Iwamoto, M. Enomoto-Iwamoto, and K. Kurisu (1999)
Critical Reviews in Oral Biology & Medicine 10, 477-486
 |  Abstract »  |  Full Text »  |  PDF »

Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity.

K. Williams, P Rayhorn, G Chi-Rosso, E. Garber, K. Strauch, G. Horan, J. Reilly, D. Baker, F. Taylor, V Koteliansky, et al. (1999)
J. Cell Sci. 112, 4405-4414
 |  Abstract »  |  PDF »

Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease.

U Muller and A. Brandli (1999)
J. Cell Sci. 112, 3855-3867
 |  Abstract »  |  PDF »

Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment.

U Gritzan, V Hatini, and S DiNardo (1999)
Development 126, 4107-4115
 |  Abstract »  |  PDF »

A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve.

V. Wallace and M. Raff (1999)
Development 126, 2901-2909
 |  Abstract »  |  PDF »

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase.

S. L. Bullock, J. M. Fletcher, R. S.P. Beddington, and V. A. Wilson (1998)
Genes & Dev. 12, 1894-1906
 |  Abstract »  |  Full Text »

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling.

M. K. Cooper, J. A. Porter, K. E. Young, and P. A. Beachy (1998)
Science 280, 1603-1607
 |  Abstract »  |  Full Text »

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog.

R. B. Pepinsky, C. Zeng, D. Wen, P. Rayhorn, D. P. Baker, K. P. Williams, S. A. Bixler, C. M. Ambrose, E. A. Garber, K. Miatkowski, et al. (1998)
J. Biol. Chem. 273, 14037-14045
 |  Abstract »  |  Full Text »  |  PDF »

A genetic screen for the isolation and characterization of site-specific proteases.

H. J. Sices and T. M. Kristie (1998)
PNAS 95, 2828-2833
 |  Abstract »  |  Full Text »  |  PDF »

Genetic definition of a protein-splicing domain: Functional mini-inteins support structure predictions and a model for intein evolution.

V. Derbyshire, D. W. Wood, W. Wu, J. T. Dansereau, J. Z. Dalgaard, and M. Belfort (1997)
PNAS 94, 11466-11471
 |  Abstract »  |  Full Text »  |  PDF »

Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal Cells In Vitro.

E. M. Levine, H. Roelink, J. Turner, and T. A. Reh (1997)
J. Neurosci. 17, 6277-6288
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Indian Hedgehog in Osteoblasts and Its Posttranscriptional Regulation by Transforming Growth Factor-{beta}.

S. Murakami, A. Nifuji, and M. Noda (1997)
Endocrinology 138, 1972-1978
 |  Abstract »  |  Full Text »  |  PDF »

Post-translational Processing and Renal Expression of Mouse Indian Hedgehog.

R. P. Valentini, W. T. Brookhiser, J. Park, T. Yang, J. Briggs, G. Dressler, and L. B. Holzman (1997)
J. Biol. Chem. 272, 8466-8473
 |  Abstract »  |  Full Text »  |  PDF »

Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog.

J Royet and R Finkelstein (1997)
Development 124, 4793-4800
 |  Abstract »  |  PDF »

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.

M Strigini and S. Cohen (1997)
Development 124, 4697-4705
 |  Abstract »  |  PDF »

dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp.

S. Jackson, H Nakato, M Sugiura, A Jannuzi, R Oakes, V Kaluza, C Golden, and S. Selleck (1997)
Development 124, 4113-4120
 |  Abstract »  |  PDF »

Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc.

D. Strutt and M Mlodzik (1997)
Development 124, 3233-3240
 |  Abstract »  |  PDF »

Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila.

T. Haerry, T. Heslip, J. Marsh, and M. O'Connor (1997)
Development 124, 3055-3064
 |  Abstract »  |  PDF »

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

S. Johnston, C Rauskolb, R Wilson, B Prabhakaran, K. Irvine, and T. Vogt (1997)
Development 124, 2245-2254
 |  Abstract »  |  PDF »

Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling.

P.A. Beachy, M.K. Cooper, K.E. Young, D.P. von Kessler, W.-J. Park, T.M. T. Hall, D.J. Leahy, and J.A. Porter (1997)
Cold Spring Harb Symp Quant Biol 62, 191-204
 |  Abstract »  |  PDF »

Graded Sonic Hedgehog Signaling and the Specification of Cell Fate in the Ventral Neural Tube.

J. Ericson, J. Briscoe, P. Rashbass, V. van Heyningen, and T.M. Jessell (1997)
Cold Spring Harb Symp Quant Biol 62, 451-466
 |  Abstract »  |  PDF »

Ectopic eye development in Drosophila induced by directed dachshund expression.

W Shen and G Mardon (1997)
Development 124, 45-52
 |  Abstract »  |  PDF »

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing..

T Kadowaki, E Wilder, J Klingensmith, K Zachary, and N Perrimon (1996)
Genes & Dev. 10, 3116-3128
 |  Abstract »  |  PDF »

Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish.

R. Zardoya, E. Abouheif, and A. Meyer (1996)
PNAS 93, 13036-13041
 |  Abstract »  |  Full Text »  |  PDF »

Protein Splicing Involving the Saccharomyces cerevisiae VMA Intein. THE STEPS IN THE SPLICING PATHWAY, SIDE REACTIONS LEADING TO PROTEIN CLEAVAGE, AND ESTABLISHMENT OF AN IN VITRO SPLICING SYSTEM.

S. Chong, Y. Shao, H. Paulus, J. Benner, F. B. Perler, and M.-Q. Xu (1996)
J. Biol. Chem. 271, 22159-22168
 |  Abstract »  |  Full Text »  |  PDF »

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog..

L V Goodrich, R L Johnson, L Milenkovic, J A McMahon, and M P Scott (1996)
Genes & Dev. 10, 301-312
 |  Abstract »  |  PDF »

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

D. Epstein, E Marti, M. Scott, and A. McMahon (1996)
Development 122, 2885-2894
 |  Abstract »  |  PDF »

The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila.

P Bokor and S DiNardo (1996)
Development 122, 1083-1092
 |  Abstract »  |  PDF »

hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila.

A. Forbes, H Lin, P. Ingham, and A. Spradling (1996)
Development 122, 1125-1135
 |  Abstract »  |  PDF »

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite..

A E Munsterberg, J Kitajewski, D A Bumcrot, A P McMahon, and A B Lassar (1995)
Genes & Dev. 9, 2911-2922
 |  Abstract »  |  PDF »

The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila.

H Nakato, T. Futch, and S. Selleck (1995)
Development 121, 3687-3702
 |  Abstract »  |  PDF »

Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut.

D. Roberts, R. Johnson, A. Burke, C. Nelson, B. Morgan, and C Tabin (1995)
Development 121, 3163-3174
 |  Abstract »  |  PDF »

Midline signalling is required for Pax gene regulation and patterning of the eyes.

R Macdonald, K. Barth, Q Xu, N Holder, I Mikkola, and S. Wilson (1995)
Development 121, 3267-3278
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Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage.

C. Lai, S. Ekker, P. Beachy, and R. Moon (1995)
Development 121, 2349-2360
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Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.

E Marti, R Takada, D. Bumcrot, H Sasaki, and A. McMahon (1995)
Development 121, 2537-2547
 |  Abstract »  |  PDF »

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain.

K. Barth and S. Wilson (1995)
Development 121, 1755-1768
 |  Abstract »  |  PDF »

The two faces of hedgehog.

M Peifer (1994)
Science 266, 1492-1493
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Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal.

Z. Chamoun, R. K. Mann, D. Nellen, D. P. von Kessler, M. Bellotto, P. A. Beachy, and K. Basler (2001)
Science 293, 2080-2084
 |  Abstract »  |  Full Text »  |  PDF »

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