Science 2 September 1994: Vol. 265. no. 5177, pp. 1445 - 1447 DOI: 10.1126/science.8073287

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Articles

Ligand-independent Thrombopoietin Mutant Receptor Requires Cell Surface Localization for Endogenous Activity.

C. Marty, R. Chaligne, C. Lacout, S. N. Constantinescu, W. Vainchenker, and J.-L. Villeval (2009)
J. Biol. Chem. 284, 11781-11791
 |  Abstract »  |  Full Text »  |  PDF »

Mpl and thrombocytosis: levels matter.

S. N. Constantinescu (2009)
Blood 113, 1617-1618
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Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.

B. J. Lannutti, A. Epp, J. Roy, J. Chen, and N. C. Josephson (2009)
Blood 113, 1778-1785
 |  Abstract »  |  Full Text »  |  PDF »

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.

R. Tiedt, J. Coers, S. Ziegler, A. Wiestner, H. Hao-Shen, C. Bornmann, J. Schenkel, S. Karakhanova, F. J. de Sauvage, C. W. Jackson, et al. (2009)
Blood 113, 1768-1777
 |  Abstract »  |  Full Text »  |  PDF »

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice.

M. Kauppi, J. M. Murphy, C. A. de Graaf, C. D. Hyland, K. T. Greig, D. Metcalf, A. A. Hilton, N. A. Nicola, B. T. Kile, D. J. Hilton, et al. (2008)
Blood 112, 3148-3153
 |  Abstract »  |  Full Text »  |  PDF »

The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis.

W. Nogami, H. Yoshida, K. Koizumi, H. Yamada, K. Abe, A. Arimura, N. Yamane, K. Takahashi, A. Yamane, A. Oda, et al. (2008)
Haematologica 93, 1495-1504
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-{alpha}2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes.

A. Yamane, T. Nakamura, H. Suzuki, M. Ito, Y. Ohnishi, Y. Ikeda, and Y. Miyakawa (2008)
Blood 112, 542-550
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Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

N. Takayama, H. Nishikii, J. Usui, H. Tsukui, A. Sawaguchi, T. Hiroyama, K. Eto, and H. Nakauchi (2008)
Blood 111, 5298-5306
 |  Abstract »  |  Full Text »  |  PDF »

Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.

E. Sitnicka, N. Buza-Vidas, H. Ahlenius, C. M. Cilio, C. Gekas, J. M. Nygren, R. Mansson, M. Cheng, C. T. Jensen, M. Svensson, et al. (2007)
Blood 110, 2955-2964
 |  Abstract »  |  Full Text »  |  PDF »

Dual role of Mpl receptor during the establishment of definitive hematopoiesis.

L. Petit-Cocault, C. Volle-Challier, M. Fleury, B. Peault, and M. Souyri (2007)
Development 134, 3031-3040
 |  Abstract »  |  Full Text »  |  PDF »

The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.

H. Wang, S. Cnhen, Y. Chen, H. Wang, H. Wu, H. Tang, W. Xiong, J. Ma, Y. Ge, Q. Lu, et al. (2007)
Haematologica 92, 643-650
 |  Abstract »  |  Full Text »  |  PDF »

Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells.

S. Ito, C. R. Mantel, M.-K. Han, S. Basu, S. Fukuda, S. Cooper, and H. E. Broxmeyer (2007)
Blood 109, 1923-1930
 |  Abstract »  |  Full Text »  |  PDF »

Novel insights into the pathogenesis of the graffi murine leukemia retrovirus..

V. Voisin, C. Barat, T. Hoang, and E. Rassart (2006)
J. Virol. 80, 4026-4037
 |  Abstract »  |  Full Text »  |  PDF »

Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-{alpha} and its possible role in hemophagocytic syndrome.

K. Saito, M. Hirokawa, K. Inaba, H. Fukaya, Y. Kawabata, A. Komatsuda, J. Yamashita, and K. Sawada (2006)
Blood 107, 1366-1374
 |  Abstract »  |  Full Text »  |  PDF »

Differential Amplification of Murine Bipotent Megakaryocytic/Erythroid Progenitor and Precursor Cells During Recovery from Acute and Chronic Erythroid Stress.

M. Sanchez, I. L. Weissman, M. Pallavicini, M. Valeri, P. Guglielmelli, A. M. Vannucchi, G. Migliaccio, and A. R. Migliaccio (2006)
Stem Cells 24, 337-348
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of thrombocyte development in CD41-GFP transgenic zebrafish.

H.-F. Lin, D. Traver, H. Zhu, K. Dooley, B. H. Paw, L. I. Zon, and R. I. Handin (2005)
Blood 106, 3803-3810
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Gene Transfer-Mediated Enhancement of Angiogenic Responses to Acute Ischemia.

H. Amano, N. R. Hackett, S. Rafii, and R. G. Crystal (2005)
Circ. Res. 97, 337-345
 |  Abstract »  |  Full Text »  |  PDF »

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression.

H.-G. Kopp, S. T. Avecilla, A. T. Hooper, S. V. Shmelkov, C. A. Ramos, F. Zhang, and S. Rafii (2005)
Blood 106, 505-513
 |  Abstract »  |  Full Text »  |  PDF »

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

D. Metcalf, M. R. Carpinelli, C. Hyland, S. Mifsud, L. DiRago, N. A. Nicola, D. J. Hilton, and W. S. Alexander (2005)
Blood 105, 3480-3487
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

L. Yang, D. Bryder, J. Adolfsson, J. Nygren, R. Mansson, M. Sigvardsson, and S. E. W. Jacobsen (2005)
Blood 105, 2717-2723
 |  Abstract »  |  Full Text »  |  PDF »

Lnk Inhibits Tpo-mpl Signaling and Tpo-mediated Megakaryocytopoiesis.

W. Tong and H. F. Lodish (2004)
J. Exp. Med. 200, 569-580
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors.

J. Antonchuk, C. D. Hyland, D. J. Hilton, and W. S. Alexander (2004)
Blood 104, 1306-1313
 |  Abstract »  |  Full Text »  |  PDF »

From The Cover: Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.

M. R. Carpinelli, D. J. Hilton, D. Metcalf, J. L. Antonchuk, C. D. Hyland, S. L. Mifsud, L. Di Rago, A. A. Hilton, T. A. Willson, A. W. Roberts, et al. (2004)
PNAS 101, 6553-6558
 |  Abstract »  |  Full Text »  |  PDF »

Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation.

T. Kamata, C. A. Pritchard, and A. D. Leavitt (2004)
Blood 103, 2568-2570
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis.

H. Shibayama, E. Takai, I. Matsumura, M. Kouno, E. Morii, Y. Kitamura, J. Takeda, and Y. Kanakura (2004)
J. Exp. Med. 199, 581-592
 |  Abstract »  |  Full Text »  |  PDF »

Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol.

Y. Nagata, J. Yoshikawa, A. Hashimoto, M. Yamamoto, A. H. Payne, and K. Todokoro (2003)
Genes & Dev. 17, 2864-2869
 |  Abstract »  |  Full Text »  |  PDF »

Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis.

E. Sitnicka, C. Brakebusch, I.-L. Martensson, M. Svensson, W. W. Agace, M. Sigvardsson, N. Buza-Vidas, D. Bryder, C. M.Cilio, H. Ahlenius, et al. (2003)
J. Exp. Med. 198, 1495-1506
 |  Abstract »  |  Full Text »  |  PDF »

NMDA receptor-mediated regulation of human megakaryocytopoiesis.

I. S. Hitchcock, T. M. Skerry, M. R. Howard, and P. G. Genever (2003)
Blood 102, 1254-1259
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Thrombopoietin in Hemangioblast Development.

R. C.R. Perlingeiro, M. Kyba, S. Bodie, and G. Q. Daley (2003)
Stem Cells 21, 272-280
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.

X. Xie, R. J. Chan, S. A. Johnson, M. Starr, J. McCarthy, R. Kapur, and M. C. Yoder (2003)
Blood 101, 1329-1335
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies.

D. J. Kuter and C. G. Begley (2002)
Blood 100, 3457-3469
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin as a Drug: Biologic Expectations, Clinical Realities, and Future Directions.

I. C. Haznedaroglu, H. Goker, M. Turgut, Y. Buyukasik, and M. Benekli (2002)
Clinical and Applied Thrombosis/Hemostasis 8, 193-212
 |  Abstract »  |  PDF »

The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia.

L. Teofili, F. Pierconti, A. Di Febo, N. Maggiano, N. Vianelli, S. Ascani, E. Rossi, S. Pileri, G. Leone, L. M. Larocca, et al. (2002)
Blood 100, 714-717
 |  Abstract »  |  Full Text »  |  PDF »

Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice.

K. Kaushansky, N. Fox, N. L. Lin, and W. C. Liles (2002)
Blood 99, 3573-3578
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Regulates Bcl-xL Gene Expression through Stat5 and Phosphatidylinositol 3-Kinase Activation Pathways.

K. Kirito, T. Watanabe, K.-i. Sawada, H. Endo, K. Ozawa, and N. Komatsu (2002)
J. Biol. Chem. 277, 8329-8337
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro.

M.-D. Filippi, F. Porteu, F. L. Pesteur, V. Schiavon, G. A. Millot, W. Vainchenker, F. J. de Sauvage, A. Dubart Kupperschmitt, and F. Sainteny (2002)
Blood 99, 1174-1182
 |  Abstract »  |  Full Text »  |  PDF »

Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells.

G. A. Millot, W. Vainchenker, D. Dumenil, and F. Svinarchuk (2002)
J. Cell Sci. 115, 2329-2337
 |  Abstract »  |  Full Text »  |  PDF »

Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes.

P. Angchaisuksiri, S. R. Grigus, P. L. Carlson, G. W. Krystal, and E. N. Dessypris (2002)
Blood 99, 130-136
 |  Abstract »  |  Full Text »  |  PDF »

Thrombocytopenia caused by the development of antibodies to thrombopoietin.

J. Li, C. Yang, Y. Xia, A. Bertino, J. Glaspy, M. Roberts, and D. J. Kuter (2001)
Blood 98, 3241-3248
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis.

A. Kaser, G. Brandacher, W. Steurer, S. Kaser, F. A. Offner, H. Zoller, I. Theurl, W. Widder, C. Molnar, O. Ludwiczek, et al. (2001)
Blood 98, 2720-2725
 |  Abstract »  |  Full Text »  |  PDF »

Thrombocytopenic c-mpl{-}/{-} mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response.

J. Levin, L. Cocault, C. Demerens, C. Challier, M. Pauchard, J. Caen, and M. Souyri (2001)
Blood 98, 1019-1027
 |  Abstract »  |  Full Text »  |  PDF »

Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets.

D. Traver, T. Miyamoto, J. Christensen, J. Iwasaki-Arai, K. Akashi, and I. L. Weissman (2001)
Blood 98, 627-635
 |  Abstract »  |  Full Text »  |  PDF »

Promegapoietin-1a, an Engineered Chimeric IL-3 and Mpl-L Receptor Agonist, Stimulates Hematopoietic Recovery in Conventional and Abbreviated Schedules Following Radiation-Induced Myelosuppression in Nonhuman Primates.

A. M. Farese, W. G. Smith, J. G. Giri, N. Siegel, J. P. McKearn, and T. J. MacVittie (2001)
Stem Cells 19, 329-338
 |  Abstract »  |  Full Text »  |  PDF »

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF {beta}-receptor null mice.

W. E. Kaminski, P. Lindahl, N. L. Lin, V. C. Broudy, J. R. Crosby, M. Hellstrom, B. Swolin, D. F. Bowen-Pope, P. J. Martin, R. Ross, et al. (2001)
Blood 97, 1990-1998
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl{-}/{-} mice: a new system for Mpl structure-function studies.

M. Gaur, G. J. Murphy, F. J. deSauvage, and A. D. Leavitt (2001)
Blood 97, 1653-1661
 |  Abstract »  |  Full Text »  |  PDF »

Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice.

B. D. Car and V. M. Eng (2001)
Vet. Pathol. 38, 20-30
 |  Abstract »  |  Full Text »  |  PDF »

c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia.

M. Ballmaier, M. Germeshausen, H. Schulze, K. Cherkaoui, S. Lang, A. Gaudig, S. Krukemeier, M. Eilers, G. Strau{beta}, and K. Welte (2001)
Blood 97, 139-146
 |  Abstract »  |  Full Text »  |  PDF »

Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10.

J. G. Drachman, G. P. Jarvik, and M. G. Mehaffey (2000)
Blood 96, 118-125
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice.

A. M. Vannucchi, F. Paoletti, S. Linari, C. Cellai, R. Caporale, P. R. Ferrini, M. Sanchez, G. Migliaccio, and A. R. Migliaccio (2000)
Blood 95, 2559-2568
 |  Abstract »  |  Full Text »  |  PDF »

Increased D-type Cyclin Expression Together with Decreased cdc2 Activity Confers Megakaryocytic Differentiation of a Human Thrombopoietin-dependent Hematopoietic Cell Line.

I. Matsumura, H. Tanaka, A. Kawasaki, J. Odajima, H. Daino, K. Hashimoto, H. Wakao, K. Nakajima, T. Kato, H. Miyazaki, et al. (2000)
J. Biol. Chem. 275, 5553-5559
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo.

S.-M. Luoh, E. Stefanich, G. Solar, H. Steinmetz, T. Lipari, T. I. Pestina, C. W. Jackson, and F. J. de Sauvage (2000)
Mol. Cell. Biol. 20, 507-515
 |  Abstract »  |  Full Text »

The residual megakaryocyte and platelet production in c-Mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.

T. Gainsford, H. Nandurkar, D. Metcalf, L. Robb, C. G. Begley, and W. S. Alexander (2000)
Blood 95, 528-534
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis.

P. Rojnuckarin, J. G. Drachman, and K. Kaushansky (1999)
Blood 94, 1273-1282
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Expression of Plasminogen Activator Inhibitor-1 Associated With Thrombopoietin-Dependent Megakaryocytic Differentiation.

S. Madoiwa, N. Komatsu, J. Mimuro, K. Kimura, M. Matsuda, and Y. Sakata (1999)
Blood 94, 475-482
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Stimulates Endothelial Cell Motility and Neoangiogenesis by a Platelet-Activating Factor–Dependent Mechanism.

M. F. Brizzi, E. Battaglia, G. Montrucchio, P. Dentelli, L. Del Sorbo, G. Garbarino, L. Pegoraro, and G. Camussi (1999)
Circ. Res. 84, 785-796
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Uptake of Circulating Thrombopoietin Is Increased in Immune-Mediated Compared With Irradiated Thrombocytopenic Mice.

M. Chang, J. X. Qian, S. m. Lee, J. Joubran, G. Fernandez, J. Nichols, A. Knoppel, and J. S. Buzby (1999)
Blood 93, 2515-2524
 |  Abstract »  |  Full Text »  |  PDF »

Soluble Interleukin-6 (IL-6) Receptor With IL-6 Stimulates Megakaryopoiesis From Human CD34+ Cells Through Glycoprotein (gp)130 Signaling.

X. Sui, K. Tsuji, Y. Ebihara, R. Tanaka, K. Muraoka, M. Yoshida, K. Yamada, K. Yasukawa, T. Taga, T. Kishimoto, et al. (1999)
Blood 93, 2525-2532
 |  Abstract »  |  Full Text »  |  PDF »

Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia.

K. Ihara, E. Ishii, M. Eguchi, H. Takada, A. Suminoe, R. A. Good, and T. Hara (1999)
PNAS 96, 3132-3136
 |  Abstract »  |  Full Text »  |  PDF »

Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.

R. Stoffel, S. Ziegler, N. Ghilardi, B. Ledermann, F. J. de Sauvage, and R. C. Skoda (1999)
PNAS 96, 698-702
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Production Is Inhibited by a Translational Mechanism.

N. Ghilardi, A. Wiestner, and R. C. Skoda (1998)
Blood 92, 4023-4030
 |  Abstract »  |  Full Text »  |  PDF »

The Efficacy of Recombinant Thrombopoietin in Murine and Nonhuman Primate Models for Radiation-Induced Myelosuppression and Stem Cell Transplantation.

G. Wagemaker, K. J. Neelis, S. C.C. Hartong, A. W. Wognum, G. R. Thomas, P. J. Fielder, and D. L. Eaton (1998)
Stem Cells 16, 375-386
 |  Abstract »  |  Full Text »

An Agonist Murine Monoclonal Antibody to the Human c-Mpl Receptor Stimulates Megakaryocytopoiesis.

B. Deng, N. Banu, B. Malloy, P. Hass, J. F. Wang, L. Cavacini, D. Eaton, and H. Avraham (1998)
Blood 92, 1981-1988
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin.

K. Kaushansky (1998)
N. Engl. J. Med. 339, 746-754
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The Molecular Control of Hematopoiesis: Progress and Problems with Gene Manipulation.

D. Metcalf (1998)
Stem Cells 16, 314-321
 |  Abstract »  |  Full Text »

Thrombopoietin in Patients with Hepatoblastoma.

E. Komura, T. Matsumura, T. Kato, T. Tahara, Y. Tsunoda, and T. Sawada (1998)
Stem Cells 16, 329-333
 |  Abstract »  |  Full Text »

A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow-Repopulating Cells.

K. J. Neelis, T. P. Visser, W. Dimjati, G. R. Thomas, P. J. Fielder, D. Bloedow, D. L. Eaton, and G. Wagemaker (1998)
Blood 92, 1586-1597
 |  Abstract »  |  Full Text »  |  PDF »

Familial Essential Thrombocythemia Associated With One-Base Deletion in the 5'-Untranslated Region of the Thrombopoietin Gene.

T. Kondo, M. Okabe, M. Sanada, M. Kurosawa, S. Suzuki, M. Kobayashi, M. Hosokawa, and M. Asaka (1998)
Blood 92, 1091-1096
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Promotes the Survival of Murine Hematopoietic Long-Term Reconstituting Cells: Comparison With the Effects of FLT3/FLK-2 Ligand and Interleukin-6.

T. Matsunaga, T. Kato, H. Miyazaki, and M. Ogawa (1998)
Blood 92, 452-461
 |  Abstract »  |  Full Text »  |  PDF »

Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation.

D. Metcalf (1998)
Blood 92, 345-347
 |  Full Text »  |  PDF »

Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line.

I. Matsumura, K. Nakajima, H. Wakao, S. Hattori, K. Hashimoto, H. Sugahara, T. Kato, H. Miyazaki, T. Hirano, and Y. Kanakura (1998)
Mol. Cell. Biol. 18, 4282-4290
 |  Abstract »  |  Full Text »

Role of c-mpl in Early Hematopoiesis.

G. P. Solar, W. G. Kerr, F. C. Zeigler, D. Hess, C. Donahue, F. J. de Sauvage, and D. L. Eaton (1998)
Blood 92, 4-10
 |  Abstract »  |  Full Text »  |  PDF »

Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.

M. A. Goldsmith, A. Mikami, Y. You, K. D. Liu, L. Thomas, P. Pharr, and G. D. Longmore (1998)
PNAS 95, 7006-7011
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin Requires Additional Megakaryocyte-Active Cytokines for Optimal Ex Vivo Expansion of Megakaryocyte Precursor Cells.

J. L. Williams, G. G. Pipia, N. S. Datta, and M. W. Long (1998)
Blood 91, 4118-4126
 |  Abstract »  |  Full Text »  |  PDF »

Thrombopoietin (TPO) Knockout Phenotype Induced by Cross-Reactive Antibodies Against TPO Following Injection of Mice with Recombinant Adenovirus Encoding Human TPO.

M.-A. Abina, M. Tulliez, M.-T. Duffour, N. Debili, C. Lacout, J.-L. Villeval, F. Wendling, W. Vainchenker, and H. Haddada (1998)
J. Immunol. 160, 4481-4489
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Production and Function in c-mpl-Deficient Mice: No Physiologic Role for Interleukin-3 in Residual Megakaryocyte and Platelet Production.

T. Gainsford, A. W. Roberts, S. Kimura, D. Metcalf, G. Dranoff, R. C. Mulligan, C. G. Begley, L. Robb, and W. S. Alexander (1998)
Blood 91, 2745-2752
 |  Abstract »  |  Full Text »  |  PDF »

c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities.

S. D. Lyman and S. E. W. Jacobsen (1998)
Blood 91, 1101-1134
 |  Full Text »  |  PDF »

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.

S. Kimura, A. W. Roberts, D. Metcalf, and W. S. Alexander (1998)
PNAS 95, 1195-1200
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl-Expressing UT-7 Cells.

Y. Hong, D. Dumenil, B. van der Loo, F. Goncalves, W. Vainchenker, and J. D. Erusalimsky (1998)
Blood 91, 813-822
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Cytokines on Platelet Production From Blood and Marrow CD34+ Cells.

F. Norol, N. Vitrat, E. Cramer, J. Guichard, S. A. Burstein, W. Vainchenker, and N. Debili (1998)
Blood 91, 830-843
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Effects of C-Mpl Ligand on Cytoplasmic Maturation of Murine Megakaryocytes and on Platelet Production.

Y. Ishida, T. Ito, and S.-i. Kuriya (1998)
J. Histochem. Cytochem. 46, 49-58
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Hematopoietic Deficiencies in c-mpl and TPO Knockout Mice.

M. Murone, D. A. Carpenter, and F. J. de Sauvage (1998)
Stem Cells 16, 1-6
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Markedly Reduced Expression of Platelet c-mpl Receptor in Essential Thrombocythemia.

Y. Horikawa, I. Matsumura, K. Hashimoto, M. Shiraga, S. Kosugi, S. Tadokoro, T. Kato, H. Miyazaki, Y. Tomiyama, Y. Kurata, et al. (1997)
Blood 90, 4031-4038
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Normal Platelets and Megakaryocytes Are Produced In Vivo in the Absence of Thrombopoietin.

S. Bunting, R. Widmer, T. Lipari, L. Rangell, H. Steinmetz, K. Carver-Moore, M. W. Moore, G.-A. Keller, and F. J. de Sauvage (1997)
Blood 90, 3423-3429
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Chronic Thrombocytopenia Is Induced in Dogs by Development of Cross-Reacting Antibodies to the MpL Ligand.

D. C. Dale, J. L. Nichol, D. A. Rich, D. M. Best, S. J. Slichter, W. Sheridan, and P. Hunt (1997)
Blood 90, 3456-3461
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A 2.7-kb Portion of the 5' Flanking Region of the Murine Glycoprotein alpha IIb Gene Is Transcriptionally Active in Primitive Hematopoietic Progenitor Cells.

P. Tropel, V. Roullot, M. Vernet, C. Poujol, H. Pointu, P. Nurden, G. Marguerie, and D. Tronik-Le Roux (1997)
Blood 90, 2995-3004
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Thrombopoietin Inhibits in Vitro Osteoclastogenesis from Murine Bone Marrow Cells.

T. Wakikawa, A. Shioi, M. Hino, M. Inaba, Y. Nishizawa, N. Tatsumi, H. Morii, and S. Otani (1997)
Endocrinology 138, 4160-4166
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Megakaryocyte Growth and Development Factor: A Review of Early Clinical Studies.

R. Abraham and R. L. Basser (1997)
Oncologist 2, 311-318
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The Efficacy of Single-Dose Administration of Thrombopoietin With Coadministration of Either Granulocyte/Macrophage or Granulocyte Colony-Stimulating Factor in Myelosuppressed Rhesus Monkeys.

K. J. Neelis, S. C.C. Hartong, T. Egeland, G. R. Thomas, D. L. Eaton, and G. Wagemaker (1997)
Blood 90, 2565-2573
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Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis.

H. H. Nandurkar, L. Robb, D. Tarlinton, L. Barnett, F. Kontgen, and C. G. Begley (1997)
Blood 90, 2148-2159
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In Vitro Senescence and Apoptotic Cell Death of Human Megakaryocytes.

G. Zauli, M. Vitale, E. Falcieri, D. Gibellini, A. Bassini, C. Celeghini, M. Columbaro, and S. Capitani (1997)
Blood 90, 2234-2243
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Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38- Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin.

O. J. Borge, V. Ramsfjell, L. Cui, and S. E.W. Jacobsen (1997)
Blood 90, 2282-2292
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Regulation of the Serum Concentration of Thrombopoietin in Thrombocytopenic NF-E2 Knockout Mice.

R. A. Shivdasani, P. Fielder, G.-A. Keller, S. H. Orkin, and F. J. de Sauvage (1997)
Blood 90, 1821-1827
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Metabolism of Thrombopoietin (TPO) In Vivo: Determination of the Binding Dynamics for TPO in Mice.

E. Stefanich, T. Senn, R. Widmer, C. Fratino, G.-A. Keller, and P. J. Fielder (1997)
Blood 89, 4063-4070
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Thrombopoietin Does Not Induce Lineage-Restricted Commitment of Mpl-R Expressing Pluripotent Progenitors But Permits Their Complete Erythroid and Megakaryocytic Differentiation.

F. Goncalves, C. Lacout, J.-L. Villeval, F. Wendling, W. Vainchenker, and D. Dumenil (1997)
Blood 89, 3544-3553
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Human Platelets as a Model for the Binding and Degradation of Thrombopoietin.

P. J. Fielder, P. Hass, M. Nagel, E. Stefanich, R. Widmer, G. L. Bennett, G.-A. Keller, F. J. de Sauvage, and D. Eaton (1997)
Blood 89, 2782-2788
 |  Abstract »  |  Full Text »  |  PDF »

Human Platelets Display High-Affinity Receptors for Thrombopoietin.

V. C. Broudy, N. L. Lin, D. F. Sabath, T. Papayannopoulou, and K. Kaushansky (1997)
Blood 89, 1896-1904
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Thrombopoietin Enhances Proliferation and Differentiation of Murine Yolk Sac Erythroid Progenitors.

T. Era, T. Takahashi, K. Sakai, K. Kawamura, and T. Nakano (1997)
Blood 89, 1207-1213
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Effects of Polyethylene Glycol-Conjugated Recombinant Human Megakaryocyte Growth and Development Factor on Platelet Counts after Chemotherapy for Lung Cancer.

M. Fanucchi, J. Glaspy, J. Crawford, J. Garst, R. Figlin, W. Sheridan, D. Menchaca, D. Tomita, H. Ozer, and L. Harker (1997)
N. Engl. J. Med. 336, 404-409
 |  Abstract »  |  Full Text »  |  PDF »

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