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Science 18 November 1994:
Vol. 266. no. 5188, pp. 1253 - 1255
DOI: 10.1126/science.7973709

Articles

Science, Vol 266, Issue 5188, 1253-1255
Copyright © 1994 by American Association for the Advancement of Science


articles

Modulation of epithelial cell growth by intraepithelial gamma delta T cells

R Boismenu and WL Havran

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

The role played in immune surveillance by gamma delta T cells residing in various epithelia has not been clear. It is shown here that activated gamma delta T cells obtained from skin and intestine express the epithelial cell mitogen keratinocyte growth factor (KGF). In contrast, intraepithelial alpha beta T cells, as well as all lymphoid alpha beta and gamma delta T cell populations tested, did not produce KGF or promote the growth of cultured epithelial cells. These results suggest that intraepithelial gamma delta T cells function in surveillance and in repair of damaged epithelial tissues.


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   Abstract »    Full Text »    PDF »
HIV-1/Simian Immunodeficiency Virus Infection of Human and Nonhuman Primate Lymphocytes Results in the Migration of CD2+ T Cells into the Intestine of Engrafted SCID Mice.
H. H. Donze, J. E. Cummins Jr., R. S. Schwiebert, A. Kantele, Y. Han, P. N. Fultz, S. Jackson, and J. Mestecky (1998)
J. Immunol. 160, 2506-2513
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Science. ISSN 0036-8075 (print), 1095-9203 (online)