Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 November 1994:
Vol. 266. no. 5189, pp. 1373 - 1376
DOI: 10.1126/science.7973726
Prev | Table of Contents | Next

Articles

Science, Vol 266, Issue 5189, 1373-1376
Copyright © 1994 by American Association for the Advancement of Science

articles

Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

N Kasahara, AM Dozy, and YW Kan

Department of Laboratory Medicine, University of California, San Francisco 94143-0724.

The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad applications to a variety of gene delivery systems.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The block to membrane fusion differs with the site of ligand insertion in modified retroviral envelope proteins.
B. Y. Ryu, T. Zavorotinskaya, B. Trentin, and L. M. Albritton (2008)
J. Gen. Virol. 89, 1049-1058
   Abstract »    Full Text »    PDF »
Tumor-Selective Gene Expression in a Hepatic Metastasis Model after Locoregional Delivery of a Replication-Competent Retrovirus Vector.
K. Hiraoka, T. Kimura, C. R. Logg, and N. Kasahara (2006)
Clin. Cancer Res. 12, 7108-7116
   Abstract »    Full Text »    PDF »
Targeting lentiviral vectors to specific cell types in vivo.
L. Yang, L. Bailey, D. Baltimore, and P. Wang (2006)
PNAS 103, 11479-11484
   Abstract »    Full Text »    PDF »
Targeted retroviral transduction of c-kit+ hematopoietic cells using novel ligand display technology.
A. Chandrashekran, M. Y. Gordon, and C. Casimir (2004)
Blood 104, 2697-2703
   Abstract »    Full Text »    PDF »
Manipulation of Mouse Hematopoietic Progenitors by Specific Retroviral Infection.
G. J. Murphy, B. Gottgens, A. Vegiopoulos, M.-J. Sanchez, A. D. Leavitt, S. P. Watson, A. R. Green, and J. Frampton (2003)
J. Biol. Chem. 278, 43556-43563
   Abstract »    Full Text »    PDF »
BP1, a Homeodomain-Containing Isoform of DLX4, Represses the {beta}-Globin Gene.
M. B. Chase, S. Fu, S. B. Haga, G. Davenport, H. Stevenson, K. Do, D. Morgan, A. L. Mah, and P. E. Berg (2002)
Mol. Cell. Biol. 22, 2505-2514
   Abstract »    Full Text »    PDF »
Redirecting Retroviral Tropism by Insertion of Short, Nondisruptive Peptide Ligands into Envelope.
T. J. Gollan and M. R. Green (2002)
J. Virol. 76, 3558-3563
   Abstract »    Full Text »    PDF »
Comprehensive Mutational Analysis of the Moloney Murine Leukemia Virus Envelope Protein.
S. M. Rothenberg, M. N. Olsen, L. C. Laurent, R. A. Crowley, and P. O. Brown (2001)
J. Virol. 75, 11851-11862
   Abstract »    Full Text »
Efficient c-kit Receptor-Targeted Gene Transfer to Primary Human CD34-Selected Hematopoietic Stem Cells.
Q. Zhong, P. Oliver, W. Huang, D. Good, V. La Russa, Z. Zhang, J. R. Cork, R. W. Veith, C. Theodossiou, J. K. Kolls, et al. (2001)
J. Virol. 75, 10393-10400
   Abstract »    Full Text »    PDF »
Antibody-Directed Targeting of Retroviral Vectors via Cell Surface Antigens.
K. Morizono, G. Bristol, Y.-m. Xie, S. K.-P. Kung, and I. S. Y. Chen (2001)
J. Virol. 75, 8016-8020
   Abstract »    Full Text »    PDF »
Interleukin-13 Receptor-targeted Cancer Therapy in an Immunodeficient Animal Model of Human Head and Neck Cancer.
K. Kawakami, M. Kawakami, B. H. Joshi, and R. K. Puri (2001)
Cancer Res. 61, 6194-6200
   Abstract »    Full Text »    PDF »
The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse.
X. Yu, C.-S. Lin, F. Costantini, and C. T. Noguchi (2001)
Blood 98, 475-477
   Abstract »    Full Text »    PDF »
Replacement of the V3 Region of gp120 with SDF-1 Preserves the Infectivity of T-Cell Line-Tropic Human Immunodeficiency Virus Type 1.
A. Yonezawa, T. Hori, A. Takaori-Kondo, R. Morita, and T. Uchiyama (2001)
J. Virol. 75, 4258-4267
   Abstract »    Full Text »
Variations in Disparate Regions of the Murine Coronavirus Spike Protein Impact the Initiation of Membrane Fusion.
D. K. Krueger, S. M. Kelly, D. N. Lewicki, R. Ruffolo, and T. M. Gallagher (2001)
J. Virol. 75, 2792-2802
   Abstract »    Full Text »
Single-Chain Antibody Displayed on a Recombinant Measles Virus Confers Entry through the Tumor-Associated Carcinoembryonic Antigen.
A. L. Hammond, R. K. Plemper, J. Zhang, U. Schneider, S. J. Russell, and R. Cattaneo (2001)
J. Virol. 75, 2087-2096
   Abstract »    Full Text »
Gene and Stem Cell Therapies.
E. H. Kaji and J. M. Leiden (2001)
JAMA 285, 545-550
   Abstract »    Full Text »    PDF »
Specifically Targeted Killing of Carcinoembryonic Antigen (CEA)-expressing Cells by a Retroviral Vector Displaying Single-Chain Variable Fragmented Antibody to CEA and Carrying the Gene for Inducible Nitric Oxide Synthase.
P. D. Khare, L. Shao-Xi, M. Kuroki, Y. Hirose, F. Arakawa, K. Nakamura, Y. Tomita, and M. Kuroki (2001)
Cancer Res. 61, 370-375
   Abstract »    Full Text »
Design of Retroviral Vectors and Helper Cells for Gene Therapy.
W.-S. Hu and V. K. Pathak (2000)
Pharmacol. Rev. 52, 493-512
   Abstract »    Full Text »    PDF »
A TVA-Single-Chain Antibody Fusion Protein Mediates Specific Targeting of a Subgroup A Avian Leukosis Virus Vector to Cells Expressing a Tumor-Specific Form of Epidermal Growth Factor Receptor.
S. Snitkovsky, T. M. J. Niederman, B. S. Carter, R. C. Mulligan, and J. A. T. Young (2000)
J. Virol. 74, 9540-9545
   Abstract »    Full Text »
Inhibition of Metastatic Tumor Growth in Nude Mice by Portal Vein Infusions of Matrix-targeted Retroviral Vectors Bearing a Cytocidal Cyclin G1 Construct.
E. M. Gordon, P. X. Liu, Z. H. Chen, L. Liu, M. D. Whitley, C. Gee, S. Groshen, D. R. Hinton, R. W. Beart, and F. L. Hall (2000)
Cancer Res. 60, 3343-3347
   Abstract »    Full Text »
Single-Step Conversion of Cells to Retrovirus Vector Producers with Herpes Simplex Virus-Epstein-Barr Virus Hybrid Amplicons.
M. Sena-Esteves, Y. Saeki, S. M. Camp, E. A. Chiocca, and X. O. Breakefield (1999)
J. Virol. 73, 10426-10439
   Abstract »    Full Text »
Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.
A. L. Boerger, S. Snitkovsky, and J. A. T. Young (1999)
PNAS 96, 9867-9872
   Abstract »    Full Text »    PDF »
Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens.
J. S. Smith, J. R. Keller, N. C. Lohrey, C. S. McCauslin, M. Ortiz, K. Cowan, and S. E. Spence (1999)
PNAS 96, 8855-8860
   Abstract »    Full Text »    PDF »
Retrovirus Targeting by Tropism Restriction to Melanoma Cells.
F. Martin, S. Neil, J. Kupsch, M. Maurice, F.-L. Cosset, and M. Collins (1999)
J. Virol. 73, 6923-6929
   Abstract »    Full Text »
Engineering Novel Cell Surface Receptors for Virus-mediated Gene Transfer.
J. H. Lee, T. J. Baker, L. K. Mahal, J. Zabner, C. R. Bertozzi, D. F. Wiemer, and M. J. Welsh (1999)
J. Biol. Chem. 274, 21878-21884
   Abstract »    Full Text »    PDF »
Gene Transfer Technology in Therapy: Current Applications and Future Goals.
G. Romano, C. Pacilio, and A. Giordano (1999)
Stem Cells 17, 191-202
   Abstract »    Full Text »
The Breast Cancer-associated MUC1 Gene Generates Both a Receptor and Its Cognate Binding Protein.
A. Baruch, M.-l. Hartmann, M. Yoeli, Y. Adereth, S. Greenstein, Y. Stadler, Y. Skornik, J. Zaretsky, N. I. Smorodinsky, I. Keydar, et al. (1999)
Cancer Res. 59, 1552-1561
   Abstract »    Full Text »    PDF »
Identification of the block in targeted retroviral-mediated gene transfer.
Y. Zhao, L. Zhu, S. Lee, L. Li, E. Chang, N.-W. Soong, D. Douer, and W. F. Anderson (1999)
PNAS 96, 4005-4010
   Abstract »    Full Text »    PDF »
The Hypervariable Domain of the Murine Leukemia Virus Surface Protein Tolerates Large Insertions and Deletions, Enabling Development of a Retroviral Particle Display System.
S. C. Kayman, H. Park, M. Saxon, and A. Pinter (1999)
J. Virol. 73, 1802-1808
   Abstract »    Full Text »
Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symporter Gene.
R. B. Mandell, L. Z. Mandell, and C. J. Link Jr. (1999)
Cancer Res. 59, 661-668
   Abstract »    Full Text »    PDF »
Vascular Gene Transfer : From Bench to Bedside.
I. J. Kullo, R. D. Simari, and R. S. Schwartz (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 196-207
   Full Text »    PDF »
Renal Drug Targeting Using a Vector "Alkylglycoside".
K. Suzuki, H. Susaki, S. Okuno, and Y. Sugiyama (1999)
J. Pharmacol. Exp. Ther. 288, 57-64
   Abstract »    Full Text »
Protein Replacement by Receptor-Mediated Endocytosis Corrects the Sensitivity of Fanconi Anemia Group C Cells to Mitomycin C.
H. Youssoufian, F. A.E. Kruyt, and X. Li (1999)
Blood 93, 363-369
   Abstract »    Full Text »    PDF »
Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells.
S. Laquerre, D. B. Anderson, D. B. Stolz, and J. C. Glorioso (1998)
J. Virol. 72, 9683-9697
   Abstract »    Full Text »    PDF »
Gene Transfer Technology in Therapy: Current Applications and Future Goals.
G. Romano, C. Pacilio, and A. Giordano (1998)
Oncologist 3, 225-236
   Abstract »    Full Text »
Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein.
S. Snitkovsky and J. A. T. Young (1998)
PNAS 95, 7063-7068
   Abstract »    Full Text »    PDF »
Evidence for Cooperation between Murine Leukemia Virus Env Molecules in Mixed Oligomers.
A. Rein, C. Yang, J. A. Haynes, J. Mirro, and R. W. Compans (1998)
J. Virol. 72, 3432-3435
   Abstract »    Full Text »    PDF »
Construction of Retroviral Vectors with Improved Safety, Gene Expression, and Versatility.
S. H. Kim, S. S. Yu, J. S. Park, P. D. Robbins, C. S. An, and S. Kim (1998)
J. Virol. 72, 994-1004
   Abstract »    Full Text »    PDF »
Definition of a 14-Amino-Acid Peptide Essential for the Interaction between the Murine Leukemia Virus Amphotropic Envelope Glycoprotein and Its Receptor.
J. L. Battini, O. Danos, and J. M. Heard (1998)
J. Virol. 72, 428-435
   Abstract »    Full Text »    PDF »
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression.
D. K. ROHRER and B. K. KOBILKA (1998)
Physiol Rev 78, 35-52
   Abstract »    Full Text »    PDF »
Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells.
E. S. Massuda, E. J. Dunphy, R. A. Redman, J. J. Schreiber, L. E. Nauta, F. G. Barr, I. H. Maxwell, and T. P. Cripe (1997)
PNAS 94, 14701-14706
   Abstract »    Full Text »    PDF »
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
H. Su, R. Lu, J. C. Chang, and Y. W. Kan (1997)
PNAS 94, 13891-13896
   Abstract »    Full Text »    PDF »
Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents.
S. Sharma, F. Murai, A. Miyanohara, and T. Friedmann (1997)
PNAS 94, 10803-10808
   Abstract »    Full Text »    PDF »
Stem Cell Factor and Hematopoiesis.
V. C. Broudy (1997)
Blood 90, 1345-1364
   Full Text »    PDF »
Keratinocyte Gene Transfer and Gene Therapy.
J.A. Garlick and E.S. Fenjves (1996)
Critical Reviews in Oral Biology & Medicine 7, 204-221
   Abstract »    Full Text »    PDF »
Retrovirus Molecular Conjugates. A NOVEL, HIGH TRANSDUCTION EFFICIENCY, POTENTIALLY SAFETY-IMPROVED, GENE TRANSFER SYSTEM.
Q. Zhong, J. K. Kolls, and P. Schwarzenberger (2001)
J. Biol. Chem. 276, 24601-24607
   Abstract »    Full Text »    PDF »
Retroviral membrane display of apoptotic effector molecules.
D. Strehlow, S. Jodo, and S.-T. Ju (2000)
PNAS 97, 4209-4214
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)