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Science 28 October 1994:
Vol. 266. no. 5185, pp. 596 - 604
DOI: 10.1126/science.7939714
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Articles

Science, Vol 266, Issue 5185, 596-604
Copyright © 1994 by American Association for the Advancement of Science

articles

Vertebrate embryonic induction: mesodermal and neural patterning

DS Kessler and DA Melton

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138.

Within the fertilized egg lies the information necessary to generate a diversity of cell types in the precise pattern of tissues and organs that comprises the vertebrate body. Seminal embryological experiments established the importance of induction, or cell interactions, in the formation of embryonic tissues and provided a foundation for molecular studies. In recent years, secreted gene products capable of inducing or patterning embryonic tissues have been identified. Despite these advances, embryologists remain challenged by fundamental questions: What are the endogenous inducing molecules? How is the action of an inducer spatially and temporally restricted? How does a limited group of inducers give rise to diversity of tissues? In this review, the focus is on the induction and patterning of mesodermal and neural tissues in the frog Xenopus laevis, with an emphasis on families of secreted molecules that appear to underlie inductive events throughout vertebrate embryogenesis.


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A functional homologue of goosecoid in Drosophila.
A Goriely, M Stella, C Coffinier, D Kessler, C Mailhos, S Dessain, and C Desplan (1996)
Development 122, 1641-1650
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Polyembryonic development: insect pattern formation in a cellularized environment.
M Grbic, L. Nagy, S. Carroll, and M Strand (1996)
Development 122, 795-804
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TGF-beta signals and a pattern in Xenopus laevis endodermal development.
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Development 122, 1007-1015
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Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning.
J Schmidt, V Francois, E Bier, and D Kimelman (1995)
Development 121, 4319-4328
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D. Stainier, B. Weinstein, H. Detrich, L. Zon, and M. Fishman (1995)
Development 121, 3141-3150
   Abstract »    PDF »
Distribution of tissue progenitors within the shield region of the zebrafish gastrula.
J Shih and S. Fraser (1995)
Development 121, 2755-2765
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FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction.
R. Cornell, T. Musci, and D Kimelman (1995)
Development 121, 2429-2437
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Order and coherence in the fate map of the zebrafish nervous system.
K Woo and S. Fraser (1995)
Development 121, 2595-2609
   Abstract »    PDF »
Induction of dorsal mesoderm by soluble, mature Vg1 protein.
D. Kessler and D. Melton (1995)
Development 121, 2155-2164
   Abstract »    PDF »
Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut.
M. Pankratz and M Hoch (1995)
Development 121, 1885-1898
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Abl Family Kinases and Cbl Cooperate with the Nck Adaptor to Modulate Xenopus Development.
C. E. Adler, T. Miyoshi-Akiyama, L. M. Aleman, M. Tanaka, J. M. Smith, and B. J. Mayer (2000)
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   Abstract »    Full Text »    PDF »


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