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Science 11 November 1994:
Vol. 266. no. 5187, pp. 1051 - 1054
DOI: 10.1126/science.7973660
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Articles

Science, Vol 266, Issue 5187, 1051-1054
Copyright © 1994 by American Association for the Advancement of Science

articles

A potential noninvasive neurobiological test for Alzheimer's disease

LF Scinto, KR Daffner, D Dressler, BI Ransil, D Rentz, S Weintraub, M Mesulam, and H Potter

Laboratory of Eye Movements and Higher Cortical Functions, Brigham and Women's Hospital, MA 02115.

Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitely diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnostic test of Alzheimer's disease. Here it is reported that patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. It was possible to distinguish 18 of 19 individuals (95%) either clinically diagnosed with Alzheimer's disease or classified as suspect Alzheimer's individuals by neuropsychological screening from 30 of 32 normal elderly controls (94%).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biomarkers in the Diagnosis of Alzheimer's Disease: Are We Ready?.
T. Sunderland, H. Hampel, M. Takeda, K. T. Putnam, and R. M. Cohen (2006)
J Geriatr Psychiatry Neurol 19, 172-179
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Multiple-Level Studies Are Needed to Assess the True Value of Diagnostic Tests for Dementia.
W. A. Van Gool (2006)
Arch Neurol 63, 142-143
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Cocaine and Phenylephrine Eye Drop Test for Parkinson Disease.
H. Sawada, K. Yamakawa, H. Yamakado, R. Hosokawa, M. Ohba, K. Miyamoto, T. Kawamura, and S. Shimohama (2005)
JAMA 293, 932-934
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Is videopupillography useful in diagnosing Alzheimer's disease?.
J. Verghese, E. Ferrario, M. Molaschi, L. Villa, O. Varetto, C. Bogetto, and R. Nuzzi (1999)
Neurology 52, 673
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Pupil Dilation to Tropicamide Is Not Specific for Alzheimer Disease.
J. H. Growdon, K. Graefe, M. Tennis, D. Hayden, D. Schoenfeld, and S. H. Wray (1997)
Arch Neurol 54, 841-844
   Abstract »    PDF »
Response of the Pupil to Tropicamide Is Not a Reliable Test for Alzheimer Disease.
J. S. FitzSimon, S. C. Waring, E. Kokmen, J. W. McLaren, and R. F. Brubaker (1997)
Arch Neurol 54, 155-159
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Cautiousness in testing for Alzheimer's disease.
L.-G. Gunnarsson and C. Lundberg (1995)
American Journal of Alzheimer's Disease and Other Dementias 10, 37-38
   Abstract »    PDF »
Geriatric Medicine.
T. M. Gill and M. E. Tinetti (1995)
JAMA 273, 1684-1686
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Neurology.
R. J. Joynt (1995)
JAMA 273, 1695-1697
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Ophthalmology.
L. A. Levin (1995)
JAMA 273, 1703-1705
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Simple Early Test Eyed for Alzheimer's Disease.
(1995)
Journal Watch Dermatology 1995, 15
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SIMPLE, EARLY TEST IS EYED FOR ALZHEIMER'S DISEASE.
(1994)
Journal Watch (General) 1994, 2
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Possible new test found for Alzheimer's disease.
M Barinaga (1994)
Science 266, 973
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