Science 30 September 1994: Vol. 265. no. 5181, pp. 2091 - 2093 DOI: 10.1126/science.8091232

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Articles

Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage.

M. M. A. E. L. Salem, M. Shalbaf, N. C. J. Gibbons, B. Chavan, J. M. Thornton, and K. U. Schallreuter (2009)
FASEB J 23, 3790-3807
 |  Abstract »  |  Full Text »  |  PDF »

PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic {beta} Cells.

A. Radziszewska, D. Choi, K.-T. T. Nguyen, S. A. Schroer, P. Tajmir, L. Wang, A. Suzuki, T. W. Mak, G. I. Evan, and M. Woo (2009)
J. Biol. Chem. 284, 2917-2922
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis.

W.-H. Wang, R. L. Hullinger, and O. M. Andrisani (2008)
J. Biol. Chem. 283, 25455-25467
 |  Abstract »  |  Full Text »  |  PDF »

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.

T. Terzian, Y.-A. Suh, T. Iwakuma, S. M. Post, M. Neumann, G. A. Lang, C. S. Van Pelt, and G. Lozano (2008)
Genes & Dev. 22, 1337-1344
 |  Abstract »  |  Full Text »  |  PDF »

Cell Growth Inhibition by Okadaic Acid Involves Gut-Enriched Kruppel-like Factor Mediated Enhanced Expression of c-Myc.

L. Zhang, A. Wali, C. V. Ramana, and A. K. Rishi (2007)
Cancer Res. 67, 10198-10206
 |  Abstract »  |  Full Text »  |  PDF »

Atm Deficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis.

K. H. Maclean, M. B. Kastan, and J. L. Cleveland (2007)
Mol. Cancer Res. 5, 705-711
 |  Abstract »  |  Full Text »  |  PDF »

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA.

J.-S. Kim, C. Lee, C. L. Bonifant, H. Ressom, and T. Waldman (2007)
Mol. Cell. Biol. 27, 662-677
 |  Abstract »  |  Full Text »  |  PDF »

DNA Replication Licensing Factor Minichromosome Maintenance Deficient 5 Rescues p53-Mediated Growth Arrest.

M. K. Agarwal, A.R.M. R. Amin, and M. L. Agarwal (2007)
Cancer Res. 67, 116-121
 |  Abstract »  |  Full Text »  |  PDF »

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.

V. S. Budhram-Mahadeo, S. Bowen, S. Lee, C. Perez-Sanchez, E. Ensor, P. J. Morris, and D. S. Latchman (2006)
Nucleic Acids Res. 34, 6640-6652
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Proteomic Analysis of Myc-induced Apoptosis: A DIRECT ROLE FOR Myc INDUCTION OF THE MITOCHONDRIAL CHLORIDE ION CHANNEL, mtCLIC/CLIC4.

Y. Shiio, K. S. Suh, H. Lee, S. H. Yuspa, R. N. Eisenman, and R. Aebersold (2006)
J. Biol. Chem. 281, 2750-2756
 |  Abstract »  |  Full Text »  |  PDF »

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

R. V. Pusapati, R. J. Rounbehler, S. Hong, J. T. Powers, M. Yan, K. Kiguchi, M. J. McArthur, P. K. Wong, and D. G. Johnson (2006)
PNAS 103, 1446-1451
 |  Abstract »  |  Full Text »  |  PDF »

A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.

A. D. Boiko, S. Porteous, O. V. Razorenova, V. I. Krivokrysenko, B. R. Williams, and A. V. Gudkov (2006)
Genes & Dev. 20, 236-252
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway.

T. Shibata, K. Iio, Y. Kawai, N. Shibata, M. Kawaguchi, S. Toi, M. Kobayashi, M. Kobayashi, K. Yamamoto, and K. Uchida (2006)
J. Biol. Chem. 281, 1196-1204
 |  Abstract »  |  Full Text »  |  PDF »

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.

M. Jaworski, S. Hailfinger, A. Buchmann, M. Hergenhahn, M. Hollstein, C. Ittrich, and M. Schwarz (2005)
Carcinogenesis 26, 1829-1834
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.

H. Luo, Q. Li, J. O'Neal, F. Kreisel, M. M. Le Beau, and M. H. Tomasson (2005)
Blood 106, 2452-2461
 |  Abstract »  |  Full Text »  |  PDF »

Induction of p53 by Urokinase in Lung Epithelial Cells.

S. Shetty, M. R. Gyetko, and A. P. Mazar (2005)
J. Biol. Chem. 280, 28133-28141
 |  Abstract »  |  Full Text »  |  PDF »

The ATM/p53/p21 Pathway Influences Cell Fate Decision between Apoptosis and Senescence in Reoxygenated Hematopoietic Progenitor Cells.

X. Zhang, J. Li, D. P. Sejas, and Q. Pang (2005)
J. Biol. Chem. 280, 19635-19640
 |  Abstract »  |  Full Text »  |  PDF »

The Role of p53 and Fas in a Model of Acute Murine Graft-versus-Host Disease.

S. Yada, N. Takamura, K. Inagaki-Ohara, M. K. O'Leary, C. Wasem, T. Brunner, D. R. Green, T. Lin, and M. J. Pinkoski (2005)
J. Immunol. 174, 1291-1297
 |  Abstract »  |  Full Text »  |  PDF »

Oncogene-dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy.

G.I. EVAN, M. CHRISTOPHOROU, E.A. LAWLOR, I. RINGSHAUSEN, J. PRESCOTT, T. DANSEN, A. FINCH, C. MARTINS, and D. MURPHY (2005)
Cold Spring Harb Symp Quant Biol 70, 263-273
 |  Abstract »  |  PDF »

c-Fos Is a Mediator of the c-Myc-induced Apoptotic Signaling in Serum-deprived Hepatoma Cells via the p38 Mitogen-activated Protein Kinase Pathway.

N. Kalra and V. Kumar (2004)
J. Biol. Chem. 279, 25313-25319
 |  Abstract »  |  Full Text »  |  PDF »

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation.

R. A. Woo and R. Y.C. Poon (2004)
Genes & Dev. 18, 1317-1330
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2.

H. A. Rogoff, M. T. Pickering, F. M. Frame, M. E. Debatis, Y. Sanchez, S. Jones, and T. F. Kowalik (2004)
Mol. Cell. Biol. 24, 2968-2977
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1.

J. K. Brunelle, M. T. Santore, G. R. S. Budinger, Y. Tang, T. A. Barrett, W.-X. Zong, E. Kandel, B. Keith, M. C. Simon, C. B. Thompson, et al. (2004)
J. Biol. Chem. 279, 4305-4312
 |  Abstract »  |  Full Text »  |  PDF »

Stress-induced Premature Senescence in hTERT-expressing Ataxia Telangiectasia Fibroblasts.

K. Naka, A. Tachibana, K. Ikeda, and N. Motoyama (2004)
J. Biol. Chem. 279, 2030-2037
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of {alpha}7 Integrin Expression during Muscle Differentiation.

J. Xiao, P. Jethanandani, B. L. Ziober, and R. H. Kramer (2003)
J. Biol. Chem. 278, 49780-49788
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Response Elements and Differential p53 Binding Control Perp Expression During Apoptosis.

E. E. Reczek, E. R. Flores, A. S. Tsay, L. D. Attardi, and T. Jacks (2003)
Mol. Cancer Res. 1, 1048-1057
 |  Abstract »  |  Full Text »  |  PDF »

Guanine Nucleotide Exchange Factor, Tiam1, Directly Binds to c-Myc and Interferes with c-Myc-mediated Apoptosis in Rat-1 Fibroblasts.

Y. Otsuki, M. Tanaka, T. Kamo, C. Kitanaka, Y. Kuchino, and H. Sugimura (2003)
J. Biol. Chem. 278, 5132-5140
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione Influences c-Myc-induced Apoptosis in M14 Human Melanoma Cells.

A. Biroccio, B. Benassi, G. Filomeni, S. Amodei, S. Marchini, G. Chiorino, G. Rotilio, G. Zupi, and M. R. Ciriolo (2002)
J. Biol. Chem. 277, 43763-43770
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation.

M Murphy, M J E M F Mabruk, P Lenane, A Liew, P McCann, A Buckley, C O Flatharta, D Hevey, P Billet, W Robertson, et al. (2002)
J. Clin. Pathol. 55, 829-833
 |  Abstract »  |  Full Text »  |  PDF »

Thioredoxin Reductase Plays a Critical Role in IFN Retinoid-mediated Tumor-Growth Control in Vivo.

D. J. Lindner, X. Ma, J. Hu, S. Karra, and D. V. Kalvakolanu (2002)
Clin. Cancer Res. 8, 3210-3218
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Functionally Cooperates with Bax To Induce Apoptosis.

P. Juin, A. Hunt, T. Littlewood, B. Griffiths, L. B. Swigart, S. Korsmeyer, and G. Evan (2002)
Mol. Cell. Biol. 22, 6158-6169
 |  Abstract »  |  Full Text »  |  PDF »

E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis.

H. A. Rogoff, M. T. Pickering, M. E. Debatis, S. Jones, and T. F. Kowalik (2002)
Mol. Cell. Biol. 22, 5308-5318
 |  Abstract »  |  Full Text »  |  PDF »

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.

M. T. Jack, R. A. Woo, A. Hirao, A. Cheung, T. W. Mak, and P. W. K. Lee (2002)
PNAS 99, 9825-9829
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Controls Proliferation Versus Differentiation in Human Pancreatic Endocrine Cells.

C. Demeterco, P. Itkin-Ansari, B. Tyrberg, L. P. Ford, R. A. Jarvis, and F. Levine (2002)
J. Clin. Endocrinol. Metab. 87, 3475-3485
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of E2f1 Enhances Tumorigenesis in a Myc Transgenic Model.

R. J. Rounbehler, P. M. Rogers, C. J. Conti, and D. G. Johnson (2002)
Cancer Res. 62, 3276-3281
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.

Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence.

G. Ferbeyre, E. de Stanchina, A. W. Lin, E. Querido, M. E. McCurrach, G. J. Hannon, and S. W. Lowe (2002)
Mol. Cell. Biol. 22, 3497-3508
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of keratinocytes to TGF{beta}-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds.

C. Amendt, A. Mann, P. Schirmacher, and M. Blessing (2002)
J. Cell Sci. 115, 2189-2198
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes.

A. Menssen and H. Hermeking (2002)
PNAS 99, 6274-6279
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Myc-mediated Death Response Pathways by Microarray Analysis.

Q. Yu, M. He, N. H. Lee, and E. T. Liu (2002)
J. Biol. Chem. 277, 13059-13066
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of p21WAF1/CIP1 Deficiency on MMTV-ras and MMTV-myc Mammary Tumor Properties.

D. J. Bearss, R. J. Lee, D. A. Troyer, R. G. Pestell, and J. J. Windle (2002)
Cancer Res. 62, 2077-2084
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Bax Alters Tumor Spectrum and Tumor Numbers in ARF-deficient Mice.

C. M. Eischen, J. E. Rehg, S. J. Korsmeyer, and J. L. Cleveland (2002)
Cancer Res. 62, 2184-2191
 |  Abstract »  |  Full Text »  |  PDF »

c-myc-induced Apoptosis in Polycystic Kidney Disease Is Independent of FasL/Fas Interaction.

M. Couillard, R. Guillaume, N. Tanji, V. D'Agati, and M. Trudel (2002)
Cancer Res. 62, 2210-2214
 |  Abstract »  |  Full Text »  |  PDF »

SIV-associated Lymphomas in Rhesus Monkeys (Macaca mulatta) in Comparison with HIV-associated Lymphomas.

K. Kahnt, K. Matz-Rensing, P. Hofmann, C. Stahl-Hennig, and F.-J. Kaup (2002)
Vet. Pathol. 39, 42-55
 |  Abstract »  |  Full Text »  |  PDF »

Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view.

A. D. Schimmer, D. W. Hedley, L. Z. Penn, and M. D. Minden (2001)
Blood 98, 3541-3553
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c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle.

S. Adachi, A. J. Obaya, Z. Han, N. Ramos-Desimone, J. H. Wyche, and J. M. Sedivy (2001)
Mol. Cell. Biol. 21, 4929-4937
 |  Abstract »  |  Full Text »  |  PDF »

C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells.

A. Biroccio, B. Benassi, S. Amodei, C. Gabellini, D. Del Bufalo, and G. Zupi (2001)
Mol. Pharmacol. 60, 174-182
 |  Abstract »  |  Full Text »

Involvement of p38 in Apoptosis-associated Membrane Blebbing and Nuclear Condensation.

R. G. Deschesnes, J. Huot, K. Valerie, and J. Landry (2001)
Mol. Biol. Cell 12, 1569-1582
 |  Abstract »  |  Full Text »  |  PDF »

DNA-damaging carcinogen 3-amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) induces apoptosis via caspase-9 in primary cultured rat hepatocytes.

B. Shiotani, Y. Nonaka, T. Hashimoto, K. Kihara, K. Kanazawa, G.-i. Danno, and H. Ashida (2001)
Carcinogenesis 22, 693-700
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Deletion of the S-Phase-Specific Myc Antagonist Mad3 Sensitizes Neuronal and Lymphoid Cells to Radiation-Induced Apoptosis.

C. Queva, G. A. McArthur, B. M. Iritani, and R. N. Eisenman (2001)
Mol. Cell. Biol. 21, 703-712
 |  Abstract »  |  Full Text »  |  PDF »

Role of NF-{kappa}B and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein.

F. Su, C. N. Theodosis, and R. J. Schneider (2001)
J. Virol. 75, 215-225
 |  Abstract »  |  Full Text »  |  PDF »

v-Src Generates a p53-Independent Apoptotic Signal.

B. L. Webb, E. Jimenez, and G. S. Martin (2000)
Mol. Cell. Biol. 20, 9271-9280
 |  Abstract »  |  Full Text »  |  PDF »

Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions.

J.-H. Dannenberg, A. van Rossum, L. Schuijff, and H. te Riele (2000)
Genes & Dev. 14, 3051-3064
 |  Abstract »  |  Full Text »

Molecular Biology of Burkitt's Lymphoma.

J. L. Hecht and J. C. Aster (2000)
J. Clin. Oncol. 18, 3707-3721
 |  Abstract »  |  Full Text »  |  PDF »

Proapoptotic p53-Interacting Protein 53BP2 Is Induced by UV Irradiation but Suppressed by p53.

C. D. Lopez, Y. Ao, L. H. Rohde, T. D. Perez, D. J. O'Connor, X. Lu, J. M. Ford, and L. Naumovski (2000)
Mol. Cell. Biol. 20, 8018-8025
 |  Abstract »  |  Full Text »  |  PDF »

Bax Is a Transcriptional Target and Mediator of c-Myc-induced Apoptosis.

K. O. Mitchell, M. S. Ricci, T. Miyashita, D. T. Dicker, Z. Jin, J. C. Reed, and W. S. El-Deiry (2000)
Cancer Res. 60, 6318-6325
 |  Abstract »  |  Full Text »

A Modified p53 Overcomes mdm2-mediated Oncogenic Transformation: A Potential Cancer Therapeutic Agent.

J. Lin, X. Jin, C. Page, V. K. Sondak, G. Jiang, and R. K. Reynolds (2000)
Cancer Res. 60, 5895-5901
 |  Abstract »  |  Full Text »

Induction of Cell Cycle Progression and Acceleration of Apoptosis Are Two Separable Functions of c-Myc: Transrepression Correlates with Acceleration of Apoptosis.

S. D. Conzen, K. Gottlob, E. S. Kandel, P. Khanduri, A. J. Wagner, M. O'Leary, and N. Hay (2000)
Mol. Cell. Biol. 20, 6008-6018
 |  Abstract »  |  Full Text »  |  PDF »

Different Combinations of Genetic/Epigenetic Alterations Inactivate the p53 and pRb Pathways in Invasive Human Bladder Cancers.

S. Sarkar, K. P. Jülicher, M. S. Burger, V. Della Valle, C.-J. Larsen, T. R. Yeager, T. B. Grossman, R. W. Nickells, C. Protzel, D. F. Jarrard, et al. (2000)
Cancer Res. 60, 3862-3871
 |  Abstract »  |  Full Text »

Expression of Fas Ligand in Activated T Cells Is Regulated by c-Myc.

T. Brunner, S. Kasibhatla, M. J. Pinkoski, C. Frutschi, N. J. Yoo, F. Echeverri, A. Mahboubi, and D. R. Green (2000)
J. Biol. Chem. 275, 9767-9772
 |  Abstract »  |  Full Text »  |  PDF »

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.

L. D. Attardi, E. E. Reczek, C. Cosmas, E. G. Demicco, M. E. McCurrach, S. W. Lowe, and T. Jacks (2000)
Genes & Dev. 14, 704-718
 |  Abstract »  |  Full Text »

Apoptosis in cancer.

S. W. Lowe and A. W. Lin (2000)
Carcinogenesis 21, 485-495
 |  Abstract »  |  Full Text »  |  PDF »

Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2.

L. J. Strobl, H. Hofelmayr, G. Marschall, M. Brielmeier, G. W. Bornkamm, and U. Zimber-Strobl (2000)
J. Virol. 74, 1727-1735
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Instability, Oncogenes, and the p53 Pathway.

G. WAHL and O. VAFA (2000)
Cold Spring Harb Symp Quant Biol 65, 511-520
 |  Abstract »  |  PDF »

Regulation of the p53 Tumor Suppressor Protein.

M. Oren (1999)
J. Biol. Chem. 274, 36031-36034
 |  Full Text »  |  PDF »

P53 Inhibits {alpha}6{beta}4 Integrin Survival Signaling by Promoting the Caspase 3-Dependent Cleavage of Akt/PKB.

R. E. Bachelder, M. J. Ribick, A. Marchetti, R. Falcioni, S. Soddu, K. R. Davis, and A. M. Mercurio (1999)
J. Cell Biol. 147, 1063-1072
 |  Abstract »  |  Full Text »  |  PDF »

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

C. A. Schmitt, M. E. McCurrach, E. de Stanchina, R. R. Wallace-Brodeur, and S. W. Lowe (1999)
Genes & Dev. 13, 2670-2677
 |  Abstract »  |  Full Text »

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

J. J.L. Jacobs, B. Scheijen, J.-W. Voncken, K. Kieboom, A. Berns, and M. van Lohuizen (1999)
Genes & Dev. 13, 2678-2690
 |  Abstract »  |  Full Text »

twist is a potential oncogene that inhibits apoptosis.

R. Maestro, A. P. D. Tos, Y. Hamamori, S. Krasnokutsky, V. Sartorelli, L. Kedes, C. Doglioni, D. H. Beach, and G. J. Hannon (1999)
Genes & Dev. 13, 2207-2217
 |  Abstract »  |  Full Text »

Thiol Depletion Induces Apoptosis in Cultured Lung Fibroblasts.

K. Aoshiba, S. Yasui, K. Nishimura, and A. Nagai (1999)
Am. J. Respir. Cell Mol. Biol. 21, 54-64
 |  Abstract »  |  Full Text »

Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins.

G. M. Kasof, L. Goyal, and E. White (1999)
Mol. Cell. Biol. 19, 4390-4404
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release.

P. Juin, A.-O. Hueber, T. Littlewood, and G. Evan (1999)
Genes & Dev. 13, 1367-1381
 |  Abstract »  |  Full Text »

Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies.

R. G. Wickremasinghe and A. V. Hoffbrand (1999)
Blood 93, 3587-3600
 |  Full Text »  |  PDF »

Nuclear Factor kappa B Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum.

Z.-H. Qin, R.-W. Chen, Y. Wang, M. Nakai, D.-M. Chuang, and T. N. Chase (1999)
J. Neurosci. 19, 4023-4033
 |  Abstract »  |  Full Text »  |  PDF »

Loss of the ARF Tumor Suppressor Reverses Premature Replicative Arrest but not Radiation Hypersensitivity Arising from Disabled Atm Function.

T. Kamijo, E. van de Kamp, M. J. Chong, F. Zindy, J. A. Diehl, C. J. Sherr, and P. J. McKinnon (1999)
Cancer Res. 59, 2464-2469
 |  Abstract »  |  Full Text »  |  PDF »

cdc25A Is Necessary but Not Sufficient for Optimal c-myc–Induced Apoptosis and Cell Proliferation of Vascular Smooth Muscle Cells.

K. Macdonald and M. R. Bennett (1999)
Circ. Res. 84, 820-830
 |  Abstract »  |  Full Text »  |  PDF »

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition.

M. S. Soengas, R. M. Alarcón, H. Yoshida, A. J. Giaccia, R. Hakem, T. W. Mak, and S. W. Lowe (1999)
Science 284, 156-159
 |  Abstract »  |  Full Text »

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.

T. Nomura, M. M. Khan, S. C. Kaul, H.-D. Dong, R. Wadhwa, C. Colmenares, I. Kohno, and S. Ishii (1999)
Genes & Dev. 13, 412-423
 |  Abstract »  |  Full Text »

High Affinity Insertion/Deletion Lesion Binding by p53. EVIDENCE FOR A ROLE OF THE p53 CENTRAL DOMAIN.

S. T. Szak and J. A. Pietenpol (1999)
J. Biol. Chem. 274, 3904-3909
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Apoptosis-related Genes in Human Head and Neck Squamous Cell Carcinomas Undergoing p53-mediated Programmed Cell Death.

M. J. Frederick, P. R. Holton, M. Hudson, M. Wang, and G. L. Clayman (1999)
Clin. Cancer Res. 5, 361-369
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Programmed Cell Death in Kaposi's Sarcoma Cells by Preparations of Human Chorionic Gonadotropin.

F. Samaniego, J. L. Bryant, N. Liu, J. E. Karp, A. L. Sabichi, A. Thierry, Y. Lunardi-Iskandar, and R. C. Gallo (1999)
J Natl Cancer Inst 91, 135a-143a
 |  Abstract »  |  Full Text »  |  PDF »

p53-independent apoptosis induced by muscle differentiation stimuli in polyomavirus large T-expressing myoblasts.

V Gottifredi, A Peschiaroli, G. Fimia, and R Maione (1999)
J. Cell Sci. 112, 2397-2407
 |  Abstract »  |  PDF »

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism.

C. V. Dang (1999)
Mol. Cell. Biol. 19, 1-11
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Alveolar macrophage apoptosis and TNF-alpha , but not p53, expression correlate with murine response to bleomycin.

L. A. Ortiz, K. Moroz, J.-Y. Liu, G. W. Hoyle, T. Hammond, R. F. Hamilton, A. Holian, W. Banks, A. R. Brody, and M. Friedman (1998)
Am J Physiol Lung Cell Mol Physiol 275, L1208-L1218
 |  Abstract »  |  Full Text »  |  PDF »

Thioredoxin Reductase Mediates Cell Death Effects of the Combination of Beta Interferon and Retinoic Acid.

E. R. Hofman, M. Boyanapalli, D. J. Lindner, X. Weihua, B. A. Hassel, R. Jagus, P. L. Gutierrez, and D. V. Kalvakolanu (1998)
Mol. Cell. Biol. 18, 6493-6504
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis.

M. P. Soares, A. Muniappan, E. Kaczmarek, K. Koziak, C. J. Wrighton, F. Steinhauslin, C. Ferran, H. Winkler, F. H. Bach, and J. Anrather (1998)
J. Immunol. 161, 4572-4582
 |  Abstract »  |  Full Text »  |  PDF »

The complexity of p53 modulation: emerging patterns from divergent signals.

A. J. Giaccia and M. B. Kastan (1998)
Genes & Dev. 12, 2973-2983
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Tumor surveillance via the ARF-p53 pathway.

C. J. Sherr (1998)
Genes & Dev. 12, 2984-2991
 |  Full Text »

A Matter of Life and Cell Death.

G. Evan and T. Littlewood (1998)
Science 281, 1317-1322
 |  Abstract »  |  Full Text »

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.

F. Zindy, C. M. Eischen, D. H. Randle, T. Kamijo, J. L. Cleveland, C. J. Sherr, and M. F. Roussel (1998)
Genes & Dev. 12, 2424-2433
 |  Abstract »  |  Full Text »

E1A signaling to p53 involves the p19ARF tumor suppressor.

E. de Stanchina, M. E. McCurrach, F. Zindy, S.-Y. Shieh, G. Ferbeyre, A. V. Samuelson, C. Prives, M. F. Roussel, C. J. Sherr, and S. W. Lowe (1998)
Genes & Dev. 12, 2434-2442
 |  Abstract »  |  Full Text »

Distinct Apoptotic Responses Imparted by c-myc and max.

C. E. Nesbit, S. Fan, H. Zhang, and E. V. Prochownik (1998)
Blood 92, 1003-1010
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease.

A. Haunstetter and S. Izumo (1998)
Circ. Res. 82, 1111-1129
 |  Full Text »  |  PDF »

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights.

L. Facchini and L. Z. Penn (1998)
FASEB J 12, 633-651
 |  Abstract »  |  Full Text »

Roles of the Tumor Suppressor p53 and the Cyclin-dependent Kinase Inhibitor p21WAF1/CIP1 in Receptor-mediated Apoptosis of WEHI 231 B Lymphoma Cells.

M. Wu, R. E. Bellas, J. Shen, and G. E. Sonenshein (1998)
J. Exp. Med. 187, 1671-1679
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Positive and Negative Regulatory Regions Involved in Regulating Expression of the Human Cytomegalovirus UL94 Late Promoter: Role of IE2-86 and Cellular p53 in Mediating Negative Regulatory Function.

B. A. Wing, R. A. Johnson, and E.-S. Huang (1998)
J. Virol. 72, 1814-1825
 |  Abstract »  |  Full Text »  |  PDF »

p16/INK4a and p15/INK4b Gene Methylation and Absence of p16/INK4a mRNA and Protein Expression in Burkitt's Lymphoma.

U. Klangby, I. Okan, K. P. Magnusson, M. Wendland, P. Lind, and K. G. Wiman (1998)
Blood 91, 1680-1687
 |  Abstract »  |  Full Text »  |  PDF »

A unique glucose-dependent apoptotic pathway induced by c-Myc.

H. Shim, Y. S. Chun, B. C. Lewis, and C. V. Dang (1998)
PNAS 95, 1511-1516
 |  Abstract »  |  Full Text »  |  PDF »

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