Science 2 September 1994: Vol. 265. no. 5177, pp. 1442 - 1445 DOI: 10.1126/science.8073286

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Articles

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.

L. Schulte-Uentrop, R. A. El-Awady, L. Schliecker, H. Willers, and J. Dahm-Daphi (2008)
Nucleic Acids Res. 36, 2561-2569
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer.

H. Li, H. Vogel, V. B. Holcomb, Y. Gu, and P. Hasty (2007)
Mol. Cell. Biol. 27, 8205-8214
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 Participates in the Targeting of Retroviral Transgenes to the Chromatin of CHO Cells.

C. Masson, S. Bury-Mone, E. Guiot, A. Saez-Cirion, D. Schoevaert-Brossault, C. Brachet-Ducos, O. Delelis, F. Subra, L. Jeanson-Leh, and J.-F. Mouscadet (2007)
J. Virol. 81, 7924-7932
 |  Abstract »  |  Full Text »  |  PDF »

Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase.

A. E. O. Fisher, H. Hochegger, S. Takeda, and K. W. Caldecott (2007)
Mol. Cell. Biol. 27, 5597-5605
 |  Abstract »  |  Full Text »  |  PDF »

The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death.

A. G. Polischouk, A. Holgersson, D. Zong, B. Stenerlow, H. L. Karlsson, L. Moller, K. Viktorsson, and R. Lewensohn (2007)
Mol. Cancer Ther. 6, 2303-2309
 |  Abstract »  |  Full Text »  |  PDF »

Saccharomyces cerevisiae Sae2- and Tel1-Dependent Single-Strand DNA Formation at DNA Break Promotes Microhomology-Mediated End Joining.

K. Lee and S. E. Lee (2007)
Genetics 176, 2003-2014
 |  Abstract »  |  Full Text »  |  PDF »

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends.

C. J. Tsai, S. A. Kim, and G. Chu (2007)
PNAS 104, 7851-7856
 |  Abstract »  |  Full Text »  |  PDF »

Loading of the Nonhomologous End Joining Factor, Ku, on Protein-occluded DNA Ends.

S. A. Roberts and D. A. Ramsden (2007)
J. Biol. Chem. 282, 10605-10613
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionary and Functional Conservation of the DNA Non-homologous End-joining Protein, XLF/Cernunnos.

P. Hentges, P. Ahnesorg, R. S. Pitcher, C. K. Bruce, B. Kysela, A. J. Green, J. Bianchi, T. E. Wilson, S. P. Jackson, and A. J. Doherty (2006)
J. Biol. Chem. 281, 37517-37526
 |  Abstract »  |  Full Text »  |  PDF »

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

T. L Blundell, B. L Sibanda, R. W. Montalvao, S. Brewerton, V. Chelliah, C. L Worth, N. J Harmer, O. Davies, and D. Burke (2006)
Phil Trans R Soc B 361, 413-423
 |  Abstract »  |  Full Text »  |  PDF »

Distinct modes of DNA damage response in S. pombe G0 and vegetative cells.

S. Mochida and M. Yanagida (2006)
Genes Cells 11, 13-27
 |  Abstract »  |  Full Text »  |  PDF »

Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein.

K. R. Jones, D. A. Gewirtz, S. M. Yannone, S. Zhou, D. G. Schatz, K. Valerie, and L. F. Povirk (2005)
Mol. Cancer Ther. 4, 1541-1547
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic H-Ras Up-regulates Expression of Ku80 to Protect Cells from {gamma}-Ray Irradiation in NIH3T3 Cells.

I.-Y. Chang, C.-K. Youn, H.-B. Kim, M.-H. Kim, H.-J. Cho, Y. Yoon, Y.-S. Lee, M.-H. Chung, and H. J. You (2005)
Cancer Res. 65, 6811-6819
 |  Abstract »  |  Full Text »  |  PDF »

Ku86 preserves chromatin integrity in cells adapted to high NaCl.

N. I. Dmitrieva, A. Celeste, A. Nussenzweig, and M. B. Burg (2005)
PNAS 102, 10730-10735
 |  Abstract »  |  Full Text »  |  PDF »

DNA-Dependent Protein Kinase Is a Molecular Target for the Development of Noncytotoxic Radiation-Sensitizing Drugs.

E. T. Shinohara, L. Geng, J. Tan, H. Chen, Y. Shir, E. Edwards, J. Halbrook, E. A. Kesicki, A. Kashishian, and D. E. Hallahan (2005)
Cancer Res. 65, 4987-4992
 |  Abstract »  |  Full Text »  |  PDF »

Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway.

L. Deriano, O. Guipaud, H. Merle-Beral, J.-L. Binet, M. Ricoul, G. Potocki-Veronese, V. Favaudon, Z. Maciorowski, C. Muller, B. Salles, et al. (2005)
Blood 105, 4776-4783
 |  Abstract »  |  Full Text »  |  PDF »

DNA damage response and Ku80 function in the vertebrate embryo.

C. L. Bladen, W. K. Lam, W. S. Dynan, and D. J. Kozlowski (2005)
Nucleic Acids Res. 33, 3002-3010
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of a Novel Ku70/80 Pause Site at the H19/Igf2 Imprinting Control Region.

D. J. Katz, M. A. Beer, J. M. Levorse, and S. M. Tilghman (2005)
Mol. Cell. Biol. 25, 3855-3863
 |  Abstract »  |  Full Text »  |  PDF »

Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and {gamma} radiation.

I. S. Ayene, L. P. Ford, and C. J. Koch (2005)
Mol. Cancer Ther. 4, 529-536
 |  Abstract »  |  Full Text »  |  PDF »

Fluorescence Anisotropy Studies on the Ku-DNA Interaction: ANION AND CATION EFFECTS.

D. Arosio, S. Costantini, Y. Kong, and A. Vindigni (2004)
J. Biol. Chem. 279, 42826-42835
 |  Abstract »  |  Full Text »  |  PDF »

A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.

S. L. Donahue and C. Campbell (2004)
Nucleic Acids Res. 32, 3248-3257
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility.

J. Byrum, S. Jordan, S. T. Safrany, and W. Rodgers (2004)
Nucleic Acids Res. 32, 2776-2784
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of P450scc Gene Expression in the Embryonic Rodent Nervous System.

F. Hammer, N. A. Compagnone, J.-L. Vigne, S. R. Bair, and S. H. Mellon (2004)
Endocrinology 145, 901-912
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.

S. Zhang, B. Schlott, M. Gorlach, and F. Grosse (2004)
Nucleic Acids Res. 32, 1-10
 |  Abstract »  |  Full Text »  |  PDF »

Which end: dissecting Ku's function at telomeres and double-strand breaks.

A. A. Bertuch and V. Lundblad (2003)
Genes & Dev. 17, 2347-2350
 |  Full Text »  |  PDF »

Nonhomologous end joining and V(D)J recombination require an additional factor.

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo (2003)
PNAS 100, 2462-2467
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.

D. Matheos, O. Novac, G. B. Price, and M. Zannis-Hadjopoulos (2003)
J. Cell Sci. 116, 111-124
 |  Abstract »  |  Full Text »  |  PDF »

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

T. Woods, W. Wang, E. Convery, A. Errami, M. Z. Zdzienicka, and K. Meek (2002)
Nucleic Acids Res. 30, 5120-5128
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Ku70 and Ku80 Mediated by NF-kappa B and Cyclooxygenase-2 Is Related to Proliferation of Human Gastric Cancer Cells.

J. W. Lim, H. Kim, and K. H. Kim (2002)
J. Biol. Chem. 277, 46093-46100
 |  Abstract »  |  Full Text »  |  PDF »

Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites.

X. Mo and W. S. Dynan (2002)
Mol. Cell. Biol. 22, 8088-8099
 |  Abstract »  |  Full Text »  |  PDF »

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.

S. K. Mauldin, R. C. Getts, W. Liu, and T. D. Stamato (2002)
Nucleic Acids Res. 30, 4075-4087
 |  Abstract »  |  Full Text »  |  PDF »

Studies on the Mode of Ku Interaction with DNA.

D. Arosio, S. Cui, C. Ortega, M. Chovanec, S. Di Marco, G. Baldini, A. Falaschi, and A. Vindigni (2002)
J. Biol. Chem. 277, 9741-9748
 |  Abstract »  |  Full Text »  |  PDF »

DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei.

P. Grandi, M. Eltsov, I. Nielsen, and I. Raska (2002)
J. Cell Sci. 114, 3345-3357
 |  Abstract »  |  Full Text »  |  PDF »

Restriction enzymes increase efficiencies of illegitimate DNA integration but decrease homologous integration in mammalian cells.

P. Manivasakam, J. Aubrecht, S. Sidhom, and R. H. Schiestl (2001)
Nucleic Acids Res. 29, 4826-4833
 |  Abstract »  |  Full Text »  |  PDF »

High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.

M. Ochiai, T. Ubagai, T. Kawamori, H. Imai, T. Sugimura, and H. Nakagama (2001)
Carcinogenesis 22, 1551-1555
 |  Abstract »  |  Full Text »  |  PDF »

Increased Gene Amplification in Immortal Rodent Cells Deficient for the DNA-dependent Protein Kinase Catalytic Subunit.

C. Mondello, P. Rebuzzini, M. Dolzan, S. Edmonson, G. E. Taccioli, and E. Giulotto (2001)
Cancer Res. 61, 4520-4525
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase.

M. M. Purugganan, S. Shah, J. F. Kearney, and D. B. Roth (2001)
Nucleic Acids Res. 29, 1638-1646
 |  Abstract »  |  Full Text »  |  PDF »

Gestational Age and Gender-specific In Utero V(D)J Recombinase-mediated Deletions.

M. Yoshioka, J. P. O’Neill, P. M. Vacek, and B. A. Finette (2001)
Cancer Res. 61, 3432-3438
 |  Abstract »  |  Full Text »

Gene Expression Patterns in the Lungs of Patients With Primary Pulmonary Hypertension : A Gene Microarray Analysis.

M. W. Geraci, M. Moore, T. Gesell, M. E. Yeager, L. Alger, H. Golpon, B. Gao, J. E. Loyd, R. M. Tuder, and N. F. Voelkel (2001)
Circ. Res. 88, 555-562
 |  Abstract »  |  Full Text »  |  PDF »

RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors.

C. Arnaudeau, L. Rozier, C. Cazaux, M. Defais, D. Jenssen, and T. Helleday (2001)
Nucleic Acids Res. 29, 662-667
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits.

J Bertinato, C Schild-Poulter, and R. Hache (2001)
J. Cell Sci. 114, 89-99
 |  Abstract »  |  PDF »

A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells.

E. Marangoni, N. Foray, M. O'Driscoll, S. Douc-Rasy, J. Bernier, J. Bourhis, and P. Jeggo (2000)
Nucleic Acids Res. 28, 4778-4782
 |  Abstract »  |  Full Text »  |  PDF »

Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage.

Y.-T. Tai, G. Teoh, B. Lin, F. E. Davies, D. Chauhan, S. P. Treon, N. Raje, T. Hideshima, Y. Shima, K. Podar, et al. (2000)
J. Immunol. 165, 6347-6355
 |  Abstract »  |  Full Text »  |  PDF »

Ku acts in a unique way at the mammalian telomere to prevent end joining.

H.-L. Hsu, D. Gilley, S. A. Galande, M. P. Hande, B. Allen, S.-H. Kim, G. C. Li, J. Campisi, T. Kohwi-Shigematsu, and D. J. Chen (2000)
Genes & Dev. 14, 2807-2812
 |  Abstract »  |  Full Text »

An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.

G. Coffey and C. Campbell (2000)
Nucleic Acids Res. 28, 3793-3800
 |  Abstract »  |  Full Text »  |  PDF »

Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells.

R. Fukumura, R. Araki, A. Fujimori, Y. Tsutsumi, A. Kurimasa, G. C. Li, D. J. Chen, K. Tatsumi, and M. Abe (2000)
J. Immunol. 165, 3883-3889
 |  Abstract »  |  Full Text »  |  PDF »

DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.

E. Feldmann, V. Schmiemann, W. Goedecke, S. Reichenberger, and P. Pfeiffer (2000)
Nucleic Acids Res. 28, 2585-2596
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53.

D.-S. Lim, H. Vogel, D. M. Willerford, A. T. Sands, K. A. Platt, and P. Hasty (2000)
Mol. Cell. Biol. 20, 3772-3780
 |  Abstract »  |  Full Text »

Evidence for Class-Specific Factors in Immunoglobulin Isotype Switching.

A. Shanmugam, M.-J. Shi, L. Yauch, J. Stavnezer, and A. L. Kenter (2000)
J. Exp. Med. 191, 1365-1380
 |  Abstract »  |  Full Text »  |  PDF »

Ionizing Radiation Exposure Results in Up-regulation of Ku70 via a p53/Ataxia-Telangiectasia-mutated Protein-dependent Mechanism.

K. D. Brown, T. A. Lataxes, S. Shangary, J. L. Mannino, J. F. Giardina, J. Chen, and R. Baskaran (2000)
J. Biol. Chem. 275, 6651-6656
 |  Abstract »  |  Full Text »  |  PDF »

Analyses of TCRB Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination.

E. K. Shin, T. Rijkers, A. Pastink, and K. Meek (2000)
J. Immunol. 164, 1416-1424
 |  Abstract »  |  Full Text »  |  PDF »

Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action.

M. E. Cardenas, M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman (1999)
Clin. Microbiol. Rev. 12, 583-611
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase.

S. Mickelsen, C. Snyder, K. Trujillo, M. Bogue, D. B. Roth, and K. Meek (1999)
J. Immunol. 163, 834-843
 |  Abstract »  |  Full Text »  |  PDF »

Photocross-linking of an Oriented DNA Repair Complex. Ku BOUND AT A SINGLE DNA END.

S. Yoo, A. Kimzey, and W. S. Dynan (1999)
J. Biol. Chem. 274, 20034-20039
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.

G. Luo, M. S. Yao, C. F. Bender, M. Mills, A. R. Bladl, A. Bradley, and J. H. J. Petrini (1999)
PNAS 96, 7376-7381
 |  Abstract »  |  Full Text »  |  PDF »

Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription.

W. Giffin, W. Gong, C. Schild-Poulter, and R. J. G. Hache (1999)
Mol. Cell. Biol. 19, 4065-4078
 |  Abstract »  |  Full Text »  |  PDF »

The Ability of p53 to Activate Downstream Genes p21WAF1/cip1 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase.

L. A. Kachnic, B. Wu, H. Wunsch, K. L. Mekeel, J. S. DeFrank, W. Tang, and S. N. Powell (1999)
J. Biol. Chem. 274, 13111-13117
 |  Abstract »  |  Full Text »  |  PDF »

The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit.

B. K. Singleton, M. I. Torres-Arzayus, S. T. Rottinghaus, G. E. Taccioli, and P. A. Jeggo (1999)
Mol. Cell. Biol. 19, 3267-3277
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-dependent protein kinase.

G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
 |  Full Text »

Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts.

P. Labhart (1999)
Mol. Cell. Biol. 19, 2585-2593
 |  Abstract »  |  Full Text »  |  PDF »

OBA/Ku86: DNA Binding Specificity and Involvement in Mammalian DNA Replication.

M. T. Ruiz, D. Matheos, G. B. Price, and M. Zannis-Hadjopoulos (1999)
Mol. Biol. Cell 10, 567-580
 |  Abstract »  |  Full Text »

Bacteriophage T4 gp2 Interferes with Cell Viability and with Bacteriophage Lambda Red Recombination.

K. Appasani, D. S. Thaler, and E. B. Goldberg (1999)
J. Bacteriol. 181, 1352-1355
 |  Abstract »  |  Full Text »

The Ku70 autoantigen interacts with p40phox in B lymphocytes.

N Grandvaux, S Grizot, P. Vignais, and M. Dagher (1999)
J. Cell Sci. 112, 503-513
 |  Abstract »  |  PDF »

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance.

S. Moreau, J. R. Ferguson, and L. S. Symington (1999)
Mol. Cell. Biol. 19, 556-566
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous End-joining Proteins Are Required for V(D)J Recombination, Normal Growth, and Neurogenesis.

J.M. SEKIGUCHI, Y. GAO, Y. GU, K. FRANK, Y. SUN, J. CHAUDHURI, C. ZHU, H.-L. CHENG, J. MANIS, D. FERGUSON, et al. (1999)
Cold Spring Harb Symp Quant Biol 64, 169-182
 |  Abstract »  |  PDF »

Nuclear Extracts Lacking DNA-dependent Protein Kinase Are Deficient in Multiple Round Transcription.

R. L. Woodard, M. G. Anderson, and W. S. Dynan (1999)
J. Biol. Chem. 274, 478-485
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos and DNA Double Strand Breaks.

R. Okayasu, S. Takahashi, S. Yamada, T. K. Hei, and R. L. Ullrich (1999)
Cancer Res. 59, 298-300
 |  Abstract »  |  Full Text »  |  PDF »

Terminal Deoxynucleotidyl Transferase Expression During Neonatal Life Alters DH Reading Frame Usage and Ig-Receptor-Dependent Selection of V Regions.

A. J. Marshall, N. Doyen, L. A. Bentolila, C. J. Paige, and G. E. Wu (1998)
J. Immunol. 161, 6657-6663
 |  Abstract »  |  Full Text »  |  PDF »

DNA end-joining catalyzed by human cell-free extracts.

P. Baumann and S. C. West (1998)
PNAS 95, 14066-14070
 |  Abstract »  |  Full Text »  |  PDF »

Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination.

V. Smider, W. K. Rathmell, G. Brown, S. Lewis, and G. Chu (1998)
Mol. Cell. Biol. 18, 6853-6858
 |  Abstract »  |  Full Text »

Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle.

P. Muñoz, M. Z. Zdzienicka, J.-M. Blanchard, and J. Piette (1998)
Mol. Cell. Biol. 18, 5797-5808
 |  Abstract »  |  Full Text »

Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini.

R. B. West, M. Yaneva, and M. R. Lieber (1998)
Mol. Cell. Biol. 18, 5908-5920
 |  Abstract »  |  Full Text »

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo.

D. K. Bishop, U. Ear, A. Bhattacharyya, C. Calderone, M. Beckett, R. R. Weichselbaum, and A. Shinohara (1998)
J. Biol. Chem. 273, 21482-21488
 |  Abstract »  |  Full Text »  |  PDF »

Sequence-specific Binding of Ku Autoantigen to Single-stranded DNA.

H. Torrance, W. Giffin, D. J. Rodda, L. Pope, and R. J. G. Hache (1998)
J. Biol. Chem. 273, 20810-20819
 |  Abstract »  |  Full Text »  |  PDF »

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching.

J. P. Manis, Y. Gu, R. Lansford, E. Sonoda, R. Ferrini, L. Davidson, K. Rajewsky, and F. W. Alt (1998)
J. Exp. Med. 187, 2081-2089
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase.

T. Ruscetti, B. E. Lehnert, J. Halbrook, H. Le Trong, M. F. Hoekstra, D. J. Chen, and S. R. Peterson (1998)
J. Biol. Chem. 273, 14461-14467
 |  Abstract »  |  Full Text »  |  PDF »

Murine Cell Line SX9 Bearing a Mutation in the dna-pkcs Gene Exhibits Aberrant V(D)J Recombination Not Only in the Coding Joint but Also in the Signal Joint.

R. Fukumura, R. Araki, A. Fujimori, M. Mori, T. Saito, F. Watanabe, M. Sarashi, H. Itsukaichi, K. Eguchi-Kasai, K. Sato, et al. (1998)
J. Biol. Chem. 273, 13058-13064
 |  Abstract »  |  Full Text »  |  PDF »

A Negative Vitamin D Response DNA Element in the Human Parathyroid Hormone-related Peptide Gene Binds to Vitamin D Receptor Along with Ku Antigen to Mediate Negative Gene Regulation by Vitamin D.

T. Nishishita, T. Okazaki, T. Ishikawa, T. Igarashi, K. Hata, E. Ogata, and T. Fujita (1998)
J. Biol. Chem. 273, 10901-10907
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat.

R. F. Chun, O. J. Semmes, C. Neuveut, and K.-T. Jeang (1998)
J. Virol. 72, 2615-2629
 |  Abstract »  |  Full Text »  |  PDF »

Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku-DNA-Dependent Protein Kinase Complex.

N. A. Barlev, V. Poltoratsky, T. Owen-Hughes, C. Ying, L. Liu, J. L. Workman, and S. L. Berger (1998)
Mol. Cell. Biol. 18, 1349-1358
 |  Abstract »  |  Full Text »

Analysis of DNA Binding Proteins Associated With Hemin-Induced Transcriptional Inhibition. The Hemin Response Element Binding Protein Is a Heterogeneous Complex That Includes the Ku Protein.

S.V. Reddy, O. Alcantara, and D.H. Boldt (1998)
Blood 91, 1793-1801
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.

O. Hammarsten and G. Chu (1998)
PNAS 95, 525-530
 |  Abstract »  |  Full Text »  |  PDF »

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase.

R. Leber, T. W. Wise, R. Mizuta, and K. Meek (1998)
J. Biol. Chem. 273, 1794-1801
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Two Domains of the p70 Ku Protein Mediating Dimerization with p80 and DNA Binding.

J. Wang, X. Dong, K. Myung, E. A. Hendrickson, and W. H. Reeves (1998)
J. Biol. Chem. 273, 842-848
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of Proliferating Cell Nuclear Antigen-dependent Apurinic/Apyrimidinic Site Repair on Linear DNA.

S. Biade, R. W. Sobol, S. H. Wilson, and Y. Matsumoto (1998)
J. Biol. Chem. 273, 898-902
 |  Abstract »  |  Full Text »  |  PDF »

Defining the Minimal Domain of Ku80 for Interaction with Ku70.

O. Osipovich, S. K. Durum, and K. Muegge (1997)
J. Biol. Chem. 272, 27259-27265
 |  Abstract »  |  Full Text »  |  PDF »

Double Strand Break Repair.

G. Chu (1997)
J. Biol. Chem. 272, 24097-24100
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Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo.

H. Ouyang, A. Nussenzweig, A. Kurimasa, V. d. C. Soares, X. Li, C. Cordon-Cardo, W.-h. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. (1997)
J. Exp. Med. 186, 921-929
 |  Abstract »  |  Full Text »  |  PDF »

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

N. Liu, J. E. Lamerdin, J. D. Tucker, Z.-Q. Zhou, C. A. Walter, J. S. Albala, D. B. Busch, and L. H. Thompson (1997)
PNAS 94, 9232-9237
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila P-element transposase is a novel site-specific endonuclease.

E. L. Beall and D. C. Rio (1997)
Genes & Dev. 11, 2137-2151
 |  Abstract »  |  Full Text »  |  PDF »

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Y. Gu, S. Jin, Y. Gao, D. T. Weaver, and F. W. Alt (1997)
PNAS 94, 8076-8081
 |  Abstract »  |  Full Text »  |  PDF »

Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fos Inhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner.

D. W. Abbott and J. T. Holt (1997)
J. Biol. Chem. 272, 14005-14008
 |  Abstract »  |  Full Text »  |  PDF »

DNA looping by Ku and the DNA-dependent protein kinase.

R. B. Cary, S. R. Peterson, J. Wang, D. G. Bear, E. M. Bradbury, and D. J. Chen (1997)
PNAS 94, 4267-4272
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Two DNA Double-stranded Break Repair-deficient Cell Lines That Express Inactive DNA-dependent Protein Kinase Catalytic Subunits.

S. R. Peterson, M. Stackhouse, M. J. Waltman, F. Chen, K. Sato, and D. J. Chen (1997)
J. Biol. Chem. 272, 10227-10231
 |  Abstract »  |  Full Text »  |  PDF »

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase. PHOSPHORYLATION OF Ser-527 OF THE RAT GLUCOCORTICOID RECEPTOR.

W. Giffin, J. Kwast-Welfeld, D. J. Rodda, G. G. Prefontaine, M. Traykova-Andonova, Y. Zhang, N. L. Weigel, Y. A. Lefebvre, and R. J.G. Hache (1997)
J. Biol. Chem. 272, 5647-5658
 |  Abstract »  |  Full Text »  |  PDF »

Ku Selectively Transfers between DNA Molecules with Homologous Ends.

T. M. Bliss and D. P. Lane (1997)
J. Biol. Chem. 272, 5765-5773
 |  Abstract »  |  Full Text »  |  PDF »

End-joining of Free Radical-mediated DNA Double-strand Breaks in Vitro Is Blocked by the Kinase Inhibitor Wortmannin at a Step Preceding Removal of Damaged 3' Termini.

X.-Y. Gu, R. A.O. Bennett, and L. F. Povirk (1996)
J. Biol. Chem. 271, 19660-19663
 |  Abstract »  |  Full Text »  |  PDF »

DNA Binding Specificities of YPF1, a Drosophila Homolog to the DNA Binding Subunit of Human DNA-dependent Protein Kinase, Ku.

D. B. Jacoby and P. C. Wensink (1996)
J. Biol. Chem. 271, 16827-16832
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Ku86 Variant Protein That Results in Altered DNA Binding and Diminished DNA-dependent Protein Kinase Activity.

Z. Han, C. Johnston, W. H. Reeves, T. Carter, J. H. Wyche, and E. A. Hendrickson (1996)
J. Biol. Chem. 271, 14098-14104
 |  Abstract »  |  Full Text »  |  PDF »

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