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Science 4 November 1994:
Vol. 266. no. 5186, pp. 819 - 822
DOI: 10.1126/science.7973639

Articles

Science, Vol 266, Issue 5186, 819-822
Copyright © 1994 by American Association for the Advancement of Science


articles

The function of KGF in morphogenesis of epithelium and reepithelialization of wounds

S Werner, H Smola, X Liao, MT Longaker, T Krieg, PH Hofschneider, and LT Williams

Cardiovascular Research Institute, University of California at San Francisco (UCSF) 94143-0130.

The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.


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Development 129, 2303-2315
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The Effects of Repeated Doses of Keratinocyte Growth Factor on Cell Proliferation in the Cellular Hierarchy of the Crypts of the Murine Small Intestine.
C. S. Potten, J. A. O'Shea, C. L. Farrell, K. Rex, and C. Booth (2001)
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Mrp3, a Mitogen-Regulated Protein/Proliferin Gene Expressed in Wound Healing and in Hair Follicles.
J. T. Fassett and M. Nilsen-Hamilton (2001)
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Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system.
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A. Capone, V. Visco, F. Belleudi, C. Marchese, G. Cardinali, M. Bellocci, M. Picardo, L. Frati, and M. R. Torrisi (2000)
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Role of Hormones in Pilosebaceous Unit Development.
D. Deplewski and R. L. Rosenfield (2000)
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L De Moerlooze, B Spencer-Dene, J Revest, M Hajihosseini, I Rosewell, and C Dickson (2000)
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Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy.
Y. Wang, H. G. Folkesson, C. Jayr, L. B. Ware, and M. A. Matthay (1999)
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Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair.
S. FRANK, B. STALLMEYER, H. KÄMPFER, N. KOLB, and J. PFEILSCHIFTER (1999)
FASEB J 13, 2002-2014
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Cutaneous Wound Healing.
A. J. Singer and R. A.F. Clark (1999)
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Isolation of Mouse Stromal Cells Associated with a Human Tumor Using Differential Diphtheria Toxin Sensitivity.
J. L. Arbiser, G. Raab, R. M. Rohan, S. Paul, K. Hirschi, E. Flynn, E. R. Price, D. E. Fisher, C. Cohen, and M. Klagsbrun (1999)
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The Biology of Hair Follicles.
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Vascular endothelial growth factor (VEGF) and its receptors.
G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak (1999)
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Preclinical and Early Clinical Development of Keratinocyte Growth Factor, an Epithelial- Specific Tissue Growth Factor.
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Hyperoxia increases keratinocyte growth factor mRNA expression in neonatal rabbit lung.
L. Charafeddine, C. T. D'Angio, J. L. Richards, B. R. Stripp, J. N. Finkelstein, C. C. Orlowski, M. B. LoMonaco, A. Paxhia, and R. M. Ryan (1999)
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G. M. VERGHESE, K. MCCORMICK-SHANNON, R. J. MASON, and M. A. MATTHAY (1998)
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Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
P. Jaakkola, S. Kontusaari, T. Kauppi, A. Määttä, and M. Jalkanen (1998)
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Modulation of T1alpha expression with alveolar epithelial cell phenotype in vitro.
Z. Borok, S. I. Danto, R. L. Lubman, Y. Cao, M. C. Williams, and E. D. Crandall (1998)
Am J Physiol Lung Cell Mol Physiol 275, L155-L164
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Keratinocyte Growth Factor Expression by the Bovine Corpus Luteum.
U. Salli, F.F. Bartol, A.A. Wiley, B.J. Tarleton, and T.D. Braden (1998)
Biol Reprod 59, 77-83
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Characterization of Recombinant Human Fibroblast Growth Factor (FGF)-10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7).
M. Igarashi, P. W. Finch, and S. A. Aaronson (1998)
J. Biol. Chem. 273, 13230-13235
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Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development.
E. Arman, R. Haffner-Krausz, Y. Chen, J. K. Heath, and P. Lonai (1998)
PNAS 95, 5082-5087
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Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5 .
Z. Borok, R. L. Lubman, S. I. Danto, X.-L. Zhang, S. M. Zabski, L. S. King, D. M. Lee, P. Agre, and E. D. Crandall (1998)
Am. J. Respir. Cell Mol. Biol. 18, 554-561
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A Rho-associated Protein Kinase, ROKalpha , Binds Insulin Receptor Substrate-1 and Modulates Insulin Signaling.
S. Farah, Y. Agazie, N. Ohan, J. K. Ngsee, and X. J. Liu (1998)
J. Biol. Chem. 273, 4740-4746
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Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice.
F. Lovicu and P. Overbeek (1998)
Development 125, 3365-3377
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Structure and Expression of Human Fibroblast Growth Factor-10.
H. Emoto, S. Tagashira, M.-G. Mattei, M. Yamasaki, G. Hashimoto, T. Katsumata, T. Negoro, M. Nakatsuka, D. Birnbaum, F. Coulier, et al. (1997)
J. Biol. Chem. 272, 23191-23194
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Cell Type-specific Inhibition of Keratinocyte Collagenase-1 Expression by Basic Fibroblast Growth Factor and Keratinocyte Growth Factor. A COMMON RECEPTOR PATHWAY.
B. K. Pilcher, J. Gaither-Ganim, W. C. Parks, and H. G. Welgus (1997)
J. Biol. Chem. 272, 18147-18154
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Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.
D Jackson, J Bresnick, I Rosewell, T Crafton, R Poulsom, G Stamp, and C Dickson (1997)
J. Cell Sci. 110, 1261-1268
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The Human Homologue of the Yeast CHL1 Gene Is a Novel Keratinocyte Growth Factor-regulated Gene.
S. Frank and S. Werner (1996)
J. Biol. Chem. 271, 24337-24340
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Expression of Keratinocyte Growth Factor in Periapical Lesions.
Z. Gao, C.M. Flaitz, and I.C. Mackenzie (1996)
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Keratinocyte Growth Factor Induces Granulation Tissue in Ischemic Dermal Wounds: Importance of Epithelial-Mesenchymal Cell Interactions.
L. Wu, G. F. Pierce, R. D. Galiano, and T. A. Mustoe (1996)
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Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes.
M. D. Hines and B. L. Allen-Hoffmann (1996)
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Impaired Insulin Signaling in Skeletal Muscles from Transgenic Mice Expressing Kinase-deficient Insulin Receptors.
P.-Y. Chang, L. J. Goodyear, H. Benecke, J. S. Markuns, and D. E. Moller (1995)
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