Science 18 November 1994: Vol. 266. no. 5188, pp. 1208 - 1212 DOI: 10.1126/science.7973703

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Articles

Identification of the Last Cog in a Ligand-Independent Signaling Machine?.

D. L. Wiest (2009)
J. Immunol. 182, 5163-5164
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GPR30 Contributes to Estrogen-Induced Thymic Atrophy.

C. Wang, B. Dehghani, I. J. Magrisso, E. A. Rick, E. Bonhomme, D. B. Cody, L. A. Elenich, S. Subramanian, S. J. Murphy, M. J. Kelly, et al. (2008)
Mol. Endocrinol. 22, 636-648
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Mouse Sertoli Cells Display Phenotypical and Functional Traits of Antigen-Presenting Cells in Response to Interferon Gamma.

V. Dal Secco, A. Riccioli, F. Padula, E. Ziparo, and A. Filippini (2008)
Biol Reprod 78, 234-242
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Histone Deacetylase 7 Functions as a Key Regulator of Genes Involved in both Positive and Negative Selection of Thymocytes.

H. G. Kasler and E. Verdin (2007)
Mol. Cell. Biol. 27, 5184-5200
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Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition.

C. Mao, E. G. Tili, M. Dose, M. C. Haks, S. E. Bear, I. Maroulakou, K. Horie, G. A. Gaitanaris, V. Fidanza, T. Ludwig, et al. (2007)
J. Immunol. 178, 5443-5453
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Importance of the CD3{gamma} Ectodomain Terminal beta-Strand and Membrane Proximal Stalk in Thymic Development and Receptor Assembly.

M. Touma, Z.-Y. J. Sun, L. K. Clayton, W. E. Marissen, A. M. Kruisbeek, G. Wagner, and E. L. Reinherz (2007)
J. Immunol. 178, 3668-3679
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The Bloom's Syndrome Helicase Is Critical for Development and Function of the {alpha}{beta} T-Cell Lineage.

H. Babbe, N. Chester, P. Leder, and B. Reizis (2007)
Mol. Cell. Biol. 27, 1947-1959
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A Natural Structural Variant of the Mouse TCR beta-Chain Displays Intrinsic Receptor Function and Antigen Specificity.

A. Aublin, M. Ciofani, N. Willkomm, A. Hamrouni, A. L. Szymczak-Workman, T. Takahashi, Y. Sandjeu, P. Guillaume, D. A. A. Vignali, O. Michielin, et al. (2006)
J. Immunol. 177, 8587-8594
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Impaired Generation of CD8+ Thymocytes in Ets-1-Deficient Mice.

J. L. Clements, S. A. John, and L. A. Garrett-Sinha (2006)
J. Immunol. 177, 905-912
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The E{delta} enhancer controls the generation of CD4-CD8- {alpha}{beta}TCR-expressing T cells that can give rise to different lineages of {alpha}{beta} T cells.

I. Aifantis, C. H. Bassing, A. I. Garbe, K. Sawai, F. W. Alt, and H. von Boehmer (2006)
J. Exp. Med. 203, 1543-1550
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Differential synergy of Notch and T cell receptor signaling determines {alpha}{beta} versus {gamma}{delta} lineage fate.

A. I. Garbe, A. Krueger, F. Gounari, J. C. Zuniga-Pflucker, and H. von Boehmer (2006)
J. Exp. Med. 203, 1579-1590
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The TCR Cbeta FG Loop Regulates {alpha}beta T Cell Development..

M. Touma, H.-C. Chang, T. Sasada, M. Handley, L. K. Clayton, and E. L. Reinherz (2006)
J. Immunol. 176, 6812-6823
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Expression of TCR{alpha}beta Partly Rescues Developmental Arrest and Apoptosis of {alpha}beta T cells in Bcl11b-/- Mice.

J. Inoue, T. Kanefuji, K. Okazuka, H. Watanabe, Y. Mishima, and R. Kominami (2006)
J. Immunol. 176, 5871-5879
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Assembly of the {kappa} PreB Receptor Requires a V{kappa}-like Protein Encoded by a Germline Transcript.

R. Rangel, M. R. McKeller, J. C. Sims-Mourtada, C. Kashi, K. Cain, E. D. Wieder, J. J. Molldrem, L. V. Pham, R. J. Ford, P. Yotnda, et al. (2005)
J. Biol. Chem. 280, 17807-17814
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Phenotypic Characterization of CD3-7+ Cells in Developing Human Intestine and an Analysis of Their Ability to Differentiate into T Cells.

U. Gunther, J. A. Holloway, J. G. Gordon, A. Knight, V. Chance, N. A. Hanley, D. I. Wilson, R. French, J. Spencer, H. Steer, et al. (2005)
J. Immunol. 174, 5414-5422
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Intestinal {gamma}{delta} T Cells Develop in Mice Lacking Thymus, All Lymph Nodes, Peyer's Patches, and Isolated Lymphoid Follicles.

S. Nonaka, T. Naito, H. Chen, M. Yamamoto, K. Moro, H. Kiyono, H. Hamada, and H. Ishikawa (2005)
J. Immunol. 174, 1906-1912
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New insights into the proliferation and differentiation of early mouse thymocytes.

J. Laurent, N. Bosco, P. N. Marche, and R. Ceredig (2004)
Int. Immunol. 16, 1069-1080
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Defined {alpha}{beta} T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation.

B. Erman, T. I. Guinter, and A. Singer (2004)
J. Exp. Med. 199, 1719-1724
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Overexpression of IL-7R{alpha} provides a competitive advantage during early T-cell development.

Y. Laouar, I. N. Crispe, and R. A. Flavell (2004)
Blood 103, 1985-1994
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Effect of CD3{delta} Deficiency on Maturation of {alpha}/{beta} and {gamma}/{delta} T-Cell Lineages in Severe Combined Immunodeficiency.

H. K. Dadi, A. J. Simon, and C. M. Roifman (2003)
N. Engl. J. Med. 349, 1821-1828
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Increase of TCR V{beta} Accessibility within E{beta} Regulatory Region Influences its Recombination Frequency But Not Allelic Exclusion.

M. Senoo, L. Wang, D. Suzuki, N. Takeda, Y. Shinkai, and S. Habu (2003)
J. Immunol. 171, 829-835
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Regulation of pTalpha Gene Expression by a Dosage of E2A, HEB, and SCL.

M. Tremblay, S. Herblot, E. Lecuyer, and T. Hoang (2003)
J. Biol. Chem. 278, 12680-12687
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T Cell Receptor Gene Rearrangement Lineage Analysis Reveals Clues for the Origin of Highly Restricted Antigen-specific Repertoires.

A. Hamrouni, A. Aublin, P. Guillaume, and J. L. Maryanski (2003)
J. Exp. Med. 197, 601-614
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Positive Selection by the Pre-TCR Yields Mature CD8+ T Cells.

Y. Ito, S. Arai, N. S. C. van Oers, I. Aifantis, H. von Boehmer, and T. Miyazaki (2002)
J. Immunol. 169, 4913-4919
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Molecular Mechanisms of Pre-T Cell Receptor-induced Survival.

C. Murga and D. F. Barber (2002)
J. Biol. Chem. 277, 39156-39162
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Involvement of the TCR C{beta} FG Loop in Thymic Selection and T Cell Function.

T. Sasada, M. Touma, H.-C. Chang, L. K. Clayton, J.-h. Wang, and E. L. Reinherz (2002)
J. Exp. Med. 195, 1419-1431
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Dysregulated Expression of Pre-T{alpha} Reveals the Opposite Effects of Pre-TCR at Successive Stages of T Cell Development.

H. D. Lacorazza, H. E. Porritt, and J. Nikolich-Zugich (2001)
J. Immunol. 167, 5689-5696
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Differential Developmental Regulation and Functional Effects on Pre-TCR Surface Expression of Human pT{alpha}a and pT{alpha}b Spliced Isoforms.

A. R. Ramiro, M. N. Navarro, A. Carreira, Y. R. Carrasco, V. G. de Yebenes, G. Carrillo, J. L. San Millan, B. Rubin, and M. L. Toribio (2001)
J. Immunol. 167, 5106-5114
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Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity.

T. Taghon, M. De Smedt, F. Stolz, M. Cnockaert, J. Plum, and G. Leclercq (2001)
J. Immunol. 167, 4468-4475
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TCRA Gene Rearrangement in Immature Thymocytes in Absence of CD3, Pre-TCR, and TCR Signaling.

S. J. C. Mancini, S. M. Candeias, J. P. Di Santo, P. Ferrier, P. N. Marche, and E. Jouvin-Marche (2001)
J. Immunol. 167, 4485-4493
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The Upstream Enhancer Is Necessary and Sufficient for the Expression of the Pre-T Cell Receptor {alpha} Gene in Immature T Lymphocytes.

B. Reizis and P. Leder (2001)
J. Exp. Med. 194, 979-990
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The Biological Activity of Natural and Mutant pT{alpha} Alleles.

D. Gibbons, N. C. Douglas, D. F. Barber, Q. Liu, R. Sullo, L. Geng, H.-J. Fehling, H. von Boehmer, and A. C. Hayday (2001)
J. Exp. Med. 194, 695-704
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E2A and HEB Activate the Pre-TCR{alpha} Promoter During Immature T Cell Development.

A. Takeuchi, S. Yamasaki, K. Takase, F. Nakatsu, H. Arase, M. Onodera, and T. Saito (2001)
J. Immunol. 167, 2157-2163
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Expression and selection of productively rearranged TCR{beta} VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1+ {alpha}{beta} T cells.

N. Baur, G. Nerz, A. Nil, and K. Eichmann (2001)
Int. Immunol. 13, 1031-1042
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Identification of a novel, human multilymphoid progenitor in cord blood.

Q.-L. Hao, J. Zhu, M. A. Price, K. J. Payne, L. W. Barsky, and G. M. Crooks (2001)
Blood 97, 3683-3690
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Early TCR {{alpha}}{{beta}} Expression Promotes Maturation of T Cells Expressing Fc{{epsilon}}RI{{gamma}} Containing TCR/CD3 Complexes.

K. Petersson and F. Ivars (2001)
J. Immunol. 166, 6616-6624
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An Endoplasmic Reticulum Retention Function for the Cytoplasmic Tail of the Human Pre-T Cell Receptor (TCR) {{alpha}} Chain: Potential Role in the Regulation of Cell Surface pre-TCR Expression Levels.

Y. R. Carrasco, A. R. Ramiro, C. Trigueros, V. G. de Yebenes, M. Garcia-Peydro, and M. L. Toribio (2001)
J. Exp. Med. 193, 1045-1058
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Opposite Ability of Pre-TCR and {{alpha}}{{beta}}TCR to Induce Apoptosis.

A.-M. Steff, S. Trop, M. Maira, J. Drouin, and P. Hugo (2001)
J. Immunol. 166, 5044-5050
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Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes.

S. Trop, P. De Sepulveda, J. C. Zuniga-Pflucker, and R. Rottapel (2001)
Blood 97, 2269-2277
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Premature TCR{{alpha}}{{beta}} Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development.

H. D. Lacorazza, C. Tucek-Szabo, L. V. Vasovic, K. Remus, and J. Nikolich-Zugich (2001)
J. Immunol. 166, 3184-3193
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A Redundant Role of the CD3{{gamma}}-Immunoreceptor Tyrosine-Based Activation Motif in Mature T Cell Function.

M. C. Haks, T. A. Cordaro, J. H. N. van den Brakel, J. B. A. G. Haanen, E. F. R. de Vries, J. Borst, P. Krimpenfort, and A. M. Kruisbeek (2001)
J. Immunol. 166, 2576-2588
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Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity.

C. Shimizu, H. Kawamoto, M. Yamashita, M. Kimura, E. Kondou, Y. Kaneko, S. Okada, T. Tokuhisa, M. Yokoyama, M. Taniguchi, et al. (2001)
Int. Immunol. 13, 105-117
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Competitive Displacement of pT{alpha} by TCR-{alpha} During TCR Assembly Prevents Surface Coexpression of Pre-TCR and {alpha}{beta} TCR.

S. Trop, M. Rhodes, D. L. Wiest, P. Hugo, and J. C. Zuniga-Pflucker (2000)
J. Immunol. 165, 5566-5572
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Identification of a novel pre-TCR isoform in which the accessibility of the TCR{beta} subunit is determined by occupancy of the `missing' V domain of pre-T{alpha}.

M. A. Berger, M. Carleton, M. Rhodes, J. M. Sauder, S. Trop, R. L. Dunbrack, P. Hugo, and D. L. Wiest (2000)
Int. Immunol. 12, 1579-1591
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Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).

S. Zuklys, G. Balciunaite, A. Agarwal, E. Fasler-Kan, E. Palmer, and G. A. Hollander (2000)
J. Immunol. 165, 1976-1983
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T Cell Development in TCR{beta} Enhancer-Deleted Mice: Implications for {alpha}{beta} T Cell Lineage Commitment and Differentiation.

I. Leduc, W. M. Hempel, N. Mathieu, C. Verthuy, G. Bouvier, F. Watrin, and P. Ferrier (2000)
J. Immunol. 165, 1364-1373
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Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications.

G. J. Wiegers, I. E. M. Stec, W. E. F. Klinkert, and J. M. H. M. Reul (2000)
J. Immunol. 164, 6213-6220
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Hoxa3 and Pax1 Transcription Factors Regulate the Ability of Fetal Thymic Epithelial Cells to Promote Thymocyte Development.

D.-m. Su and N. R. Manley (2000)
J. Immunol. 164, 5753-5760
 |  Abstract »  |  Full Text »  |  PDF »

Facilitation of {beta} Selection and Modification of Positive Selection in the Thymus of PD-1-deficient Mice.

H. Nishimura, T. Honjo, and N. Minato (2000)
J. Exp. Med. 191, 891-898
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-regulated Kinase (ERK) Activation by the Pre-T Cell Receptor in Developing Thymocytes In Vivo.

A. M. Michie, S. Trop, D. L. Wiest, and J. C. Zuniga-Pflucker (1999)
J. Exp. Med. 190, 1647-1656
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TCR {alpha}-Chain Repertoire in pT{alpha}-Deficient Mice Is Diverse and Developmentally Regulated: Implications for Pre-TCR Functions and TCRA Gene Rearrangement.

S. Mancini, S. M. Candeias, H. J. Fehling, H. von Boehmer, E. Jouvin-Marche, and P. N. Marche (1999)
J. Immunol. 163, 6053-6059
 |  Abstract »  |  Full Text »  |  PDF »

beta -Selection Is Associated With the Onset of CD8beta Chain Expression on CD4+CD8alpha alpha + Pre-T Cells During Human Intrathymic Development.

Y. R. Carrasco, C. Trigueros, A. R. Ramiro, V. G. de Yebenes, and M. L. Toribio (1999)
Blood 94, 3491-3498
 |  Abstract »  |  Full Text »  |  PDF »

Antigen Receptor-induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein-deficient Lymphocytes.

J. Zhang, A. Shehabeldin, L. A.G. da Cruz, J. Butler, A.-K. Somani, M. McGavin, I. Kozieradzki, A. O. dos Santos, A. Nagy, S. Grinstein, et al. (1999)
J. Exp. Med. 190, 1329-1342
 |  Abstract »  |  Full Text »  |  PDF »

Unique CD4+ T cells in TCR {alpha} chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process.

R. J. Hayashi and O. Kanagawa (1999)
Int. Immunol. 11, 1581-1590
 |  Abstract »  |  Full Text »  |  PDF »

Signals Transduced by CD3{epsilon}, But Not by Surface Pre-TCR Complexes, Are Able to Induce Maturation of an Early Thymic Lymphoma In Vitro.

M. Carleton, N. R. Ruetsch, M. A. Berger, M. Rhodes, S. Kaptik, and D. L. Wiest (1999)
J. Immunol. 163, 2576-2585
 |  Abstract »  |  Full Text »  |  PDF »

A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4–CD8– to CD4+CD8+ thymocytes.

L. B. King, E. Tolosa, J. M. Lenczowski, F. Lu, E. F. Lind, R. Hunziker, H. T. Petrie, and J. D. Ashwell (1999)
Int. Immunol. 11, 1203-1216
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Differentiation in Culture of Murine Primitive Lymphohematopoietic Progenitors Toward T-Cell Lineage.

F. Hirayama, Y. Aiba, K. Ikebuchi, S. Sekiguchi, and M. Ogawa (1999)
Blood 93, 4187-4195
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Mouse Pre-T Cell Receptor alpha  Gene Is Controlled by an Upstream Region Containing a Transcriptional Enhancer.

B. Reizis and P. Leder (1999)
J. Exp. Med. 189, 1669-1678
 |  Abstract »  |  Full Text »  |  PDF »

TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation.

B. Blom, M. C.M. Verschuren, M. H.M. Heemskerk, A. Q. Bakker, E. J. van Gastel-Mol, I. L.M. Wolvers-Tettero, J. J.M. van Dongen, and H. Spits (1999)
Blood 93, 3033-3043
 |  Abstract »  |  Full Text »  |  PDF »

Multivalent structure of an alpha beta T cell receptor.

G. Fernandez-Miguel, B. Alarcon, A. Iglesias, H. Bluethmann, M. Alvarez-Mon, E. Sanz, and A. de la Hera (1999)
PNAS 96, 1547-1552
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Distinct Effects of Jak3 Signaling on {alpha}{beta} and {gamma}{delta} Thymocyte Development.

E. E. Eynon, F. Livak, K. Kuida, D. G. Schatz, and R. A. Flavell (1999)
J. Immunol. 162, 1448-1459
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Expansion of CD4+ TCR{beta}{beta}+ T Cells in TCR {alpha}-Chain- Deficient Mice by Gut-Derived Antigens.

I. Takahashi, H. Iijima, R. Katashima, M. Itakura, and H. Kiyono (1999)
J. Immunol. 162, 1843-1850
 |  Abstract »  |  Full Text »  |  PDF »

The Impact of Pre-T-cell Receptor Signals on Gene Expression in Developing T Cells.

H. VON BOEHMER, I. AIFANTIS, O. AZOGUI, C. SAINT-RUF, and F. GRASSI (1999)
Cold Spring Harb Symp Quant Biol 64, 283-290
 |  Abstract »  |  PDF »

In Vitro Intrathymic Differentiation Kinetics of Human Fetal Liver CD34+CD38- Progenitors Reveals a Phenotypically Defined Dendritic/T-NK Precursor Split.

J. Plum, M. De Smedt, B. Verhasselt, F. Offner, T. Kerre, D. Vanhecke, G. Leclercq, and B. Vandekerckhove (1999)
J. Immunol. 162, 60-68
 |  Abstract »  |  Full Text »  |  PDF »

Extrathymic T Cell Differentiation in the Human Intestine Early in Life.

D. Howie, J. Spencer, D. DeLord, C. Pitzalis, N. C. Wathen, A. Dogan, A. Akbar, and T. T. MacDonald (1998)
J. Immunol. 161, 5862-5872
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Cloning of pTAC12 an Alternative Splicing Product of the CD3gamma Chain as a Component of the Pre-T Cell Antigen-Receptor Complex.

K. Takase, Y. Okazaki, K. Wakizaka, A. Shevchenko, M. Mann, and T. Saito (1998)
J. Biol. Chem. 273, 30675-30679
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirements for ZAP-70 in TCR Signaling and T Cell Development.

T. A. Kadlecek, N. S. C. van Oers, L. Lefrancois, S. Olson, D. Finlay, D. H. Chu, K. Connolly, N. Killeen, and A. Weiss (1998)
J. Immunol. 161, 4688-4694
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Late Stage of Small Noncycling pTalpha -  Pre-T Cells as Immediate Precursors of T Cell Receptor alpha /beta +  Thymocytes.

C. Trigueros, A. R. Ramiro, Y. R. Carrasco, V. G. de Yebenes, J. P. Albar, and M. L. Toribio (1998)
J. Exp. Med. 188, 1401-1412
 |  Abstract »  |  Full Text »  |  PDF »

SLP-76 Expression Is Restricted to Hemopoietic Cells of Monocyte, Granulocyte, and T Lymphocyte Lineage and Is Regulated During T Cell Maturation and Activation.

J. L. Clements, S. E. Ross-Barta, L. T. Tygrett, T. J. Waldschmidt, and G. A. Koretzky (1998)
J. Immunol. 161, 3880-3889
 |  Abstract »  |  Full Text »  |  PDF »

Critical Involvement of Tcf-1 in Expansion of Thymocytes.

M. W. Schilham, A. Wilson, P. Moerer, B. J. Benaissa-Trouw, A. Cumano, and H. C. Clevers (1998)
J. Immunol. 161, 3984-3991
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage.

S. T. Page, L. Y. Bogatzki, J. A. Hamerman, C. H. Sweenie, P. J. Hogarth, M. Malissen, R. M. Perlmutter, and A. M. Pullen (1998)
PNAS 95, 9459-9464
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development.

J. L. Clements, B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky (1998)
Science 281, 416-419
 |  Abstract »  |  Full Text »

Cross-lineage expression of Ig-beta (B29) in thymocytes: Positive and negative gene regulation to establish T cell identity.

H. Wang, R. A. Diamond, and E. V. Rothenberg (1998)
PNAS 95, 6831-6836
 |  Abstract »  |  Full Text »  |  PDF »

T Cells Expressing Receptors of Different Affinity for Antigen Ligands Reveal a Unique Role for p59fyn in T Cell Development and Optimal Stimulation of T Cells by Antigen.

O. Utting, S.-J. Teh, and H.-S. Teh (1998)
J. Immunol. 160, 5410-5419
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Region Involved in CD3 Pairwise Interactions within the T Cell Receptor Complex.

A. Borroto, A. Mallabiabarrena, J. P. Albar, C. Martinez-A., and B. Alarcon (1998)
J. Biol. Chem. 273, 12807-12816
 |  Abstract »  |  Full Text »  |  PDF »

Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains.

B. A. Irving, F. W. Alt, and N. Killeen (1998)
Science 280, 905-908
 |  Abstract »  |  Full Text »

One of the CD3epsilon Subunits within a T Cell Receptor Complex Lies in Close Proximity to the Cbeta FG Loop.

Y. Ghendler, A. Smolyar, H.-C. Chang, and E. L. Reinherz (1998)
J. Exp. Med. 187, 1529-1536
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirement for p56lck in Fetal and Adult Thymopoiesis.

T. J. Molina, J.-Y. Perrot, J. Penninger, A. Ramos, J. Audouin, P. Briand, T. W. Mak, and J. Diebold (1998)
J. Immunol. 160, 3828-3834
 |  Abstract »  |  Full Text »  |  PDF »

The CD3-gamma delta epsilon and CD3-zeta /eta Modules Are Each Essential for Allelic Exclusion at the T Cell Receptor beta  Locus but Are Both Dispensable for the Initiation of  V to (D)J Recombination at the T Cell Receptor-beta , -gamma , and -delta Loci.

L. Ardouin, J. Ismaili, B. Malissen, and M. Malissen (1998)
J. Exp. Med. 187, 105-116
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Composition of Pre-T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3delta Is Physically Associated but Not Functionally Required.

M. A. Berger, V. Dave, M. R. Rhodes, G. C. Bosma, M. J. Bosma, D. J. Kappes, and D. L. Wiest (1997)
J. Exp. Med. 186, 1461-1467
 |  Abstract »  |  Full Text »  |  PDF »

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.

A. M. Cheng, I. Negishi, S. J. Anderson, A. C. Chan, J. Bolen, D. Y. Loh, and T. Pawson (1997)
PNAS 94, 9797-9801
 |  Abstract »  |  Full Text »  |  PDF »

Allelic Exclusion in pTalpha -deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-beta Chains, but Less Efficient Inhibition of Endogeneous Vbeta right-arrow (D)Jbeta Rearrangements in the Presence of a Functional TCR-beta Transgene.

A. Krotkova, H. v. Boehmer, and H. J. Fehling (1997)
J. Exp. Med. 186, 767-775
 |  Abstract »  |  Full Text »  |  PDF »

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

D. Melamed and D. Nemazee (1997)
PNAS 94, 9267-9272
 |  Abstract »  |  Full Text »  |  PDF »

Role of Different T Cell Receptors in the Development of Pre-T Cells.

J. Buer, I. Aifantis, J. P. DiSanto, H. J. Fehling, and H. v. Boehmer (1997)
J. Exp. Med. 185, 1541-1548
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Receptor (TCR)-beta Gene Recombination: Dissociation from Cell Cycle Regulation and Developmental Progression During T Cell Ontogeny.

M. R. Tourigny, S. Mazel, D. B. Burtrum, and H. T. Petrie (1997)
J. Exp. Med. 185, 1549-1556
 |  Abstract »  |  Full Text »  |  PDF »

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperones.

D. L. Wiest, A. Bhandoola, J. Punt, G. Kreibich, D. McKean, and A. Singer (1997)
PNAS 94, 1884-1889
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Committed T Cell Precursor Population in Adult Human Peripheral Blood.

L. Bruno, P. Res, M. Dessing, M. Cella, and H. Spits (1997)
J. Exp. Med. 185, 875-884
 |  Abstract »  |  Full Text »  |  PDF »

Replacement of Pre-T Cell Receptor Signaling Functions by the CD4 Coreceptor.

A. M. Norment, K. A. Forbush, N. Nguyen, M. Malissen, and R. M. Perlmutter (1997)
J. Exp. Med. 185, 121-130
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Regulation of  VDJ Recombination By the Core Fragment of the T Cell Receptor alpha  Enhancer.

J. L. Roberts, P. Lauzurica, and M. S. Krangel (1997)
J. Exp. Med. 185, 131-140
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation Kinetics Associated with T Cell Receptor-beta Chain Selection of Fetal Murine Thymocytes.

I. Falk, J. Biro, H. Kohler, and K. Eichmann (1996)
J. Exp. Med. 184, 2327-2340
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development.

J. Ashwell, L. King, and M. Vacchio (1996)
Stem Cells 14, 490-500
 |  Abstract »

Assembled Pre-B Cell Receptor Complexes Are Retained in the Endoplasmic Reticulum by a Mechanism That Is Not Selective for the Pseudo-light Chain.

G. S. Brouns, E. d. Vries, J. J. Neefjes, and J. Borst (1996)
J. Biol. Chem. 271, 19272-19278
 |  Abstract »  |  Full Text »  |  PDF »

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo..

E S Hoffman, L Passoni, T Crompton, T M Leu, D G Schatz, A Koff, M J Owen, and A C Hayday (1996)
Genes & Dev. 10, 948-962
 |  Abstract »  |  PDF »

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes..

M A Bogue, C Zhu, E Aguilar-Cordova, L A Donehower, and D B Roth (1996)
Genes & Dev. 10, 553-565
 |  Abstract »  |  PDF »

Crystal structure of the beta chain of a T cell antigen receptor.

G. Bentley, G Boulot, K Karjalainen, and R. Mariuzza (1995)
Science 267, 1984-1987
 |  Abstract »  |  PDF »

The Identification of a Nonclassical Cadherin Expressed during B Cell Development and Its Interaction with Surrogate Light Chain.

K. Ohnishi, T. Shimizu, H. Karasuyama, and F. Melchers (2000)
J. Biol. Chem. 275, 31134-31144
 |  Abstract »  |  Full Text »  |  PDF »

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