Science 11 November 1994: Vol. 266. no. 5187, pp. 1039 - 1042 DOI: 10.1126/science.7973657

Prev | Table of Contents | Next

Articles

Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma.

J. Kline, I. E. Brown, Y.-Y. Zha, C. Blank, J. Strickler, H. Wouters, L. Zhang, and T. F. Gajewski (2008)
Clin. Cancer Res. 14, 3156-3167
 |  Abstract »  |  Full Text »  |  PDF »

Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergy.

M. A. Kriegel, S. Adam-Klages, C. Gabler, N. Blank, M. Schiller, C. Scheidig, J. R. Kalden, and H.-M. Lorenz (2008)
Int. Immunol. 20, 601-613
 |  Abstract »  |  Full Text »  |  PDF »

Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes.

R. M. Thomas, N. Chunder, C. Chen, S. E. Umetsu, S. Winandy, and A. D. Wells (2007)
J. Immunol. 179, 7305-7315
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells from Simian Immunodeficiency Virus Disease-Resistant Sooty Mangabeys Produce More IL-2 Than Cells from Disease-Susceptible Species: Involvement of p300 and CREB at the Proximal IL-2 Promoter in IL-2 Up-Regulation.

P. Bostik, E. S. Noble, S. T. Stephenson, F. Villinger, and A. A. Ansari (2007)
J. Immunol. 178, 7720-7729
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy.

Y. Zheng, S. L. Collins, M. A. Lutz, A. N. Allen, T. P. Kole, P. E. Zarek, and J. D. Powell (2007)
J. Immunol. 178, 2163-2170
 |  Abstract »  |  Full Text »  |  PDF »

Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection.

I. E. Brown, C. Blank, J. Kline, A. K. Kacha, and T. F. Gajewski (2006)
J. Immunol. 177, 4521-4529
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte-Derived Human Macrophages Mediate Anergy in Allogeneic T Cells and Induce Regulatory T Cells.

S. Hoves, S. W. Krause, C. Schutz, D. Halbritter, J. Scholmerich, H. Herfarth, and M. Fleck (2006)
J. Immunol. 177, 2691-2698
 |  Abstract »  |  Full Text »  |  PDF »

Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment..

T. F. Gajewski (2006)
Clin. Cancer Res. 12, 2326s-2330s
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: An Alternative Pathway of CD4+ T Cell Differentiation Is Induced Following Activation in the Absence of {gamma}-Chain-Dependent Cytokine Signals.

S. R. Mayack and L. J. Berg (2006)
J. Immunol. 176, 2059-2063
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Jak/STAT pathway for immunosuppression.

J J O'Shea (2004)
Ann Rheum Dis 63, ii67-ii71
 |  Full Text »  |  PDF »

Protection of Mice against Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia by Cell-based Vaccination Using Nonviral, Minimalistic Expression Vectors and Immunomodulatory Oligonucleotides.

J. Kochling, S. A. Konig-Merediz, R. Stripecke, D. Buchwald, A. Korte, H. G. von Einsiedel, F. Sack, G. Henze, K. Seeger, B. Wittig, et al. (2003)
Clin. Cancer Res. 9, 3142-3149
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Dysfunctional CD8+ T Cells Reside in Nonlymphoid Tissues During Chronic Trypanosoma cruzi Infection.

J. K. Leavey and R. L. Tarleton (2003)
J. Immunol. 170, 2264-2268
 |  Abstract »  |  Full Text »  |  PDF »

Clonal Anergy Is Maintained Independently of T Cell Proliferation.

S. Colombetti, F. Benigni, V. Basso, and A. Mondino (2002)
J. Immunol. 169, 6178-6186
 |  Abstract »  |  Full Text »  |  PDF »

Galpha and Gbeta gamma Require Distinct Src-dependent Pathways to Activate Rap1 and Ras.

J. M. Schmitt and P. J. S. Stork (2002)
J. Biol. Chem. 277, 43024-43032
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

B7 Costimulation Plays an Important Role in Protection from Herpes Simplex Virus Type 2-Mediated Pathology.

L. G. Thebeau and L. A. Morrison (2002)
J. Virol. 76, 2563-2566
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.

D. Tzachanis, A. Berezovskaya, L. M. Nadler, and V. A. Boussiotis (2002)
Blood 99, 1465-1473
 |  Abstract »  |  Full Text »  |  PDF »

Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness.

T. L. Vanasek, A. Khoruts, T. Zell, and D. L. Mueller (2001)
J. Immunol. 167, 5636-5644
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD47 in the Induction of Human Naive T Cell Anergy.

M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati (2001)
J. Immunol. 167, 2459-2468
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The Common {{gamma}}-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex.

H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura (2001)
J. Immunol. 167, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells.

P. A. Reche, V. Soumelis, D. M. Gorman, T. Clifford, M.-r. Liu, M. Travis, S. M. Zurawski, J. Johnston, Y.-J. Liu, H. Spits, et al. (2001)
J. Immunol. 167, 336-343
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells.

E. Prager, G. Staffler, O. Majdic, M. D. Saemann, S. Godar, G. J. Zlabinger, and H. Stockinger (2001)
J. Immunol. 166, 2364-2371
 |  Abstract »  |  Full Text »  |  PDF »

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.

B. Sporri, P. E. Kovanen, A. Sasaki, A. Yoshimura, and W. J. Leonard (2001)
Blood 97, 221-226
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor {alpha} chain 1: redundancy of requirement of tyrosine residue for STAT3 activation.

R. Umeshita-Suyama, R. Sugimoto, M. Akaiwa, K. Arima, B. Yu, M. Wada, M. Kuwano, K. Nakajima, N. Hamasaki, and K. Izuhara (2000)
Int. Immunol. 12, 1499-1509
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy.

H. Dooms, T. Van Belle, M. Desmedt, P. Rottiers, and J. Grooten (2000)
Blood 96, 1006-1012
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells.

M. Kimura, M. Yamashita, M. Kubo, M. Iwashima, C. Shimizu, K. Tokoyoda, J. Chiba, M. Taniguchi, M. Katsumata, and T. Nakayama (2000)
Int. Immunol. 12, 817-824
 |  Abstract »  |  Full Text »  |  PDF »

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains.

M. Chen, A. Cheng, F. Candotti, Y.-J. Zhou, A. Hymel, A. Fasth, L. D. Notarangelo, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 947-956
 |  Abstract »  |  Full Text »

IL-2 Unresponsiveness in Anergic CD4+ T Cells Is Due to Defective Signaling Through the Common {gamma}-Chain of the IL-2 Receptor.

S. Grundstrom, M. Dohlsten, and A. Sundstedt (2000)
J. Immunol. 164, 1175-1184
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Requirements for the Induction of CD4+ T Cell Alloantigen Hyporesponsiveness by Ex Vivo Anti-CD40 Ligand Antibody.

P. A. Taylor, A. Panoskaltsis-Mortari, R. J. Noelle, and B. R. Blazar (2000)
J. Immunol. 164, 612-622
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression.

L. J. Appleman, A. Berezovskaya, I. Grass, and V. A. Boussiotis (2000)
J. Immunol. 164, 144-151
 |  Abstract »  |  Full Text »  |  PDF »

Anergic T Lymphocytes Selectively Express an Integrin Regulatory Protein of the Cytohesin Family.

U. Korthauer, W. Nagel, E. M. Davis, M. M. Le Beau, R. S. Menon, E. O. Mitchell, C. A. Kozak, W. Kolanus, and J. A. Bluestone (2000)
J. Immunol. 164, 308-318
 |  Abstract »  |  Full Text »  |  PDF »

CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits Interleukin-2-dependent Signaling.

M. J. Aman, T.-S. Migone, A. Sasaki, D. P. Ascherman, M.-h. Zhu, E. Soldaini, K. Imada, A. Miyajima, A. Yoshimura, and W. J. Leonard (1999)
J. Biol. Chem. 274, 30266-30272
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis of Transforming Growth Factor {beta}1 and 2 in Ovarian Carcinoma.

M. E. Gordinier, H.-Z. Zhang, R. Patenia, L. B. Levy, E. N. Atkinson, M. A. Nash, R. L. Katz, C. D. Platsoucas, and R. S. Freedman (1999)
Clin. Cancer Res. 5, 2498-2505
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of JAK3 Protein Levels in T Lymphocytes by Prostaglandin E2 and Other Cyclic Adenosine Monophosphate-Elevating Agents: Impact on Interleukin-2 Receptor Signaling Pathway.

V. Kolenko, P. Rayman, B. Roy, M. K. Cathcart, J. O'Shea, R. Tubbs, L. Rybicki, R. Bukowski, and J. Finke (1999)
Blood 93, 2308-2318
 |  Abstract »  |  Full Text »  |  PDF »

A logical analysis of T cell activation and anergy.

M. Kaufman, F. Andris, and O. Leo (1999)
PNAS 96, 3894-3899
 |  Abstract »  |  Full Text »  |  PDF »

The Significance of Tetramerization in Promoter Recruitment by Stat5.

S. John, U. Vinkemeier, E. Soldaini, J. E. Darnell Jr., and W. J. Leonard (1999)
Mol. Cell. Biol. 19, 1910-1918
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation.

J. D. Powell, C. G. Lerner, and R. H. Schwartz (1999)
J. Immunol. 162, 2775-2784
 |  Abstract »  |  Full Text »  |  PDF »

Dose-Dependent Induction of Distinct Anergic Phenotypes: Multiple Levels of T Cell Anergy.

L. S. Taams, W. van Eden, and M. H. M. Wauben (1999)
J. Immunol. 162, 1974-1981
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency.

S. Kumaki, N. Ishii, M. Minegishi, S. Tsuchiya, D. Cosman, K. Sugamura, and T. Konno (1999)
Blood 93, 607-612
 |  Abstract »  |  Full Text »  |  PDF »

Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus.

W.J. LEONARD, K. IMADA, H. NAKAJIMA, A. PUEL, E. SOLDAINI, and S. JOHN (1999)
Cold Spring Harb Symp Quant Biol 64, 417-424
 |  Abstract »  |  PDF »

Interleukin 7 Receptor Control of  T Cell Receptor gamma  Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility.

S. K. Durum, S. Candeias, H. Nakajima, W. J. Leonard, A. M. Baird, L. J. Berg, and K. Muegge (1998)
J. Exp. Med. 188, 2233-2241
 |  Abstract »  |  Full Text »  |  PDF »

The Dual Phases of the Response to Neonatal Exposure to a VH Family-Restricted Staphylococcal B Cell Superantigen.

G. J. Silverman, J. V. Nayak, K. Warnatz, F. F. Hajjar, S. Cary, H. Tighe, and V. E. Curtiss (1998)
J. Immunol. 161, 5720-5732
 |  Abstract »  |  Full Text »  |  PDF »

Functional Cooperation of the Interleukin-2 Receptor beta  Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation.

T.-S. Migone, S. Rodig, N. A. Cacalano, M. Berg, R. D. Schreiber, and W. J. Leonard (1998)
Mol. Cell. Biol. 18, 6416-6422
 |  Abstract »  |  Full Text »

Response of human intestinal lamina propria T lymphocytes to interleukin 12: additive effects of interleukin 15 and 7.

G Monteleone, T Parrello, F Luzza, and F Pallone (1998)
Gut 43, 620-628
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mapping with Functional Antibodies Localizes Critical Sites on the Human IL Receptor Common {gamma} ({gamma}c) Chain.

N. Raskin, A. Jakubowski, I. Sizing, D. L. Olson, S. L. Kalled, C. A. Hession, C. D. Benjamin, D. P. Baker, and L. C. Burkly (1998)
J. Immunol. 161, 3474-3483
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: JAK3 Activation and Rescue of T Cells from HIV gp120-Induced Unresponsiveness.

N. Selliah and T. H. Finkel (1998)
J. Immunol. 160, 5697-5701
 |  Abstract »  |  Full Text »  |  PDF »

Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation.

J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini (1998)
J. Virol. 72, 4408-4412
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Regions of Interleukin-2 (IL-2) Receptor beta  Chain Important for Association of Jak1 and Jak3. Jak1-INDEPENDENT FUNCTIONAL RECRUITMENT OF Jak3 TO IL-2Rbeta.

M.-h. Zhu, J. A. Berry, S. M. Russell, and W. J. Leonard (1998)
J. Biol. Chem. 273, 10719-10725
 |  Abstract »  |  Full Text »  |  PDF »

Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras.

P. Porcu, J. Gaddy, and H. E. Broxmeyer (1998)
PNAS 95, 4538-4543
 |  Abstract »  |  Full Text »  |  PDF »

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.

T.-S. Migone, N. A. Cacalano, N. Taylor, T. Yi, T. A. Waldmann, and J. A. Johnston (1998)
PNAS 95, 3845-3850
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis.

S. J. Sohn, K. A. Forbush, N. Nguyen, B. Witthuhn, T. Nosaka, J. N. Ihle, and R. M. Perlmutter (1998)
J. Immunol. 160, 2130-2138
 |  Abstract »  |  Full Text »  |  PDF »

Costimulation through CD28 Suppresses T Cell Receptor-dependent Activation of the Ras-like Small GTPase Rap1 in Human T Lymphocytes.

K. A. Reedquist and J. L. Bos (1998)
J. Biol. Chem. 273, 4944-4949
 |  Abstract »  |  Full Text »  |  PDF »

Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient With Autosomal Recessive Severe Combined Immunodeficiency Caused by Defects of the Jak3 Tyrosine Kinase.

D. Brugnoni, L. D. Notarangelo, A. Sottini, P. Airo, M. Pennacchio, E. Mazzolari, S. Signorini, F. Candotti, A. Villa, P. Mella, et al. (1998)
Blood 91, 949-955
 |  Abstract »  |  Full Text »  |  PDF »

Persistence of Peptide-induced CD4+ T cell Anergy In Vitro.

K. R. Ryan and B. D. Evavold (1998)
J. Exp. Med. 187, 89-96
 |  Abstract »  |  Full Text »  |  PDF »

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.

Y.-J. Zhou, E. P. Hanson, Y.-Q. Chen, K. Magnuson, M. Chen, P. G. Swann, R. L. Wange, P. S. Changelian, and J. J. O'Shea (1997)
PNAS 94, 13850-13855
 |  Abstract »  |  Full Text »  |  PDF »

Functional cleavage of the common cytokine receptor gamma  chain (gamma c) by calpain.

M. Noguchi, A. Sarin, M. J. Aman, H. Nakajima, E. W. Shores, P. A. Henkart, and W. J. Leonard (1997)
PNAS 94, 11534-11539
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1.

V. A. Boussiotis, G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler (1997)
Science 278, 124-128
 |  Abstract »  |  Full Text »

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma c chain for Janus kinase activation leading to T cell proliferation.

B. H. Nelson, B. C. McIntosh, L. L. Rosencrans, and P. D. Greenberg (1997)
PNAS 94, 1878-1883
 |  Abstract »  |  Full Text »  |  PDF »

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function.

D. C. Thomis and L. J. Berg (1997)
J. Exp. Med. 185, 197-206
 |  Abstract »  |  Full Text »  |  PDF »

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells.

K. Saijo, S. Y. Park, Y. Ishida, H. Arase, and T. Saito (1997)
J. Exp. Med. 185, 351-356
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of Human Stat5B.

J.-X. Lin, J. Mietz, W. S. Modi, S. John, and W. J. Leonard (1996)
J. Biol. Chem. 271, 10738-10744
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of the Human Interleukin-15 Receptor alpha Chain and Close Linkage of IL15RA and IL2RA Genes.

D. M. Anderson, S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. (1995)
J. Biol. Chem. 270, 29862-29869
 |  Abstract »  |  Full Text »  |  PDF »

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3.

D. C. Thomis, C. B. Gurniak, E. Tivol, A. H. Sharpe, and L. J. Berg (1995)
Science 270, 794-797
 |  Abstract »  |  PDF »

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development.

S. M. Russell, N. Tayebi, H. Nakajima, M. C. Riedy, J. L. Roberts, M. J. Aman, T.-S. Migone, M. Noguchi, M. L. Markert, R. H. Buckley, et al. (1995)
Science 270, 797-800
 |  Abstract »  |  PDF »

Identification of a Variable Region within the Cytoplasmic Tail of the IL-2 Receptor beta Chain That Is Required for Growth Signal Transduction.

K. D. Liu, S. Y. Lai, M. A. Goldsmith, and W. C. Greene (1995)
J. Biol. Chem. 270, 22176-22181
 |  Abstract »  |  Full Text »  |  PDF »

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

T. Migone, J. Lin, A Cereseto, J. Mulloy, J. O'Shea, G Franchini, and W. Leonard (1995)
Science 269, 79-81
 |  Abstract »  |  PDF »

Species-specific Agonist/Antagonist Activities of Human Interleukin-4 Variants Suggest Distinct Ligand Binding Properties of Human and Murine Common Receptor [IMAGE] Chain.

D. Bönsch, W. Kammer, A. Lischke, and K. Friedrich (1995)
J. Biol. Chem. 270, 8452-8457
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-activated Protein Kinase Plays an Essential Role in the Erythropoietin-dependent Proliferation of CTLL-2 Cells.

H. Sakamoto, T. Kitamura, and A. Yoshimura (2000)
J. Biol. Chem. 275, 35857-35862
 |  Abstract »  |  Full Text »  |  PDF »

Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.

S. Tsujino, J. P. Di Santo, A. Takaoka, T. L. McKernan, S. Noguchi, C. Taya, H. Yonekawa, T. Saito, T. Taniguchi, and H. Fujii (2000)
PNAS 97, 10514-10519
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products