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Science 9 September 1994:
Vol. 265. no. 5178, pp. 1573 - 1577
DOI: 10.1126/science.8079170
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Articles

Science, Vol 265, Issue 5178, 1573-1577
Copyright © 1994 by American Association for the Advancement of Science

articles

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

EW Scott, MC Simon, J Anastasi, and H Singh

Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, IL 60637.

The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.


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   Abstract »    Full Text »    PDF »
Enforced Expression of PU.1 Rescues Osteoclastogenesis from Embryonic Stem Cells Lacking Tal-1.
M. Tsuneto, A. Tominaga, H. Yamazaki, M. Yoshino, S. H. Orkin, and S.-I. Hayashi (2005)
Stem Cells 23, 134-143
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The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells.
H.-G. Kim, C. G. de Guzman, C. S. Swindle, C. V. Cotta, L. Gartland, E. W. Scott, and C. A. Klug (2004)
Blood 104, 3894-3900
   Abstract »    Full Text »    PDF »
The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development.
R. Schotte, M. Nagasawa, K. Weijer, H. Spits, and B. Blom (2004)
J. Exp. Med. 200, 1503-1509
   Abstract »    Full Text »    PDF »
PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.
W. D. Cook, B. J. McCaw, C. Herring, D. L. John, S. J. Foote, S. L. Nutt, and J. M. Adams (2004)
Blood 104, 3437-3444
   Abstract »    Full Text »    PDF »
Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression.
A. Ushmorov, O. Ritz, M. Hummel, F. Leithauser, P. Moller, H. Stein, and T. Wirth (2004)
Blood 104, 3326-3334
   Abstract »    Full Text »    PDF »
Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells.
M. Witcher, H. Y. Shiu, Q. Guo, and W. H. Miller Jr (2004)
Blood 104, 3335-3342
   Abstract »    Full Text »    PDF »
Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.
P. C. Hollenhorst, D. A. Jones, and B. J. Graves (2004)
Nucleic Acids Res. 32, 5693-5702
   Abstract »    Full Text »    PDF »
PAX5 Expression in Acute Leukemias: Higher B-Lineage Specificity Than CD79a and Selective Association with t(8;21)-Acute Myelogenous Leukemia.
E. Tiacci, S. Pileri, A. Orleth, R. Pacini, A. Tabarrini, F. Frenguelli, A. Liso, D. Diverio, F. Lo-Coco, and B. Falini (2004)
Cancer Res. 64, 7399-7404
   Abstract »    Full Text »    PDF »
The pu.1 promoter drives myeloid gene expression in zebrafish.
K. Hsu, D. Traver, J. L. Kutok, A. Hagen, T.-X. Liu, B. H. Paw, J. Rhodes, J. N. Berman, L. I. Zon, J. P. Kanki, et al. (2004)
Blood 104, 1291-1297
   Abstract »    Full Text »    PDF »
From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8{alpha}- dendritic cell development.
S. Suzuki, K. Honma, T. Matsuyama, K. Suzuki, K. Toriyama, I. Akitoyo, K. Yamamoto, T. Suematsu, M. Nakamura, K. Yui, et al. (2004)
PNAS 101, 8981-8986
   Abstract »    Full Text »    PDF »
The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15Ink4b in murine myeloid cells.
M. Schmidt, J. Bies, T. Tamura, K. Ozato, and L. Wolff (2004)
Blood 103, 4142-4149
   Abstract »    Full Text »    PDF »
pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.
F. Rosenbauer, K. Wagner, P. Zhang, K.-P. Knobeloch, A. Iwama, and D. G. Tenen (2004)
Blood 103, 4294-4301
   Abstract »    Full Text »    PDF »
Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a Cartilaginous Fish.
M. K. Anderson, R. Pant, A. L. Miracle, X. Sun, C. A. Luer, C. J. Walsh, J. C. Telfer, G. W. Litman, and E. V. Rothenberg (2004)
J. Immunol. 172, 5851-5860
   Abstract »    Full Text »    PDF »
PU.1 determines the self-renewal capacity of erythroid progenitor cells.
J. Back, A. Dierich, C. Bronn, P. Kastner, and S. Chan (2004)
Blood 103, 3615-3623
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Mouse {micro} Opioid Receptor Gene by PU.1.
C. K. Hwang, C. S. Kim, H. S. Choi, S. R. McKercher, and H. H. Loh (2004)
J. Biol. Chem. 279, 19764-19774
   Abstract »    Full Text »    PDF »


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