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Science 30 September 1994: Vol. 265. no. 5181, pp. 2037 - 2048 DOI: 10.1126/science.8091226
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Articles
Science, Vol 265, Issue 5181, 2037-2048
Copyright © 1994 by American Association for the Advancement of Science
Genetic dissection of complex traits
ES Lander
and
NJ Schork
Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Genetics have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
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- A. Bulotta, O. Ludovico, A. Coco, R. Di Paola, A. Quattrone, M. Carella, F. Pellegrini, S. Prudente, and V. Trischitta (2005)
J. Clin. Endocrinol. Metab.
90, 1176-1180
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- Determination of Sequence Variation and Haplotype Structure for the Gonadotropin-Releasing Hormone (GnRH) and GnRH Receptor Genes: Investigation of Role in Pubertal Timing.
- I. L. Sedlmeyer, C. L. Pearce, J. A. Trueman, J. L. Butler, T. Bersaglieri, A. P. Read, P. E. Clayton, L. N. Kolonel, B. E. Henderson, J. N. Hirschhorn, et al. (2005)
J. Clin. Endocrinol. Metab.
90, 1091-1099
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- Coalescent-Based Association Mapping and Fine Mapping of Complex Trait Loci.
- S. Zollner and J. K. Pritchard (2005)
Genetics
169, 1071-1092
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- Performance of the Log-Linear Approach to Case-Parent Triad Data for Assessing Maternal Genetic Associations with Offspring Disease: Type I Error, Power, and Bias.
- J. R. Starr, L. Hsu, and S. M. Schwartz (2005)
Am. J. Epidemiol.
161, 196-204
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- Haplotype-Based Localization of an Alcohol Dependence Gene to the 5q34 {gamma}-Aminobutyric Acid Type A Gene Cluster.
- M. Radel, R. L. Vallejo, N. Iwata, R. Aragon, J. C. Long, M. Virkkunen, and D. Goldman (2005)
Arch Gen Psychiatry
62, 47-55
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- Recombination hotspots and block structure of linkage disequilibrium in the human genome exemplified by detailed analysis of PGM1 on 1p31.
- N. A. Rana, N. D. Ebenezer, A. R. Webster, A. R. Linares, D. B. Whitehouse, S. Povey, and A. J. Hardcastle (2004)
Hum. Mol. Genet.
13, 3089-3102
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- Genome-Wide Scan for Japanese Familial Intracranial Aneurysms: Linkage to Several Chromosomal Regions.
- S. Yamada, M. Utsunomiya, K. Inoue, K. Nozaki, S. Inoue, K. Takenaka, N. Hashimoto, and A. Koizumi (2004)
Circulation
110, 3727-3733
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- Polymorphisms of IL4, IL13, and ADRB2 Genes in COPD.
- A. E. Hegab, T. Sakamoto, W. Saitoh, H. H. Massoud, H. M. Massoud, K. M. Hassanein, and K. Sekizawa (2004)
Chest
126, 1832-1839
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- Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels.
- Y. Bosse, Y. C. Chagnon, J.-P. Despres, T. Rice, D. C. Rao, C. Bouchard, L. Perusse, and M.-C. Vohl (2004)
J. Lipid Res.
45, 2174-2184
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- The Genetic Architecture of Response to Long-Term Artificial Selection for Oil Concentration in the Maize Kernel.
- C. C. Laurie, S. D. Chasalow, J. R. LeDeaux, R. McCarroll, D. Bush, B. Hauge, C. Lai, D. Clark, T. R. Rocheford, and J. W. Dudley (2004)
Genetics
168, 2141-2155
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- Patterns of hormonal response to the GnRH agonist leuprolide in brothers of women with polycystic ovary syndrome: a pilot study.
- T. S. Petermann, A. Cartes, M. Maliqueo, D. Vantman, C. Gutierrez, H. Toloza, B. Echiburu, and S.E. Recabarren (2004)
Hum. Reprod.
19, 2742-2747
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- Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice.
- N. Yi, S. Chiu, D. B. Allison, J. S. Fisler, and C. H. Warden (2004)
J. Lipid Res.
45, 2063-2070
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- Dissection of Maize Kernel Composition and Starch Production by Candidate Gene Association.
- L. M. Wilson, S. R. Whitt, A. M. Ibanez, T. R. Rocheford, M. M. Goodman, and E. S. Buckler IV (2004)
PLANT CELL
16, 2719-2733
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