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Science 21 October 1994:
Vol. 266. no. 5184, pp. 404 - 409
DOI: 10.1126/science.7545955
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Articles

Science, Vol 266, Issue 5184, 404-409
Copyright © 1994 by American Association for the Advancement of Science

articles

TLC1: template RNA component of Saccharomyces cerevisiae telomerase

MS Singer and DE Gottschling

Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637.

Telomeres, the natural ends of linear eukaryotic chromosomes, are essential for chromosome stability. Because of the nature of DNA replication, telomeres require a specialized mechanism to ensure their complete duplication. Telomeres are also capable of silencing the transcription of genes that are located near them. In order to identify genes in the budding yeast Saccharomyces cerevisiae that are important for telomere function, a screen was conducted for genes that, when expressed in high amounts, would suppress telomeric silencing. This screen lead to the identification of the gene TLC1 (telomerase component 1). TLC1 encodes the template RNA of telomerase, a ribonucleoprotein required for telomere replication in a variety of organisms. The discovery of TLC1 confirms the existence of telomerase in S. cerevisiae and may facilitate both the analysis of this enzyme and an understanding of telomere structure and function.


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M. Tsukamoto, K. Yamashita, T. Miyazaki, M. Shinohara, and A. Shinohara (2003)
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A. A. Bertuch and V. Lundblad (2003)
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   Abstract »    Full Text »    PDF »
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
A. E. Stellwagen, Z. W. Haimberger, J. R. Veatch, and D. E. Gottschling (2003)
Genes & Dev. 17, 2384-2395
   Abstract »    Full Text »    PDF »
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K. J. Bitterman, O. Medvedik, and D. A. Sinclair (2003)
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   Abstract »    Full Text »    PDF »
Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans.
D. X. Mason, E. Goneska, and C. W. Greider (2003)
Mol. Cell. Biol. 23, 5606-5613
   Abstract »    Full Text »    PDF »
Telomerase-Independent Proliferation Is Influenced by Cell Type in Saccharomyces cerevisiae.
J. E. Lowell, A. I. Roughton, V. Lundblad, and L. Pillus (2003)
Genetics 164, 909-921
   Abstract »    Full Text »    PDF »
Telomeric Position Effect Variegation in Saccharomyces cerevisiae by Caenorhabditis elegans Linker Histones Suggests a Mechanistic Connection between Germ Line and Telomeric Silencing.
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Short Telomeres Induce a DNA Damage Response in Saccharomyces cerevisiae.
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Mol. Biol. Cell 14, 987-1001
   Abstract »    Full Text »    PDF »
mRNAs Encoding Telomerase Components and Regulators Are Controlled by UPF Genes in Saccharomyces cerevisiae.
J. N. Dahlseid, J. Lew-Smith, M. J. Lelivelt, S. Enomoto, A. Ford, M. Desruisseaux, M. McClellan, N. Lue, M. R. Culbertson, and J. Berman (2003)
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Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in Vivo.
D. Bosoy, Y. Peng, I. S. Mian, and N. F. Lue (2003)
J. Biol. Chem. 278, 3882-3890
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Long Telomeric C-rich 5'-Tails in Human Replicating Cells.
G. Cimino-Reale, E. Pascale, E. Alvino, G. Starace, and E. D'Ambrosio (2003)
J. Biol. Chem. 278, 2136-2140
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N-terminal Domain of Yeast Telomerase Reverse Transcriptase: Recruitment of Est3p to the Telomerase Complex.
K. L. Friedman, J. J. Heit, D. M. Long, and T. R. Cech (2003)
Mol. Biol. Cell 14, 1-13
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R. C. Allsopp, S. Cheshier, and I. L. Weissman (2002)
J. Exp. Med. 196, 1427-1433
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A bulged stem tethers Est1p to telomerase RNA in budding yeast.
A. G. Seto, A. J. Livengood, Y. Tzfati, E. H. Blackburn, and T. R. Cech (2002)
Genes & Dev. 16, 2800-2812
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The Est1 Subunit of Saccharomyces cerevisiae Telomerase Makes Multiple Contributions to Telomere Length Maintenance.
S. K. Evans and V. Lundblad (2002)
Genetics 162, 1101-1115
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Delineation of the high-affinity single-stranded telomeric DNA-binding domain of Saccharomyces cerevisiae Cdc13.
E. M. Anderson, W. A. Halsey, and D. S. Wuttke (2002)
Nucleic Acids Res. 30, 4305-4313
   Abstract »    Full Text »    PDF »
Functional Analysis of the C-terminal Extension of Telomerase Reverse Transcriptase. A PUTATIVE "THUMB" DOMAIN.
S. Hossain, S. Singh, and N. F. Lue (2002)
J. Biol. Chem. 277, 36174-36180
   Abstract »    Full Text »    PDF »
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F. Ferrezuelo, B. Steiner, M. Aldea, and B. Futcher (2002)
Mol. Cell. Biol. 22, 6046-6055
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C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity.
S. S. R. Banik, C. Guo, A. C. Smith, S. S. Margolis, D. A. Richardson, C. A. Tirado, and C. M. Counter (2002)
Mol. Cell. Biol. 22, 6234-6246
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Maintenance of Genome Stability in Saccharomyces cerevisiae.
R. D. Kolodner, C. D. Putnam, and K. Myung (2002)
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J. Biol. Chem. 277, 28099-28108
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The genome-wide expression response to telomerase deletion in Saccharomycescerevisiae.
S. Nautiyal, J. L. DeRisi, and E. H. Blackburn (2002)
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Recombinational Telomere Elongation Promoted by DNA Circles.
S. Natarajan and M. J. McEachern (2002)
Mol. Cell. Biol. 22, 4512-4521
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Regulation of Genome Stability by TEL1 and MEC1, Yeast Homologs of the Mammalian ATM and ATR Genes.
R. J. Craven, P. W. Greenwell, M. Dominska, and T. D. Petes (2002)
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Conserved Structure for Single-Stranded Telomeric DNA Recognition.
R. M. Mitton-Fry, E. M. Anderson, T. R. Hughes, V. Lundblad, and D. S. Wuttke (2002)
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Maintenance of Double-Stranded Telomeric Repeats as the Critical Determinant for Cell Viability in Yeast Cells Lacking Ku.
S. Gravel and R. J. Wellinger (2002)
Mol. Cell. Biol. 22, 2182-2193
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Essential Regions of Saccharomyces cerevisiae Telomerase RNA: Separate Elements for Est1p and Est2p Interaction.
A. J. Livengood, A. J. Zaug, and T. R. Cech (2002)
Mol. Cell. Biol. 22, 2366-2374
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Senescence Induced by Altered Telomere State, Not Telomere Loss.
J. Karlseder, A. Smogorzewska, and T. de Lange (2002)
Science 295, 2446-2449
   Abstract »    Full Text »    PDF »
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.
Y. Liu, H. Kha, M. Ungrin, M. O. Robinson, and L. Harrington (2002)
PNAS 99, 3597-3602
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Chromatin Assembly Factor I Mutants Defective for PCNA Binding Require Asf1/Hir Proteins for Silencing.
D. C. Krawitz, T. Kama, and P. D. Kaufman (2002)
Mol. Cell. Biol. 22, 614-625
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A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.
J.-L. Chen, K. K. Opperman, and C. W. Greider (2002)
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Yeast hnRNP K-Like Genes Are Involved in Regulation of the Telomeric Position Effect and Telomere Length.
O. Denisenko and K. Bomsztyk (2002)
Mol. Cell. Biol. 22, 286-297
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Differential Suppression of DNA Repair Deficiencies of Yeast rad50, mre11 and xrs2 Mutants by EXO1 and TLC1 (the RNA Component of Telomerase).
L. K. Lewis, G. Karthikeyan, J. W. Westmoreland, and M. A. Resnick (2002)
Genetics 160, 49-62
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Dynamics of Telomeric DNA Turnover in Yeast.
M. J. McEachern, D. H. Underwood, and E. H. Blackburn (2002)
Genetics 160, 63-73
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Multiple Regulators of Ty1 Transposition in Saccharomyces cerevisiae Have Conserved Roles in Genome Maintenance.
D. T. Scholes, M. Banerjee, B. Bowen, and M. J. Curcio (2001)
Genetics 159, 1449-1465
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Functional Analysis of Conserved Residues in the Putative "Finger" Domain of Telomerase Reverse Transcriptase.
D. Bosoy and N. F. Lue (2001)
J. Biol. Chem. 276, 46305-46312
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Molecular Basis for Telomere Repeat Divergence in Budding Yeast.
K. Forstemann and J. Lingner (2001)
Mol. Cell. Biol. 21, 7277-7286
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Intrachromatid Excision of Telomeric DNA as a Mechanism for Telomere Size Control in Saccharomyces cerevisiae.
M. Bucholc, Y. Park, and A. J. Lustig (2001)
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In Vitro Reconstitution of the End Replication Problem.
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New Function of CDC13 in Positive Telomere Length Regulation.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)