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Science 23 September 1994:
Vol. 265. no. 5180, pp. 1878 - 1882
DOI: 10.1126/science.7916482
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Articles

Science, Vol 265, Issue 5180, 1878-1882
Copyright © 1994 by American Association for the Advancement of Science

articles

Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

MG Weisskopf, PE Castillo, RA Zalutsky, and RA Nicoll

Neuroscience Graduate Program, University of California, San Francisco 94143-0450.

Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.


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L-Type Calcium Channels Are Required for One Form of Hippocampal Mossy Fiber LTP.
A. Kapur, M. F. Yeckel, R. Gray, and D. Johnston (1998)
J Neurophysiol 79, 2181-2190
   Abstract »    Full Text »    PDF »
Comparison of Plasticity In Vivo and In Vitro in the Developing Visual Cortex of Normal and Protein Kinase A RIbeta -Deficient Mice.
T. K. Hensch, J. A. Gordon, E. P. Brandon, G. S. McKnight, R. L. Idzerda, and M. P. Stryker (1998)
J. Neurosci. 18, 2108-2117
   Abstract »    Full Text »    PDF »
Selective Enhancement of P-Type Calcium Currents by Isoproterenol in the Rat Amygdala.
C.-C. Huang, S.-J. Wang, and P.-W. Gean (1998)
J. Neurosci. 18, 2276-2282
   Abstract »    Full Text »    PDF »
Target-Specific Expression of Presynaptic Mossy Fiber Plasticity.
G. Maccaferri, K. Tóth, and C. J. McBain (1998)
Science 279, 1368-1371
   Abstract »    Full Text »
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia.
D. Michael, K. C. Martin, R. Seger, M.-M. Ning, R. Baston, and E. R. Kandel (1998)
PNAS 95, 1864-1869
   Abstract »    Full Text »    PDF »
Long-Term Potentiation of Synaptic Transmission in the Avian Hippocampus.
T. W. Margrie, J. A. P. Rostas, and P. Sah (1998)
J. Neurosci. 18, 1207-1216
   Abstract »    Full Text »    PDF »
Outward Currents in Drosophila Larval Neurons: dunce Lacks a Maintained Outward Current Component Downregulated by cAMP.
R. Delgado, R. Davis, M. R. Bono, R. Latorre, and P. Labarca (1998)
J. Neurosci. 18, 1399-1407
   Abstract »    Full Text »    PDF »
The Mechanism of cAMP-Mediated Enhancement at a Cerebellar Synapse.
C. Chen and W. G. Regehr (1997)
J. Neurosci. 17, 8687-8694
   Abstract »    Full Text »    PDF »


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