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Science 11 November 1994:
Vol. 266. no. 5187, pp. 1039 - 1042
DOI: 10.1126/science.7973657
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Articles

Science, Vol 266, Issue 5187, 1039-1042
Copyright © 1994 by American Association for the Advancement of Science

articles

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

VA Boussiotis, DL Barber, T Nakarai, GJ Freeman, JG Gribben, GM Bernstein, AD D'Andrea, J Ritz, and LM Nadler

Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA 02115.

When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.


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Mitogen-activated Protein Kinase Plays an Essential Role in the Erythropoietin-dependent Proliferation of CTLL-2 Cells.
H. Sakamoto, T. Kitamura, and A. Yoshimura (2000)
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Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
S. Tsujino, J. P. Di Santo, A. Takaoka, T. L. McKernan, S. Noguchi, C. Taya, H. Yonekawa, T. Saito, T. Taniguchi, and H. Fujii (2000)
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