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Science 2 December 1994:
Vol. 266. no. 5190, pp. 1524 - 1527
DOI: 10.1126/science.7985022

Articles

Science, Vol 266, Issue 5190, 1524-1527
Copyright © 1994 by American Association for the Advancement of Science


articles

Insights from the study of animals lacking functional estrogen receptor

KS Korach

Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.

Estrogen hormones produce physiological actions within a variety of target sites in the body and during development by activating a specific receptor protein. Hormone responsiveness for the estrogen receptor protein was investigated at different stages of development with the use of gene knockout techniques because no natural genetic mutants have been described. A mutant mouse line without a functional estrogen receptor was created and is being used to assess estrogen responsiveness. Both sexes of these mutant animals are infertile and show a variety of phenotypic changes, some of which are associated with the gonads, mammary glands, reproductive tracts, and skeletal tissues.


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G. G. Long, I. R. Cohen, C. L. Gries, J. K. Young, P. C. Francis, and C. C. Capen (2001)
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   Abstract »    Full Text »
Chronic Hypersecretion of Luteinizing Hormone in Transgenic Mice Selectively Alters Responsiveness of the {alpha}-Subunit Gene to Gonadotropin-Releasing Hormone and Estrogens.
R. A. Abbud, R. K. Ameduri, J. S. Rao, T. M. Nett, and J. H. Nilson (1999)
Mol. Endocrinol. 13, 1449-1459
   Abstract »    Full Text »
Association of oestrogen receptor gene polymorphisms with outcome of ovarian stimulation in patients undergoing IVF.
C. Sundarrajan, W.-X. Liao, A.C. Roy, and S.C. Ng (1999)
Mol. Hum. Reprod. 5, 797-802
   Abstract »    Full Text »    PDF »
Studies on the Potential Mediators of Skeletal Changes Occurring during Puberty in Girls.
C. Libanati, D. J. Baylink, E. Lois-Wenzel, N. Srinivasan, and S. Mohan (1999)
J. Clin. Endocrinol. Metab. 84, 2807-2814
   Abstract »    Full Text »
Expression of oestrogen receptor-{alpha} and -{beta} in ovarian endometriomata.
J. Fujimoto, R. Hirose, H. Sakaguchi, and T. Tamaya (1999)
Mol. Hum. Reprod. 5, 742-747
   Abstract »    Full Text »    PDF »
Expression and Hormonal Regulation of the Sox4 Gene in Mouse Female Reproductive Tissues.
S. M.N. Hunt and C. L. Clarke (1999)
Biol Reprod 61, 476-481
   Abstract »    Full Text »
Binding Characteristics of Estrogen Receptor (ER) in Atlantic Croaker (Micropogonias undulatus) Testis: Different Affinity for Estrogens and Xenobiotics from that of Hepatic ER.
A. K. Loomis and P. Thomas (1999)
Biol Reprod 61, 51-60
   Abstract »    Full Text »
Estrogen Actions in the Central Nervous System.
B. S. McEwen and S. E. Alves (1999)
Endocr. Rev. 20, 279-307
   Abstract »    Full Text »
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?.
J. F. Couse and K. S. Korach (1999)
Endocr. Rev. 20, 358-417
   Abstract »    Full Text »
The Molecular and Neuroanatomical Basis for Estrogen Effects in the Central Nervous System.
B. S. McEwen (1999)
J. Clin. Endocrinol. Metab. 84, 1790-1797
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Expression of Estrogen Receptor-{beta} Protein in Rodent Ovary.
S. L. Fitzpatrick, J. M. Funkhouser, D. M. Sindoni, P. E. Stevis, D. C. Deecher, A. R. Bapat, I. Merchenthaler, and D. E. Frail (1999)
Endocrinology 140, 2581-2591
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Differential Regulation and Action of Estrogen Receptors {alpha} and {beta} in GH3 Cells.
N. A. Mitchner, C. Garlick, R. W. Steinmetz, and N. Ben-Jonathan (1999)
Endocrinology 140, 2651-2658
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P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor.
C. McMahon, T. Suthiphongchai, J. DiRenzo, and M. E. Ewen (1999)
PNAS 96, 5382-5387
   Abstract »    Full Text »    PDF »
Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha  knockout mouse uterus.
S. W. Curtis, J. Clark, P. Myers, and K. S. Korach (1999)
PNAS 96, 3646-3651
   Abstract »    Full Text »    PDF »
Editorial: Genetic Regulation of Estrogen Responsiveness.
J. W. Pollard (1999)
Endocrinology 140, 553-555
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Rapid Action of 17{beta}-Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors.
Q. Gu, K. S. Korach, and R. L. Moss (1999)
Endocrinology 140, 660-666
   Abstract »    Full Text »



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