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Science 7 October 1994:
Vol. 266. no. 5182, pp. 120 - 122
DOI: 10.1126/science.7939630
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Articles

Science, Vol 266, Issue 5182, 120-122
Copyright © 1994 by American Association for the Advancement of Science

articles

BRCA1 mutations in primary breast and ovarian carcinomas

PA Futreal, Q Liu, D Shattuck-Eidens, C Cochran, K Harshman, S Tavtigian, LM Bennett, A Haugen-Strano, J Swensen, Y Miki, and al. et

Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.

Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors. The BRCA1 coding region was examined for mutations in primary breast and ovarian tumors that show allele loss at the BRCA1 locus. Mutations were detected in 3 of 32 breast and 1 of 12 ovarian carcinomas; all four mutations were germline alterations and occurred in early-onset cancers. These results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.


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PNAS 96, 4983-4988
   Abstract »    Full Text »    PDF »
High frequency of BRCA1/2 germline mutations in 42 Belgian families with a small number of symptomatic subjects.
G Goelen, E Teugels, M Bonduelle, B Neyns, and J De Grève (1999)
J. Med. Genet. 36, 304-308
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Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain.
D. T. Haile and J. D. Parvin (1999)
J. Biol. Chem. 274, 2113-2117
   Abstract »    Full Text »    PDF »
Cancer Control in Susceptible Groups: Opportunities and Challenges.
F. P. Li (1999)
J. Clin. Oncol. 17, 719
   Abstract »    Full Text »    PDF »
Genome Scanning Detects Amplification of the Cathepsin B Gene (CtsB) in Transformed Rat Ovarian Surface Epithelial Cells.
A. Abdollahi, L. A. Getts, G. Sonoda, P. D. Miller, T. Taguchi, A. K. Godwin, J. R. Testa, and T. C. Hamilton (1999)
Reproductive Sciences 6, 32-40
   Abstract »    PDF »
The BRCA2 gene product functionally interacts with p53 and RAD51.
L. Y. Marmorstein, T. Ouchi, and S. A. Aaronson (1998)
PNAS 95, 13869-13874
   Abstract »    Full Text »    PDF »
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
R. M. Gemmill, J. D. West, F. Boldog, N. Tanaka, L. J. Robinson, D. I. Smith, F. Li, and H. A. Drabkin (1998)
PNAS 95, 9572-9577
   Abstract »    Full Text »    PDF »
Rapid sequencing of the p53 gene with a new automated DNA sequencer.
B. S. Bharaj, K. Angelopoulou, and E. P. Diamandis (1998)
Clin. Chem. 44, 1397-1403
   Abstract »    Full Text »    PDF »
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
P.-L. Chen, C.-F. Chen, Y. Chen, J. Xiao, Z. D. Sharp, and W.-H. Lee (1998)
PNAS 95, 5287-5292
   Abstract »    Full Text »    PDF »
Hypermutability in Carcinogenesis.
B. S. Strauss (1998)
Genetics 148, 1619-1626
   Abstract »    Full Text »    PDF »
BRCA1 regulates p53-dependent gene expression.
T. Ouchi, A. N. A. Monteiro, A. August, S. A. Aaronson, and H. Hanafusa (1998)
PNAS 95, 2302-2306
   Abstract »    Full Text »    PDF »
The Progression of Neoplasia, Cell Replication, and Electromagnetic Fields.
H. C. Pitot (1998)
International Journal of Toxicology 17, 59-108
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Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains.
Y. Jin, X. L. Xu, M.-C. W. Yang, F. Wei, T.-C. Ayi, A. M. Bowcock, and R. Baer (1997)
PNAS 94, 12075-12080
   Abstract »    Full Text »    PDF »
Localization of BRCA1 Gene Expression in Adult Cynomolgus Monkey Tissues.
F. Durocher, J. Simard, J. Ouellette, V. Richard, F. Labrie, and G. Pelletier (1997)
J. Histochem. Cytochem. 45, 1173-1188
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Complex Regulation of the BRCA1 Gene.
C.-F. Xu, J. A. Chambers, and E. Solomon (1997)
J. Biol. Chem. 272, 20994-20997
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Control of Differentiation, Transformation, and Apoptosis in Granulosa Cells by Oncogenes, Oncoviruses, and Tumor Suppressor Genes.
A. Amsterdam and N. Selvaraj (1997)
Endocr. Rev. 18, 435-461
   Abstract »    Full Text »    PDF »
BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
H. Ruffner and I. M. Verma (1997)
PNAS 94, 7138-7143
   Abstract »    Full Text »    PDF »
BRCA1 is a component of the RNA polymerase II holoenzyme.
R. Scully, S. F. Anderson, D. M. Chao, W. Wei, L. Ye, R. A. Young, D. M. Livingston, and J. D. Parvin (1997)
PNAS 94, 5605-5610
   Abstract »    Full Text »    PDF »


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