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Science 18 November 1994:
Vol. 266. no. 5188, pp. 1236 - 1240
DOI: 10.1126/science.7973707
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Articles

Science, Vol 266, Issue 5188, 1236-1240
Copyright © 1994 by American Association for the Advancement of Science

articles

Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD

S Kaushal, JW Schneider, B Nadal-Ginard, and V Mahdavi

Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.

Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.


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