Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 September 1994:
Vol. 265. no. 5179, pp. 1701 - 1706
DOI: 10.1126/science.8085155
Prev | Table of Contents | Next

Articles

Science, Vol 265, Issue 5179, 1701-1706
Copyright © 1994 by American Association for the Advancement of Science

articles

An interleukin-4-induced transcription factor: IL-4 Stat

J Hou, U Schindler, WJ Henzel, TC Ho, M Brasseur, and SL McKnight

Tularik, Inc., South San Francisco, CA 94080.

Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell subsets, favoring expansion of the Th2 lineage relative to Th1. Imbalance of these T lymphocyte subsets has been implicated in immunological diseases including allergy, inflammation, and autoimmune disease. IL-4 may mediate its biological effects, at least in part, by activating a tyrosine-phosphorylated DNA binding protein. This protein has now been purified and its encoding gene cloned. Examination of the primary amino acid sequence of this protein indicates that it is a member of the signal transducers and activators of transcription (Stat) family of DNA binding proteins, hereby designated IL-4 Stat. Study of the inhibitory activities of phosphotyrosine-containing peptides derived from the intracellular domain of the IL-4 receptor provided evidence for direct coupling of receptor and transcription factor during the IL-4 Stat activation cycle. Such observations indicate that IL-4 Stat has the same functional domain for both receptor coupling and dimerization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice.
Y. Darcan-Nicolaisen, H. Meinicke, G. Fels, O. Hegend, A. Haberland, A. Kuhl, C. Loddenkemper, M. Witzenrath, S. Kube, W. Henke, et al. (2009)
J. Immunol. 182, 7501-7508
   Abstract »    Full Text »    PDF »
Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells.
P. Kivisakk, B. C. Healy, V. Viglietta, F. J. Quintana, M. A. Hootstein, H. L. Weiner, and S. J. Khoury (2009)
Neurology 72, 1922-1930
   Abstract »    Full Text »    PDF »
IL-4 Is Proangiogenic in the Lung under Hypoxic Conditions.
K. Yamaji-Kegan, Q. Su, D. J. Angelini, and R. A. Johns (2009)
J. Immunol. 182, 5469-5476
   Abstract »    Full Text »    PDF »
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.
K. R. Calvo, B. Dabir, A. Kovach, C. Devor, R. Bandle, A. Bond, J. H. Shih, and E. S. Jaffe (2008)
Blood 112, 3818-3826
   Abstract »    Full Text »    PDF »
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy.
G. Verdeil, K. Marquardt, C. D. Surh, and L. A. Sherman (2008)
PNAS 105, 16683-16688
   Abstract »    Full Text »    PDF »
Intradermal Administration of Thymic Stromal Lymphopoietin Induces a T Cell- and Eosinophil-Dependent Systemic Th2 Inflammatory Response.
H. K. Jessup, A. W. Brewer, M. Omori, E. A. Rickel, A. L. Budelsky, B.-R. P. Yoon, S. F. Ziegler, and M. R. Comeau (2008)
J. Immunol. 181, 4311-4319
   Abstract »    Full Text »    PDF »
A Conserved IFN-{alpha} Receptor Tyrosine Motif Directs the Biological Response to Type I IFNs.
W. Zhao, C. Lee, R. Piganis, C. Plumlee, N. de Weerd, P. J. Hertzog, and C. Schindler (2008)
J. Immunol. 180, 5483-5489
   Abstract »    Full Text »    PDF »
IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6.
S. Sehra, H. A. Bruns, A.-N. N. Ahyi, E. T. Nguyen, N. W. Schmidt, E. G. Michels, G.-U. von Bulow, and M. H. Kaplan (2008)
J. Immunol. 180, 3551-3559
   Abstract »    Full Text »    PDF »
Analysis of Promoter Regions Regulating Basal and Interleukin-4-Inducible Expression of the Human CB1 Receptor Gene in T Lymphocytes.
C. Borner, A. Bedini, V. Hollt, and J. Kraus (2008)
Mol. Pharmacol. 73, 1013-1019
   Abstract »    Full Text »    PDF »
Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.
T. Weimbs (2007)
Am J Physiol Renal Physiol 293, F1423-F1432
   Abstract »    Full Text »    PDF »
Inhibition of Experimental Allergic Airways Disease by Local Application of a Cell-Penetrating Dominant-Negative STAT-6 Peptide.
C. T. McCusker, Y. Wang, J. Shan, M. W. Kinyanjui, A. Villeneuve, H. Michael, and E. D. Fixman (2007)
J. Immunol. 179, 2556-2564
   Abstract »    Full Text »    PDF »
The molecular basis of IL-21-mediated proliferation.
R. Zeng, R. Spolski, E. Casas, W. Zhu, D. E. Levy, and W. J. Leonard (2007)
Blood 109, 4135-4142
   Abstract »    Full Text »    PDF »
Intracellular Tat of Human Immunodeficiency Virus Type 1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus: Role of JAK/STAT Signaling.
Y. Zeng, X. Zhang, Z. Huang, L. Cheng, S. Yao, D. Qin, X. Chen, Q. Tang, Z. Lv, L. Zhang, et al. (2007)
J. Virol. 81, 2401-2417
   Abstract »    Full Text »    PDF »
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo.
A. Frohlich, B. J. Marsland, I. Sonderegger, M. Kurrer, M. R. Hodge, N. L. Harris, and M. Kopf (2007)
Blood 109, 2023-2031
   Abstract »    Full Text »    PDF »
p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28-stimulated CD4+ T cells--II.
S. M. L. Tamma, K. W. Chung, T. Patel, S. P. Balan, and S. Pahwa (2006)
J. Leukoc. Biol. 79, 1339-1347
   Abstract »    Full Text »    PDF »
Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6.
D. K. Fritz, C. Kerr, L. Tong, D. Smyth, and C. D. Richards (2006)
J. Immunol. 176, 4352-4360
   Abstract »    Full Text »    PDF »
RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines.
B. Zhao, S. Maruo, A. Cooper, M. R. Chase, E. Johannsen, E. Kieff, and E. Cahir-McFarland (2006)
PNAS 103, 1900-1905
   Abstract »    Full Text »    PDF »
Induction of Uteroglobin-Related Protein 2 (Ugrp2) Gene Expression by the Th2 Cytokines IL-4 and IL-13.
A. Yamada, F. Sheikh, T. Niimi, F. J. DeMayo, A. D. Keegan, R. P. Donnelly, and S. Kimura (2005)
J. Immunol. 175, 5708-5715
   Abstract »    Full Text »    PDF »
Molecular Biology of the 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Gene Family.
J. Simard, M.-L. Ricketts, S. Gingras, P. Soucy, F. A. Feltus, and M. H. Melner (2005)
Endocr. Rev. 26, 525-582
   Abstract »    Full Text »    PDF »
B Cell Receptor (BCR) Cross-Talk: IL-4 Creates an Alternate Pathway for BCR-Induced ERK Activation That Is Phosphatidylinositol 3-Kinase Independent.
B. Guo and T. L. Rothstein (2005)
J. Immunol. 174, 5375-5381
   Abstract »    Full Text »    PDF »
IFN-{gamma} Suppresses STAT6 Phosphorylation by Inhibiting Its Recruitment to the IL-4 Receptor.
Z. Huang, J. Xin, J. Coleman, and H. Huang (2005)
J. Immunol. 174, 1332-1337
   Abstract »    Full Text »    PDF »
Interferon-{gamma} Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial Cells.
N. M. Heller, S. Matsukura, S. N. Georas, M. R. Boothby, P. B. Rothman, C. Stellato, and R. P. Schleimer (2004)
Am. J. Respir. Cell Mol. Biol. 31, 573-582
   Abstract »    Full Text »    PDF »
Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6: ROLES FOR MULTIPLE PHOSPHORYLATION SITES AND Stat6 FUNCTION.
Y. Wang, M. G. Malabarba, Z. S. Nagy, and R. A. Kirken (2004)
J. Biol. Chem. 279, 25196-25203
   Abstract »    Full Text »    PDF »
Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity.
W. Chen, M. O. Daines, and G. K. K. Hershey (2004)
J. Immunol. 172, 6744-6750
   Abstract »    Full Text »    PDF »
Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell line.
K. Takamura, Y. Nasuhara, M. Kobayashi, T. Betsuyaku, Y. Tanino, I. Kinoshita, E. Yamaguchi, S. Matsukura, R. P. Schleimer, and M. Nishimura (2004)
Am J Physiol Lung Cell Mol Physiol 286, L777-L785
   Abstract »    Full Text »    PDF »
IL-4 Induces Differentiation and Expansion of Th2 Cytokine-Producing Eosinophils.
L. Chen, K. A. Grabowski, J.-p. Xin, J. Coleman, Z. Huang, B. Espiritu, S. Alkan, H. B. Xie, Y. Zhu, F. A. White, et al. (2004)
J. Immunol. 172, 2059-2066
   Abstract »    Full Text »    PDF »
Differential Roles of C-terminal Activation Motifs in the Establishment of Stat6 Transcriptional Specificity.
S. Goenka, C. Marlar, U. Schindler, and M. Boothby (2003)
J. Biol. Chem. 278, 50362-50370
   Abstract »    Full Text »    PDF »
Identification of Novel Genes Regulated by IL-12, IL-4, or TGF-{beta} during the Early Polarization of CD4+ Lymphocytes.
R. Lund, T. Aittokallio, O. Nevalainen, and R. Lahesmaa (2003)
J. Immunol. 171, 5328-5336
   Abstract »    Full Text »    PDF »
Targeted Inactivation of the IL-4 Receptor {alpha} Chain I4R Motif Promotes Allergic Airway Inflammation.
F. Blaeser, P. J. Bryce, N. Ho, V. Raman, F. Dedeoglu, D. D. Donaldson, R. S. Geha, H. C. Oettgen, and T. A. Chatila (2003)
J. Exp. Med. 198, 1189-1200
   Abstract »    Full Text »    PDF »
New Programming of IL-4 Receptor Signal Transduction in Activated T Cells: Stat6 Induction and Th2 Differentiation Mediated by IL-4R{alpha} Lacking Cytoplasmic Tyrosines.
A. L. Mora, L. M. Stephenson, B. Enerson, J. Youn, A. D. Keegan, and M. Boothby (2003)
J. Immunol. 171, 1891-1900
   Abstract »    Full Text »    PDF »
DNA Binding Activity of Cytoplasmic Phosphorylated Stat6 Is Masked by an Interaction with a Detergent-sensitive Factor.
M. O. Daines, R. P. Andrews, W. Chen, S. A. El-Zayaty, and G. K. K. Hershey (2003)
J. Biol. Chem. 278, 30971-30974
   Abstract »    Full Text »    PDF »
STAT signaling in ischemic heart: a role of STAT5A in ischemic preconditioning.
G. Yamaura, T. Turoczi, F. Yamamoto, M. A. Q. Siddqui, N. Maulik, and D. K. Das (2003)
Am J Physiol Heart Circ Physiol 285, H476-H482
   Abstract »    Full Text »    PDF »
Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells.
H. A. Bruns, U. Schindler, and M. H. Kaplan (2003)
J. Immunol. 170, 3478-3487
   Abstract »    Full Text »    PDF »
The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule {alpha} Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism.
A. M. Stutz, L. A. Pickart, A. Trifilieff, T. Baumruker, E. Prieschl-Strassmayr, and M. Woisetschlager (2003)
J. Immunol. 170, 1789-1796
   Abstract »    Full Text »    PDF »
Regression of a Mammary Adenocarcinoma in STAT6-/- Mice Is Dependent on the Presence of STAT6-Reactive T Cells.
S. M. Jensen, S. L. Meijer, R. A. Kurt, W. J. Urba, H.-M. Hu, and B. A. Fox (2003)
J. Immunol. 170, 2014-2021
   Abstract »    Full Text »    PDF »
Regulation of the Dephosphorylation of Stat6. PARTICIPATION OF TYR-713 IN THE INTERLEUKIN-4 RECEPTOR alpha , THE TYROSINE PHOSPHATASE SHP-1, AND THE PROTEASOME.
E. M. Hanson, H. Dickensheets, C.-K. Qu, R. P. Donnelly, and A. D. Keegan (2003)
J. Biol. Chem. 278, 3903-3911
   Abstract »    Full Text »    PDF »
Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4.
N. Tominaga, K. Ohkusu-Tsukada, H. Udono, R. Abe, T. Matsuyama, and K. Yui (2003)
Int. Immunol. 15, 1-10
   Abstract »    Full Text »    PDF »
Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages.
Y. Delneste, P. Charbonnier, N. Herbault, G. Magistrelli, G. Caron, J.-Y. Bonnefoy, and P. Jeannin (2003)
Blood 101, 143-150
   Abstract »    Full Text »    PDF »
Neonatal Tolerance in the Absence of Stat4- and Stat6- Dependent Th Cell Differentiation.
H.-C. Chang, S. Zhang, and M. H. Kaplan (2002)
J. Immunol. 169, 4124-4128
   Abstract »    Full Text »    PDF »
IL-4 Induces the Proteolytic Processing of Mast Cell STAT6.
M. A. Sherman, D. R. Powell, and M. A. Brown (2002)
J. Immunol. 169, 3811-3818
   Abstract »    Full Text »    PDF »
Analysis of the Life Cycle of Stat6. CONTINUOUS CYCLING OF STAT6 IS REQUIRED FOR IL-4 SIGNALING.
R. P. Andrews, M. B. Ericksen, C. M. Cunningham, M. O. Daines, and G. K. K. Hershey (2002)
J. Biol. Chem. 277, 36563-36569
   Abstract »    Full Text »    PDF »
Th2 Activities Induced During Virgin T Cell Priming in the Absence of IL-4, IL-13, and B Cells.
A. F. Cunningham, P. G. Fallon, M. Khan, S. Vacheron, H. Acha-Orbea, I. C. M. MacLennan, A. N. McKenzie, and K.-M. Toellner (2002)
J. Immunol. 169, 2900-2906
   Abstract »    Full Text »    PDF »
Autocrine IL-4 Gene Regulation at Late Phases of TCR Activation in Differentiated Th2 Cells.
B. Dorado, M. J. Jerez, N. Flores, F. M. Martin-Saavedra, C. Duran, and S. Ballester (2002)
J. Immunol. 169, 3030-3037
   Abstract »    Full Text »    PDF »
IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms.
A. Finnegan, M. J. Grusby, C. D. Kaplan, S. K. O'Neill, H. Eibel, T. Koreny, M. Czipri, K. Mikecz, and J. Zhang (2002)
J. Immunol. 169, 3345-3352
   Abstract »    Full Text »    PDF »
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.
M. Lohoff, H.-W. Mittrucker, S. Prechtl, S. Bischof, F. Sommer, S. Kock, D. A. Ferrick, G. S. Duncan, A. Gessner, and T. W. Mak (2002)
PNAS 99, 11808-11812
   Abstract »    Full Text »    PDF »
Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation.
L. Xia, L. Wang, A. S. Chung, S. S. Ivanov, M. Y. Ling, A. M. Dragoi, A. Platt, T. M. Gilmer, X.-Y. Fu, and Y. E. Chin (2002)
J. Biol. Chem. 277, 30716-30723
   Abstract »    Full Text »    PDF »
Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor-mediated Pathways and Can Be Rescued by CD40 Signaling.
L. Liang, E. M. Porter, and W. C. Sha (2002)
J. Exp. Med. 196, 97-108
   Abstract »    Full Text »    PDF »
IL-4 Up-Regulates the Expression of Tissue Inhibitor of Metalloproteinase-2 in Dermal Fibroblasts Via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway.
H. Ihn, K. Yamane, Y. Asano, M. Kubo, and K. Tamaki (2002)
J. Immunol. 168, 1895-1902
   Abstract »    Full Text »    PDF »
Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC/Nga Mice.
R. Yagi, H. Nagai, Y. Iigo, T. Akimoto, T. Arai, and M. Kubo (2002)
J. Immunol. 168, 2020-2027
   Abstract »    Full Text »    PDF »
IL-13R{alpha}2, a Decoy Receptor for IL-13 Acts As an Inhibitor of IL-4-dependent Signal Transduction in Glioblastoma Cells.
S. O. Rahaman, P. Sharma, P. C. Harbor, M. J. Aman, M. A. Vogelbaum, and S. J. Haque (2002)
Cancer Res. 62, 1103-1109
   Abstract »    Full Text »    PDF »
Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis.
A. L. Wurster, D. J. Withers, T. Uchida, M. F. White, and M. J. Grusby (2002)
Mol. Cell. Biol. 22, 117-126
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor {alpha} (TNF-{alpha}) Activates Jak1/Stat3-Stat5B Signaling through TNFR-1 in Human B Cells.
S. Miscia, M. Marchisio, A. Grilli, V. Di Valerio, L. Centurione, G. Sabatino, F. Garaci, G. Zauli, E. Bonvini, and A. Di Baldassarre (2002)
Cell Growth Differ. 13, 13-18
   Abstract »    Full Text »    PDF »
NF-{kappa}B activation plays an important role in the IL-4-induced protection from apoptosis.
J. Zamorano, A. L. Mora, M. Boothby, and A. D. Keegan (2001)
Int. Immunol. 13, 1479-1487
   Abstract »    Full Text »    PDF »
Regulation of {micro}-Opioid Receptor Gene Transcription by Interleukin-4 and Influence of an Allelic Variation within a STAT6 Transcription Factor Binding Site.
J. Kraus, C. Borner, E. Giannini, K. Hickfang, H. Braun, P. Mayer, M. R. Hoehe, A. Ambrosch, W. Konig, and V. Hollt (2001)
J. Biol. Chem. 276, 43901-43908
   Abstract »    Full Text »    PDF »
Bryostatin-1 Specifically Inhibits In Vitro IgE Synthesis.
D. Rabah, S. Grant, C. Ma, and D. H. Conrad (2001)
J. Immunol. 167, 4910-4918
   Abstract »    Full Text »    PDF »
HS1,2 Enhancer Regulation of Germline {epsilon} and {gamma}2b Promoters in Murine B Lymphocytes: Evidence for Specific Promoter-Enhancer Interactions.
J. Laurencikiene, V. Deveikaite, and E. Severinson (2001)
J. Immunol. 167, 3257-3265
   Abstract »    Full Text »    PDF »
Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40.
C.-s. Mao and J. Stavnezer (2001)
J. Immunol. 167, 1522-1534
   Abstract »    Full Text »    PDF »
Stat6 Is Necessary and Sufficient for IL-4's Role in Th2 Differentiation and Cell Expansion.
J. Zhu, L. Guo, C. J. Watson, J. Hu-Li, and W. E. Paul (2001)
J. Immunol. 166, 7276-7281
   Abstract »    Full Text »    PDF »
Interleukin-13 Upregulates Eotaxin Expression in Airway Epithelial Cells by a STAT6-Dependent Mechanism.
S. Matsukura, C. Stellato, S. N. Georas, V. Casolaro, J. R. Plitt, K. Miura, S. Kurosawa, U. Schindler, and R. P. Schleimer (2001)
Am. J. Respir. Cell Mol. Biol. 24, 755-761
   Abstract »    Full Text »    PDF »
A Murine IL-4 Receptor Antagonist That Inhibits IL-4- and IL-13-Induced Responses Prevents Antigen-Induced Airway Eosinophilia and Airway Hyperresponsiveness.
A. Tomkinson, C. Duez, G. Cieslewicz, J. C. Pratt, A. Joetham, M.-C. Shanafelt, R. Gundel, and E. W. Gelfand (2001)
J. Immunol. 166, 5792-5800
   Abstract »    Full Text »    PDF »
NF-{{kappa}}B/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells.
A. L. Mora, J. Youn, A. D. Keegan, and M. Boothby (2001)
J. Immunol. 166, 2218-2227
   Abstract »    Full Text »    PDF »
Fes Mediates the IL-4 Activation of Insulin Receptor Substrate-2 and Cellular Proliferation.
H. Jiang, K. Foltenyi, M. Kashiwada, L. Donahue, B. Vuong, B. Hehn, and P. Rothman (2001)
J. Immunol. 166, 2627-2634
   Abstract »    Full Text »    PDF »
Activation of the Mouse Ig Germline {{epsilon}} Promoter by IL-4 Is Dependent on AP-1 Transcription Factors.
C.-H. Shen and J. Stavnezer (2001)
J. Immunol. 166, 411-423
   Abstract »    Full Text »    PDF »
IL-4-Activated STAT-6 Inhibits IFN-{gamma}-Induced CD40 Gene Expression in Macrophages/Microglia.
V. T. Nguyen and E. N. Benveniste (2000)
J. Immunol. 165, 6235-6243
   Abstract »    Full Text »    PDF »
IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells.
L. H. Wei, A. T. Jacobs, S. M. Morris Jr., and L. J. Ignarro (2000)
Am J Physiol Cell Physiol 279, C248-C256
   Abstract »    Full Text »    PDF »
Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
L. H. Wang, R. A. Kirken, X. Y. Yang, R. A. Erwin, L. DaSilva, C.-R. Yu, and W. L. Farrar (2000)
Blood 95, 3816-3822
   Abstract »    Full Text »    PDF »
Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma.
P-S GAO, X-Q MAO, M H ROBERTS, Y ARINOBU, M AKAIWA, T ENOMOTO, Y DAKE, M KAWAI, S SASAKI, N HAMASAKI, et al. (2000)
J. Med. Genet. 37, 380a-382
   Full Text »
Activation of the IL-4 STAT Pathway in Rheumatoid Synovium.
U. Muller-Ladner, M. Judex, W. Ballhorn, F. Kullmann, O. Distler, K. Schlottmann, R. E. Gay, J. Scholmerich, and S. Gay (2000)
J. Immunol. 164, 3894-3901
   Abstract »    Full Text »    PDF »
Interleukin-4 Mediates Cell Growth Inhibition through Activation of Stat1.
T. L.-Y. Chang, X. Peng, and X.-Y. Fu (2000)
J. Biol. Chem. 275, 10212-10217
   Abstract »    Full Text »    PDF »
Regulation of c-myc Transcription by Interleukin-2 (IL-2). IDENTIFICATION OF A NOVEL IL-2 RESPONSE ELEMENT INTERACTING WITH STAT-4.
I. Grigorieva, V. G. Grigoriev, M. K. Rowney, and R. G. Hoover (2000)
J. Biol. Chem. 275, 7343-7350
   Abstract »    Full Text »    PDF »
Multiple Signaling Pathways Mediate Interleukin-4-Induced 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Type 1 Gene Expression in Human Breast Cancer Cells.
S. Gingras, S. Côté, and J. Simard (2000)
Mol. Endocrinol. 14, 229-240
   Abstract »    Full Text »
Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6.
M. Pesu, K. Takaluoma, S. Aittomaki, A. Lagerstedt, K. Saksela, P. E. Kovanen, and O. Silvennoinen (2000)
Blood 95, 494-502
   Abstract »    Full Text »    PDF »
The Jak-Stat pathway in normal and perturbed hematopoiesis.
A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
   Full Text »    PDF »
Aluminium Hydroxide Adjuvant Initiates Strong Antigen-Specific Th2 Responses in the Absence of IL-4- or IL-13-Mediated Signaling.
J. M. Brewer, M. Conacher, C. A. Hunter, M. Mohrs, F. Brombacher, and J. Alexander (1999)
J. Immunol. 163, 6448-6454
   Abstract »    Full Text »    PDF »
Stat6-Dependent and -Independent Pathways for IL-4 Production.
M. H. Kaplan, A. L. Wurster, S. T. Smiley, and M. J. Grusby3 (1999)
J. Immunol. 163, 6536-6540
   Abstract »    Full Text »    PDF »
Activation of Eotaxin Gene Transcription by NF-{kappa}B and STAT6 in Human Airway Epithelial Cells.
S. Matsukura, C. Stellato, J. R. Plitt, C. Bickel, K. Miura, S. N. Georas, V. Casolaro, and R. P. Schleimer (1999)
J. Immunol. 163, 6876-6883
   Abstract »    Full Text »    PDF »
Paired Stat6 C-Terminal Transcription Activation Domains Required Both for Inhibition of an IFN-Responsive Promoter and Trans-Activation.
S. Goenka, J. Youn, L. M. Dzurek, U. Schindler, L.-y. Yu-Lee, and M. Boothby (1999)
J. Immunol. 163, 4663-4672
   Abstract »    Full Text »    PDF »
Genetic Evidence for Lyn as a Negative Regulator of IL-4 Signaling.
M. L. Janas, P. Hodgkin, M. Hibbs, and D. Tarlinton (1999)
J. Immunol. 163, 4192-4198
   Abstract »    Full Text »    PDF »
Functional Synergism of STAT6 with Either NF-{kappa}B or PU.1 to Mediate IL-4-Induced Activation of IgE Germline Gene Transcription.
A. M. Stutz and M. Woisetschlager (1999)
J. Immunol. 163, 4383-4391
   Abstract »    Full Text »    PDF »
Induction of 3{beta}-Hydroxysteroid Dehydrogenase/ Isomerase Type 1 Expression by Interleukin-4 in Human Normal Prostate Epithelial Cells, Immortalized Keratinocytes, Colon, and Cervix Cancer Cell Lines.
S. Gingras and J. Simard (1999)
Endocrinology 140, 4573-4584
   Abstract »    Full Text »
IFN-{alpha} Activates Stat6 and Leads to the Formation of Stat2:Stat6 Complexes in B Cells.
S. Gupta, M. Jiang, and A. B. Pernis (1999)
J. Immunol. 163, 3834-3841
   Abstract »    Full Text »    PDF »
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.
H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly (1999)
PNAS 96, 10800-10805
   Abstract »    Full Text »    PDF »
BCL-6-Deficient Mice Reveal an IL-4-Independent, STAT6-Dependent Pathway That Controls Susceptibility to Infection by Leishmania major.
A. L. Dent, T. M. Doherty, W. E. Paul, A. Sher, and L. M. Staudt (1999)
J. Immunol. 163, 2098-2103
   Abstract »    Full Text »    PDF »
STAT6-Deficient Mice Exhibit Normal Induction of Murine AIDS and Expression of Immunoglobulin E following Infection with LP-BM5 Murine Leukemia Viruses.
H. C. Morse III, T. McCarty, N. A. Giese, L. Taddesse-Heath, and M. J. Grusby (1999)
J. Virol. 73, 7093-7095
   Abstract »    Full Text »
Altered Memory T Cell Differentiation in Patients with Early Rheumatoid Arthritis.
A. Skapenko, J. Wendler, P. E. Lipsky, J. R. Kalden, and H. Schulze-Koops (1999)
J. Immunol. 163, 491-499
   Abstract »    Full Text »    PDF »
Functional Roles of STAT Family Proteins: Lessons from Knockout Mice.
S. Akira (1999)
Stem Cells 17, 138-146
   Abstract »    Full Text »
Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function.
L. H. Milocco, J. A. Haslam, J. Rosen, and H. M. Seidel (1999)
Mol. Cell. Biol. 19, 2913-2920
   Abstract »    Full Text »    PDF »
Repression of IL-4-Induced Gene Expression by IFN-{gamma} Requires Stat1 Activation.
C. Venkataraman, S. Leung, A. Salvekar, H. Mano, and U. Schindler (1999)
J. Immunol. 162, 4053-4061
   Abstract »    Full Text »    PDF »
Interleukin-12 Induces Expression of Interferon Regulatory Factor-1 via Signal Transducer and Activator of Transcription-4 in Human T Helper Type 1 Cells.
E. M. Coccia, N. Passini, A. Battistini, C. Pini, F. Sinigaglia, and L. Rogge (1999)
J. Biol. Chem. 274, 6698-6703
   Abstract »    Full Text »    PDF »
IL-4 Preferentially Activates a Novel STAT6 Isoform in Mast Cells.
M. A. Sherman, V. H. Secor, and M. A. Brown (1999)
J. Immunol. 162, 2703-2708
   Abstract »    Full Text »    PDF »
IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3'-Kinase, and Grb2.
M. Gadina, C. Sudarshan, and J. J. O'Shea (1999)
J. Immunol. 162, 2081-2086
   Abstract »    Full Text »    PDF »
Identification of a STAT4 Binding Site in the Interleukin-12 Receptor Required for Signaling.
L. K. Naeger, J. McKinney, A. Salvekar, and T. Hoey (1999)
J. Biol. Chem. 274, 1875-1878
   Abstract »    Full Text »    PDF »
Induction of 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Type 1 Gene Transcription in Human Breast Cancer Cell Lines and in Normal Mammary Epithelial Cells by Interleukin-4 and Interleukin-13.
S. Gingras, R. Moriggl, B. Groner, and J. Simard (1999)
Mol. Endocrinol. 13, 66-81
   Abstract »    Full Text »
The PTK-STAT Signaling Pathway Has Essential Roles in T-cell Activation in Response to Antigen Stimulation.
T. WELTE, D. LEITENBERG, B.N. DITTEL, B.K. AL-RAMADI, W.R. HANSEN, B. XIE, C.A. JANEWAY, A.L.M. BOTHWELL, K. BOTTOMLY, and X.Y. FU (1999)
Cold Spring Harb Symp Quant Biol 64, 291-302
   Abstract »    PDF »
Presence or Absence of TGF-{beta} Determines IL-4-Induced Generation of Type 1 or Type 2 CD8 T Cell Subsets.
F. Erard, J. A. Garcia-Sanz, R. Moriggl, and M.-T. Wild (1999)
J. Immunol. 162, 209-214
   Abstract »    Full Text »    PDF »
Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor.
A. Chakraborty, K. F. Dyer, M. Cascio, T. A. Mietzner, and D. J. Tweardy (1999)
Blood 93, 15-24
   Abstract »    Full Text »    PDF »
Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration.
A. C. Ward, M. H.A. Hermans, L. Smith, Y. M. van Aesch, A. M. Schelen, C. Antonissen, and I. P. Touw (1999)
Blood 93, 113-124
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction.
S. J. Haque, P. Harbor, M. Tabrizi, T. Yi, and B. R. G. Williams (1998)
J. Biol. Chem. 273, 33893-33896
   Abstract »    Full Text »    PDF »
The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs.
L. Rogge, D. D'Ambrosio, M. Biffi, G. Penna, L. J. Minetti, D. H. Presky, L. Adorini, and F. Sinigaglia (1998)
J. Immunol. 161, 6567-6574
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)