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Science 2 September 1994:
Vol. 265. no. 5177, pp. 1401 - 1404
DOI: 10.1126/science.7521064
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Articles

Science, Vol 265, Issue 5177, 1401-1404
Copyright © 1994 by American Association for the Advancement of Science

articles

Vaccine technologies: view to the future

NR Rabinovich, P McInnes, DL Klein, and BF Hall

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982-9902.

The development of vaccines to prevent infectious diseases has been one of the most important contributions of biomedical science. Recent advances in the basic sciences are now fueling the development of a new generation of vaccines that will be based on rational design approaches. Two factors are making this possible: an improved understanding of the microbial factors required for virulence and the nature of the immune response to infection. The status of new vaccine technologies is summarized here.


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