Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 September 1994:
Vol. 265. no. 5180, pp. 1860 - 1862
DOI: 10.1126/science.8091211
Prev | Table of Contents | Next

Articles

Science, Vol 265, Issue 5180, 1860-1862
Copyright © 1994 by American Association for the Advancement of Science

articles

Thymus-neuroendocrine interactions in extrathymic T cell development

J Wang and Klein JR

Department of Biological Science, University of Tulsa, OK 74104.

Studies of the development of murine intestinal intraepithelial lymphocytes (IELs) have yielded markedly different results depending on the experimental system used. In athymic radiation chimeras, IELs consist of all subsets found in euthymic mice; adult mice that were athymic at birth have only IELs that are positive for T cell receptor gamma delta and CD8 alpha alpha. These differences are resolved by the finding that administration of the neuropeptide thyrotropin-releasing hormone to adult mice thymectomized as neonates leads to the development of all IEL T cells. Thus, a neuroendocrine signal initiated by the thymus during fetal or neonatal life appears to be required for subsequent extrathymic maturation of gut alpha beta T cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Immune System as a Regulator of Thyroid Hormone Activity.
J. R. Klein (2006)
Exp Biol Med 231, 229-236
   Abstract »    Full Text »    PDF »
Extrathymic Hemopoietic Progenitors Committed to T Cell Differentiation in the Adult Mouse.
M.-L. Arcangeli, C. Lancrin, F. Lambolez, C. Cordier, E. Schneider, B. Rocha, and S. Ezine (2005)
J. Immunol. 174, 1980-1988
   Abstract »    Full Text »    PDF »
Functionally active CD8{alpha}{beta}+ TCR{gamma}{delta} intestinal intraepithelial lymphocytes in athymic nu/nu mice.
Y. Emoto, M. Emoto, M. Miyamoto, I. Yoshizawa, and S. H. E. Kaufmann (2004)
Int. Immunol. 16, 111-117
   Abstract »    Full Text »    PDF »
Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis.
J. R. Klein and H.-C. Wang (2004)
J. Exp. Biol. 207, 55-65
   Abstract »    Full Text »    PDF »
An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells.
H.-C. Wang, J. Dragoo, Q. Zhou, and J. R. Klein (2003)
Blood 101, 119-123
   Abstract »    Full Text »    PDF »
Evidence for the Extrathymic Origin of Intestinal TCR{gamma}{delta}+ T Cells in Normal Rats and for an Impairment of This Differentiation Pathway in BB Rats.
S. Ramanathan, L. Marandi, and P. Poussier (2002)
J. Immunol. 168, 2182-2187
   Abstract »    Full Text »    PDF »
The Thyrotropin (Thyroid-Stimulating Hormone) Receptor Is Expressed on Murine Dendritic Cells and on a Subset of CD45RBhigh Lymph Node T Cells: Functional Role for Thyroid-Stimulating Hormone During Immune Activation.
E. U. Bagriacik and J. R. Klein (2000)
J. Immunol. 164, 6158-6165
   Abstract »    Full Text »    PDF »
Role of Gut Cryptopatches in Early Extrathymic Maturation of Intestinal Intraepithelial T Cells.
T. Oida, K. Suzuki, M. Nanno, Y. Kanamori, H. Saito, E. Kubota, S. Kato, M. Itoh, S. Kaminogawa, and H. Ishikawa (2000)
J. Immunol. 164, 3616-3626
   Abstract »    Full Text »    PDF »
Eimeria tenella Infection Induces Local Gamma Interferon Production and Intestinal Lymphocyte Subpopulation Changes.
C. H. Yun, H. S. Lillehoj, and K. D. Choi (2000)
Infect. Immun. 68, 1282-1288
   Abstract »    Full Text »    PDF »
Differential Requirements of CD45 Protein Tyrosine Phosphatase for Cytolytic Activities and Intrathymic and Extrathymic Development of Intestinal Intraepithelial Lymphocytes.
S. Yada, K. Kishihara, Y.-Y. Kong, and K. Nomoto (1998)
J. Immunol. 161, 2208-2216
   Abstract »    Full Text »    PDF »
An Opposite Pattern of Selection of a Single T Cell Antigen Receptor in the Thymus and among Intraepithelial Lymphocytes.
D. Cruz, B. C. Sydora, K. Hetzel, G. Yakoub, M. Kronenberg, and H. Cheroutre (1998)
J. Exp. Med. 188, 255-265
   Abstract »    Full Text »    PDF »
Generation of Intestinal Mucosal Lymphocytes in SCID Mice Reconstituted with Mature, Thymus-Derived T Cells.
V. Camerini, B. C. Sydora23, R. Aranda, C. Nguyen, C. MacLean, W. H. McBride, and M. Kronenberg (1998)
J. Immunol. 160, 2608-2618
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)