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Science 16 September 1994:
Vol. 265. no. 5179, pp. 1728 - 1732
DOI: 10.1126/science.7916164
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Articles

Science, Vol 265, Issue 5179, 1728-1732
Copyright © 1994 by American Association for the Advancement of Science

articles

Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1

M Studer, H Popperl, H Marshall, A Kuroiwa, and R Krumlauf

Lab of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK.

After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point mutations in which allow expression to spread into adjacent rhombomeres. Retinoids and their nuclear receptors may therefore participate in sharpening segment-restricted expression of Hoxb-1 during rhombomere boundary formation.


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