Science 9 September 1994: Vol. 265. no. 5178, pp. 1573 - 1577 DOI: 10.1126/science.8079170

Prev | Table of Contents | Next

Articles

c-Myb Is Required for Pro-B Cell Differentiation.

S. P. Fahl, R. B. Crittenden, D. Allman, and T. P. Bender (2009)
J. Immunol. 183, 5582-5592
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 Regulates Positive Regulatory Domain I-Binding Factor 1/Blimp-1 Transcription in Lymphoma Cells.

S. Desai, S. C. E. Bolick, M. Maurin, and K. L. Wright (2009)
J. Immunol. 183, 5778-5787
 |  Abstract »  |  Full Text »  |  PDF »

Developmental trajectories in early hematopoiesis.

C. Murre (2009)
Genes & Dev. 23, 2366-2370
 |  Abstract »  |  Full Text »  |  PDF »

Bone Marrow Angiotensin AT1 Receptor Regulates Differentiation of Monocyte Lineage Progenitors From Hematopoietic Stem Cells.

Y. Tsubakimoto, H. Yamada, H. Yokoi, S. Kishida, H. Takata, H. Kawahito, A. Matsui, N. Urao, Y. Nozawa, H. Hirai, et al. (2009)
Arterioscler Thromb Vasc Biol 29, 1529-1536
 |  Abstract »  |  Full Text »  |  PDF »

M-CSF elevates c-Fos and phospho-C/EBP{alpha}(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification.

G. D. Jack, L. Zhang, and A. D. Friedman (2009)
Blood 114, 2172-2180
 |  Abstract »  |  Full Text »  |  PDF »

Opening act in a hematopoietic program.

E. Dzierzak (2009)
Blood 114, 229-230
 |  Full Text »  |  PDF »

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.

M. Hoogenkamp, M. Lichtinger, H. Krysinska, C. Lancrin, D. Clarke, A. Williamson, L. Mazzarella, R. Ingram, H. Jorgensen, A. Fisher, et al. (2009)
Blood 114, 299-309
 |  Abstract »  |  Full Text »  |  PDF »

Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-{gamma}.

T. Ito, C. Nishiyama, N. Nakano, M. Nishiyama, Y. Usui, K. Takeda, S. Kanada, K. Fukuyama, H. Akiba, T. Tokura, et al. (2009)
Int. Immunol. 21, 803-816
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-dependent interaction between PU.1 and cJun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.

M. Joo, M. Kwon, Y.-J. Cho, N. Hu, T. V. Pedchenko, R. T. Sadikot, T. S. Blackwell, and J. W. Christman (2009)
Am J Physiol Lung Cell Mol Physiol 296, L771-L779
 |  Abstract »  |  Full Text »  |  PDF »

Shhh! Silencing by microRNA-155.

G. Teng and F. N. Papavasiliou (2009)
Phil Trans R Soc B 364, 631-637
 |  Abstract »  |  Full Text »  |  PDF »

Blimp-1/PRDM1 Mediates Transcriptional Suppression of the NLR Gene NLRP12/Monarch-1.

C. A. Lord, D. Savitsky, R. Sitcheran, K. Calame, J. R. Wright, J. P.-Y. Ting, and K. L. Williams (2009)
J. Immunol. 182, 2948-2958
 |  Abstract »  |  Full Text »  |  PDF »

EVI1 Impairs Myelopoiesis by Deregulation of PU.1 Function.

L. Laricchia-Robbio, K. Premanand, C. R. Rinaldi, and G. Nucifora (2009)
Cancer Res. 69, 1633-1642
 |  Abstract »  |  Full Text »  |  PDF »

E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.

C. L. Semerad, E. M. Mercer, M. A. Inlay, I. L. Weissman, and C. Murre (2009)
PNAS 106, 1930-1935
 |  Abstract »  |  Full Text »  |  PDF »

Myeloid-Specific Expression of Api6/AIM/Sp{alpha} Induces Systemic Inflammation and Adenocarcinoma in the Lung.

P. Qu, H. Du, Y. Li, and C. Yan (2009)
J. Immunol. 182, 1648-1659
 |  Abstract »  |  Full Text »  |  PDF »

IRF8 regulates B-cell lineage specification, commitment, and differentiation.

H. Wang, C. H. Lee, C. Qi, P. Tailor, J. Feng, S. Abbasi, T. Atsumi, and H. C. Morse III (2008)
Blood 112, 4028-4038
 |  Abstract »  |  Full Text »  |  PDF »

spib is required for primitive myeloid development in Xenopus.

R. M. B. Costa, X. Soto, Y. Chen, A. M. Zorn, and E. Amaya (2008)
Blood 112, 2287-2296
 |  Abstract »  |  Full Text »  |  PDF »

PU.1, a Shared Transcriptional Regulator of Innate and Adaptive Immune Cell Fates.

H. Singh (2008)
J. Immunol. 181, 1595-1596
 |  Full Text »  |  PDF »

Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation.

F. Wang and Q. Tong (2008)
Am J Physiol Cell Physiol 295, C213-C220
 |  Abstract »  |  Full Text »  |  PDF »

Osteoimmunology: Interactions of the Bone and Immune System.

J. Lorenzo, M. Horowitz, and Y. Choi (2008)
Endocr. Rev. 29, 403-440
 |  Abstract »  |  Full Text »  |  PDF »

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.

X. Zhao, V. Jankovic, A. Gural, G. Huang, A. Pardanani, S. Menendez, J. Zhang, R. Dunne, A. Xiao, H. Erdjument-Bromage, et al. (2008)
Genes & Dev. 22, 640-653
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

J. Seita, M. Asakawa, J. Ooehara, S.-i. Takayanagi, Y. Morita, N. Watanabe, K. Fujita, M. Kudo, J. Mizuguchi, H. Ema, et al. (2008)
Blood 111, 1903-1912
 |  Abstract »  |  Full Text »  |  PDF »

The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation.

A. Rosa, M. Ballarino, A. Sorrentino, O. Sthandier, F. G. De Angelis, M. Marchioni, B. Masella, A. Guarini, A. Fatica, C. Peschle, et al. (2007)
PNAS 104, 19849-19854
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation.

M. B. Miranda, R. L. Redner, and D. E. Johnson (2007)
Mol. Cancer Ther. 6, 3081-3090
 |  Abstract »  |  Full Text »  |  PDF »

The Pu.1 Locus Is Differentially Regulated at the Level of Chromatin Structure and Noncoding Transcription by Alternate Mechanisms at Distinct Developmental Stages of Hematopoiesis.

M. Hoogenkamp, H. Krysinska, R. Ingram, G. Huang, R. Barlow, D. Clarke, A. Ebralidze, P. Zhang, H. Tagoh, P. N. Cockerill, et al. (2007)
Mol. Cell. Biol. 27, 7425-7438
 |  Abstract »  |  Full Text »  |  PDF »

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1.

J. A. F. Marteijn, L. T. van der Meer, L. van Emst, S. van Reijmersdal, W. Wissink, T. de Witte, J. H. Jansen, and B. A. Van der Reijden (2007)
Blood 110, 3128-3135
 |  Abstract »  |  Full Text »  |  PDF »

C/EBP{alpha} binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.

C. Yeamans, D. Wang, I. Paz-Priel, B. E. Torbett, D. G. Tenen, and A. D. Friedman (2007)
Blood 110, 3136-3142
 |  Abstract »  |  Full Text »  |  PDF »

Reprogramming Leukemia Cells to Terminal Differentiation and Growth Arrest by RNA Interference of PU.1.

M. Papetti and A. I. Skoultchi (2007)
Mol. Cancer Res. 5, 1053-1062
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse.

B. T. Spike, B. C. Dibling, and K. F. Macleod (2007)
Blood 110, 2173-2181
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor PU.1 Controls Transcription Start Site Positioning and Alternative TLR4 Promoter Usage.

M. Lichtinger, R. Ingram, M. Hornef, C. Bonifer, and M. Rehli (2007)
J. Biol. Chem. 282, 26874-26883
 |  Abstract »  |  Full Text »  |  PDF »

PML-Retinoic Acid Receptor {alpha} Inhibits PML IV Enhancement of PU.1-Induced C/EBP{varepsilon} Expression in Myeloid Differentiation.

H. Yoshida, H. Ichikawa, Y. Tagata, T. Katsumoto, K. Ohnishi, Y. Akao, T. Naoe, P. P. Pandolfi, and I. Kitabayashi (2007)
Mol. Cell. Biol. 27, 5819-5834
 |  Abstract »  |  Full Text »  |  PDF »

CCAAT Enhancer-binding Protein beta Regulates Constitutive Gene Expression during Late Stages of Monocyte to Macrophage Differentiation.

T.-H. Pham, S. Langmann, L. Schwarzfischer, C. El Chartouni, M. Lichtinger, M. Klug, S. W. Krause, and M. Rehli (2007)
J. Biol. Chem. 282, 21924-21933
 |  Abstract »  |  Full Text »  |  PDF »

Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function.

X. Dai, Y. Chen, L. Di, A. Podd, G. Li, K. D. Bunting, L. Hennighausen, R. Wen, and D. Wang (2007)
J. Immunol. 179, 1068-1079
 |  Abstract »  |  Full Text »  |  PDF »

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.

R. T. Sasmono, A. Ehrnsperger, S. L. Cronau, T. Ravasi, R. Kandane, M. J. Hickey, A. D. Cook, S. R. Himes, J. A. Hamilton, and D. A. Hume (2007)
J. Leukoc. Biol. 82, 111-123
 |  Abstract »  |  Full Text »  |  PDF »

Eos, MITF, and PU.1 Recruit Corepressors to Osteoclast-Specific Genes in Committed Myeloid Progenitors.

R. Hu, S. M. Sharma, A. Bronisz, R. Srinivasan, U. Sankar, and M. C. Ostrowski (2007)
Mol. Cell. Biol. 27, 4018-4027
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun Homodimers Can Function as a Context-Specific Coactivator.

B. Grondin, M. Lefrancois, M. Tremblay, M. Saint-Denis, A. Haman, K. Waga, A. Bedard, D. G. Tenen, and T. Hoang (2007)
Mol. Cell. Biol. 27, 2919-2933
 |  Abstract »  |  Full Text »  |  PDF »

The Transcriptional Repressor GFI-1 Antagonizes PU.1 Activity through Protein-Protein Interaction.

R. Dahl, S. R. Iyer, K. S. Owens, D. D. Cuylear, and M. C. Simon (2007)
J. Biol. Chem. 282, 6473-6483
 |  Abstract »  |  Full Text »  |  PDF »

PU.1, Interferon Regulatory Factor (IRF) 2, and the Interferon Consensus Sequence-binding Protein (ICSBP/IRF8) Cooperate to Activate NF1 Transcription in Differentiating Myeloid Cells.

W. Huang, E. Horvath, and E. A. Eklund (2007)
J. Biol. Chem. 282, 6629-6643
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 Activates Transcription of SHP-1 Gene in Hematopoietic Cells.

P. Wlodarski, Q. Zhang, X. Liu, M. Kasprzycka, M. Marzec, and M. A. Wasik (2007)
J. Biol. Chem. 282, 6316-6323
 |  Abstract »  |  Full Text »  |  PDF »

A Two-Step, PU.1-Dependent Mechanism for Developmentally Regulated Chromatin Remodeling and Transcription of the c-fms Gene.

H. Krysinska, M. Hoogenkamp, R. Ingram, N. Wilson, H. Tagoh, P. Laslo, H. Singh, and C. Bonifer (2007)
Mol. Cell. Biol. 27, 878-887
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5.

S. Roessler, I. Gyory, S. Imhof, M. Spivakov, R. R. Williams, M. Busslinger, A. G. Fisher, and R. Grosschedl (2007)
Mol. Cell. Biol. 27, 579-594
 |  Abstract »  |  Full Text »  |  PDF »

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes.

J. A. F. Marteijn, L. T. van der Meer, L. Van Emst, T. de Witte, J. H. Jansen, and B. A. van der Reijden (2007)
Blood 109, 100-108
 |  Abstract »  |  Full Text »  |  PDF »

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages..

H. Iwasaki, S.-i. Mizuno, Y. Arinobu, H. Ozawa, Y. Mori, H. Shigematsu, K. Takatsu, D. G. Tenen, and K. Akashi (2006)
Genes & Dev. 20, 3010-3021
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1.

C. W. Liew, K. D. Rand, R. J. Y. Simpson, W. W. Yung, R. E. Mansfield, M. Crossley, M. Proetorius-Ibba, C. Nerlov, F. M. Poulsen, and J. P. Mackay (2006)
J. Biol. Chem. 281, 28296-28306
 |  Abstract »  |  Full Text »  |  PDF »

Fetal spleen stroma drives macrophage commitment.

J. Y. Bertrand, G. E. Desanti, R. Lo-Man, C. Leclerc, A. Cumano, and R. Golub (2006)
Development 133, 3619-3628
 |  Abstract »  |  Full Text »  |  PDF »

The {alpha} Subunit of the Granulocyte-Macrophage Colony-stimulating Factor Receptor Interacts with c-Kit and Inhibits c-Kit Signaling.

J. Chen, J. M. Carcamo, and D. W. Golde (2006)
J. Biol. Chem. 281, 22421-22426
 |  Abstract »  |  Full Text »  |  PDF »

Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.

H. Sakamoto, G. Dai, K. Tsujino, K. Hashimoto, X. Huang, T. Fujimoto, M. Mucenski, J. Frampton, and M. Ogawa (2006)
Blood 108, 896-903
 |  Abstract »  |  Full Text »  |  PDF »

Interferon Regulatory Factor 8 Regulates RANTES Gene Transcription in Cooperation with Interferon Regulatory Factor-1, NF-{kappa}B, and PU.1.

J. Liu and X. Ma (2006)
J. Biol. Chem. 281, 19188-19195
 |  Abstract »  |  Full Text »  |  PDF »

Coordination of erythropoiesis by the transcription factor c-Myb.

A. Vegiopoulos, P. Garcia, N. Emambokus, and J. Frampton (2006)
Blood 107, 4703-4710
 |  Abstract »  |  Full Text »  |  PDF »

T-cell protein tyrosine phosphatase (tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation..

P. D. Simoncic, A. Bourdeau, A. Lee-Loy, L. R. Rohrschneider, M. L. Tremblay, E. R. Stanley, and C. J. McGlade (2006)
Mol. Cell. Biol. 26, 4149-4160
 |  Abstract »  |  Full Text »  |  PDF »

MOZ is essential for maintenance of hematopoietic stem cells..

T. Katsumoto, Y. Aikawa, A. Iwama, S. Ueda, H. Ichikawa, T. Ochiya, and I. Kitabayashi (2006)
Genes & Dev. 20, 1321-1330
 |  Abstract »  |  Full Text »  |  PDF »

Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors.

R. F. de Pooter, T. M. Schmitt, J. L. de la Pompa, Y. Fujiwara, S. H. Orkin, and J. C. Zuniga-Pflucker (2006)
J. Immunol. 176, 5267-5275
 |  Abstract »  |  Full Text »  |  PDF »

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.

B. U. Mueller, T. Pabst, J. Fos, V. Petkovic, M. F. Fey, N. Asou, U. Buergi, and D. G. Tenen (2006)
Blood 107, 3330-3338
 |  Abstract »  |  Full Text »  |  PDF »

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1.

G. Anderson, M. Gries, N. Kurihara, T. Honjo, J. Anderson, V. Donnenberg, A. Donnenberg, I. Ghobrial, M. Y. Mapara, D. Stirling, et al. (2006)
Blood 107, 3098-3105
 |  Abstract »  |  Full Text »  |  PDF »

Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs.

S. Appel, A. Bringmann, F. Grunebach, M. M. Weck, J. Bauer, and P. Brossart (2006)
Blood 107, 3265-3270
 |  Abstract »  |  Full Text »  |  PDF »

Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation.

J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al. (2006)
Blood 107, 2686-2693
 |  Abstract »  |  Full Text »  |  PDF »

Multipotential differentiation ability of GATA-1-null erythroid-committed cells..

K. Kitajima, J. Zheng, H. Yen, D. Sugiyama, and T. Nakano (2006)
Genes & Dev. 20, 654-659
 |  Abstract »  |  Full Text »  |  PDF »

TLS, EWS and TAF15: a model for transcriptional integration of gene expression.

W. J. Law, K. L. Cann, and G. G. Hicks (2006)
Brief Funct Genomic Proteomic 5, 8-14
 |  Abstract »  |  Full Text »  |  PDF »

Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment.

L. X. Heinz, B. Platzer, P. M. Reisner, A. Jorgl, S. Taschner, F. Gobel, and H. Strobl (2006)
Blood 107, 1445-1453
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.

D. Metcalf, A. Dakic, S. Mifsud, L. Di Rago, L. Wu, and S. Nutt (2006)
PNAS 103, 1486-1491
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 Regulates Cathepsin S Expression in Professional APCs.

Y. Wang, R. M. Baron, G. Zhu, M. Joo, J. W. Christman, E. S. Silverman, M. A. Perrella, R. J. Riese, and M. Cernadas (2006)
J. Immunol. 176, 275-283
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-Specific Genetic Lesions and Their Influence on Therapy in Pediatric Acute Lymphoblastic Leukemia.

J. R. Downing and C. G. Mullighan (2006)
Hematology 2006, 118-122
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch.

M. Ye, O. Ermakova, and T. Graf (2005)
J. Exp. Med. 202, 1411-1422
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Immunoglobulin Transcription Factors in Primary Intraocular Lymphoma and Primary Central Nervous System Lymphoma.

S. E. Coupland, C. Loddenkemper, J. R. Smith, R. M. Braziel, F. Charlotte, I. Anagnostopoulos, and H. Stein (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3957-3964
 |  Abstract »  |  Full Text »  |  PDF »

Ig Gene Rearrangement Steps Are Initiated in Early Human Precursor B Cell Subsets and Correlate with Specific Transcription Factor Expression.

M. C. van Zelm, M. van der Burg, D. de Ridder, B. H. Barendregt, E. F. E. de Haas, M. J. T. Reinders, A. C. Lankester, T. Revesz, F. J. T. Staal, and J. J. M. van Dongen (2005)
J. Immunol. 175, 5912-5922
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome.

A. Sternberg, S. Killick, T. Littlewood, C. Hatton, A. Peniket, T. Seidl, S. Soneji, J. Leach, D. Bowen, C. Chapman, et al. (2005)
Blood 106, 2982-2991
 |  Abstract »  |  Full Text »  |  PDF »

Protein Acetylation Regulates Both PU.1 Transactivation and Ig{kappa} 3' Enhancer Activity.

Y. Bai, L. Srinivasan, L. Perkins, and M. L. Atchison (2005)
J. Immunol. 175, 5160-5169
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 Regulates the Tissue-specific Expression of Dendritic Cell-specific Intercellular Adhesion Molecule (ICAM)-3-grabbing Nonintegrin.

A. Dominguez-Soto, A. Puig-Kroger, M. A. Vega, and A. L. Corbi (2005)
J. Biol. Chem. 280, 33123-33131
 |  Abstract »  |  Full Text »  |  PDF »

The development of functional B lymphocytes in conditional PU.1 knock-out mice.

M. Polli, A. Dakic, A. Light, L. Wu, D. M. Tarlinton, and S. L. Nutt (2005)
Blood 106, 2083-2090
 |  Abstract »  |  Full Text »  |  PDF »

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.

K. Maki, T. Yamagata, T. Asai, I. Yamazaki, H. Oda, H. Hirai, and K. Mitani (2005)
Blood 106, 2147-2155
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profiling of 17{beta}-Estradiol and Genistein Effects on Mouse Thymus.

V. Selvaraj, D. Bunick, C. Finnigan-Bunick, R. W. Johnson, H. Wang, L. Liu, and P. S. Cooke (2005)
Toxicol. Sci. 87, 97-112
 |  Abstract »  |  Full Text »  |  PDF »

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

H. Iwasaki, C. Somoza, H. Shigematsu, E. A. Duprez, J. Iwasaki-Arai, S.-i. Mizuno, Y. Arinobu, K. Geary, P. Zhang, T. Dayaram, et al. (2005)
Blood 106, 1590-1600
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.

E. Le Scolan, D. Pchejetski, Y. Banno, N. Denis, P. Mayeux, W. Vainchenker, T. Levade, and F. Moreau-Gachelin (2005)
Blood 106, 1808-1816
 |  Abstract »  |  Full Text »  |  PDF »

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RAR{alpha}.

M. J. Walter, J. S. Park, R. E. Ries, S. K. M. Lau, M. McLellan, S. Jaeger, R. K. Wilson, E. R. Mardis, and T. J. Ley (2005)
PNAS 102, 12513-12518
 |  Abstract »  |  Full Text »  |  PDF »

From The Cover: Identification of mast cell progenitors in adult mice.

C.-C. Chen, M. A. Grimbaldeston, M. Tsai, I. L. Weissman, and S. J. Galli (2005)
PNAS 102, 11408-11413
 |  Abstract »  |  Full Text »  |  PDF »

Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.

V. Goffin, D. Demonte, C. Vanhulle, S. de Walque, Y. de Launoit, A. Burny, Y. Collette, and C. Van Lint (2005)
Nucleic Acids Res. 33, 4285-4310
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of CD1D1 by Ets Family Transcription Factors.

Y. Geng, P. Laslo, K. Barton, and C.-R. Wang (2005)
J. Immunol. 175, 1022-1029
 |  Abstract »  |  Full Text »  |  PDF »

Loss of C/EBP{alpha} cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

B. T. Porse, D. Bryder, K. Theilgaard-Monch, M. S. Hasemann, K. Anderson, I. Damgaard, S. E. W. Jacobsen, and C. Nerlov (2005)
J. Exp. Med. 202, 85-96
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of the Mouse IL-7 Receptor {alpha} Promoter by Glucocorticoid Receptor.

H.-C. Lee, H. Shibata, S. Ogawa, K. Maki, and K. Ikuta (2005)
J. Immunol. 174, 7800-7806
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.

A. Dakic, D. Metcalf, L. Di Rago, S. Mifsud, L. Wu, and S. L. Nutt (2005)
J. Exp. Med. 201, 1487-1502
 |  Abstract »  |  Full Text »  |  PDF »

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

T. N. Taghon, E.-S. David, J. C. Zuniga-Pflucker, and E. V. Rothenberg (2005)
Genes & Dev. 19, 965-978
 |  Abstract »  |  Full Text »  |  PDF »

Gene Regulatory Networks Special Feature: Contingent gene regulatory networks and B cell fate specification.

H. Singh, K. L. Medina, and J. M. R. Pongubala (2005)
PNAS 102, 4949-4953
 |  Abstract »  |  Full Text »  |  PDF »

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element.

Y. Okuno, G. Huang, F. Rosenbauer, E. K. Evans, H. S. Radomska, H. Iwasaki, K. Akashi, F. Moreau-Gachelin, Y. Li, P. Zhang, et al. (2005)
Mol. Cell. Biol. 25, 2832-2845
 |  Abstract »  |  Full Text »  |  PDF »

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.

Y. Bakri, S. Sarrazin, U. P. Mayer, S. Tillmanns, C. Nerlov, A. Boned, and M. H. Sieweke (2005)
Blood 105, 2707-2716
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation.

J. F. Cailhier, M. Partolina, S. Vuthoori, S. Wu, K. Ko, S. Watson, J. Savill, J. Hughes, and R. A. Lang (2005)
J. Immunol. 174, 2336-2342
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors.

S. L. Nutt, D. Metcalf, A. D'Amico, M. Polli, and L. Wu (2005)
J. Exp. Med. 201, 221-231
 |  Abstract »  |  Full Text »  |  PDF »

Mast Cells Acquire Monocyte-Specific Gene Expression and Monocyte-Like Morphology by Overproduction of PU.1.

T. Ito, C. Nishiyama, M. Nishiyama, H. Matsuda, K. Maeda, Y. Akizawa, R. Tsuboi, K. Okumura, and H. Ogawa (2005)
J. Immunol. 174, 376-383
 |  Abstract »  |  Full Text »  |  PDF »

The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells.

H.-G. Kim, C. G. de Guzman, C. S. Swindle, C. V. Cotta, L. Gartland, E. W. Scott, and C. A. Klug (2004)
Blood 104, 3894-3900
 |  Abstract »  |  Full Text »  |  PDF »

The ETS Transcription Factor Spi-B Is Required for Human Plasmacytoid Dendritic Cell Development.

R. Schotte, M. Nagasawa, K. Weijer, H. Spits, and B. Blom (2004)
J. Exp. Med. 200, 1503-1509
 |  Abstract »  |  Full Text »  |  PDF »

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.

W. D. Cook, B. J. McCaw, C. Herring, D. L. John, S. J. Foote, S. L. Nutt, and J. M. Adams (2004)
Blood 104, 3437-3444
 |  Abstract »  |  Full Text »  |  PDF »

Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression.

A. Ushmorov, O. Ritz, M. Hummel, F. Leithauser, P. Moller, H. Stein, and T. Wirth (2004)
Blood 104, 3326-3334
 |  Abstract »  |  Full Text »  |  PDF »

Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells.

M. Witcher, H. Y. Shiu, Q. Guo, and W. H. Miller Jr (2004)
Blood 104, 3335-3342
 |  Abstract »  |  Full Text »  |  PDF »

Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.

P. C. Hollenhorst, D. A. Jones, and B. J. Graves (2004)
Nucleic Acids Res. 32, 5693-5702
 |  Abstract »  |  Full Text »  |  PDF »

PAX5 Expression in Acute Leukemias: Higher B-Lineage Specificity Than CD79a and Selective Association with t(8;21)-Acute Myelogenous Leukemia.

E. Tiacci, S. Pileri, A. Orleth, R. Pacini, A. Tabarrini, F. Frenguelli, A. Liso, D. Diverio, F. Lo-Coco, and B. Falini (2004)
Cancer Res. 64, 7399-7404
 |  Abstract »  |  Full Text »  |  PDF »

The pu.1 promoter drives myeloid gene expression in zebrafish.

K. Hsu, D. Traver, J. L. Kutok, A. Hagen, T.-X. Liu, B. H. Paw, J. Rhodes, J. N. Berman, L. I. Zon, J. P. Kanki, et al. (2004)
Blood 104, 1291-1297
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8{alpha}- dendritic cell development.

S. Suzuki, K. Honma, T. Matsuyama, K. Suzuki, K. Toriyama, I. Akitoyo, K. Yamamoto, T. Suematsu, M. Nakamura, K. Yui, et al. (2004)
PNAS 101, 8981-8986
 |  Abstract »  |  Full Text »  |  PDF »

The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15Ink4b in murine myeloid cells.

M. Schmidt, J. Bies, T. Tamura, K. Ozato, and L. Wolff (2004)
Blood 103, 4142-4149
 |  Abstract »  |  Full Text »  |  PDF »

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.

F. Rosenbauer, K. Wagner, P. Zhang, K.-P. Knobeloch, A. Iwama, and D. G. Tenen (2004)
Blood 103, 4294-4301
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products