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Science 28 October 1994:
Vol. 266. no. 5185, pp. 590 - 596
DOI: 10.1126/science.7939713
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Articles

Science, Vol 266, Issue 5185, 590-596
Copyright © 1994 by American Association for the Advancement of Science

articles

Cytoskeletal functions during Drosophila oogenesis

L Cooley and WE Theurkauf

Department of Genetics, Yale University School of Medicine, New Haven, CT 06510.

Organismal morphogenesis is driven by a complex series of developmentally coordinated changes in cell shape, size, and number. These changes in cell morphology are in turn dependent on alterations in basic cytoarchitecture. Elucidating the mechanisms of development thus requires an understanding of the cytoskeletal elements that organize the cytoplasm of differentiating cells. Drosophila oogenesis has emerged as a versatile system for the study of cytoskeletal function during development. A series of highly coordinated changes in cytoskeletal organization are required to produce a mature Drosophila oocyte, and these cytoskeletal transformations are amenable to a variety of experimental approaches. Genetic, molecular, and cytological studies have shed light on the specific functions of the cytoskeleton during oogenesis. The results of these studies are reviewed here, and their mechanistic implications are considered.


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