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Science 23 September 1994:
Vol. 265. no. 5180, pp. 1875 - 1878
DOI: 10.1126/science.8091214

Articles

Science, Vol 265, Issue 5180, 1875-1878
Copyright © 1994 by American Association for the Advancement of Science


articles

Enhanced aggressive behavior in mice lacking 5-HT1B receptor

F Saudou, DA Amara, A Dierich, M LeMeur, S Ramboz, L Segu, MC Buhot, and R Hen

Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U184 de l'INSERM, Faculte de Medecine, Strasbourg, France.

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.


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