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Science 23 September 1994:
Vol. 265. no. 5180, pp. 1860 - 1862
DOI: 10.1126/science.8091211
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Articles

Science, Vol 265, Issue 5180, 1860-1862
Copyright © 1994 by American Association for the Advancement of Science

articles

Thymus-neuroendocrine interactions in extrathymic T cell development

J Wang and Klein JR

Department of Biological Science, University of Tulsa, OK 74104.

Studies of the development of murine intestinal intraepithelial lymphocytes (IELs) have yielded markedly different results depending on the experimental system used. In athymic radiation chimeras, IELs consist of all subsets found in euthymic mice; adult mice that were athymic at birth have only IELs that are positive for T cell receptor gamma delta and CD8 alpha alpha. These differences are resolved by the finding that administration of the neuropeptide thyrotropin-releasing hormone to adult mice thymectomized as neonates leads to the development of all IEL T cells. Thus, a neuroendocrine signal initiated by the thymus during fetal or neonatal life appears to be required for subsequent extrathymic maturation of gut alpha beta T cells.


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