Science 21 October 1994: Vol. 266. no. 5184, pp. 443 - 448 DOI: 10.1126/science.7939685

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Articles

Epigallocatechin-3-gallate Inhibits Osteoclastogenesis by Down-Regulating c-Fos Expression and Suppressing the Nuclear Factor-{kappa}B Signal.

J.-H. Lee, H. Jin, H.-E. Shim, H.-N. Kim, H. Ha, and Z. H. Lee (2010)
Mol. Pharmacol. 77, 17-25
 |  Abstract »  |  Full Text »  |  PDF »

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis.

N. Irie, Y. Takada, Y. Watanabe, Y. Matsuzaki, C. Naruse, M. Asano, Y. Iwakura, T. Suda, and K. Matsuo (2009)
J. Biol. Chem. 284, 14637-14644
 |  Abstract »  |  Full Text »  |  PDF »

Trolox Prevents Osteoclastogenesis by Suppressing RANKL Expression and Signaling.

J.-H. Lee, H.-N. Kim, D. Yang, K. Jung, H.-M. Kim, H.-H. Kim, H. Ha, and Z. H. Lee (2009)
J. Biol. Chem. 284, 13725-13734
 |  Abstract »  |  Full Text »  |  PDF »

PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.

T. Hikata, H. Takaishi, J. Takito, A. Hakozaki, M. Furukawa, S. Uchikawa, T. Kimura, Y. Okada, M. Matsumoto, A. Yoshimura, et al. (2009)
Blood 113, 2202-2212
 |  Abstract »  |  Full Text »  |  PDF »

Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.

T. Mizoguchi, A. Muto, N. Udagawa, A. Arai, T. Yamashita, A. Hosoya, T. Ninomiya, H. Nakamura, Y. Yamamoto, S. Kinugawa, et al. (2009)
J. Cell Biol. 184, 541-554
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function.

T. Sugatani and K. A. Hruska (2009)
J. Biol. Chem. 284, 4667-4678
 |  Abstract »  |  Full Text »  |  PDF »

IL-3 Inhibits TNF-{alpha}-Induced Bone Resorption and Prevents Inflammatory Arthritis.

S. D. Yogesha, S. M. Khapli, R. K. Srivastava, L. S. Mangashetti, S. T. Pote, G. C. Mishra, and M. R. Wani (2009)
J. Immunol. 182, 361-370
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{gamma}2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis.

Y. Chen, X. Wang, L. Di, G. Fu, Y. Chen, L. Bai, J. Liu, X. Feng, J. M. McDonald, S. Michalek, et al. (2008)
J. Biol. Chem. 283, 29593-29601
 |  Abstract »  |  Full Text »  |  PDF »

The Association of Notch2 and NF-{kappa}B Accelerates RANKL-Induced Osteoclastogenesis.

H. Fukushima, A. Nakao, F. Okamoto, M. Shin, H. Kajiya, S. Sakano, A. Bigas, E. Jimi, and K. Okabe (2008)
Mol. Cell. Biol. 28, 6402-6412
 |  Abstract »  |  Full Text »  |  PDF »

The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells.

M. L. Gavala, Z. A. Pfeiffer, and P. J. Bertics (2008)
J. Leukoc. Biol. 84, 1159-1171
 |  Abstract »  |  Full Text »  |  PDF »

The JNK-dependent CaMK pathway restrains the reversion of committed cells during osteoclast differentiation.

E.-J. Chang, J. Ha, H. Huang, H. J. Kim, J. H. Woo, Y. Lee, Z. H. Lee, J. H. Kim, and H.-H. Kim (2008)
J. Cell Sci. 121, 2555-2564
 |  Abstract »  |  Full Text »  |  PDF »

A New PPAR-{gamma} Function in Bone.

I. Takada and S. Kato (2008)
IBMS BoneKEy 5, 258-261
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Mechanisms of Tooth Eruption and Orthodontic Tooth Movement.

G.E. Wise and G.J. King (2008)
Journal of Dental Research 87, 414-434
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Activator of Nuclear Factor-{kappa}B Ligand-Induced Nuclear Factor of Activated T Cells (C1) Autoregulates Its Own Expression in Osteoclasts and Mediates the Up-Regulation of Tartrate-Resistant Acid Phosphatase.

J. A. Fretz, N. K. Shevde, S. Singh, B. G. Darnay, and J. W. Pike (2008)
Mol. Endocrinol. 22, 737-750
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation by TLR5 Modulates Osteoclast Differentiation through STAT1/IFN-{beta}.

H. Ha, J.-H. Lee, H.-N. Kim, H. B. Kwak, H.-M. Kim, S. E. Lee, J. H. Rhee, H.-H. Kim, and Z. H. Lee (2008)
J. Immunol. 180, 1382-1389
 |  Abstract »  |  Full Text »  |  PDF »

The Matricellular Protein CYR61 Inhibits Osteoclastogenesis by a Mechanism Independent of {alpha}v{beta}3 and {alpha}v{beta}5.

J. C. Crockett, N. Schutze, D. Tosh, S. Jatzke, A. Duthie, F. Jakob, and M. J. Rogers (2007)
Endocrinology 148, 5761-5768
 |  Abstract »  |  Full Text »  |  PDF »

MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.

S. Vallet, N. Raje, K. Ishitsuka, T. Hideshima, K. Podar, S. Chhetri, S. Pozzi, I. Breitkreutz, T. Kiziltepe, H. Yasui, et al. (2007)
Blood 110, 3744-3752
 |  Abstract »  |  Full Text »  |  PDF »

Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation.

S. Yang, W. Chen, P. Stashenko, and Y.-P. Li (2007)
J. Cell Sci. 120, 3362-3371
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B p50 and p52 Regulate Receptor Activator of NF-{kappa}B Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1.

T. Yamashita, Z. Yao, F. Li, Q. Zhang, I. R. Badell, E. M. Schwarz, S. Takeshita, E. F. Wagner, M. Noda, K. Matsuo, et al. (2007)
J. Biol. Chem. 282, 18245-18253
 |  Abstract »  |  Full Text »  |  PDF »

Update on the Transcriptional Control of Osteoblast Differentiation.

G. Karsenty (2007)
IBMS BoneKEy 4, 164-170
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Schnurri-2 Expression Associates with Reduced Bone Remodeling and Osteopenia.

Y. Saita, T. Takagi, K. Kitahara, M. Usui, K. Miyazono, Y. Ezura, K. Nakashima, H. Kurosawa, S. Ishii, and M. Noda (2007)
J. Biol. Chem. 282, 12907-12915
 |  Abstract »  |  Full Text »  |  PDF »

c-Fos-Deficient Mice Are Susceptible to Salmonella enterica Serovar Typhimurium Infection.

K. Maruyama, G.-i. Sano, N. Ray, Y. Takada, and K. Matsuo (2007)
Infect. Immun. 75, 1520-1523
 |  Abstract »  |  Full Text »  |  PDF »

Osteoclasts: What Do They Do and How Do They Do It?.

S. L. Teitelbaum (2007)
Am. J. Pathol. 170, 427-435
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of the Precursors Committed to Osteoclasts Induced by TNF-Related Activation-Induced Cytokine/Receptor Activator of NF-{kappa}B Ligand.

A. Mochizuki, M. Takami, T. Kawawa, R. Suzumoto, T. Sasaki, A. Shiba, H. Tsukasaki, B. Zhao, R. Yasuhara, T. Suzawa, et al. (2006)
J. Immunol. 177, 4360-4368
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Activator of NF-{kappa}B Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice.

K. Maruyama, Y. Takada, N. Ray, Y. Kishimoto, J. M. Penninger, H. Yasuda, and K. Matsuo (2006)
J. Immunol. 177, 3799-3805
 |  Abstract »  |  Full Text »  |  PDF »

Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling.

M. M. Rahman, A. Bhattacharya, and G. Fernandes (2006)
J. Lipid Res. 47, 1739-1748
 |  Abstract »  |  Full Text »  |  PDF »

Bone Remodeling in Post-menopausal Osteoporosis.

U.H. Lerner (2006)
Journal of Dental Research 85, 584-595
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone Destruction.

G. Mbalaviele, G. Anderson, A. Jones, P. De Ciechi, S. Settle, S. Mnich, M. Thiede, Y. Abu-Amer, J. Portanova, and J. Monahan (2006)
J. Pharmacol. Exp. Ther. 317, 1044-1053
 |  Abstract »  |  Full Text »  |  PDF »

Current, New and Emerging Anti-Resorptive Drugs; Antibody Blockade Of RANKL Action.

T. J. Martin (2006)
IBMS BoneKEy 3, 42-46
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c-Fos suppresses systemic inflammatory response to endotoxin.

N. Ray, M. Kuwahara, Y. Takada, K. Maruyama, T. Kawaguchi, H. Tsubone, H. Ishikawa, and K. Matsuo (2006)
Int. Immunol. 18, 671-677
 |  Abstract »  |  Full Text »  |  PDF »

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1.

G. Anderson, M. Gries, N. Kurihara, T. Honjo, J. Anderson, V. Donnenberg, A. Donnenberg, I. Ghobrial, M. Y. Mapara, D. Stirling, et al. (2006)
Blood 107, 3098-3105
 |  Abstract »  |  Full Text »  |  PDF »

Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-Induced Osteoclast Differentiation..

H. Yoshida, K. Okamoto, T. Iwamoto, E. Sakai, K. Kanaoka, J.-P. Hu, M. Shibata, H. Hotokezaka, K. Nishishita, A. Mizuno, et al. (2006)
J. Biochem. 139, 583-590
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Receptor Activator of NF-{kappa}B (RANK) Cytoplasmic Motif Plays an Essential Role in Osteoclastogenesis by Committing Macrophages to the Osteoclast Lineage.

D. Xu, S. Wang, W. Liu, J. Liu, and X. Feng (2006)
J. Biol. Chem. 281, 4678-4690
 |  Abstract »  |  Full Text »  |  PDF »

A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C.

C. Ivorra, M. Kubicek, J. M. Gonzalez, S. M. Sanz-Gonzalez, A. Alvarez-Barrientos, J.-E. O'Connor, B. Burke, and V. Andres (2006)
Genes & Dev. 20, 307-320
 |  Abstract »  |  Full Text »  |  PDF »

The intracellular domain of CD44 promotes the fusion of macrophages.

W. Cui, J. Z. Ke, Q. Zhang, H.-Z. Ke, C. Chalouni, and A. Vignery (2006)
Blood 107, 796-805
 |  Abstract »  |  Full Text »  |  PDF »

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

M. Asagiri, K. Sato, T. Usami, S. Ochi, H. Nishina, H. Yoshida, I. Morita, E. F. Wagner, T. W. Mak, E. Serfling, et al. (2005)
J. Exp. Med. 202, 1261-1269
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Histone Deacetylase Suppresses Osteoclastogenesis and Bone Destruction by Inducing IFN-{beta} Production.

T. Nakamura, T. Kukita, T. Shobuike, K. Nagata, Z. Wu, K. Ogawa, T. Hotokebuchi, O. Kohashi, and A. Kukita (2005)
J. Immunol. 175, 5809-5816
 |  Abstract »  |  Full Text »  |  PDF »

Cells of the Osteoclast Lineage as Mediators of the Anabolic Actions of Parathyroid Hormone in Bone.

A. J. Koh, B. Demiralp, K. G. Neiva, J. Hooten, R. M. Nohutcu, H. Shim, N. S. Datta, R. S. Taichman, and L. K. McCauley (2005)
Endocrinology 146, 4584-4596
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun/Activator Protein-1 Mediates Interleukin-1{beta}-induced Dedifferentiation but Not Cyclooxygenase-2 Expression in Articular Chondrocytes.

S.-G. Hwang, S.-S. Yu, H. Poo, and J.-S. Chun (2005)
J. Biol. Chem. 280, 29780-29787
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional induction of cyclooxygenase-2 in osteoclast precursors is involved in RANKL-induced osteoclastogenesis.

S. Y. Han, N. K. Lee, K. H. Kim, I. W. Jang, M. Yim, J. H. Kim, W. J. Lee, and S. Y. Lee (2005)
Blood 106, 1240-1245
 |  Abstract »  |  Full Text »  |  PDF »

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells.

M. Yagi, T. Miyamoto, Y. Sawatani, K. Iwamoto, N. Hosogane, N. Fujita, K. Morita, K. Ninomiya, T. Suzuki, K. Miyamoto, et al. (2005)
J. Exp. Med. 202, 345-351
 |  Abstract »  |  Full Text »  |  PDF »

I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.

M. G. Ruocco, S. Maeda, J. M. Park, T. Lawrence, L.-C. Hsu, Y. Cao, G. Schett, E. F. Wagner, and M. Karin (2005)
J. Exp. Med. 201, 1677-1687
 |  Abstract »  |  Full Text »  |  PDF »

Calmodulin and Calmodulin-dependent Kinase II{alpha} Regulate Osteoblast Differentiation by Controlling c-fos Expression.

M. Zayzafoon, K. Fulzele, and J. M. McDonald (2005)
J. Biol. Chem. 280, 7049-7059
 |  Abstract »  |  Full Text »  |  PDF »

Osteopetrosis.

J. Tolar, S. L. Teitelbaum, and P. J. Orchard (2004)
N. Engl. J. Med. 351, 2839-2849
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Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of {kappa}B Kinase {alpha}.

M. L. Chaisson, D. G. Branstetter, J. M. Derry, A. P. Armstrong, M. E. Tometsko, K. Takeda, S. Akira, and W. C. Dougall (2004)
J. Biol. Chem. 279, 54841-54848
 |  Abstract »  |  Full Text »  |  PDF »

The AP1 transcription factor Fra2 is required for efficient cartilage development.

F. Karreth, A. Hoebertz, H. Scheuch, R. Eferl, and E. F. Wagner (2004)
Development 131, 5717-5725
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of Dentin Matrix Protein 1 by JunB and p300 during Osteoblast Differentiation.

K. Narayanan, R. Srinivas, M. C. Peterson, A. Ramachandran, J. Hao, B. Thimmapaya, P. E. Scherer, and A. George (2004)
J. Biol. Chem. 279, 44294-44302
 |  Abstract »  |  Full Text »  |  PDF »

c-Fos as a Regulator of Degranulation and Cytokine Production in Fc{epsilon}RI-Activated Mast Cells.

Y.-N. Lee, J. Tuckerman, H. Nechushtan, G. Schutz, E. Razin, and P. Angel (2004)
J. Immunol. 173, 2571-2577
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos.

K. Matsuo, D. L. Galson, C. Zhao, L. Peng, C. Laplace, K. Z. Q. Wang, M. A. Bachler, H. Amano, H. Aburatani, H. Ishikawa, et al. (2004)
J. Biol. Chem. 279, 26475-26480
 |  Abstract »  |  Full Text »  |  PDF »

The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells.

H. Hirotani, N. A. Tuohy, J.-T. Woo, P. H. Stern, and N. A. Clipstone (2004)
J. Biol. Chem. 279, 13984-13992
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Cell Cycle Progression in Osteoblasts Overexpressing the c-fos Proto-oncogene: INDUCTION OF CYCLIN A AND ENHANCED CDK2 ACTIVITY.

A. Sunters, D. P. Thomas, W. A. Yeudall, and A. E. Grigoriadis (2004)
J. Biol. Chem. 279, 9882-9891
 |  Abstract »  |  Full Text »  |  PDF »

NEW MOLECULES IN THE TUMOR NECROSIS FACTOR LIGAND AND RECEPTOR SUPERFAMILIES WITH IMPORTANCE FOR PHYSIOLOGICAL AND PATHOLOGICAL BONE RESORPTION.

U. H. Lerner (2004)
Critical Reviews in Oral Biology & Medicine 15, 64-81
 |  Abstract »  |  Full Text »  |  PDF »

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects.

L. Kenner, A. Hoebertz, T. Beil, N. Keon, F. Karreth, R. Eferl, H. Scheuch, A. Szremska, M. Amling, M. Schorpp-Kistner, et al. (2004)
J. Cell Biol. 164, 613-623
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone-Smad3 Axis Exerts Anti-apoptotic Action and Augments Anabolic Action of Transforming Growth Factor {beta} in Osteoblasts.

H. Sowa, H. Kaji, M. F. Iu, T. Tsukamoto, T. Sugimoto, and K. Chihara (2003)
J. Biol. Chem. 278, 52240-52252
 |  Abstract »  |  Full Text »  |  PDF »

Defective endochondral ossification in mice with strongly compromised expression of JunB.

J. Hess, B. Hartenstein, S. Teurich, D. Schmidt, M. Schorpp-Kistner, and P. Angel (2003)
J. Cell Sci. 116, 4587-4596
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Osteoclast Precursors in the Bone Marrow and Extramedullary Organs Characterized by Responsiveness to Toll-Like Receptor Ligands and TNF-{alpha}.

S.-I. Hayashi, T. Yamada, M. Tsuneto, T. Yamane, M. Takahashi, L. D. Shultz, and H. Yamazaki (2003)
J. Immunol. 171, 5130-5139
 |  Abstract »  |  Full Text »  |  PDF »

Signalling in osteoclasts and the role of Fos/AP1 proteins.

E F Wagner and K Matsuo (2003)
Ann Rheum Dis 62, ii83-85
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Transcriptional regulation by calcium, calcineurin, and NFAT.

P. G. Hogan, L. Chen, J. Nardone, and A. Rao (2003)
Genes & Dev. 17, 2205-2232
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IL-3 Acts Directly on Osteoclast Precursors and Irreversibly Inhibits Receptor Activator of NF-{kappa}B Ligand-Induced Osteoclast Differentiation by Diverting the Cells to Macrophage Lineage.

S. M. Khapli, L. S. Mangashetti, S. D. Yogesha, and M. R. Wani (2003)
J. Immunol. 171, 142-151
 |  Abstract »  |  Full Text »  |  PDF »

Cysteine 64 of Ref-1 Is Not Essential for Redox Regulation of AP-1 DNA Binding.

J. M. Ordway, D. Eberhart, and T. Curran (2003)
Mol. Cell. Biol. 23, 4257-4266
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Upstream Stimulatory Factors 1 and 2 in RANKL-induced Transcription of Tartrate-resistant Acid Phosphatase Gene during Osteoclast Differentiation.

Y. Liu, Z. Shi, A. Silveira, J. Liu, M. Sawadogo, H. Yang, and X. Feng (2003)
J. Biol. Chem. 278, 20603-20611
 |  Abstract »  |  Full Text »  |  PDF »

A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function.

A. P. Armstrong, M. E. Tometsko, M. Glaccum, C. L. Sutherland, D. Cosman, and W. C. Dougall (2002)
J. Biol. Chem. 277, 44347-44356
 |  Abstract »  |  Full Text »  |  PDF »

Functions of AP1 (Fos/Jun) in bone development.

E F Wagner (2002)
Ann Rheum Dis 61, ii40-42
 |  Abstract »  |  Full Text »  |  PDF »

Large Scale Gene Expression Analysis of Osteoclastogenesis in Vitro and Elucidation of NFAT2 as a Key Regulator.

N. Ishida, K. Hayashi, M. Hoshijima, T. Ogawa, S. Koga, Y. Miyatake, M. Kumegawa, T. Kimura, and T. Takeya (2002)
J. Biol. Chem. 277, 41147-41156
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profiling of Ameloblastoma and Human Tooth Germ by Means of a cDNA Microarray.

K. Heikinheimo, K.J. Jee, T. Niini, Y. Aalto, R.-P. Happonen, I. Leivo, and S. Knuutila (2002)
Journal of Dental Research 81, 525-530
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK-Mediated Signals Are Required for Inducing Osteoclast Differentiation But Not for Osteoclast Function.

X. Li, N. Udagawa, K. Itoh, K. Suda, Y. Murase, T. Nishihara, T. Suda, and N. Takahashi (2002)
Endocrinology 143, 3105-3113
 |  Abstract »  |  Full Text »  |  PDF »

CELLULAR, MOLECULAR, AND GENETIC DETERMINANTS OF TOOTH ERUPTION.

G.E. Wise, S. Frazier-Bowers, and R.N. D'Souza (2002)
Critical Reviews in Oral Biology & Medicine 13, 323-335
 |  Abstract »  |  Full Text »  |  PDF »

Composition and Function of AP-1 Transcription Complexes during Muscle Cell Differentiation.

J. J. Andreucci, D. Grant, D. M. Cox, L. K. Tomc, R. Prywes, D. J. Goldhamer, N. Rodrigues, P.-A. Bedard, and J. C. McDermott (2002)
J. Biol. Chem. 277, 16426-16432
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-kappa B and Mitogen-activated Protein Kinase Signaling.

S. Wei, M. W.-H. Wang, S. L. Teitelbaum, and F. P. Ross (2002)
J. Biol. Chem. 277, 6622-6630
 |  Abstract »  |  Full Text »  |  PDF »

Brain and Bone: Central Regulation of Bone Mass : A New Paradigm in Skeletal Biology.

M. Haberland, A. F. Schilling, J. M. Rueger, and M. Amling (2001)
J. Bone Joint Surg. Am. 83, 1871-1876
 |  Full Text »  |  PDF »

Bifurcation of osteoclasts and dendritic cells from common progenitors.

T. Miyamoto, O. Ohneda, F. Arai, K. Iwamoto, S. Okada, K. Takagi, D. M. Anderson, and T. Suda (2001)
Blood 98, 2544-2554
 |  Abstract »  |  Full Text »  |  PDF »

When developmental biology meets human pathology.

G. Karsenty (2001)
PNAS 98, 5385-5386
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Parathyroid Hormone Stimulates fra-2 Expression in Osteoblastic Cells in Vitro and in Vivo.

L. K. Mccauley, A. J. Koh-Paige, H. Chen, C. Chen, C. Ontiveros, R. Irwin, and L. R. Mccabe (2001)
Endocrinology 142, 1975-1981
 |  Abstract »  |  Full Text »

Receptor Activator of Nuclear Factor-{{kappa}}B Ligand Activates Nuclear Factor-{{kappa}}B in Osteoclast Precursors.

S. Wei, S. L. Teitelbaum, M. W.-H. Wang, and F. P. Ross (2001)
Endocrinology 142, 1290-1295
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Responses to Mechanical Stress: Selected Contribution: Regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells.

M. A. Peake, L. M. Cooling, J. L. Magnay, P. B. M. Thomas, and A. J. El Haj (2000)
J Appl Physiol 89, 2498-2507
 |  Abstract »  |  Full Text »  |  PDF »

Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones.

M. T. Engsig, Q.-J. Chen, T. H. Vu, A.-C. Pedersen, B. Therkidsen, L. R. Lund, K. Henriksen, T. Lenhard, N. T. Foged, Z. Werb, et al. (2000)
J. Cell Biol. 151, 879-890
 |  Abstract »  |  Full Text »  |  PDF »

Fra-1 replaces c-Fos-dependent functions in mice.

A. Fleischmann, F. Hafezi, C. Elliott, C. E. Remé, U. Rüther, and E. F. Wagner (2000)
Genes & Dev. 14, 2695-2700
 |  Abstract »  |  Full Text »

Bone Resorption by Osteoclasts.

S. L. Teitelbaum (2000)
Science 289, 1504-1508
 |  Abstract »  |  Full Text »

Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts.

N. X. Chen, K. D. Ryder, F. M. Pavalko, C. H. Turner, D. B. Burr, J. Qiu, and R. L. Duncan (2000)
Am J Physiol Cell Physiol 278, C989-C997
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Function of Rabbit Peroxisome Proliferator-activated Receptor delta /beta in Mature Osteoclasts.

H. Mano, C. Kimura, Y. Fujisawa, T. Kameda, M. Watanabe-Mano, H. Kaneko, T. Kaneda, Y. Hakeda, and M. Kumegawa (2000)
J. Biol. Chem. 275, 8126-8132
 |  Abstract »  |  Full Text »  |  PDF »

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism.

J. Li, I. Sarosi, X.-Q. Yan, S. Morony, C. Capparelli, H.-L. Tan, S. McCabe, R. Elliott, S. Scully, G. Van, et al. (2000)
PNAS 97, 1566-1571
 |  Abstract »  |  Full Text »  |  PDF »

Placental vascularisation requires the AP-1 component fra1.

M Schreiber, Z. Wang, W Jochum, I Fetka, C Elliott, and E. Wagner (2000)
Development 127, 4937-4948
 |  Abstract »  |  PDF »

Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene.

D. Thomas, A Sunters, A Gentry, and A. Grigoriadis (2000)
J. Cell Sci. 113, 439-450
 |  Abstract »  |  PDF »

Prostaglandin E2-Induced Up-Regulation of c-fos Messenger Ribonucleic Acid Is Primarily Mediated by 3',5'-Cyclic Adenosine Monophosphate in MC3T3-E1 Osteoblasts.

J. Fitzgerald, T. J. Dietz, and M. Hughes-Fulford (2000)
Endocrinology 141, 291-298
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Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.

D Thepot, J. Weitzman, J Barra, D Segretain, M. Stinnakre, C Babinet, and M Yaniv (2000)
Development 127, 143-153
 |  Abstract »  |  PDF »

Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of C-Fms and Receptor Activator of Nuclear Factor {kappa}b (Rank) Receptors.

F. Arai, T. Miyamoto, O. Ohneda, T. Inada, T. Sudo, K. Brasel, T. Miyata, D. M. Anderson, and T. Suda (1999)
J. Exp. Med. 190, 1741-1754
 |  Abstract »  |  Full Text »  |  PDF »

The genetic transformation of bone biology.

G. Karsenty (1999)
Genes & Dev. 13, 3037-3051
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RANK is essential for osteoclast and lymph node development.

W. C. Dougall, M. Glaccum, K. Charrier, K. Rohrbach, K. Brasel, T. De Smedt, E. Daro, J. Smith, M. E. Tometsko, C. R. Maliszewski, et al. (1999)
Genes & Dev. 13, 2412-2424
 |  Abstract »  |  Full Text »

Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis.

A. Kukita, T. Kukita, M. Ouchida, H. Maeda, H. Yatsuki, and O. Kohashi (1999)
Blood 94, 1987-1997
 |  Abstract »  |  Full Text »  |  PDF »

Onset and Dynamics of Osteosclerosis in Mice Induced by Reilly-Finkel-Biskis (RFB) Murine Leukemia Virus : Increase in Bone Mass Precedes Lymphomagenesis.

J. Schmidt, K. Lumniczky, B. D. Tzschaschel, H. L. Guenther, A. Luz, S. Riemann, W. Gimbel, V. Erfle, and R. G. Erben (1999)
Am. J. Pathol. 155, 557-570
 |  Abstract »  |  Full Text »  |  PDF »

Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption.

H. Yoshitake, S. R. Rittling, D. T. Denhardt, and M. Noda (1999)
PNAS 96, 8156-8160
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families.

T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. T. Gillespie, and T. J. Martin (1999)
Endocr. Rev. 20, 345-357
 |  Abstract »  |  Full Text »

Estrogen has rapid tissue-specific effects on rat bone.

R. T. Turner, L. S. Kidder, M. Zhang, S. A. Harris, K. C. Westerlind, A. Maran, and T. J. Wronski (1999)
J Appl Physiol 86, 1950-1958
 |  Abstract »  |  Full Text »  |  PDF »

Functions of c-Jun in Liver and Heart Development.

R. Eferl, M. Sibilia, F. Hilberg, A. Fuchsbichler, I. Kufferath, B. Guertl, R. Zenz, E. F. Wagner, and K. Zatloukal (1999)
J. Cell Biol. 145, 1049-1061
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Signaling in Human Osteoblasts by Extracellular Nucleotides. THEIR WEAK INDUCTION OF THE c-fos PROTO-ONCOGENE VIA Ca2+ MOBILIZATION IS STRONGLY POTENTIATED BY A PARATHYROID HORMONE/cAMP-DEPENDENT PROTEIN KINASE PATHWAY INDEPENDENTLY OF MITOGEN-ACTIVATED PROTEIN KINASE.

W. B. Bowler, C. J. Dixon, C. Halleux, R. Maier, G. Bilbe, W. D. Fraser, J. A. Gallagher, and R. A. Hipskind (1999)
J. Biol. Chem. 274, 14315-14324
 |  Abstract »  |  Full Text »  |  PDF »

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

M. A. Lomaga, W.-C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, et al. (1999)
Genes & Dev. 13, 1015-1024
 |  Abstract »  |  Full Text »

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

H. Hsu, D. L. Lacey, C. R. Dunstan, I. Solovyev, A. Colombero, E. Timms, H.-L. Tan, G. Elliott, M. J. Kelley, I. Sarosi, et al. (1999)
PNAS 96, 3540-3545
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2.

N. Franchimont, D. Durant, S. Rydziel, and E. Canalis (1999)
J. Biol. Chem. 274, 6783-6789
 |  Abstract »  |  Full Text »  |  PDF »

Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts.

J. FITZGERALD and M. HUGHES-FULFORD (1999)
FASEB J 13, 553-557
 |  Abstract »  |  Full Text »

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