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Science 11 November 1994:
Vol. 266. no. 5187, pp. 1062 - 1064
DOI: 10.1126/science.7973664
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Articles

Science, Vol 266, Issue 5187, 1062-1064
Copyright © 1994 by American Association for the Advancement of Science

articles

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

CE Henderson, HS Phillips, RA Pollock, AM Davies, C Lemeulle, M Armanini, L Simmons, B Moffet, RA Vandlen, L Simpson LC [corrected to Simmons, and al. et

INSERM U.382, IBDM, Marseille, France.

For survival, embryonic motoneurons in vertebrates depend on as yet undefined neurotrophic factors present in the limb bud. Members of the neurotrophin family are currently the best candidates for such neurotrophic factors, but inactivation of their receptor genes leads to only partial loss of motoneurons, which suggests that other factors are involved. Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture. GDNF messenger RNA was found in the immediate vicinity of motoneurons during the period of cell death in development. In vivo, GDNF rescues and prevents the atrophy of facial motoneurons that have been deprived of target-derived survival factors by axotomy. GDNF may therefore be a physiological trophic factor for spinal motoneurons. Its potency and specificity in vitro and in vivo also make it a good candidate for treatment of motoneuron disease.


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J. Neurosci. 18, 7361-7371
   Abstract »    Full Text »    PDF »
Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons.
B. A. Horger, M. C. Nishimura, M. P. Armanini, L.-C. Wang, K. T. Poulsen, C. Rosenblad, D. Kirik, B. Moffat, L. Simmons, E. Johnson Jr, et al. (1998)
J. Neurosci. 18, 4929-4937
   Abstract »    Full Text »    PDF »
Reduction of Ischemic Brain Injury by Topical Application of Glial Cell Line–Derived Neurotrophic Factor After Permanent Middle Cerebral Artery Occlusion in Rats • Editorial Comment.
H. Kitagawa, T. Hayashi, Y. Mitsumoto, N. Koga, Y. Itoyama, K. Abe, and H. A. Kontos (1998)
Stroke 29, 1417-1422
   Abstract »    Full Text »    PDF »
Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction.
T. Yu, S. Scully, Y. Yu, G. M. Fox, S. Jing, and R. Zhou (1998)
J. Neurosci. 18, 4684-4696
   Abstract »    Full Text »    PDF »
Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor.
A. G. Estevez, N. Spear, J. A. Thompson, T. L. Cornwell, R. Radi, L. Barbeito, and J. S. Beckman (1998)
J. Neurosci. 18, 3708-3714
   Abstract »    Full Text »    PDF »
GFRalpha 3 is an orphan member of the GDNF/neurturin/persephin receptor family.
R. H. Baloh, A. Gorodinsky, J. P. Golden, M. G. Tansey, C. L. Keck, N. C. Popescu, E. M. Johnson Jr., and J. Milbrandt (1998)
PNAS 95, 5801-5806
   Abstract »    Full Text »    PDF »
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury.
D. L. H. Bennett, G. J. Michael, N. Ramachandran, J. B. Munson, S. Averill, Q. Yan, S. B. McMahon, and J. V. Priestley (1998)
J. Neurosci. 18, 3059-3072
   Abstract »    Full Text »    PDF »
Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2.
K. Durick, G. N. Gill, and S. S. Taylor (1998)
Mol. Cell. Biol. 18, 2298-2308
   Abstract »    Full Text »
Hyperinnervation of Neuromuscular Junctions Caused by GDNF Overexpression in Muscle.
Q. T. Nguyen, A. S. Parsadanian, W. D. Snider, and J. W. Lichtman (1998)
Science 279, 1725-1729
   Abstract »    Full Text »
Calmodulin Is Involved in Membrane Depolarization-Mediated Survival of Motoneurons by Phosphatidylinositol-3 Kinase- and MAPK-Independent Pathways.
R. M. Soler, J. Egea, G. M. Mintenig, C. Sanz-Rodriguez, M. Iglesias, and J. X. Comella (1998)
J. Neurosci. 18, 1230-1239
   Abstract »    Full Text »    PDF »
Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1).
V. Arce, R. A. Pollock, J.-M. Philippe, D. Pennica, C. E. Henderson, and O. deLapeyriere (1998)
J. Neurosci. 18, 1440-1448
   Abstract »    Full Text »    PDF »
Expression and regulation of GFRalpha 3, a glial cell line-derived neurotrophic factor family receptor.
P. Naveilhan, C. Baudet, A. Mikaels, L. Shen, H. Westphal, and P. Ernfors (1998)
PNAS 95, 1295-1300
   Abstract »    Full Text »    PDF »
Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation.
A. G. Estevez, N. Spear, S. M. Manuel, R. Radi, C. E. Henderson, L. Barbeito, and J. S. Beckman (1998)
J. Neurosci. 18, 923-931
   Abstract »    Full Text »    PDF »
Differential Effects of Neurotrophic Factors on Motoneuron Retrograde Labeling in a Murine Model of Motoneuron Disease.
Y. Sagot, T. Rosse, R. Vejsada, D. Perrelet, and A. C. Kato (1998)
J. Neurosci. 18, 1132-1141
   Abstract »    Full Text »    PDF »
Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway.
A. C. Maroney, M. A. Glicksman, A. N. Basma, K. M. Walton, E. Knight Jr, C. A. Murphy, B. A. Bartlett, J. P. Finn, T. Angeles, Y. Matsuda, et al. (1998)
J. Neurosci. 18, 104-111
   Abstract »    Full Text »    PDF »
GFRalpha -2 and GFRalpha -3 Are Two New Receptors for Ligands of the GDNF Family.
S. Jing, Y. Yu, M. Fang, Z. Hu, P. L. Holst, T. Boone, J. Delaney, H. Schultz, R. Zhou, and G. M. Fox (1997)
J. Biol. Chem. 272, 33111-33117
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Murine Glial Cell-Derived Neurotrophic Factor Inducible Transcription Factor (MGIF).
S. Yajima, C.-H. Lammers, S.-H. Lee, Y. Hara, K. Mizuno, and M. M. Mouradian (1997)
J. Neurosci. 17, 8657-8666
   Abstract »    Full Text »    PDF »
Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-beta (GDNFR-beta ), Novel Proteins Related to GDNF and GDNFR-alpha with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs.
J. Widenfalk, C. Nosrat, A. Tomac, H. Westphal, B. Hoffer, and L. Olson (1997)
J. Neurosci. 17, 8506-8519
   Abstract »    Full Text »    PDF »
Endogenous Ciliary Neurotrophic Factor Is a Lesion Factor for Axotomized Motoneurons in Adult Mice.
M. Sendtner, R. Gotz, B. Holtmann, and H. Thoenen (1997)
J. Neurosci. 17, 6999-7006
   Abstract »    Full Text »    PDF »


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