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Science 21 October 1994:
Vol. 266. no. 5184, pp. 448 - 450
DOI: 10.1126/science.7939686
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Articles

Science, Vol 266, Issue 5184, 448-450
Copyright © 1994 by American Association for the Advancement of Science

articles

Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1

RJ White, BC Khoo, JA Inostroza, D Reinberg, and SP Jackson

Wellcome/CRC Institute, University of Cambridge, UK.

RNA polymerases I, II, and III each use the TATA-binding protein (TBP). Regulators that target this shared factor may therefore provide a means to coordinate the activities of the three nuclear RNA polymerases. The repressor Dr1 binds to TBP and blocks the interaction of TBP with polymerase II- and polymerase III-specific factors. This enables Dr1 to coordinately regulate transcription by RNA polymerases II and III. Under the same conditions, Dr1 does not inhibit polymerase I transcription. By selectively repressing polymerases II and III, Dr1 may shift the physiological balance of transcriptional output in favor of polymerase I.


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