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Science 14 October 1994:
Vol. 266. no. 5183, pp. 276 - 279
DOI: 10.1126/science.7939663
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Articles

Science, Vol 266, Issue 5183, 276-279
Copyright © 1994 by American Association for the Advancement of Science

articles

Quantitative trait locus for reading disability on chromosome 6

LR Cardon, SD Smith, DW Fulker, WJ Kimberling, BF Pennington, and JC DeFries

Health Sciences Program, SRI International, Menlo Park, CA 94025.

Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a chi 2 value of 16.73 (P = 0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (chi 2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.


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