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Science 11 November 1994:
Vol. 266. no. 5187, pp. 1068 - 1072
DOI: 10.1126/science.7973666
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Articles

Science, Vol 266, Issue 5187, 1068-1072
Copyright © 1994 by American Association for the Advancement of Science

articles

Spermine and spermidine as gating molecules for inward rectifier K+ channels

E Ficker, M Taglialatela, BA Wible, CM Henley, and AM Brown

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030.

Inward rectifier K+ channels pass prominent inward currents, while outward currents are largely blocked. The inward rectification is due to block by intracellular Mg2+ and a Mg(2+)-independent process described as intrinsic gating. The rapid loss of gating upon patch excision suggests that cytoplasmic factors participate in gating. "Intrinsic" gating can be restored in excised patches by nanomolar concentrations of two naturally occurring polyamines, spermine and spermidine. Spermine and spermidine may function as physiological blockers of inward rectifier K+ channels and "intrinsic" gating may largely reflect voltage-dependent block by these cations.


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C Dart, M L Leyland, R Barrett-Jolley, P A Shelton, P J Spencer, E C Conley, M J Sutcliffe, and P R Stanfield (1998)
J. Physiol. 511, 15-24
   Abstract »    Full Text »    PDF »
Coupled Ion Movement Underlies Rectification in an Inward-Rectifier K+ Channel.
M. Spassova and Z. Lu (1998)
J. Gen. Physiol. 112, 211-221
   Abstract »    Full Text »    PDF »
Neutralization of aspartate residues in the murine inwardly rectifying K+ channel IRK1 affects the substate behaviour in Mg2+ block.
K. Oishi, K. Omori, H. Ohyama, K. Shingu, and H. Matsuda (1998)
J. Physiol. 510, 675-683
   Abstract »    Full Text »    PDF »
A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes.
K. Ishihara and T. Ehara (1998)
J. Physiol. 510, 755-771
   Abstract »    Full Text »    PDF »


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